Ukutya kweSifo se-Paget esigqithisileyo!

intshayelelo

Ukutya kwi-Extramammary Paget Disease kufuneka ilungiselelwe umntu ngamnye kwaye kufuneka ilungelelanise xa unyango lomhlaza okanye utshintsho lwemfuza yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

Isifo se-Extramammary Paget, umhlaza wolusu onqabileyo ochaphazela kakhulu iindawo ezinoxinano oluphezulu lwamadlala e-apocrine, zibonakalisa imingeni ekhethekileyo ekuxilongeni nasekunyangweni. Le meko inokuthi yenzeke kumadoda kunye nabasetyhini, kunye neziganeko eziphawulekayo kwi-vulva yabasetyhini kunye neendawo zangasese okanye ze-perinaal emadodeni. Inkcazo ye-pathology ye-extramammary ye-Paget's disease ibonelela ngengqiqo ebalulekileyo kwiimpawu zayo zeselula kunye nokunceda ukukhokela izigqibo zonyango. Unyango lubandakanya uqhaqho, kwaye kwezinye iimeko, unyango lwangaphakathi okanye unyango lweradiyo lunokuqwalaselwa. Ikhowudi ye-ICD-10 ye-extramammary ye-Paget's disease iququzelela ingxelo esemgangathweni kunye nokulandelela unyango. I-DermNet kunye nezinye izixhobo ze-dermatological zibonelela ngolwazi oluxabisekileyo malunga nokunikezelwa kweklinikhi kunye nokulawulwa kwesi sifo. Nangona i-extramammary ye-Paget's disease ichaphazela ngokuyinhloko ulusu, i-prognosis yayo kunye nombuzo wokuba ingaba iyabulalayo ixhomekeke kwizinto ezininzi, kubandakanywa ubukho besifo esihlaselayo okanye i-malignancies ephantsi. Ukunqaba kwesifo sikaPaget songeza ubunzima bokufunda kunye nokusiqonda, nto leyo eyenza ibe ngumxholo wophando oluqhubekayo. Isishwankathelo, ulawulo olusebenzayo lwe-extramammary ye-Paget's disease ludinga ukuqonda ngokucokisekileyo kwi-pathology yayo, ukuqwalaselwa ngokucokisekileyo kwiinketho zonyango, kunye nokuqonda ubunzima obunokubakho, ngakumbi kwiimeko eziphambili okanye ezihlaselayo.

KwiSifo se-Paget e-Extramammary ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, iindongomane, iimbewu umntu azityayo?

Umbuzo oxhaphake kakhulu ngesondlo obubuzwa zizigulane ezinomhlaza kunye nabantu abakumngcipheko wemfuzo womhlaza kukuba - kwimihlaza efana neSifo se-Extramammary Paget ingaba ibalulekile into yokutya endikutyayo nendingakutyiyo? Okanye ukuba ndilandela ukutya okusekelwe kwisityalo oko kwanele umhlaza ofana neSifo se-Extramammary Paget?

Umzekelo ingaba inomsebenzi ukuba umnqathe wemifuno utyiwa kakhulu xa uthelekiswa neMalabar Spinatshi? Ngaba kuyawenza umahluko ukuba isiqhamo iBlack Elderberry siyakhethwa ngaphezu kweEvergreen Blackberry? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane/iimbewu ezifana neWalnut yaseJapan ngaphezu kweChestnut yaseYurophu kunye nezityalo ezifana ne-Pea enamehlo aMnyama ngaphezu kweBean eqhelekileyo. Kwaye ukuba into endiyidlayo ibalulekile - ngoko umntu uchonga njani ukutya okucetyiswayo kwiSifo se-Extramammary Paget kwaye ingaba impendulo efanayo kumntu wonke onokuxilongwa okufanayo okanye umngcipheko wemfuzo?

