Ukutya kokusasaza iGlioma!

intshayelelo

Ukutya kwe-Diffuse Glioma kufuneka ilungiselelwe umntu ngamnye kwaye kufuneka ilungelelanise xa unyango lomhlaza okanye utshintsho lwemfuzo yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

Kwi-Diffuse Glioma ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu ayityayo?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa ngabaguli abanomhlaza kunye nabantu abasengozini yomhlaza kukuba - kwimihlaza efana neDiffuse Glioma ingaba ibalulekile into yokutya endikutyayo kwaye ndingakwenzi? Okanye ukuba ndilandela ukutya okusekwe kwisityalo ngaba kwanele umhlaza onje ngeDiffuse Glioma?

Umzekelo ingaba ibalulekile into yokuba iJute yemifuno ityiwa kakhulu xa ithelekiswa neTuniphu? Ngaba kuyawenza umahluko ukuba isiqhamo iPummelo siyathandwa kuneRed Raspberry? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane / iimbewu ezifana ne-Almond ngaphezu kweChestnut yaseYurophu kunye nezityalo ezifana ne-Black-eyed Pea phezu kwe-Common Bean. Kwaye ukuba into endiyityayo ibalulekile - umntu ukuchonga njani ukutya okucetyiswayo kwi-Diffuse Glioma kwaye ingaba yimpendulo efanayo kuye wonke umntu onoxilongo olufanayo okanye umngcipheko wemfuzo?

Ewe! Ukutya okutyayo kubalulekile kwi-Diffuse Glioma!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Umzekelo iPummelo iqulethe izithako ezisebenzayo I-Caffeine, i-Curcumin, i-Daidzein, i-Isoliquiritigenin, i-Phloretin. Kwaye i-Red Raspberry iqulethe izithako ezisebenzayo i-Ellagic Acid, i-Curcumin, i-Daidzein, i-Isoliquiritigenin, i-Phloretin kwaye mhlawumbi nabanye.

Impazamo eqhelekileyo eyenziwa xa kusenziwa isigqibo kunye nokukhetha ukutya okutyayo kwi-Diffuse Glioma - kukuvavanya kuphela izithako ezisebenzayo ezikhethiweyo eziqulethwe kukutya kwaye ungahoyi ezinye. Kuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha izithako ezisebenzayo ekutyeni kunye nezongezelelo zokwenza isigqibo sesondlo se-Diffuse Glioma.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwi-Diffuse Glioma?

Izondlo zomntu zomhlaza ezifana ne-Diffuse Glioma zibandakanya ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwi-Diffuse Glioma biology, isayensi yokutya, imfuzo, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nokuba sesichengeni okunxulumene nonyango olunokuthi luyeke ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana ne-Diffuse Glioma

Zonke ii-cancer ezifana ne-Diffuse Glioma zinokuphawulwa ngeseti ekhethekileyo yeendlela ze-biochemical - iindlela zokutyikitya ze-Diffuse Glioma. Iindlela ze-Biochemical ezifana nokulungiswa kwe-DNA, ukulungiswa ngokuthe ngqo, i-PI3K-AKT-MTOR Ukubonakaliswa, i-Hypoxia yinxalenye yenkcazo yesignesha ye-Diffuse Glioma. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwi-Diffuse Glioma kufuneka luthathele ingqalelo utyikityo lweendlela zebhayokhemikhali kwisigulana ngasinye somhlaza kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto ezinye ukutya kunye nezongezo zicetyiswayo kwiDiffuse Glioma xa uthatha unyango lomhlaza iProcarbazine, kunye nokutya okunye kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-IDH1, i-TP53, i-ATRX, i-PTEN kunye ne-EGFR zezona zakhi zemfuza ezixeliweyo eziphezulu ze-Diffuse Glioma. I-IDH1 ixelwe kwi-50.1% yezigulane ezimele kuzo zonke izilingo zonyango. Kwaye i-TP53 ixelwe kwi-39.3%. Idatha yezigulane ezidityanisiweyo igubungela iminyaka yobudala ukusuka kwi-10 ukuya kuma-89. I-59.0 % yedatha yezigulane ichongwe njengamadoda. I-Diffuse Glioma biology kunye ne-genetics exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenziwa kwesondlo.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezelelo zokusasaza iGlioma

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha iVegetable JUTE okanye iTURNIP?

