Ukutya kweSinonasal Undifferentiated Carcinoma!

intshayelelo

Ukutya kwe-Sinonasal Undifferentiated Carcinoma kufuneka ilungiselelwe umntu ngamnye kwaye kufuneka ilungelelanise xa unyango lomhlaza okanye utshintsho lwemfuzo yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

I-Sinonasal Undifferentiated Carcinoma (i-SNUC) ngumhlaza onqabileyo kunye nobundlobongela ovela kwi-nasal cavity kunye ne-paranasal sinuses. Inkcazo ye-pathology ye-SNUC ibalulekile kuxilongo, njengoko ihlala ingenazo iimpawu ezahlukileyo kwi-histopathology. Izigulana ezine-SNUC zihlala zineempawu ezifana nokuvaleka kweempumlo kunye ne-epistaxis, kwaye i-radiology idlala indima ebalulekileyo ekuhloleni ubungakanani besi sifo. I-prognosis ye-SNUC ixhomekeke kwinqanaba lokuxilonga, kunye namazinga okusinda aphantsi ngokubanzi kumanqanaba aphezulu, njengenqanaba lesi-3 ukuya kwe-4. Unyango lubandakanya indibaniselwano yotyando, ichemotherapy, kwaye ngamanye amaxesha unyango lweradiation. Inkqubo yokuhlelwa kwe-ICD-10 ibonelela ngekhowudi esemgangathweni ye-SNUC, inceda kumaxwebhu ezempilo kunye nophando. Iprotheni ye-p16 inokudlala indima kwi-pathology yayo, kwaye uphando oluqhubekayo lujolise ekuqondeni izizathu kunye nokuphucula ulawulo lwe-SNUC. Naphezu kobume bayo obunobudlova, izinga lezehlo ze-SNUC liphantsi, kodwa ukufumanisa kwangaphambili kunye nonyango olubanzi luyimfuneko ekuphuculeni ixesha lokuphila kunye neziphumo zabantu abachaphazelekayo.

Kwi-Sinonasal Undifferentiated Carcinoma ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu ayityayo?

Umbuzo oxhaphake kakhulu wesondlo obubuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza ngowomhlaza we-cancer onje ngeSinonasal Undifferentiated Carcinoma ingaba ayinamsebenzi ukuba kukutya ntoni na endikutyayo kwaye ndingakwenzi? Okanye ukuba ndilandela ukutya okusekwe kwisityalo oko kwanele umhlaza onje ngeSinonasal Undifferentiated Carcinoma?

Umzekelo ingaba inomsebenzi ukuba iCauliflower yemifuno ityiwa kakhulu xa ithelekiswa ne {food_veg1_nr1}? Ngaba kuyawenza umahluko ukuba isiqhamo {food_fruit1_nr1} siyakhethwa kunoMdiliya oqhelekileyo? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane/iimbewu ezifana neWalnut phezu kwe {food_nut1_nr1} kunye neepulses ezifana ne-Black-eyed Pea phezu {food_pulse1_nr1}. Kwaye ukuba into endiyidlayo ibalulekile - ngoko umntu uchonga njani ukutya okucetyiswayo kwi-Sinonasal Undifferentiated Carcinoma kwaye ingaba impendulo efanayo kuye wonke umntu onokuxilongwa okufanayo okanye umngcipheko wemfuza?

Ewe! Ukutya okutyayo imiba yeSinonasal Undifferentiated Carcinoma!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Umzekelo {food_fruit1_nr1} iqulethe izithako ezisebenzayo {food_fruit1_nr1_ing}. Kwaye iDiliya eqhelekileyo iqulethe izithako ezisebenzayo iVithamin C, iGeraniin, iCatechol, iMelatonin, iKaempferol kwaye mhlawumbi nabanye.

Iphutha eliqhelekileyo elenziwe xa uthatha isigqibo kunye nokukhetha ukutya okutyayo kwi-Sinonasal Undifferentiated Carcinoma - kukuvavanya kuphela izithako ezikhethiweyo ezisebenzayo eziqulethwe kukutya kwaye ungawuhoyi ukuphumla. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha i-cherry izithako ezisebenzayo ekutyeni kunye nezongezelelo zokwenza isigqibo sesondlo se-Sinonasal Undifferentiated Carcinoma.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwi-Sinonasal Undifferentiated Carcinoma?