Ewe! Ukutya okutyayo kunemicimbi ye-Extramammary Paget Disease!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Ngokomzekelo i-Black Elderberry iqulethe izithako ezisebenzayo i-Curcumin, i-Daidzein, i-Formononetin, i-Cinnamaldehyde, i-Melatonin. Kwaye i-Evergreen Blackberry iqulethe izithako ezisebenzayo i-Ellagic Acid, iCinnamaldehyde, i-Eugenol, i-Myricetin, i-Linalool kunye nabanye.

Iphutha eliqhelekileyo elenziwe xa uthatha isigqibo kunye nokukhetha ukutya okutyayo kwi-Extramammary Paget Disease - kukuvavanya kuphela izithako ezikhethiweyo ezisebenzayo eziqulethwe kukutya kwaye ungayihoyi ezinye. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha izithako ezisebenzayo ekutyeni kunye nezongezelelo zokwenza isigqibo sesondlo kwiSifo se-Extramammary Paget.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwiSifo sePaget esiSasazayo?

Isondlo somntu somhlaza esifana neSifo se-Extramammary Paget siquka ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwibhayoloji yeSifo se-Extramammary Paget, isayensi yokutya, imfuzo, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nobuthathaka obunxulumeneyo apho unyango lunokuyeka ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana neSifo se-Extramammary Paget

Zonke ii-cancer ezifana ne-Extramammary Paget Disease zingabonakaliswa ngesethi ekhethekileyo yeendlela ze-biochemical - iindlela zokutyikitya ze-Extramammary Paget Disease. Iindlela ze-Biochemical ezifana ne-PI3K-AKT-MTOR Ukubonakaliswa, i-Growth Factor Signaling, i-Chromatin Remodeling, i-MAPK Ukubonakaliswa yinxalenye yenkcazo yesiginesha ye-Extramammary Paget Disease. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwiSifo se-Extramammary Paget kufuneka luthathele ingqalelo utyikityo olunxulumene neendlela zebhayokhemikhali kwisigulana somhlaza ngamnye kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto ezinye ukutya kunye nezongezelelo zicetyiswa kwi-Extramammary Paget Disease xa uthatha unyango lomhlaza iPazopanib, kwaye okunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-ERBB2, i-PPP2R1A kunye ne-SMARCA4 zezona ziphezulu iigenes ezixeliweyo kwi-Extramammary Paget Disease. I-ERBB2 ixelwe kwi-33.3% yezigulane ezimele kuzo zonke izilingo zonyango. Kwaye i-PPP2R1A ixelwe kwi-33.3%. Idatha yesigulana esidityanisiweyo sigubungela iminyaka ukusuka ukuya . I-50.0% yedatha yesigulane ichongwa njengamadoda. Ibhayoloji yeSifo se-Extramammary Paget kunye ne-genetics exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenziwa kwesondlo.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezelelo zeSifo se-Paget e-Extramammary

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha iVegetable CARROT okanye i-MALABAR SPINACH?

I-Carrot yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Gamma-linolenic Acid, i-Daidzein, i-Formononetin, i-Cinnamaldehyde. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Carrot inconywa kwi-Extramammary Paget Disease xa unyango oluqhubekayo lomhlaza yi-Pazopanib. Oku kungenxa yokuba i-Carrot iguqula ezo ndlela ze-biochemical eziye zaxelwa ngokwesayensi ukuze zikhuthaze umphumo we-Pazopanib.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ye-Malabar Spinach yi-Curcumin, i-Daidzein, i-Formononetin, i-Cinnamaldehyde, i-Melatonin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Malabar Spinach ayikhuthazwa kwi-Extramammary Paget Disease xa unyango oluqhubekayo lomhlaza luyi-Pazopanib kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IKHEROTHI YOMFUNO IYAKUGQIBISWA NGAPHEZU KWE-MALABAR ISIPINCHI NGESIFO SE-Pazopanib Esongezelelweyo kunye noNyango lwePazopanib.

Khetha Fruit EVERGREEN BLACKBERRY okanye EMNYAMA ELDERBERRY?

