Ukutya kweRetinoblastoma!

intshayelelo

Ukutya kweRetinoblastoma kufuneka kulungiselelwe umntu ngamnye kwaye kufuneka kuziqhelanise xa unyango lomhlaza okanye utshintsho lwemfuza yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

I-Retinoblastoma ngumhlaza wamehlo wabantwana onqabileyo ovela kwi-retina. Ibangelwa kukuguqulwa kwe-retinoblastoma gene (RB1) kwaye inokuchaphazela elinye okanye omabini amehlo. Iimpawu ze-retinoblastoma zinokubandakanya i-leukocoria (umntwana weliso ubonakala umhlophe), ukuncipha kombono, kunye ne-strabismus (ukungahambi kakuhle kwamehlo), iintlungu, ukwanda okanye ukukrala kwamehlo, igazi eliphambi kwegumbi elingaphambili okanye usulelo, ukudumba okanye ukudumba. iliso okanye izicubu ezingqongileyo. Ukuchongwa kwe-retinoblastoma ebomvu reflex ngexesha lokuhlolwa kwamehlo kubalulekile ukuze kubonwe kwangethuba. I-Genetics idlala indima ebalulekileyo kwi-retinoblastoma, njengoko inokuzuzwa njengelifa okanye yenzeke ngokuzenzekelayo. Ukhetho lonyango lwe-retinoblastoma luxhomekeke kubungakanani bethumba kwaye lunokubandakanya ichemotherapy, unyango lweradiation, cryotherapy, kunye ne-enucleation (ukususwa kweso liso). Ukuthotyelwa okungqongqo kwizikhokelo zonyango kubalulekile kwiziphumo ezizezona zilungileyo. I-prognosis kunye namazinga okusinda ayahluka ngokuxhomekeke kwizinto ezifana nenqanaba lesi sifo kunye nokuguqulwa okuthile kofuzo. Ulawulo lwe-retinoblastoma lufuna indlela ebanzi ebandakanya i-oncologists yabantwana, i-ophthalmologists, kunye nabacebisi bemfuzo.

KwiRetinoblastoma ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu ayityayo?

Umbuzo oxhaphake kakhulu wesondlo obubuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza kukuba - kwimihlaza efana ne-Retinoblastoma ingaba ayinamsebenzi ukuba kukuphi ukutya endikutyayo kwaye ndingakwenzi? Okanye ukuba ndilandela ukutya okusekwe kwisityalo oko kwanele umhlaza onje ngeRetinoblastoma?

Umzekelo ingaba inomsebenzi ukuba iTowel Gourd yemifuno ityiwa kakhulu xa ithelekiswa nePokeweed yaseMelika? Ngaba kuyawenza umahluko ukuba isiqhamo seDurian siyathandwa kunerharnati? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane / iimbewu ezifana neAlmond ngaphezulu kweChestnut yaseYurophu kunye neepulses ezifana neLentils phezu kweCatjang Pea. Kwaye ukuba into endiyityayo ibalulekile - umntu uchonga njani ukutya okucetyiswayo kwi-Retinoblastoma kwaye ingaba yimpendulo efanayo kuye wonke umntu onoxilongo olufanayo okanye umngcipheko wemfuzo?

Ewe! Ukutya okutyayo kubalulekile kwiRetinoblastoma!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Umzekelo iDurian iqulethe izithako ezisebenzayo iMyricetin, i-Apigenin, iCaffeine, i-Isoliquiritigenin, i-Allicin. Kwaye iPomegranate iqulethe izithako ezisebenzayo iMyricetin, i-Apigenin, i-Oleic Acid, i-Betulinic Acid, i-Isoliquiritigenin kwaye mhlawumbi nabanye.

Impazamo eqhelekileyo eyenziwa xa kusenziwa isigqibo kunye nokukhetha ukutya okutyayo kwi-Retinoblastoma - kukuvavanya kuphela izithako ezikhethiweyo ezisebenzayo eziqulethwe kukutya kwaye ungayihoyi enye. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha i-cherry izithako ezisebenzayo ekutyeni kunye nezongezelelo ukwenza isigqibo sesondlo se-Retinoblastoma.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwiRetinoblastoma?

Izondlo zomntu zomhlaza ezifana neRetinoblastoma zibandakanya ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwi-Retinoblastoma biology, isayensi yokutya, imfuzo, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nobuthathaka obunxulumeneyo apho unyango lunokuyeka ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza njengeRetinoblastoma

