Ukutya okunxulumene noNyango lweMyelodysplastic Syndrome!

intshayelelo

Ukutya okunxulumene noNyango lwe-Myelodysplastic Syndrome kufuneka kulungiselelwe umntu ngamnye kwaye kufuneka kuhlengahlengiswe xa unyango lomhlaza okanye utshintsho lwemfuzo yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

Kwi-Therapy-related Myelodysplastic Syndrome ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu ayityayo?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza kukuba - kwimihlaza efana ne-Therapy-related Myelodysplastic Syndrome ingaba ayinamsebenzi ukuba kukutya ntoni na endikutyayo kwaye ndingakwenzi? Okanye ukuba ndilandela ukutya okusekwe kwisityalo oko kwanele umhlaza ofana ne-Therapy-related Myelodysplastic Syndrome?

Umzekelo ingaba inomsebenzi ukuba iLettuce yemifuno ityiwa kakhulu xa ithelekiswa ne-Arrowhead? Ngaba kuyawenza umahluko ukuba isiqhamo iPummelo sikhethwa ngaphezu kweMandarin Orange (clementine, Tangerine)? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane/iimbewu ezifana neButternut phezu kweMacadamia Nut kunye neepulses ezifana neBroad Bean phezu kweCommon Bean. Kwaye ukuba into endiyityayo ibalulekile - umntu uchonga njani ukutya okucetyiswayo kwi-Therapy-related Myelodysplastic Syndrome kwaye ingaba impendulo efanayo kuye wonke umntu onoxilongo olufanayo okanye umngcipheko wemfuzo?

Ewe! Ukutya okutyayo kubalulekile kwi-Therapy-related Myelodysplastic Syndrome!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Umzekelo iPummelo iqulethe izithako ezisebenzayo Apigenin, Curcumin, Lycopene, Protocatechuic Acid, Lupeol. Kwaye i-Mandarin Orange (i-clementine, i-Tangerine) iqulethe izithako ezisebenzayo i-Curcumin, i-Linalool, i-Protocatechuic Acid, i-Lupeol, i-Daidzein kwaye mhlawumbi nabanye.

Impazamo eqhelekileyo eyenziwa xa kusenziwa isigqibo kunye nokukhetha ukutya okutyayo kwi-Therapy-related Myelodysplastic Syndrome - kukuvavanya kuphela izithako ezisebenzayo ezikhethiweyo eziqulethwe kukutya kwaye ungayihoyi intsalela. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha izithako ezisebenzayo ekutyeni kunye nezongezelelo zokwenza isigqibo sesondlo se-Therapy-related Myelodysplastic Syndrome.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwi-Therapy-related Myelodysplastic Syndrome?

Izondlo zomntu zomhlaza ezifana ne-Therapy-related Myelodysplastic Syndrome ibandakanya ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwi-Therapy-related Myelodysplastic Syndrome biology, isayensi yokutya, i-genetics, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nokuba sesichengeni okunxulumene nonyango olunokuthi luyeke ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana ne-Therapy-related Myelodysplastic Syndrome

Zonke i-cancer ezifana ne-Therapy-related Myelodysplastic Syndrome inokubonakaliswa ngeseti ekhethekileyo yeendlela ze-biochemical - iindlela zokutyikitya ze-Therapy-related Myelodysplastic Syndrome. Iindlela ze-Biochemical ezifana ne-PI3K-AKT-MTOR Ukubonakaliswa, i-mRNA Splicing, i-Oncogenic Cancer Epigenetics, i-Cell Cycle Checkpoints iyingxenye yenkcazo yesiginesha ye-Therapy-related Myelodysplastic Syndrome. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwi-Therapy-related Myelodysplastic Syndrome kufuneka luthathele ingqalelo utyikityo lweendlela zebhayokhemikhali zomguli ngamnye kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto okunye ukutya kunye nezongezo zicetyiswayo kwi-Therapy-related Myelodysplastic Syndrome xa uthatha unyango lomhlaza i-Fludarabine, kwaye okunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-TP53, TET2, ASXL1, EZH2 kunye ne-ZRSR2 zezona zakhi zemfuza ezixeliweyo eziphezulu kwi-Therapy-related Myelodysplastic Syndrome. I-TP53 ixelwe kwi-63.6% yezigulane ezimele kuzo zonke izilingo zonyango. Kwaye i-TET2 inikwe ingxelo ngama-27.3%. Idatha yesigulana esidityanisiweyo sigubungela iminyaka ukusuka ukuya . I-0.0% yedatha yesigulane ichongwa njengamadoda. Ibhayoloji enxulumene noNyango lweMyelodysplastic Syndrome kunye nemfuzo exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenziwa kwesondlo.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezelelo ze-Myelodysplastic Syndrome ezinxulumene noNyango

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha i-LETTUCE yemifuno okanye i-ARROWHEAD?

