Ngowuphi umhlaza onokuzuza ngokubandakanya iAndrographis kwisidlo sabo?

Iimbalasane

IAndrographis yamkelwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kakuhle kweAndrographis kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, i-Andrographis inokuba luncedo kwabo bane-Primary Glioblastoma ephantsi kwe-Temozolomide, kodwa isenokungabi ilungile kwizigulana ezifumana i-Carmustine yePrimary Pineoblastoma. Ngaphaya koko, ngexa i-Andrographis inokunceda abantu abanomngcipheko wemfuzo “CDKN2A”, ayinakucetyiswa kwabo banengozi yemfuzo eyahlukileyo. Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kwe-Andrographis kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, iingozi zemfuzo, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba iAndrographis lolona khetho lufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke iinxalenye ezisebenzayo ekutyeni / nezongezo ezifana ne-Andrographis endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungahoyi ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise iAndrographis kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye i-Andrographis ukuba unemfuza enokuthanani nomhlaza onxulumene ne-CDKN2A gene? Kuthekani ukuba endaweni yoko umngcipheko wakho wemfuza uvela komnye umfuzo? Ngaba kuluncedo ukuquka iAndrographis kwisidlo sakho ukuba ufunyaniswe unePrimary Pineoblastoma, okanye ukuba uxilongo lwakho yiPrimary Glioblastoma? Ngaphezu koko, ukusetyenziswa kwakho kwe-Andrographis kufuneka kulungiswe njani ukuba ufumana unyango lwe-Temozolomide okanye ukuba isicwangciso sakho sonyango sisuka kwiTemozolomide ukuya kwiCarmustine? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'ne-Andrographis yendalo, ngoko ke isoloko iluncedo' okanye 'i-Andrographis inyusa ukhuselo lomzimba' akonelanga kukhetho lokutya/lokuncedisa.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya i-Andrographis kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana ne-Andrographis kwisidlo sakho ngenxa yezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, onje ngePrimary Glioblastoma okanye iPrimary Pineoblastoma, iindlela zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kubandakanyeka kwimingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana neAndrographis. Ngaba umngcipheko wemfuzo womhlaza osuka kutshintsho kwi-CDKN2A uneempembelelo zendlela yebhayoloji efanayo njengotshintsho kwijeni? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana nePrimary Glioblastoma ulingana nePrimary Pineoblastoma? Ngapha koko, ngaba ukuqwalaselwa kokutya kuhlala kuyafana kwabo baphantsi kweCarmustine njengabo bafumana iTemozolomide? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

Andrographis - Isongezelelo seZondlo

I-Andrographis eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, kuquka i-Andrographolide, nganye ekhoyo kwiimpawu ezihlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-Cell Cycle kunye ne-Oncogenic Cancer Epigenetics, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeAndrographis, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iAndrographis kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufanayo nonyango lomhlaza, ukusetyenziswa kwe-Andrographis ayisosigqibo sehlabathi lonke esilungele zonke iimhlaza kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zeAndrographis

Ukuphendula umbuzo othi 'Ndingayiphepha nini i-Andrographis kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye iinzuzo ze-Andrographis ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye nayo nayiphi na i-allergies yonke idlala indima ekunqumeni ukuba i-Andrographis ifanelekile okanye kufuneka ithintelwe, igxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba i-Andrographis Supplements iya kuxhamla kwiZigulana zePineoblastoma eziphantsi konyango lweCarmustine?

I-Primary Pineoblastoma ibonakaliswe ngokuguqulwa kofuzo oluthile, okuyi-ATR, i-ATM kunye ne-CREBBP, ekhokelela ekutshintsheni kwiindlela ze-biochemical pathways, ngokukodwa i-Oncogenic Cancer Epigenetics, i-DNA Repair, i-Cell Cycle Checkpoints, i-G-protein-coupled Receptor Signaling kunye ne-Immune Evasion Signaling. Ukusebenza konyango lomhlaza, njengeCarmustine, kuxhomekeke kwindlela yayo yokusebenza kwezi ndlela zithile. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, isongezelelo se-Andrographis, esichaphazela i-Oncogenic Cancer Epigenetics, ayinakuba lukhetho olufanelekileyo kwimeko ye-Primary Pineoblastoma xa ihamba ngeCarmustine. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba i-Andrographis Supplements iya kuxhamla kwiZigulana zeGlioblastoma eziphambili eziphantsi koNyango lweTemozolomide?

I-Glioblastoma eyiprayimari ichongiwe ngokuguqulwa kofuzo oluthile, njenge-TRBV7-7, TAS2R46 kunye ne-TP53, ebangela utshintsho kwiindlela ze-biochemical pathways, ngokukodwa i-Cell Cycle, i-Cell Cycle Checkpoints kunye ne-Apoptosis. Ukusebenza kwonyango lomhlaza, njengeTemozolomide, kuchongwa ngokusebenzisana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo se-Andrographis lukhetho olunengqiqo kulabo abane-Primary Glioblastoma ephantsi kweTemozolomide. Oku kungenxa yokuba i-Andrographis ichaphazela iindlela ezifana ne-Cell Cycle, enokuthi inqanda izinto eziqhuba i-Primary Glioblastoma okanye izuze ukusebenza kweTemozolomide.

3. Ingaba izongezo zeAndrographis zikhuselekile kubantu abasempilweni abaneCDKN2A Mutation Associated Genetic Risk?

I-CDKN2A idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-CDKN2A kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-Cell Cycle Checkpoints kunye ne-Cell Cycle, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-CDKN2A ehambelana noMhlaza woLusu, cinga ngokubandakanya izongezo ze-Andrographis kwisicwangciso sakho sesondlo. Ezi zongezelelo zinokuphembelela ngendlela eyiyo iindlela ezifana neCell Cycle, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abaneenguqu ze-CDKN2A kunye neenkxalabo zempilo ezinxulumeneyo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezelelo ezifana neAndrographis, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• Ushicilelo lweminwe lweentlobo ngeentlobo nge-DNA probes ezenziwe kwiitemplate ze-DNA ezingashukumiyo ezinomsonto omnye.
• cBioPortal for Cancer Genomics
• I-Andrographolide ichasene nomsi wecuba-i-epithelial-mesenchymal transition kunye nokungasebenzi kakuhle kwemiphunga ngokusebenzisa i-anti-inflammatory inhibiting HOTAIR.
• Uguqulo lwe-IDH1/2 luphawu olulindelekileyo lokusinda kwaye luqikelela impendulo kwi-chemotherapy ye-gliomas yeBakala II enyangwe ngaxeshanye nonyango lwemitha.
• cBioPortal for Cancer Genomics
• Unyango lomhlaza lubumba ubume bokuqina be-clonal hematopoiesis.
• I-MGMT-inhibitor idibene ne-TGF-βRI inhibitor okanye i-CDK 4/6 inhibitor yandisa uvakalelo lwe-temozolomide kwiiseli ze-temozolomide-resistant glioblastoma.
• Imeko ye-somatic genomic ye-glioblastoma.