Ukutya kweAdenocarcinoma yesisu!

intshayelelo

Ukutya kweSisu I-Adenocarcinoma kufuneka ilungiselelwe umntu ngamnye kwaye kufuneka ilungelelanise xa unyango lomhlaza okanye utshintsho lwemfuzo yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

Kwisisu i-Adenocarcinoma ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu ayityayo?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza kukuba - kwimihlaza efana ne-Adenocarcinoma yesisu ingaba ayinamsebenzi ukuba kukutya ntoni na endikutyayo kwaye ndingakwenzi? Okanye ukuba ndilandela ukutya okusekwe kwisityalo oko kwanele umhlaza onje ngeSisu Adenocarcinoma?

Umzekelo ingaba inomsebenzi ukuba imifuno yaseNew Zealand isipinatshi ityiwa kakhulu xa ithelekiswa neJerusalem Artichoke? Ngaba kuyawenza umahluko xa kukhethwa isiqhamo iPummelo kuneFrench Plantain? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane / iimbewu ezifana neButternut phezu kweChestnut kunye neepulses ezifana neBroad Bean phezu kweCatjang Pea. Kwaye ukuba into endiyidlayo ibalulekile - ngoko umntu uchonga njani ukutya okucetyiswayo kwi-Adenocarcinoma yesisu kwaye ingaba impendulo efanayo kumntu wonke onokuxilongwa okufanayo okanye umngcipheko wemfuza?

Ewe! Ukutya okutyayo kubalulekile kwi-Adenocarcinoma yesisu!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Umzekelo iPummelo iqulethe izithako ezisebenzayo iQuercetin, iCurcumin, iPhloretin, iLycopene, iLupeol. Kwaye iPlantain yesiFrentshi iqulethe izithako ezisebenzayo iQuercetin, iMyricetin, iLuteolin, iCurcumin, iPhloretin kwaye mhlawumbi nabanye.

Iphutha eliqhelekileyo elenziwe xa kuthathwa isigqibo kunye nokukhetha ukutya okutyayo kwi-Isisu se-Adenocarcinoma - kukuvavanya kuphela izithako ezikhethiweyo ezisebenzayo eziqulethwe kukutya kwaye ungayihoyi ezinye. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha i-cherry izithako ezisebenzayo ekutyeni kunye nezongezelelo zokwenza isigqibo sesondlo se-Adenocarcinoma yesisu.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwi-Adenocarcinoma yesisu?

Isondlo somntu somhlaza esifana nesisu se-Adenocarcinoma siquka ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwi-Adenocarcinoma biology, isayensi yokutya, i-genetics, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nobuthathaka obunxulumeneyo apho unyango lunokuyeka ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana ne-Stomach Adenocarcinoma

Zonke ii-cancer ezifana ne-Adenocarcinoma yesisu zinokubonakaliswa ngoluhlu olulodwa lweendlela ze-biochemical - iindlela zokutyikitya ze-Adenocarcinoma yesisu. Iindlela ze-Biochemical ezifana ne-Apoptosis, ukubonakaliswa kwe-MAPK, ukuThuthwa kweMolekyuli encinci, i-PI3K-AKT-MTOR Ukubonakaliswa yinxalenye yenkcazo yesignesha ye-Adenocarcinoma yesisu. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwi-Adenocarcinoma yeSisu kufuneka luthathele ingqalelo utyikityo lweendlela zebhayokhemikhali kwisigulane ngasinye somhlaza kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto okunye ukutya kunye nezongezo zicetyiswayo kwi-Adenocarcinoma yesisu xa uthatha unyango lomhlaza i-Oxaliplatin, kwaye okunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-TP53, i-PDE4DIP, i-MUC16, i-SLX4 kunye ne-ADCY10 zezona zixhobo ziphezulu ezixeliweyo ze-Stomach Adenocarcinoma. I-TP53 ixelwe kwi-7.4% yezigulane ezimele kuzo zonke iimvavanyo zekliniki. Kwaye i-PDE4DIP ichazwe kwi-3.5%. Idatha yezigulane ezidityanisiweyo igubungela iminyaka yobudala ukusuka kuma-32 ukuya kuma-90. I-60.5 % yedatha yezigulane ichongwe njengamadoda. Ibhayoloji yeAdenocarcinoma yesisu kunye nemfuzo exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenziwa kwesondlo.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezo ze-Adenocarcinoma yesisu

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha imifuno NEW ZEALAND SPINACH okanye IJERUSALEM ARTICHOKE?