I-Vegetable Jute iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Daidzein, i-Isoliquiritigenin, i-Phloretin, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Oxidative Stress, i-NFKB Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Jute inconywa kwi-Diffuse Glioma xa unyango lomhlaza oluqhubekayo yiProcarbazine. Oku kungenxa yokuba iJute iguqula ezo ndlela ze-biochemical eziye zaxelwa ngokwesayensi ukwazisa umphumo weProcarbazine.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Turnip yemifuno yi-Ellagic Acid, i-Curcumin, i-Daidzein, i-Isoliquiritigenin, i-Phloretin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye nezinye. Itheniphu ayikhuthazwa kwi-Diffuse Glioma xa unyango lomhlaza oluqhubekayo yi-Procarbazine kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IJUTE YOMFUNO IYAKUNIKEZISWA PHEZU KWEJIKO LWE-Diffuse Glioma KUNYE NONYANGO I-Procarbazine.

Khetha iSiqhamo RED RASPBERRY okanye iPUMMELO?

Isiqhamo esiBomvu iRaspberry iqukethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Ellagic Acid, i-Curcumin, i-Daidzein, i-Isoliquiritigenin, i-Phloretin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-NFKB Signaling, i-PI3K-AKT-MTOR Umqondiso, umqondiso we-MAPK kunye ne-Hypoxia kunye nabanye. I-Red Raspberry iyacetyiswa kwi-Diffuse Glioma xa unyango lomhlaza oluqhubekayo yiProcarbazine. Oku kungenxa yokuba i-Red Raspberry iguqula ezo ndlela ze-biochemical eziye zachazwa ngokwesayensi ukuze zikhuthaze umphumo weProcarbazine.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo iPummelo yiCaffeine, Curcumin, Daidzein, Isoliquiritigenin, Phloretin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Oxidative Stress kunye nokulungiswa kwe-DNA kunye nezinye. IPummelo ayikhuthazwa kwi-Diffuse Glioma xa unyango lomhlaza oluqhubekayo yi-Procarbazine kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO ERED RASPBERRY KUNCEBISWA NGAPHEZU KWE-PUMMELO YE-Diffuse Glioma KUNYE NONYANGO I-Procarbazine.

Khetha Nut ALMOND okanye EUROPEAN CHESTNUT?

I-almond iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Daidzein, i-Isoliquiritigenin, i-Phloretin, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-NFKB Signaling, i-Hedgehog Signaling, i-PI3K-AKT-MTOR Umqondiso kunye ne-Hypoxia kunye nabanye. I-almond iyacetyiswa ukuba i-Diffuse Glioma xa unyango lomhlaza oluqhubekayo yiProcarbazine. Oku kungenxa yokuba i-Almond iguqula ezo ndlela ze-biochemical eziye zachazwa ngokwesayensi ukuze zikhuthaze umphumo weProcarbazine.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yaseYurophu yi-Ellagic Acid, i-Myricetin, i-Curcumin, i-Daidzein, i-Isoliquiritigenin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Oxidative Stress kunye nokulungiswa kwe-DNA kunye nezinye. I-Chestnut yaseYurophu ayikhuthazwa ukuba i-Diffuse Glioma xa unyango lomhlaza oluqhubekayo yi-Procarbazine kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

I-almond KUNCEBISIWE NGAPHEZU KWE-EUROPA CHESTNUT ye-Diffuse Glioma KUNYE NONYANGO I-Procarbazine.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwe ngabantu abasemngciphekweni wemfuzo we-Diffuse Glioma okanye imbali yosapho ngulo "Yintoni ekufuneka nditye ngokwahlukileyo kunangaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha iVegetable GIANT BUTTERBUR or SPINACH?

