Ukutya kweSalivary Adenocarcinoma!

intshayelelo

Ukutya kweSalivary Adenocarcinoma kufuneka kulungiselelwe umntu ngamnye kwaye kufuneka kuziqhelanise xa unyango lomhlaza okanye utshintsho lwemfuza yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

KwiSalivary Adenocarcinoma ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu ayityayo?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza kukuba - kwimihlaza efana neSalivary Adenocarcinoma ingaba ayinamsebenzi ukuba kukuphi ukutya endikutyayo kwaye ndingakwenzi? Okanye ukuba ndilandela ukutya okusekwe kwisityalo oko kwanele umhlaza onje ngeSalivary Adenocarcinoma?

Umzekelo ingaba inomsebenzi ukuba imifuno yeCelery Stalks idliwe ngaphezulu xa kuthelekiswa neShallot? Ngaba kuyawenza umahluko ukuba isiqhamo iMammee Apple siyakhethwa kuneSoursop? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane / iimbewu ezifana neWalnut phezu kweFlaxseed kunye neepulses ezifana neYardlong Bean phezu kweCatjang Pea. Kwaye ukuba into endiyityayo ibalulekile - umntu uchonga njani ukutya okucetyiswayo kwiSalivary Adenocarcinoma kwaye ingaba impendulo efanayo kuye wonke umntu onoxilongo olufanayo okanye umngcipheko wemfuza?

Ewe! Ukutya okutyayo kubalulekile kwiSalivary Adenocarcinoma!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Ngokomzekelo i-Apple ye-Mammee iqulethe izithako ezisebenzayo i-Apigenin, i-Curcumin, i-Lupeol, i-Lycopene, i-Phloretin. Kwaye i-Soursop iqulethe izithako ezisebenzayo Apigenin, Emodin, Curcumin, Lupeol, Phloretin kwaye mhlawumbi nabanye.

Iphutha eliqhelekileyo elenziwe xa kuthathwa isigqibo kunye nokukhetha ukutya okutyayo kwi-Salivary Adenocarcinoma - kukuvavanya kuphela izithako ezikhethiweyo ezisebenzayo eziqulethwe kukutya kwaye ungayihoyi ezinye. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha izithako ezisebenzayo ekutyeni kunye nezongezelelo zokwenza isigqibo sesondlo seSalivary Adenocarcinoma.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwiSalivary Adenocarcinoma?

Izondlo zomntu zomhlaza ezifana neSalivary Adenocarcinoma zibandakanya ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwi-Salivary Adenocarcinoma biology, isayensi yokutya, imfuzo, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nokuba sesichengeni okunxulumene nonyango olunokuthi luyeke ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza njengeSalivary Adenocarcinoma

Zonke ii-cancer ezifana ne-Salivary Adenocarcinoma zinokubonakaliswa ngeseti ekhethekileyo yeendlela ze-biochemical - iindlela zokutyikitya ze-Salivary Adenocarcinoma. Iindlela ze-Biochemical ezifana ne-Apoptosis, i-Chromatin Remodeling, i-Cell Cycle Checkpoints, i-Epithelial ukuya kwi-Mesenchymal Transition iyingxenye yenkcazo yesiginesha ye-Salivary Adenocarcinoma. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwi-Salivary Adenocarcinoma kufuneka luthathele ingqalelo utyikityo lweendlela zebhayokhemikhali kwisigulana ngasinye somhlaza kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto okunye ukutya kunye nezongezo zicetyiswayo kwi-Salivary Adenocarcinoma xa uthatha unyango lomhlaza i-Taxol, kwaye okunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-ARID1A, TP53, PIK3R1 kunye ne-KDM6A zezona ntlobo zemfuza ezixeliweyo eziphezulu ze-Salivary Adenocarcinoma. I-ARID1A ixelwe kwi-50.0% yezigulane ezimele kuzo zonke iimvavanyo zekliniki. Kwaye i-TP53 ichazwe kwi-50.0%. Idatha yezigulane ezidityanisiweyo igubungela iminyaka yobudala ukusuka kuma-54 ukuya kuma-89. Ama-25.0 % edatha yezigulane ichongwe njengamadoda. I-Salivary Adenocarcinoma biology kunye ne-genetics exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenziwa kwesondlo.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezo zeSalivary Adenocarcinoma

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha iVegetable CELERY STLKS okanye SHALLOT?