Zonke ii-cancer ezifana ne-Retinoblastoma zinokubonakaliswa ngoluhlu olulodwa lweendlela ze-biochemical - iindlela zokutyikitya ze-Retinoblastoma. Iindlela ze-Biochemical ezifana nokulungiswa kwe-DNA, i-Hypoxia, i-Cell Cycle, i-Cell Cycle Checkpoints ziyingxenye yenkcazo yesiginesha ye-Retinoblastoma. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwi-Retinoblastoma kufuneka luthathelwe ingqalelo utyikityo lweendlela zebhayomichi enxulumene nesigulana ngasinye somhlaza kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto okunye ukutya kunye nezongezo zicetyiswayo kwi-Retinoblastoma xa uthatha unyango lomhlaza i-Etoposide, kwaye okunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-RB1, i-CRTC1, i-BCOR, i-ABL2 kunye ne-SMARCA2 zezona ntlobo zemfuza ezixeliweyo eziphezulu ze-Retinoblastoma. I-RB1 ixelwe kwi-57.8% yezigulane ezimele kuwo onke amalingo onyango. Kwaye i-CRTC1 ixelwe kwi-16.7%. Idatha yezigulane ezidibeneyo zibandakanya iminyaka yobudala ukusuka kwi-1 ukuya kwi-21. I-52.8 % yedatha yesigulane ichongwa njengamadoda. Ibhayoloji yeRetinoblastoma kunye nemfuzo exeliweyo kunye zichaza inani labantu elimele utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenza isondlo somntu.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezo zeRetinoblastoma

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha iVegetable TOWEL GOURD okanye AMERICAN POKEWEED?

I-Towel yemifuno ye-Gourd iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Oleic Acid, i-Isoliquiritigenin, i-Allicin, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokuLungiswa kwe-DNA, i-Hypoxia kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Towel Gourd iyacetyiswa kwi-Retinoblastoma xa unyango lomhlaza oluqhubekayo yi-Etoposide. Oku kungenxa yokuba iTowel Gourd iguqula ezo ndlela zebhayoloji eziye zaxelwa ngokwenzululwazi ukwazisa isiphumo se-Etoposide.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno yase-American Pokeweed yiMyricetin, i-Apigenin, i-Isoliquiritigenin, i-Allicin, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokuLungiswa kwe-DNA kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-American Pokeweed ayikhuthazwa kwi-Retinoblastoma xa unyango lomhlaza oluqhubekayo yi-Etoposide kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IGORD YETAWULI YOMFUNO KUCEBISIWE NGAPHEZU KWE-AMERICAN POKEWEED YERetinoblastoma KUNYE NONYANGO Etoposide.

Khetha iSiqhamo sePOMEGRANATE okanye iDURIAN?

Iziqhamo zePomegranate ziqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana neMyricetin, i-Apigenin, i-Oleic Acid, i-Betulinic Acid, i-Isoliquiritigenin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Hedgehog Signaling, i-Hypoxia, i-DNA Repair kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. Irharnati iyacetyiswa kwi-Retinoblastoma xa unyango lomhlaza oluqhubekayo yi-Etoposide. Oku kungenxa yokuba irharnati iguqula ezo ndlela zebhayoloji eziye zaxelwa ngokwenzululwazi ukwazisa isiphumo se-Etoposide.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo zeDurian yiMyricetin, i-Apigenin, iCaffeine, i-Isoliquiritigenin, i-Allicin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokuLungiswa kwe-DNA kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Durian ayikhuthazwa kwi-Retinoblastoma xa unyango lomhlaza oluqhubekayo yi-Etoposide kuba iguqula ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO EGORGRANATE IYANCEBISWA NGAPHEZU KWEDURIAN YERetinoblastoma KUNYE NONYANGO Etoposide.

Khetha Nut ALMOND okanye EUROPEAN CHESTNUT?

I-almond iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Oleic Acid, i-Isoliquiritigenin, i-Allicin, i-Daidzein, i-Curcumin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Hypoxia kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-almond inconywa kwi-Retinoblastoma xa unyango oluqhubekayo lomhlaza yi-Etoposide. Oku kungenxa yokuba i-almond iguqula ezo ndlela ze-biochemical eziye zaxelwa ngokwesayensi ukwazisa umphumo we-Etoposide.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yaseYurophu yiMyricetin, i-Apigenin, i-Isoliquiritigenin, i-Allicin, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Chestnut yaseYurophu ayikhuthazwa i-Retinoblastoma xa unyango lomhlaza oluqhubekayo yi-Etoposide kuba iguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

I-almond INCEBISIWE NGAPHEZU KWE-EUROPA CHESTNUT YE-Retinoblastoma KUNYE NONYANGO Etoposide.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwe ngabantu abasengozini yemfuzo ye-Retinoblastoma okanye imbali yosapho "Yintoni endimele ndiyitye ngokwahlukileyo kunangaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha imifuno ye-CAULIFLOWER okanye i-MUSTARD SPINACH?

I-Cauliflower yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin, i-Beta-sitosterol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-P53 Signaling, i-Cell Cycle Checkpoints kunye ne-MYC Signaling kunye nezinye. ICauliflower iyacetyiswa kumngcipheko we-Retinoblastoma xa umngcipheko wemfuzo ohambelana ne-ABL2. Oku kungenxa yokuba iCauliflower yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ye-Mustard Spinach yi-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-PI3K-AKT-MTOR yokuSayina kunye ne-Cell Cycle Checkpoints kunye nabanye. I-Mustard Spinatshi ayikhuthazwa xa umngcipheko we-Retinoblastoma xa umngcipheko wemfuza ohambelana ne-ABL2 kuba yonyusa iindlela zokutyikitya.

