Ukutya kwentloko kunye neNtamo yeMucosal Melanoma!

intshayelelo

Ukutya kwentloko kunye neNtamo ye-Mucosal Melanoma kufuneka ilungiselelwe umntu ngamnye kwaye kufuneka ilungelelanise xa unyango lomhlaza okanye utshintsho lwemfuza yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

Kwintloko kunye neNtamo yeMucosal Melanoma ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu ayityayo?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza ngowomhlaza - kwimihlaza efana nentloko kunye neNtamo yeMucosal Melanoma ingaba ayinamsebenzi ukuba kukuphi ukutya endikutyayo kwaye ndingakwenzi? Okanye ukuba ndilandela ukutya okusekwe kwisityalo ngaba kwanele umhlaza onje ngentloko kunye neNeck Mucosal Melanoma?

Umzekelo ingaba inomsebenzi ukuba imifuno iWild Leek ityiwa kakhulu xa ithelekiswa neKale? Ngaba kuyawenza umahluko ukuba isiqhamo seStrobheli seGuava sikhethwa ngaphezu kweRed raspberry? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane/iimbewu ezifana neHazelnut eqhelekileyo phezu kweChestnut kunye nezityalo ezifana neCowpea ngaphezu kweSoy Bean. Kwaye ukuba into endiyidlayo ibalulekile - ngoko umntu uchonga njani ukutya okucetyiswayo kwiNtloko kunye neNtamo ye-Mucosal Melanoma kwaye ingaba impendulo efanayo kuye wonke umntu onokuxilongwa okufanayo okanye umngcipheko wemfuza?

Ewe! Ukutya okutyayo kubalulekile kwiNtloko kunye neNtamo yeMucosal Melanoma!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Ngokomzekelo i-Strawberry Guava iqulethe izithako ezisebenzayo i-Quercetin, i-Ellagic Acid, i-Apigenin, i-Myricetin, i-Isoliquiritigenin. Kwaye i-Red Raspberry iqulethe izithako ezisebenzayo i-Quercetin, i-Ellagic Acid, i-Isoliquiritigenin, i-Curcumin, i-Formononetin kwaye mhlawumbi nabanye.

Iphutha eliqhelekileyo elenziwe xa uthatha isigqibo kunye nokukhetha ukutya okutyayo kwiNtloko kunye neNeck Mucosal Melanoma - kukuvavanya kuphela izithako ezisebenzayo ezikhethiweyo eziqulethwe kukutya kwaye ungayihoyi ezinye. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha i-cherry izithako ezisebenzayo ekutyeni kunye nezongezelelo zokwenza isigqibo sesondlo seNtloko kunye neNtamo ye-Mucosal Melanoma.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwiNtloko kunye neNtamo ye-Mucosal Melanoma?

Isondlo esilungiselelwe wena somhlaza njengentloko kunye neNeck Mucosal Melanoma ibandakanya ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwiNtloko kunye neNtamo ye-Mucosal Melanoma biology, isayensi yokutya, imfuzo, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nobuthathaka obuhambelanayo apho unyango lunokuyeka ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza njengentloko kunye neNtamo yeMucosal Melanoma

Zonke ii-cancer ezifana neNtloko kunye neNtamo ye-Mucosal Melanoma inokubonakaliswa ngeseti ekhethekileyo yeendlela ze-biochemical - iindlela zokutyikitya zeNtloko kunye neNeck Mucosal Melanoma. Iindlela ze-Biochemical ezifana ne-RAS-RAF Signaling, i-mRNA Splicing, i-PI3K-AKT-MTOR Ukubonakaliswa, Ukubonakaliswa kwe-MAPK kuyingxenye yenkcazo yesiginesha yeNtloko kunye neNtamo ye-Mucosal Melanoma. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwiNtloko kunye neNtamo ye-Mucosal Melanoma kufuneka ithathele ingqalelo utyikityo lweendlela zebhayokhemikhali kwisigulana ngasinye somhlaza kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto okunye ukutya kunye nezongezo zicetyiswayo kwi-Head And Neck Mucosal Melanoma xa uthatha unyango lomhlaza IRadiation, kunye nokunye ukutya kunye nezongezelelo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-NRAS, i-NF1, i-PREX2, i-BRAF kunye ne-TERT zezona ziphezulu iigenes ezixeliweyo zeNtloko kunye neNeck Mucosal Melanoma. I-NRAS ixelwe kwi-19.6% yezigulane ezimele kuzo zonke izilingo zonyango. Kwaye i-NF1 ixelwe kwi-19.6%. Idatha yesigulana esidityanisiweyo sigubungela iminyaka ukusuka ukuya . I-42.0% yedatha yesigulane ichongwa njengamadoda. Intloko kunye neNtamo ye-Mucosal yebhayoloji yeMelanoma kunye ne-genetics exeliweyo kunye kunye zichaza inani labantu elimelwe utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenza isondlo somntu.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezo zeNtloko kunye neNtamo ye-Mucosal Melanoma

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha iVegetable WILD LEEK okanye i-KALE?