I-Vegetable Giant Butterbur iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Apigenin, i-Lupeol, i-Catechol, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Apoptosis, i-PI3K-AKT-MTOR yokuSayina, i-Cell Cycle Checkpoints kunye ne-P53 yokuSayina kunye nabanye. I-Giant Butterbur iyacetyiswa kumngcipheko we-Diffuse Glioma xa umngcipheko wemfuzo ohambelana ne-ATRX. Oku kungenxa yokuba i-Giant Butterbur yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno Isipinatshi yi-Curcumin, i-Quercetin, i-Apigenin, i-Lupeol, i-Catechol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Insulin Signaling kunye ne-Oncogenic Cancer Epigenetics kunye nabanye. Isipinatshi asikhuthazwa xa umngcipheko we-Diffuse Glioma xa umngcipheko wezofuzo uhambelana ne-ATRX kuba yonyusa iindlela zokutyikitya.

IBHUTTERBURE EYISINXIBA YOMFUNO IYAKUNQITSHISWA PHEZU KWESIPINACH NGE-ATRX genetic RISK YOMHLAZA.

Khetha iFruit NANCE okanye i-ACEROLA?

I-Fruit Nance iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Apigenin, i-Lupeol, i-Catechol, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Ukubonakalisa, i-Hypoxia kunye ne-P53 Ukubonisana kunye nabanye. I-Nance icetyiswa kumngcipheko we-Diffuse Glioma xa umngcipheko wemfuzo ohambelana ne-ATRX. Oku kungenxa yokuba i-Nance yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo ze-Acerola yi-Curcumin, i-Quercetin, i-Apigenin, i-Lupeol, i-Catechol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Insulin Signaling kunye ne-Oncogenic Cancer Epigenetics kunye nabanye. I-Acerola ayikhuthazwa xa umngcipheko we-Diffuse Glioma xa umngcipheko wezofuzo uhambelana ne-ATRX kuba inyusa iindlela zokutyikitya kuyo.

ISIQHAMO NANCE KUCEBISWA NGAPHEZU KWE-ACEROLA YE-ATRX GENETIC RISK YOMHLAZA.

Khetha Nut BUTTERNUT okanye BRAZIL NUT?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Apigenin, i-Lupeol, i-Catechol, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Ukubonakaliswa, ukuPhathwa kwe-Insulin kunye ne-P53 yoMbonakaliso kunye nabanye. I-Butternut iyacetyiswa kumngcipheko we-Diffuse Glioma xa umngcipheko wemfuzo ohambelana ne-ATRX. Oku kungenxa yokuba i-Butternut yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives e-Brazil Nut yi-Curcumin, i-Ellagic Acid, i-Lupeol, i-Catechol, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Insulin Signaling, i-Angiogenesis kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Brazil Nut ayikhuthazwa xa umngcipheko we-Diffuse Glioma xa umngcipheko wezofuzo uhambelana ne-ATRX kuba inyusa iindlela zokutyikitya kuyo.

IBHUTTERNUT KUCEBISWA NGAPHEZU KWE-BRAZIL NUT NGE-ATRX genetic RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana ne-Diffuse Glioma. Ukusabalalisa izigulana ze-Glioma kunye nabantu abasengozini yemfuza bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye ezingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana ne-Diffuse Glioma, nganye ine-tumor genetics eyahlukeneyo kunye nokwahluka kwe-genomic kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okufana neJute kuqulethe izinto ezahlukeneyo zebhayoloji kwimithamo eyahlukeneyo, enefuthe kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo se-addon yesondlo somntu senza ukuba isigqibo sibe lula kwaye sisuse yonke into eqikelelwayo ekuphenduleni umbuzo, "Kukuphi ukutya endimele ndikukhethe okanye ndingakhethi kwi-Diffuse Glioma?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Glioma Mskcc 2019
• I-Daidzein icinezela i-tumor necrosis factor-α ebangela ukufuduka kunye nokuhlasela ngokuthintela i-hedgehog / i-Gli1 ukubonakaliswa kwiiseli zomhlaza webele lomntu.
• I-citrus flavonoid naringenin ivuselela ukulungiswa kwe-DNA kwiiseli zomhlaza we-prostate.
• I-Betulinic acid inqanda ukukhula komhlaza we-prostate ngokunqanda izinto ezithile ezibhaliweyo zeprotheni.
• Iingcamango ezintsha kwi-phospholipase D ebonisa ukuvuvukala kunye nomhlaza.