I-Lettuce yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Protocatechuic Acid, i-Lupeol, i-Daidzein, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Apoptosis, i-PI3K-AKT-MTOR Umqondiso kunye ne-MYC Signaling kunye nabanye. I-lettuce iyacetyiswa kwi-Therapy-related Myelodysplastic Syndrome xa unyango lomhlaza oluqhubekayo yi-Fludarabine. Oku kungenxa yokuba i-Lettuce iguqula ezo ndlela ze-biochemical eziye zaxelwa ngokwesayensi ukwazisa umphumo we-Fludarabine.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ye-Arrowhead yi-Apigenin, i-Curcumin, i-Lycopene, i-Protocatechuic Acid, i-Lupeol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo zebhayochemicals ezifana neCell Cycle Checkpoints kunye ne-mRNA Splicing kunye nezinye. I-Arrowhead ayikhuthazwa kwi-Therapy-related Myelodysplastic Syndrome xa unyango lomhlaza oluqhubekayo yi-Fludarabine kuba ilungisa ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungabikho ukuphendula.

I-LETTUCE YOMFUNO IYAKUNIKEZISWA NGAPHEZU KWE-ARROWHEAD NGE-Myelodysplastic Syndrome enxulumene noNyango kunye noNyango lweFludarabine.

Khetha iSiqhamo MANDARIN ORANGE (CLEMENTINE, TANGERINE) okanye iPUMMELO?

Isiqhamo se-Mandarin Orange (i-clementine, i-Tangerine) iqulethe ezininzi izithako ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Linalool, i-Protocatechuic Acid, i-Lupeol, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Apoptosis, i-P53 Signaling, i-MAPK yokuSayina kunye ne-Cell Cycle Checkpoints kunye nezinye. I-Mandarin Orange (i-clementine, i-Tangerine) icetyiswa kwi-Therapy-related Myelodysplastic Syndrome xa unyango oluqhubekayo lomhlaza yi-Fludarabine. Oku kungenxa yokuba i-Mandarin Orange (i-clementine, i-Tangerine) iguqula ezo ndlela ze-biochemical eziye zaxelwa ngokwesayensi ukuze zikhuthaze umphumo we-Fludarabine.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo zePummelo ziyi-Apigenin, i-Curcumin, i-Lycopene, i-Protocatechuic Acid, i-Lupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle Checkpoints, i-PI3K-AKT-MTOR Umqondiso kunye ne-mRNA Splicing kunye nabanye. IPummelo ayikhuthazwa kwiTherapy-related Myelodysplastic Syndrome xa unyango lomhlaza oluqhubekayo yiFludarabine kuba ilungisa ezo ndlela zebhayoloji ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO I-MANDARIN ORANGE (CLEMENTINE, TANGERINE) KUNCEBISWA NGAPHEZU KWE-PUMMELO YE-Therapy-related Myelodysplastic Syndrome KUNYE NONYANGO Fludarabine.

Khetha Nut BUTTERNUT okanye MACADAMIA NUT?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lycopene, i-Protocatechuic Acid, i-Lupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Apoptosis, i-P53 Signaling, i-MAPK yokuSayina kunye ne-MYC yokuSayina kunye nabanye. I-Butternut iyacetyiswa kwi-Therapy-related Myelodysplastic Syndrome xa unyango lomhlaza oluqhubekayo yi-Fludarabine. Oku kungenxa yokuba i-Butternut iguqula ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukuze zikhuthaze isiphumo se-Fludarabine.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Macadamia Nut yi-Apigenin, i-Curcumin, i-Protocatechuic Acid, i-Lupeol, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Macadamia Nut ayikhuthazwa kwi-Therapy-related Myelodysplastic Syndrome xa unyango lomhlaza oluqhubekayo yi-Fludarabine kuba iguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungabikho ukuphendula.