Imifuno ye-Celery Stalks iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lycopene, i-Lupeol, i-Linalool. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo zebhayochemicals ezifana ne-Apoptosis kunye ne-MYC Signaling kunye nezinye. I-Celery Stalks icetyiswa kwi-Salivary Adenocarcinoma xa unyango oluqhubekayo lomhlaza yi-Taxol. Oku kungenxa yokuba i-Celery Stalks iguqula ezo ndlela ze-biochemical ezixelwe ngokwenzululwazi ukuze zikhuthaze isiphumo se-Taxol.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Shallot yemifuno yi-Apigenin, i-Curcumin, i-Lupeol, i-Phloretin, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo zebhayoloji efana ne-MYC Signaling kunye nezinye. I-Shallot ayikhuthazwa kwi-Salivary Adenocarcinoma xa unyango lomhlaza oluqhubekayo luyi-Taxol kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IZIDLA ZEMIFUNO YECEREY IYAKUNQITSHISWA NGAPHEZU KWE-SHALLOT YE-Salivary Adenocarcinoma KUNYE NE-Taxol YONYANGO.

Khetha iSiqhamo SOURSOP okanye MAMMEE APPLE?

I-Fruit Soursop iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Emodin, i-Curcumin, i-Lupeol, i-Phloretin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo zebhayochemicals ezifana ne-Apoptosis kunye ne-MYC Signaling kunye nezinye. I-Soursop icetyiswa kwi-Salivary Adenocarcinoma xa unyango oluqhubekayo lomhlaza luyiTaxol. Oku kungenxa yokuba i-Soursop ilungisa ezo ndlela ze-biochemical ezixelwe ngokwesayensi ukuze zenze impembelelo ye-Taxol.

Ezinye zezithako ezisebenzayo okanye i-bioactives kwiziqhamo i-Mammee Apple yi-Apigenin, i-Curcumin, i-Lupeol, i-Lycopene, i-Phloretin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo zebhayoloji efana ne-MYC Signaling kunye nezinye. I-Mammee Apple ayikhuthazwa kwi-Salivary Adenocarcinoma xa unyango lomhlaza oluqhubekayo luyi-Taxol kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO SOURSOP IYANCEBISWA NGAPHEZU KWE-MAMMEE APPLE NGE-Salivary Adenocarcinoma KUNYE NE-Taxol YONYANGO.

Khetha Nut WALNUT okanye FLEXSEED?

I-Walnut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Juglone, i-Hyperioside, i-Lupeol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo zebhayochemicals ezifana ne-Apoptosis kunye ne-MYC Signaling kunye nezinye. IWalnut icetyiswa kwiSalivary Adenocarcinoma xa unyango lomhlaza oluqhubekayo yiTaxol. Oku kungenxa yokuba iWalnut ilungisa ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukwazisa isiphumo seTaxol.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Flaxseed yi-Apigenin, i-Curcumin, i-Lupeol, i-Phloretin, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo zebhayoloji efana ne-MYC Signaling kunye nezinye. I-Flaxseed ayikhuthazwa kwi-Salivary Adenocarcinoma xa unyango lomhlaza oluqhubekayo luyi-Taxol kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

I-WALNUT IYANCEBISWA NGAPHEZU KWEFLAXSEED YE-Salivary Adenocarcinoma KUNYE NE-Taxol YONYANGO.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwa ngabantu abasengozini yemfuza ye-Salivary Adenocarcinoma okanye imbali yosapho uthi "Yintoni endifanele nditye ngokwahlukileyo kunangaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha imifuno ye-CAULIFLOWER okanye i-MALABAR SPINACH?

