Ukutya kweProstate Neuroendocrine Carcinoma!

intshayelelo

Ukutya kweProstate Neuroendocrine Carcinoma kufuneka ilungiselelwe umntu ngamnye kwaye kufuneka ilungelelanise xa unyango lomhlaza okanye utshintsho lwemfuzo yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

Kwi-Prostate Neuroendocrine Carcinoma ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu ayityayo?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza ngowomhlaza we-Prostate Neuroendocrine Carcinoma ingaba ibalulekile na into yokutya endikutyayo nendingakutyiyo? Okanye ukuba ndilandela ukutya okusekwe kwisityalo oko kwanele umhlaza onje ngeProstate Neuroendocrine Carcinoma?

Umzekelo ingaba inomsebenzi ukuba imifuno ye-Giant Butterbur ityiwa kakhulu xa ithelekiswa ne-Welsh Onion? Ngaba kuyawenza umahluko ukuba isiqhamo i-Elderberry sikhethwa ngaphezu kweJava Plum? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane / iimbewu ezifana neHazelnut eqhelekileyo ngaphezu kweChestnut yaseYurophu kunye neepulses ezifana ne-Black-eyed Pea phezu kweCatjang Pea. Kwaye ukuba into endiyidlayo ibalulekile - ngoko umntu uchonga njani ukutya okucetyiswayo kwi-Prostate Neuroendocrine Carcinoma kwaye ingaba impendulo efanayo kumntu wonke onokuxilongwa okufanayo okanye umngcipheko wemfuzo?

Ewe! Ukutya okutyayo kubalulekile kwiProstate Neuroendocrine Carcinoma!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Umzekelo i-Elderberry iqulethe izithako ezisebenzayo i-Quercetin, i-Apigenin, i-Curcumin, i-Myricetin, i-Luteolin. Kwaye i-Java Plum iqulethe izithako ezisebenzayo i-Apigenin, i-Curcumin, i-Myricetin, i-Luteolin, i-Ellagic Acid kwaye mhlawumbi nabanye.

Iphutha eliqhelekileyo elenziwe xa uthatha isigqibo kunye nokukhetha ukutya okutyayo kwi-Prostate Neuroendocrine Carcinoma - kukuvavanya kuphela izithako ezikhethiweyo ezisebenzayo eziqulethwe kukutya kwaye ungawuhoyi ukuphumla. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha i-cherry izithako ezisebenzayo ekutyeni kunye nezongezelelo zokwenza isigqibo sesondlo se-Prostate Neuroendocrine Carcinoma.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kwiSondlo soMntu kwiProstate Neuroendocrine Carcinoma?

Izondlo zomntu zomhlaza ezifana ne-Prostate Neuroendocrine Carcinoma ibandakanya ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwi-Prostate Neuroendocrine Carcinoma biology, isayensi yokutya, imfuzo, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nobuthathaka obunxulumeneyo apho unyango lunokuyeka ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana neProstate Neuroendocrine Carcinoma

Zonke ii-cancer ezifana ne-Prostate Neuroendocrine Carcinoma zinokubonakaliswa ngoluhlu olulodwa lweendlela ze-biochemical - iindlela zokutyikitya ze-Prostate Neuroendocrine Carcinoma. Iindlela ze-Biochemicals ezifana ne-Notch Signaling, i-MAPK Signaling, i-PI3K-AKT-MTOR Ukubonakaliswa, i-G-protein-coupled Receptor Signaling iyingxenye yenkcazo yesignesha ye-Prostate Neuroendocrine Carcinoma. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwi-Prostate Neuroendocrine Carcinoma kufuneka luthathelwe ingqalelo utyikityo olunxulumene neendlela zebhayokhemikhali kwisigulana somhlaza ngamnye kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto okunye ukutya kunye nezongezo zicetyiswayo kwi-Prostate Neuroendocrine Carcinoma xa uthatha unyango lomhlaza iCarboplatin, kwaye okunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-MUC16, i-CPS1, i-ERCC2, i-CACNA1B kunye ne-KMT2D zezona ziphezulu iijene ezixeliweyo ze-Prostate Neuroendocrine Carcinoma. I-MUC16 ixelwe kwi-21.2 % yezigulane ezimele kuwo onke amalingo onyango. Kwaye i-CPS1 ixelwe kwi-12.1%. Idatha yezigulane ezidityanisiweyo igubungela iminyaka yobudala ukusuka kuma-42 ukuya kuma-70. 100.0 % yedatha yezigulane ichongwe njengamadoda. I-Prostate Neuroendocrine Carcinoma biology kunye ne-genetics exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela ze-biochemical kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenziwa kwesondlo.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezo zeProstate Neuroendocrine Carcinoma