Imifuno yaseNew Zealand Isipinatshi iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Quercetin, i-Myricetin, i-Luteolin, i-Curcumin, i-Phloretin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokuLungiswa kwe-DNA, uMjikelo weSeli, umqondiso we-MAPK kunye nokusinda kweeseli kunye nabanye. ISipinatshi saseNew Zealand sicetyiswa kwi-Stomach Adenocarcinoma xa unyango lomhlaza oluqhubekayo i-Oxaliplatin. Oku kungenxa yokuba isipinatshi saseNew Zealand siguqula iindlela zebhayoloji eziye zaxelwa ngokwesayensi ukwazisa isiphumo se-Oxaliplatin.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno yaseJerusalem Artichoke yiMyricetin, Luteolin, Curcumin, Phloretin, Lupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-Epithelial ukuya kwi-Mesenchymal Transition, i-WNT Beta ye-Catenin Signaling kunye ne-Oxidative Stress kunye nabanye. I-Jerusalem Artichoke ayikhuthazwa kwi-Adenocarcinoma yesisu xa unyango oluqhubekayo lomhlaza luyi-Oxaliplatin kuba luguqula ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IMIFUNO ENTSHA ZEALAND ISIPINACH IYAKUNQITSHISWA NGAPHEZU KWEJERUSALEM ARTICHOKE NGESISI IAdenocarcinoma KUNYE NONYANGO Oxaliplatin.

Khetha iFruit FRENCH PLANTAIN okanye iPUMMELO?

Isiqhamo sePlantain yesiFrentshi sinezithako ezininzi ezisebenzayo okanye i-bioactives ezifana ne-Quercetin, i-Myricetin, i-Luteolin, i-Curcumin, i-Phloretin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokuLungiswa kwe-DNA, uMjikelo weSeli, umqondiso we-MAPK kunye nokusinda kweeseli kunye nabanye. IPlantain yesiFrentshi isinconyelwe kwi-Adenocarcinoma yesisu xa unyango oluqhubekayo lomhlaza luyi-Oxaliplatin. Oku kungenxa yokuba iFrench Plantain iguqula ezo ndlela zebhayoloji ezixelwe ngokwesayensi ukwazisa isiphumo se-Oxaliplatin.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo iPummelo yi-Quercetin, i-Curcumin, i-Phloretin, i-Lycopene, i-Lupeol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Oxidative Stress kunye nezinye. IPummelo ayikhuthazwa kwi-Adenocarcinoma yesisu xa unyango lomhlaza oluqhubekayo luyi-Oxaliplatin kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IFRUIT FRENCH PLANTAIN INCEBISWA NGAPHEZU KWE-PUMMELO NGE-Adenocarcinoma yesisu KUNYE NONYANGO Oxaliplatin.

Khetha Nut BUTTERNUT okanye CHESTNUT?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana neMyricetin, iLuteolin, iCurcumin, iPhloretin, iLycopene. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-Cell Survival, i-DNA Repair kunye ne-PI3K-AKT-MTOR Ukubonakaliswa kunye nabanye. I-Butternut inconywa kwi-Adenocarcinoma yesisu xa unyango lomhlaza oluqhubekayo luyi-Oxaliplatin. Oku kungenxa yokuba i-Butternut iguqula ezo ndlela zebhayoloji eziye zaxelwa ngokwesayensi ukwazisa isiphumo se-Oxaliplatin.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yi-Ellagic Acid, i-Myricetin, i-Luteolin, i-Curcumin, i-Phloretin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Epithelial ukuya kwi-Mesenchymal Transition, i-WNT Beta ye-Catenin Signaling kunye ne-Oxidative Stress kunye nabanye. I-Chestnut ayikhuthazwa kwi-Adenocarcinoma yesisu xa unyango lomhlaza oluqhubekayo luyi-Oxaliplatin kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IBHUTTERNUT IYANCEBISWA NGAPHEZU KWE-CHESTNUT NGE-Adenocarcinoma yesisu KUNYE NONYANGO Oxaliplatin.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwayo ngabantu abasengozini yemfuzo ye-Adenocarcinoma yesisu okanye imbali yosapho "Yintoni endimele ndiyitye ngokwahlukileyo kunangaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha imifuno ye-WILD CARROT okanye iGARLAND CHRYSANTHEMUM?