Izondlo zomntu zomhlaza ezifana neSinonasal Undifferentiated Carcinoma ibandakanya ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwi-Sinonasal Undifferentiated Carcinoma biology, isayensi yokutya, i-genetics, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nokuba sesichengeni okunxulumene nonyango olunokuthi luyeke ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana neSinonasal Undifferentiated Carcinoma

Zonke ii-cancer ezifana ne-Sinonasal Undifferentiated Carcinoma zingabonakaliswa ngesethi ekhethekileyo yeendlela ze-biochemical - iindlela zokutyikitya ze-Sinonasal Undifferentiated Carcinoma. Iindlela ze-Biochemical ezifana ne-Hypoxia, i-Oncogenic Cancer Epigenetics, i-Chromatin Remodeling, i-Suppressive Histone Methylation iyingxenye yenkcazo yesignesha ye-Sinonasal Undifferentiated Carcinoma. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwi-Sinonasal Undifferentiated Carcinoma kufuneka luthathele ingqalelo utyikityo olunxulumene neendlela zebhayokhemikhali kwisigulana somhlaza ngamnye kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto okunye ukutya kunye nezongezo zicetyiswayo kwi-Sinonasal Undifferentiated Carcinoma xa uthatha unyango lomhlaza I-Radiation, kunye nokunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-GATA1, i-POLE, i-ASXL1, i-FOXL2 kunye ne-IDH2 zezona ziphezulu iigenes ezixeliweyo ze-Sinonasal Undifferentiated Carcinoma. I-GATA1 ixelwe kwi-50.0 % yezigulane ezimele kuwo onke amalingo onyango. Kwaye i-POLE ixelwe kwi-50.0%. Idatha yesigulana esidityanisiweyo sigubungela iminyaka ukusuka ukuya . I-0.0% yedatha yesigulane ichongwa njengamadoda. I-Sinonasal Undifferentiated Carcinoma biology kunye ne-genetics exeliweyo kunye zichaza inani labantu elimele utyikityo lweendlela ze-biochemical kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenza isondlo somntu.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezelelo ze-Sinonasal Undifferentiated Carcinoma

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha iVegetable CAULIFLOWER?

I-Cauliflower yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Vitamin C, i-Catechol, i-Melatonin, i-Allicin, i-Beta-sitosterol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Hypoxia kunye nezinye. I-Cauliflower iyacetyiswa kwi-Sinonasal Undifferentiated Carcinoma xa unyango oluqhubekayo lomhlaza luyiRadiation. Oku kungenxa yokuba iCauliflower ilungisa ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukuze zikhuthaze impembelelo yeRadiation.

I-CAULIFLOWER YOMFUNO ICEBISWA NGE-Sinonasal Undifferentiated Carcinoma KUNYE NONYANGO LWERadiation.

Khetha iSiqhamo soMdiliya OQHELEKILEYO?

Isiqhamo soMdiliya oqhelekileyo sinezithako ezininzi ezisebenzayo okanye i-bioactives efana neVithamini C, iGeraniin, iCatechol, iMelatonin, iKaempferol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Hypoxia kunye nezinye. Umdiliya oqhelekileyo uyacetyiswa kwiSinonasal Undifferentiated Carcinoma xa unyango lomhlaza oluqhubekayo yiRadiation. Oku kungenxa yokuba uMdiliya oQhelekileyo uguqula ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukwazisa isiphumo seRadi.

ISIQHAMO OKUQHELEKILEYO KUMDIYA KUNCEBISWA KWI-Sinonasal Undifferentiated Carcinoma KUNYE NONYANGO lweRadiation.

Khetha Nut WALNUT?

I-Walnut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Vitamin C, i-Catechol, i-Melatonin, i-Kaempferol, i-Apigenin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Hypoxia kunye nezinye. I-Walnut inconywa kwi-Sinonasal Undifferentiated Carcinoma xa unyango oluqhubekayo lomhlaza luyiRadiation. Oku kungenxa yokuba iWalnut ilungisa ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukwazisa isiphumo seRadi.

I-WALNUT INCEBISWA NGE-Sinonasal Undifferentiated Carcinoma KUNYE NONYANGO lweRadiation.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwe ngabantu abasengozini yemfuzo ye-Sinonasal Undifferentiated Carcinoma okanye imbali yentsapho ithi "Yintoni endimele ndiyitye ngokwahlukileyo kunangaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha iVegetable GIANT BUTTERBUR or CUCUMBER?