Isiqhamo i-Evergreen Blackberry iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Ellagic Acid, iCinnamaldehyde, i-Eugenol, i-Myricetin, i-Linalool. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Evergreen Blackberry iyacetyiswa kwi-Extramammary Paget Disease xa unyango oluqhubekayo lomhlaza yi-Pazopanib. Oku kungenxa yokuba i-Evergreen Blackberry ilungisa ezo ndlela ze-biochemical eziye zaxelwa ngokwenzululwazi ukuze zikhuthaze isiphumo se-Pazopanib.

Ezinye zezithako ezisebenzayo okanye i-bioactives kwiziqhamo ze-Black Elderberry yi-Curcumin, i-Daidzein, i-Formononetin, i-Cinnamaldehyde, i-Melatonin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Black Elderberry ayikhuthazwa kwi-Extramammary Paget Disease xa unyango oluqhubekayo lomhlaza luyi-Pazopanib kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye luphendule ngaphantsi.

ISIQHAMO EVERGREEN BLACKBERRY KUNCEBISWA NGAPHEZU KWE-BLACK ELDERBERRY FOR Extramammary Paget Disease KUNYE NONYANGO I-Pazopanib.

Khetha Nut JAPANESE WALNUT okanye EUROPEAN CHESTNUT?

I-Walnut yaseJapan iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Ellagic Acid, i-Daidzein, i-Cinnamaldehyde, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. IWalnut yaseJapan icetyiswa kwi-Extramammary Paget Disease xa unyango lomhlaza oluqhubekayo yi-Pazopanib. Oku kungenxa yokuba i-Walnut yaseJapan iguqula ezo ndlela ze-biochemical eziye zaxelwa ngokwesayensi ukuze zikhuthaze umphumo we-Pazopanib.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yaseYurophu yi-Curcumin, i-Ellagic Acid, i-Daidzein, i-Cinnamaldehyde, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Chestnut yaseYurophu ayikhuthazwa kwiSifo se-Extramammary Paget xa unyango lomhlaza oluqhubekayo yi-Pazopanib kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IWALNUT YASEJAPANE IYAKUNIKEZISWA NGAPHEZU KWE-EUROPA CHESTNUT NGESIFO SE-Pazonib eyongezelelweyo kunye noNyango lwePazopanib.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwe ngabantu abasengozini yemfuzo yeSifo se-Extramammary Paget okanye imbali yosapho "Yintoni endifanele nditye ngokwahlukileyo kunangaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha imifuno NEW ZEALAND SPINACH okanye iCUCURBITA?

Imifuno yaseNew Zealand Isipinatshi iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Apigenin, i-Delphinidin, i-Quercetin, i-Lycopene. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-Phospholipase Signaling, i-Growth Factor Signaling kunye ne-MYC Signaling kunye nabanye. Isipinatshi saseNew Zealand sicetyiswa kumngcipheko we-Extramammary Paget Disease xa umngcipheko wemfuzo ohambelana ne-ERBB2. Oku kungenxa yokuba isipinatshi saseNew Zealand sonyusa ezo ndlela zebiochemical ezichasene nabaqhubi baso.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Cucurbita yemifuno yi-Curcumin, i-Delphinidin, i-Daidzein, i-Lupeol, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MYC Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Cucurbita ayikhuthazwa xa umngcipheko we-Extramammary Paget Disease xa umngcipheko wezofuzo uhambelana ne-ERBB2 kuba yonyusa iindlela zokutyikitya kuyo.

IMIFUNO ENTSHA ZEALAND ISIPINACH IYANCEBISWA PHEZU KWE-CUCURBITA NGE-ERBB2 genetic RISK YOMHLAZA.

Khetha iFruit BILBERRY okanye iPUMMELO?