IBHUTTERNUT KUCEBISWA NGAPHEZU KWE-MACADAMIA NUT NGENXA YOKWENZA Unyango iMyelodysplastic Syndrome KUNYE NONYANGO Fludarabine.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwe ngabantu abasengozini yemfuza ye-Myelodysplastic Syndrome ehlobene noNyango okanye imbali yentsapho ithi "Yintoni endimele ndiyitye ngokwahlukileyo ngaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha iVegetable CALABASH okanye YAM?

ICalabash yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-JAK-STAT Signaling, i-P53 Signaling, i-MAPK yokuSayina kunye ne-Cell Cycle Checkpoints kunye nabanye. I-Calabash icetyiswa kumngcipheko we-Therapy-related Myelodysplastic Syndrome xa umngcipheko wemfuzo ohambelana ne-ASXL1. Oku kungenxa yokuba iCalabash yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Yam yemifuno yi-Apigenin, i-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Oxidative Stress kunye ne-Oncogenic Cancer Epigenetics kunye nabanye. I-Yam ayikhuthazwa xa umngcipheko we-Therapy-related Myelodysplastic Syndrome xa umngcipheko wezofuzo uhambelana ne-ASXL1 kuba inyusa iindlela zokutyikitya kuyo.

I-CALABASH YOMFUNO ICEBISWA NGE-YAM NGE-ASXL1 GENETIC RISK YOMHLAZA.

Khetha isiQhamo WATERmeloN okanye i-ALASKA BLUEBERRY?

Isiqhamo se-Watermelon sinezithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein, i-Bergapten. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-JAK-STAT Signaling, i-P53 Signaling, i-MAPK yokuSayina kunye ne-Cell Cycle Checkpoints kunye nabanye. I-Watermelon iyacetyiswa kumngcipheko we-Therapy-related Myelodysplastic Syndrome xa umngcipheko wemfuzo ohambelana ne-ASXL1. Oku kungenxa yokuba iWatermelon yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo i-Alaska Blueberry yi-Apigenin, i-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Oxidative Stress kunye ne-Oncogenic Cancer Epigenetics kunye nabanye. I-Alaska Blueberry ayikhuthazwa xa umngcipheko we-Therapy-related Myelodysplastic Syndrome xa umngcipheko wofuzo unxulumene ne-ASXL1 kuba inyusa iindlela zokutyikitya kuyo.

ISIQHAMO WATERELON IYANCEBISWA NGE-ALASKA BLUEBERRY NGE-ASXL1 GENETIC RISK YOMHLAZA.

Khetha Nut COMMON HAZELNUT okanye CHESTNUT?

I-Hazelnut eqhelekileyo iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Quercetin, i-Formononetin, i-Lupeol, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-JAK-STAT Signaling, i-P53 Signaling, i-MAPK yokuSayina kunye ne-Cell Cycle Checkpoints kunye nabanye. I-Hazelnut eqhelekileyo icetyiswa kumngcipheko we-Therapy-related Myelodysplastic Syndrome xa umngcipheko wemfuzo ohambelana ne-ASXL1. Oku kungenxa yokuba iHazelnut eqhelekileyo yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yi-Apigenin, i-Curcumin, i-Ellagic Acid, i-Formononetin, i-Lupeol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Oxidative Stress kunye ne-Oncogenic Cancer Epigenetics kunye nabanye. I-Chestnut ayikhuthazwa xa umngcipheko we-Therapy-related Myelodysplastic Syndrome xa umngcipheko wezofuzo uhambelana ne-ASXL1 kuba yonyusa iindlela zokutyikitya.

I-HAZELNUT EQHELEKILEYO IYANCEBISWA NGAPHEZU KWE-CHESTNUT YE-ASXL1 GENETIC RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezelelo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana ne-Therapy-related Myelodysplastic Syndrome. Izigulana ezinxulumene ne-Myelodysplastic Syndrome ezinxulumene nonyango kunye nabantu abasengozini yemfuza bahlala benombuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye zingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana ne-Therapy-related Myelodysplastic Syndrome, nganye ine-tumor genetics eyahlukeneyo kunye nokwahluka kwe-genomic kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okufana neLettuce kuqulethe izinto ezahlukeneyo zebhayoloji kwimiyinge eyahlukeneyo, enempembelelo kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo somntu we-addon wesondlo senza ukuba isigqibo sibe lula kwaye sisuse yonke into eqikelelwayo ekuphenduleni umbuzo othi, "Kukuphi ukutya endimele ndikukhethe okanye ndingakhethi kwi-Therapy-related Myelodysplastic Syndrome?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

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