I-Vegetable Wild Carrot iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-P53 Signaling, i-MAPK yokuSayina kunye ne-Cell Cycle Checkpoints kunye nezinye. I-Wild Carrot icetyiswa kumngcipheko we-Stomach Adenocarcinoma xa umngcipheko wemfuzo ohambelana ne-ADCY10. Oku kungenxa yokuba i-Wild Carrot yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ye-Garland Chrysanthemum yi-Apigenin, i-Curcumin, i-Formononetin, i-Daidzein, i-Lupeol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-TGFB Signaling kunye nezinye. I-Garland Chrysanthemum ayikhuthazwa xa umngcipheko we-Adenocarcinoma yesisu xa umngcipheko wemfuzo uhambelana ne-ADCY10 kuba yonyusa iindlela zokutyikitya kuyo.

UMNQATHA WASEMHLANENI WOMFUNO UYCEBISWA PHEZU KWEGARLAND CHRYSANTHEMUM NGE-ADCY10 YOMNGCIPHEKO woMHLAZA.

Khetha iSiqhamo se-NANCE okanye iGRAPEFRUIT?

I-Fruit Nance iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Formononetin, i-Daidzein, i-Lupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-TGFB Signaling, i-P53 Signaling kunye ne-DNA Repair kunye nabanye. I-Nance icetyiswa kumngcipheko we-Stomach Adenocarcinoma xa umngcipheko wemfuzo ohambelana ne-ADCY10. Oku kungenxa yokuba i-Nance yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo zeGrapefruit yi-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein, i-Lycopene. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Extracellular Matrix Remodeling kunye ne-G-protein-coupled Receptor Signaling kunye nabanye. I-Grapefruit ayikhuthazwa xa umngcipheko we-Stomach Adenocarcinoma xa umngcipheko wezofuzo uhambelana ne-ADCY10 kuba yonyusa iindlela zokutyikitya kuyo.

ISIQHAMO NANCE IYACEBISWA NGAPHEZU KWEGRAPEFRUIT NGE-ADCY10 GENETIC RISK YOMHLAZA.

Khetha i Nut WALNUT EQHELEKILEYO okanye iFLXSEED?

I-Walnut eqhelekileyo iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Ellagic Acid, i-Formononetin, i-Lupeol, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-Cell Cycle kunye ne-G-protein-coupled Receptor Signaling kunye nabanye. IWalnut eqhelekileyo iyacetyiswa kumngcipheko we-Stomach Adenocarcinoma xa umngcipheko wemfuzo ohambelana ne-ADCY10. Oku kungenxa yokuba iWalnut eqhelekileyo yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Flaxseed yi-Apigenin, i-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-JAK-STAT Signaling, i-PI3K-AKT-MTOR Ukubonakaliswa kunye ne-G-protein-coupled Receptor Signaling kunye nabanye. I-Flaxseed ayikhuthazwa xa umngcipheko we-Stomach Adenocarcinoma xa umngcipheko wezofuzo uhambelana ne-ADCY10 kuba yonyusa iindlela zokutyikitya kuyo.

IWALNUT EQHELEKILEYO IYANCEBISWA PHEZU KWEFLAXSEED NGE-ADCY10 GENETIC RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezelelo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana ne-Stomach Adenocarcinoma. Izigulana zesisu se-Adenocarcinoma kunye nabantu abasengozini yemfuza bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye zingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana ne-Adenocarcinoma yesisu, nganye inemfuza eyahlukileyo ye-tumor enolunye utshintsho lwe-genomic kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okufana nesipinatshi saseNew Zealand kuqulethe izinto ezahlukeneyo zebhayoloji kwimiyinge eyahlukeneyo, enempembelelo kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo somntu we-addon wesondlo senza ukuba isigqibo sibe lula kwaye sisuse yonke ingqikelelo ekuphenduleni umbuzo othi, "Yintoni ukutya endimele ndiyikhethe okanye ndingayikhethi kwi-Adenocarcinoma yesisu?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Msk Impact 2017
• Ukubonakaliswa kwe-molecular ebanzi ye-adenocarcinoma yesisu.
• I-Myricetin ibangela i-apoptosis ngokuvimbela i-P21 i-activated kinase 1 (PAK1) i-cascade yomqondiso kwi-hepatocellular carcinoma.
• I-Vitamin C iphucula ukuguqulwa kwe-epigenetic eyenziwa yi-5-azacytidine kunye nokubanjwa komjikelo weseli kwi-hepatocellular carcinoma celllines HLE kunye ne-Huh7.
• I-Eugenol ibangela i-apoptosis kwiiseli zomhlaza wamabele ngokusebenzisa i-E2F1/survivin down-regulation.
• I-Geraniol, icandelo lee-oyile ezibalulekileyo zesityalo, ikhuthaza iiseli zomhlaza wekholoni yomntu kwi-5-Fluorouracil unyango.