I-CAULIFLOWER YOMFUNO INCEBISWA NGAPHEZU KWEMUSTARD SPINACH NGE-ABL2 GENETIC RISK YOMHLAZA.

Khetha iFruit NANCE okanye iPUMMELO?

I-Fruit Nance iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-P53 Signaling, i-DNA Repair kunye ne-MYC Signaling kunye nabanye. I-Nance icetyiswa kumngcipheko we-Retinoblastoma xa umngcipheko wemfuzo ohambelana ne-ABL2. Oku kungenxa yokuba i-Nance yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo zePummelo yi-Apigenin, i-Curcumin, i-Quercetin, i-Lupeol, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-PI3K-AKT-MTOR yokuSayina kunye ne-Cell Cycle Checkpoints kunye nabanye. IPummelo ayikhuthazwa xa umngcipheko we-Retinoblastoma xa umngcipheko wemfuza ohambelana ne-ABL2 kuba yonyusa iindlela zokutyikitya kuyo.

ISIQHAMO NANCE KUCEBISWA NGAPHEZU KWE-PUMMELO YE-ABL2 GENETIC RISK YOMHLAZA.

Khetha Nut COMMON HAZELNUT okanye CHESTNUT?

I-Hazelnut eqhelekileyo iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Quercetin, i-Lupeol, i-Daidzein, i-Formononetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, uMjikelo weSeli, i-Angiogenesis kunye ne-MYC Signaling kunye nabanye. IHazelnut eqhelekileyo iyacetyiswa kumngcipheko we-Retinoblastoma xa umngcipheko wemfuzo ohambelana ne-ABL2. Oku kungenxa yokuba iHazelnut eqhelekileyo yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yi-Apigenin, i-Curcumin, i-Ellagic Acid, i-Lupeol, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-PI3K-AKT-MTOR yokuSayina kunye ne-Cell Cycle Checkpoints kunye nabanye. I-Chestnut ayikhuthazwa xa umngcipheko we-Retinoblastoma xa umngcipheko wezofuzo uhambelana ne-ABL2 kuba yonyusa iindlela zokutyikitya kuyo.

I-HAZELNUT EQHELEKILEYO IYANCEBISWA NGAPHEZU KWE-CHESTNUT YE-ABL2 GENETIC RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana neRetinoblastoma. Izigulana ze-Retinoblastoma kunye nabantu abasengozini yemfuza bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye ezingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana ne-Retinoblastoma, nganye ine-tumor genetics eyahlukileyo kunye nokwahluka kwe-genomic kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okunje ngeTowel Gourd kuqulethe izinto ezahlukeneyo zebhayoloji kwimithamo eyahlukeneyo, enempembelelo kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo somhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo se-addon yesondlo somntu senza ukuba isigqibo sibe lula kwaye sisuse yonke into eqikelelwayo ekuphenduleni umbuzo othi, "Kukuphi ukutya endimele ndikukhethe okanye ndingakhethi kwi-Retinoblastoma?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• I-Kunga Msk exutywe ngo-2022
• Unyango lomhlaza lubumba ubume bokuqina be-clonal hematopoiesis.
• I-Myricetin ibamba isakhiwo se-telomeric ye-G-quadruplex yabantu: indlela entsha yokulungisa njenge-agent ye-anticancer.
• I-BRCA1 kunye ne-BRCA2 njengeethagethi ze-molecular for phytochemicals indole-3-carbinol kunye ne-genistein kwi-breast and prostate cancer cells.
• I-asidi ye-Gallic ixhokonxa umonakalo we-DNA kwaye icinezela i-DNA yokulungisa i-gene expression kwi-prostate cancer yomntu iiseli ze-PC-3.
• Imiphumo ye-Anti-tumour ye-beta-sitosterol idibene ne-AMPK / PTEN / HSP90 axis kwiiseli ze-AGS zesisu somntu we-adenocarcinoma kunye neemodeli zemouse ze-xenograft.
• Ikhompawundi yokutya i-isoliquiritigenin inqanda umhlaza wamabele i-neoangiogenesis nge-VEGF/VEGFR-2 indlela yokubonisa.
• I-asidi ye-Shikimic ikhuthaza i-estrogen receptor (ER) -iiseli zomhlaza webele ezintle zikhula ngokusebenza kwe-NF-κB yokubonisa.
• Ulawulo olubi lwe-transducer yesignali kunye ne-activator ye-transcription-3 yokubonisa i-cascade yi-lupeol inqanda ukukhula kwaye yenza i-apoptosis kwiiseli ze-hepatocellular carcinoma.
• I-Brassinin inqanda indlela yokubonisa i-STAT3 ngokumodareyithwa kwe-PIAS-3 kunye ne-SOCS-3 intetho kwaye inike amandla i-xenograft yomhlaza wemiphunga yabantu kwiimpuku ezinqunu ukuya kwi-paclitaxel.
• Sengupta S et al, Indian J Opthalmol., 2016
• https://my.clevelandclinic.org/health/diseases/retinoblastoma
• https://www.ncbi.nlm.nih.gov/books/NBK545276