I-Vegetable Wild Leek iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Isoliquiritigenin, i-Curcumin, i-Formononetin, i-Lupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, TGFB Signaling, i-NFKB Signaling kunye ne-Oxidative Stress kunye nabanye. I-Wild Leek icetyiswa kwi-Head And Neck Mucosal Melanoma xa unyango oluqhubekayo lomhlaza luyiRadiation. Oku kungenxa yokuba i-Wild Leek ilungisa ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukwazisa isiphumo soMbane.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno Kale yi-Isoliquiritigenin, i-Curcumin, i-Formononetin, i-Lupeol, i-Luteolin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye noxinzelelo lwe-Oxidative kunye nezinye. I-Kale ayikhuthazwa kwiNtloko kunye neNeck Mucosal Melanoma xa unyango lomhlaza oluqhubekayo yiRadiation kuba iguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

I-LEEK YASEMTHETHO YOMFUNO ICEBISIWE PHEZU KWE-KALE NGENXA YENTLOKO NENXA YE-Mucosal Melanoma KUNYE NONYANGO LWERadiation.

Khetha iSiqhamo RED RASPBERRY okanye STRAWBERRY GUAVA?

Isiqhamo esiBomvu iRaspberry iqukethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Quercetin, i-Ellagic Acid, i-Isoliquiritigenin, i-Curcumin, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-PI3K-AKT-MTOR yokuSayina, i-NFKB yokuSayina kunye noxinzelelo lwe-Oxidative kunye nabanye. I-Red Raspberry iyacetyiswa kwiNtloko kunye neNtamo ye-Mucosal Melanoma xa unyango oluqhubekayo lomhlaza luyiRadiation. Oku kungenxa yokuba i-Red raspberry iguqula ezo ndlela ze-biochemical eziye zaxelwa ngokwesayensi ukwazisa isiphumo seRadiation.

Ezinye zezithako ezisebenzayo okanye i-bioactives kwiziqhamo ze-Strawberry Guava yi-Quercetin, i-Ellagic Acid, i-Apigenin, i-Myricetin, i-Isoliquiritigenin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-TGFB Signaling kunye ne-Oxidative Stress kunye nezinye. I-Strawberry Guava ayikhuthazwa kwiNtloko kunye neNtamo ye-Mucosal Melanoma xa unyango oluqhubekayo lomhlaza luyiRadiation kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO ERED RASPBERRY KUNCEBISWA NGAPHEZU KWE-STRAWBERRY GUAVA NGENXA YENKOSI neNtamo ye-Mucosal Melanoma KUNYE NONYANGO lweRadiation.

Khetha Nut COMMON HAZELNUT okanye CHESTNUT?

I-Hazelnut eqhelekileyo iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Quercetin, i-Myricetin, i-Isoliquiritigenin, i-Curcumin, i-Formononetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokuSayina kwe-MAPK, ukulungiswa kwe-DNA, ukuPhathwa kwe-TGFB kunye nokusinda kweeseli kunye nabanye. I-Hazelnut eqhelekileyo icetyiswa kwiNtloko kunye neNtamo ye-Mucosal Melanoma xa unyango oluqhubekayo lomhlaza luyiRadiation. Oku kungenxa yokuba iHazelnut eqhelekileyo iguqula ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukwazisa isiphumo seRadi.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yi-Ellagic Acid, i-Apigenin, i-Myricetin, i-Isoliquiritigenin, i-Curcumin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-TGFB Signaling kunye ne-Oxidative Stress kunye nezinye. I-Chestnut ayikhuthazwa kwiNtloko kunye neNtamo ye-Mucosal Melanoma xa unyango lomhlaza oluqhubekayo luyiRadiation kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

I-HAZELNUT EQHELEKILEYO IYANCEBISWA NGAPHEZU KWE-CHESTNUT NGENXA YENHLOKO NENKQUBO ye-Mucosal Melanoma KUNYE NONYANGO LWERadiation.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwe ngabantu abasengozini yemfuza yeNtloko kunye neNeck Mucosal Melanoma okanye imbali yosapho "Yintoni endimele ndiyitye ngokwahlukileyo kunangaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha iVegetable CAULIFLOWER okanye i-ARROWROOT?