I-Cauliflower yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Lupeol, i-Beta-sitosterol, i-Phloretin, i-Formononetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-P53 Signaling, i-MAPK Signaling kunye ne-MYC Signaling kunye nabanye. ICauliflower iyacetyiswa kumngcipheko weSalivary Adenocarcinoma xa umngcipheko wemfuzo ohambelana ne-ARID1A. Oku kungenxa yokuba iCauliflower yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno iMalabar Isipinatshi yi-Apigenin, i-Curcumin, i-Quercetin, i-Lupeol, i-Beta-sitosterol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-Epithelial ukuya kwi-Mesenchymal Transition, i-WNT Beta ye-Catenin Signaling kunye ne-MAPK Signaling kunye nabanye. I-Malabar Spinatshi ayikhuthazwa xa umngcipheko we-Salivary Adenocarcinoma xa umngcipheko wemfuzo uhambelana ne-ARID1A kuba yonyusa iindlela zokutyikitya kuyo.

I-CAULIFLOWER YOMFUNO INCEBISIWE NGAPHEZU KWE-MALABAR SPINACH KU-ARID1A UMNGCIPHEKO WOMFUZO WOMHLAZA.

Khetha iSiqhamo JAVA PLUM okanye iPUMMELO?

Iziqhamo zeJava Plum ziqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Beta-sitosterol, i-Phloretin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-P53 Signaling, i-DNA Repair kunye ne-MAPK Signaling kunye nabanye. IJava Plum iyacetyiswa kumngcipheko weSalivary Adenocarcinoma xa umngcipheko wemfuzo ohambelana ne-ARID1A. Oku kungenxa yokuba iJava Plum yonyusa ezo ndlela zebhayomichi echasene nabaqhubi bayo.

Ezinye zezithako ezisebenzayo okanye i-bioactives kwisiqhamo iPummelo yi-Apigenin, i-Curcumin, i-Quercetin, i-Lupeol, i-Naringin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-Epithelial ukuya kwi-Mesenchymal Transition kunye ne-WNT Beta Catenin Signaling kunye nabanye. IPummelo ayikhuthazwa xa umngcipheko we-Salivary Adenocarcinoma xa umngcipheko wemfuzo ohambelana ne-ARID1A kuba yonyusa iindlela zokutyikitya kuyo.

ISIQHAMO JAVA PLUM IYAKUNXITSHISWA NGAPHEZU KWE-PUMMELO KU-ARID1A UMNGCIPHEKO WEFUZO LOMHLAZA.

Khetha Nut BUTTERNUT okanye CHESTNUT?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Beta-sitosterol, i-Phloretin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-Cell Cycle, i-MAPK Signaling kunye ne-Epithelial kwi-Mesenchymal Transition kunye nabanye. I-Butternut iyacetyiswa kumngcipheko we-Salivary Adenocarcinoma xa umngcipheko wemfuzo ohambelana ne-ARID1A. Oku kungenxa yokuba i-Butternut yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yi-Apigenin, i-Curcumin, i-Lupeol, i-Beta-sitosterol, i-Phloretin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-Epithelial ukuya kwi-Mesenchymal Transition kunye ne-WNT Beta Catenin Signaling kunye nabanye. I-Chestnut ayikhuthazwa xa umngcipheko we-Salivary Adenocarcinoma xa umngcipheko wemfuzo uhambelana ne-ARID1A kuba yonyusa iindlela zokutyikitya kuyo.

UBUTTERNUT UYCEBISWA PHEZU KWE-CHESTNUT NGE-ARID1A GENETIC RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezelelo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana neSalivary Adenocarcinoma. Izigulana zeSalivary Adenocarcinoma kunye nabantu abasengozini yemfuza bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye ezingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana ne-Salivary Adenocarcinoma, nganye ine-tumor genetics eyahlukeneyo kunye nokwahluka kwe-genomic kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okunje ngeCelery Stalks kuqulethe izinto ezahlukeneyo zebhayoloji kwimiyinge eyahlukeneyo, enempembelelo kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela ze-biochemical. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo se-addon yesondlo somntu senza ukuba isigqibo sibe lula kwaye sisuse yonke into eqikelelwayo ekuphenduleni umbuzo othi, "Kukuphi ukutya endimele ndikukhethe okanye ndingakhethi kwi-Salivary Adenocarcinoma?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Msk Impact 2017
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• I-asidi ye-Gallic ixhokonxa umonakalo we-DNA kwaye icinezela i-DNA yokulungisa i-gene expression kwi-prostate cancer yomntu iiseli ze-PC-3.