I-Fruit Bilberry iqukethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Apigenin, i-Delphinidin, i-Quercetin, i-Lycopene. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokuSayina kwe-MAPK, iiNdawo zokuHlola zeSeli, i-Phospholipase Signaling kunye ne-MYC Signaling kunye nezinye. I-Bilberry icetyiswa kumngcipheko we-Extramammary Paget Disease xa umngcipheko wemfuzo ohambelana ne-ERBB2. Oku kungenxa yokuba iBilberry yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezithako ezisebenzayo okanye i-bioactives kwisiqhamo iPummelo yi-Curcumin, i-Apigenin, i-Delphinidin, i-Naringenin, i-Hesperetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle Checkpoints kunye ne-Epithelial ukuya kwi-Mesenchymal Transition kunye nezinye. IPummelo ayikhuthazwa xa umngcipheko we-Extramammary Paget Disease xa umngcipheko wemfuzo uhambelana ne-ERBB2 kuba yonyusa iindlela zokutyikitya kuyo.

I-FRUIT BILBERRY ICEBISIWE PHEZU KWE-PUMMELO YE-ERBB2 genetic RISK YOMHLAZA.

Khetha Nut COMMON HAZELNUT okanye CHESTNUT?

I-Hazelnut eqhelekileyo iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Delphinidin, i-Quercetin, i-Lycopene, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-Phospholipase Signaling, i-Growth Factor Signaling kunye ne-MYC Signaling kunye nabanye. I-Hazelnut eqhelekileyo iyacetyiswa kumngcipheko we-Extramammary Paget Disease xa umngcipheko wemfuzo ohambelana ne-ERBB2. Oku kungenxa yokuba iHazelnut eqhelekileyo yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yi-Curcumin, i-Ellagic Acid, i-Apigenin, i-Delphinidin, i-Lycopene. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle Checkpoints kunye ne-Epithelial ukuya kwi-Mesenchymal Transition kunye nezinye. I-Chestnut ayikhuthazwa xa umngcipheko we-Extramammary Paget Disease xa umngcipheko wezofuzo uhambelana ne-ERBB2 kuba yonyusa iindlela zokutyikitya.

I-HAZELNUT EQHELEKILEYO INCEBISIWE NGAPHEZU KWE-CHESTNUT YE-ERBB2 genetic RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezelelo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana neSifo se-Extramammary Paget. Izigulana zeSifo se-Paget e-Extramammary kunye nabantu abasengozini yemfuza bahlala benombuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye ezingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana neSifo se-Extramammary Paget, ngasinye sinemfuza eyahlukileyo ye-tumor enolunye utshintsho lwe-genomic kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okunjengoMnqathe kuqulethe izinto ezahlukeneyo zebhayoloji kwimithamo eyahlukeneyo, enempembelelo kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo somntu we-addon wesondlo senza ukuba isigqibo sibe lula kwaye sisuse yonke ingqikelelo ekuphenduleni umbuzo othi, "Yintoni ukutya endimele ndiyikhethe okanye ndingakhethi kwiSifo se-Extramammary Paget?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Msk Impact 2017
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.
• I-Daidzein yenza umsebenzi wokulwa ne-tumor ngokuchasene neeseli zomhlaza wesinyi ngokunqanda indlela ye-FGFR3.
• I-asidi ye-Shikimic ikhuthaza i-estrogen receptor (ER) -iiseli zomhlaza webele ezintle zikhula ngokusebenza kwe-NF-κB yokubonisa.
• I-aqueous cinnamon extract (ACE-c) kwi-bark ye-Cinnamomum cassia ibangela i-apoptosis kumgca weseli yomhlaza womlomo wesibeleko (SiHa) ngokulahleka kwe-mitochondrial membrane.
• Iziphumo zokuthintela i-butyric acid, i-nicotinamide, i-calcium glucarate yodwa okanye idibene ngexesha le-7, i-12-dimethylbenz (a) i-anthracene ibangele i-tumorigenesis yesikhumba semouse ngokumodareyitha kwe-K-Ras-PI3K-AKTpathway kunye ne-RNAs ezincinci ezinxulumene nazo.
• Inkqubela phambili yophando kwiziphumo ze-anticancer ye-vitamin K2.
• https://my.clevelandclinic.org/health/diseases/24266-extramammary-pagets-disease
• https://www.ncbi.nlm.nih.gov/books/NBK493224