I-Cauliflower yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Formononetin, i-Lupeol, i-Delphinidin, i-Isoliquiritigenin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK yokuSayina, i-RAS-RAF Signaling, i-MYC Signaling kunye ne-PI3K-AKT-MTOR yokuSayina kunye nabanye. I-Cauliflower iyacetyiswa kumngcipheko we-Head And Neck Mucosal Melanoma xa umngcipheko wemfuzo ohambelana ne-BRAF. Oku kungenxa yokuba iCauliflower yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ye-Arrowroot yi-Apigenin, i-Curcumin, i-Quercetin, i-Myricetin, i-Lycopene. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle Checkpoints kunye ne-Oncogenic Cancer Epigenetics kunye nezinye. I-Arrowroot ayikhuthazwa xa umngcipheko weNtloko kunye neNtamo ye-Mucosal Melanoma xa umngcipheko wezofuzo unxulumene ne-BRAF kuba inyusa iindlela zokutyikitya kuyo.

I-CAULIFLOWER YOMFUNO INCEBISWA NGAPHEZU KWE-ARROWROOT YEBRAF genetic RISK YOMHLAZA.

Khetha iSiqhamo ILAMONI okanye iPUMMELO?

I-Fruit Lemon iqukethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-D-limonene, i-Curcumin, i-Linalool, i-Formononetin, i-Lupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK yokuSayina, i-Cell Cycle Checkpoints, i-Hypoxia kunye ne-PI3K-AKT-MTOR Ukubonakaliswa kunye nabanye. I-Lemon icetyiswa kumngcipheko weNtloko kunye neNtamo ye-Mucosal Melanoma xa umngcipheko wemfuzo ohambelana ne-BRAF. Oku kungenxa yokuba iLamuni yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezithako ezisebenzayo okanye i-bioactives kwisiqhamo iPummelo yi-Apigenin, i-Curcumin, i-Quercetin, i-Lycopene, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle Checkpoints, i-MYC Signaling kunye ne-PI3K-AKT-MTOR yokuSayina kunye nabanye. IPummelo ayikhuthazwa xa umngcipheko weNtloko kunye neNtamo yeMucosal Melanoma xa umngcipheko wezofuzo uhambelana ne-BRAF kuba yonyusa iindlela zokutyikitya kuyo.

I-LEMON YESIQHAMO IYAKUCEBISWA PHEZU KWE-PUMMELO NGE-BRAF genetic RISK YOMHLAZA.

Khetha Nut BUTTERNUT okanye EUROPEAN CHESTNUT?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Myricetin, i-Lycopene, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK yokuSayina, i-Hypoxia, i-RAS-RAF Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Butternut icetyiswa kumngcipheko weNtloko kunye neNtamo yeMucosal Melanoma xa umngcipheko wemfuzo ohambelana ne-BRAF. Oku kungenxa yokuba i-Butternut yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yaseYurophu yi-Ellagic Acid, i-Apigenin, i-Curcumin, i-Quercetin, i-Myricetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MYC Signaling, i-Oncogenic Cancer Epigenetics kunye ne-PI3K-AKT-MTOR Ukubonakaliswa kunye nabanye. I-Chestnut yaseYurophu ayikhuthazwa xa umngcipheko weNtloko kunye neNtamo ye-Mucosal Melanoma xa umngcipheko wezofuzo uhambelana ne-BRAF kuba yonyusa iindlela zokutyikitya kuyo.

IBHUTTERNUT KUCEBISWA NGAPHEZU KWE-EUROPA CHESTNUT YEBRAF genetic RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezelelo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza njengentloko kunye neNeck Mucosal Melanoma. Intloko kunye neNeck izigulane ze-Melanoma kunye nabantu abasengozini yemfuza bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye zingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza njengentloko kunye neNtamo yeMucosal Melanoma, nganye inemfuza eyahlukileyo yethumba kunye nokwahluka kwe-genomic ngakumbi kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okufana neWild Leek kuqulethe izinto ezahlukeneyo zebhayoloji kwimiyinge eyahlukeneyo, enefuthe kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo somhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo somntu we-addon wesondlo senza isigqibo esilula kwaye sisuse yonke into eqikelelwayo ekuphenduleni umbuzo othi, "Yintoni ukutya endimele ndiyikhethe okanye ndingakhethi kwiNtloko kunye neNeck Mucosal Melanoma?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Tmb Mskcc 2018
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