I-Butterbur enkulu yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Vitamin C, i-Apigenin, i-Curcumin, i-Lycopene, i-Lupeol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Stem Cell Signaling, i-Hypoxia, i-Angiogenesis kunye ne-MYC Signaling kunye nezinye. I-Giant Butterbur iyacetyiswa kumngcipheko we-Sinonasal Undifferentiated Carcinoma xa umngcipheko wemfuzo ohambelana ne-ASXL1. Oku kungenxa yokuba i-Giant Butterbur yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiCucumber yemifuno yi-Curcumin, i-Resveratrol, i-Lupeol, i-Genistein, i-Beta-carotene. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye ne-Glutathione Metabolism kunye nabanye. I-Cucumber ayikhuthazwa xa umngcipheko we-Sinonasal Undifferentiated Carcinoma xa umngcipheko wezofuzo uhambelana ne-ASXL1 kuba yonyusa iindlela zokutyikitya kuyo.

IBHUTTERBURE EYISINXIBA YOMFUNO IYACEBISWA PHEZU KWEKUKHUMBER NGE-ASXL1 GENETIC RISK YOMHLAZA.

Khetha iSiqhamo se-NANCE okanye iGRAPEFRUIT?

I-Fruit Nance iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Vitamin C, i-Apigenin, i-Curcumin, i-Lupeol, i-Genistein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Hypoxia, i-Angiogenesis kunye ne-MYC Signaling kunye nezinye. I-Nance icetyiswa kumngcipheko we-Sinonasal Undifferentiated Carcinoma xa umngcipheko wemfuzo ohambelana ne-ASXL1. Oku kungenxa yokuba i-Nance yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo zeGrapefruit yiCurcumin, iLycopene, iLupeol, iNaringin, iDelphinidin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye ne-Glutathione Metabolism kunye nabanye. I-Grapefruit ayikhuthazwa xa umngcipheko we-Sinonasal Undifferentiated Carcinoma xa umngcipheko wezofuzo uhambelana ne-ASXL1 kuba yonyusa iindlela zokutyikitya kuyo.

ISIQHAMO NANCE KUCEBISWA NGAPHEZU KWEGRAPEFRUIT NGE-ASXL1 GENETIC RISK YOMHLAZA.

Khetha i-Nutt BUTTERNUT okanye i-FLEXSEED?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lycopene, i-Lupeol, i-Genistein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Stem Cell Signaling, i-Hypoxia, i-Angiogenesis kunye ne-Glutathione Metabolism kunye nabanye. I-Butternut icetyiswa kumngcipheko we-Sinonasal Undifferentiated Carcinoma xa ingozi yemfuzo ehambelana nayo yi-ASXL1. Oku kungenxa yokuba i-Butternut yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Flaxseed yi-Apigenin, i-Curcumin, i-Lupeol, i-Delphinidin, i-Formononetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Stem Cell Signaling, i-Angiogenesis kunye ne-MYC Signaling kunye nezinye. I-Flaxseed ayikhuthazwa xa umngcipheko we-Sinonasal Undifferentiated Carcinoma xa umngcipheko wezofuzo uhambelana ne-ASXL1 kuba yonyusa iindlela zokutyikitya kuyo.

IBHUTTERNUT KUCEBISWA NGAPHEZU KWEFLAXSEED YE-ASXL1 GENETIC RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezelelo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana neSinonasal Undifferentiated Carcinoma. Izigulana ze-Sinonasal Undifferentiated Carcinoma kunye nabantu abasengozini yemfuza bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye ezingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana ne-Sinonasal Undifferentiated Carcinoma, nganye ine-tumor genetics eyahlukeneyo kunye nokwahluka kwe-genomic kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okufana neCauliflower kuqulethe izinto ezahlukeneyo zebhayoloji kwimithamo eyahlukeneyo, enefuthe kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo somntu we-addon wesondlo senza ukuba isigqibo sibe lula kwaye sisuse yonke ingqikelelo ekuphenduleni umbuzo othi, "Kukuphi ukutya endimele ndikhethe okanye ndingakhethi kwi-Sinonasal Undifferentiated Carcinoma?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

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