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha iVegetable GIANT BUTTERBUR or WELSH ONION?

I-Butterbur enkulu yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Myricetin, i-Luteolin, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-P53 Signaling, i-DNA Repair kunye ne-MYC Signaling kunye nabanye. I-Giant Butterbur iyacetyiswa kwi-Prostate Neuroendocrine Carcinoma xa unyango lomhlaza oluqhubekayo yiCarboplatin. Oku kungenxa yokuba i-Giant Butterbur ilungisa ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukuze zikhuthaze isiphumo seCarboplatin.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ye-Welsh Onion yi-Curcumin, i-Luteolin, i-Daidzein, i-Lupeol, i-Isorhamnetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-WNT Beta Catenin Signaling kunye ne-Oxidative Stress kunye nezinye. Itswele le-Welsh alikhuthazwa kwi-Prostate Neuroendocrine Carcinoma xa unyango lomhlaza oluqhubekayo yiCarboplatin kuba luguqula ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IBHUTTERBURE EYINGXAKI YOMFUNO IYAKUNIKEZWA NGAPHEZU KWE-WELSH anyanisi kwiProstate Neuroendocrine Carcinoma KUNYE NONYANGO ICarboplatin.

Khetha iSiqhamo JAVA PLUM okanye ELDERBERRY?

Iziqhamo zeJava Plum ziqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Myricetin, i-Luteolin, i-Ellagic Acid. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-P53 Signaling, i-DNA Repair kunye ne-MAPK Signaling kunye nabanye. IJava Plum iyacetyiswa kwiProstate Neuroendocrine Carcinoma xa unyango lomhlaza oluqhubekayo yiCarboplatin. Oku kungenxa yokuba iJava Plum ilungisa ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukuze zikhuthaze isiphumo seCarboplatin.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo i-Elderberry yi-Quercetin, i-Apigenin, i-Curcumin, i-Myricetin, i-Luteolin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-WNT Beta Catenin Signaling kunye ne-Oxidative Stress kunye nezinye. I-Elderberry ayikhuthazwa kwi-Prostate Neuroendocrine Carcinoma xa unyango lomhlaza oluqhubekayo yiCarboplatin kuba luguqula ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO se-JAVA PLUM IYANCEBISWA NGAPHEZU KWE-ELDERBERRY YE-Prostate Neuroendocrine Carcinoma KUNYE NONYANGO I-Carboplatin.

Khetha i-Nutt EQHELEKILEYO IHAZELNUT okanye i-EUROPEAN CHESTNUT?

I-Hazelnut eqhelekileyo iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Quercetin, i-Curcumin, i-Myricetin, i-Daidzein, i-Lupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-Cell Cycle, i-MAPK Signaling kunye ne-Hedgehog Signaling kunye nabanye. IHazelnut eqhelekileyo iyacetyiswa kwiProstate Neuroendocrine Carcinoma xa unyango lomhlaza oluqhubekayo yiCarboplatin. Oku kungenxa yokuba iHazelnut eqhelekileyo ilungisa ezo ndlela zebhayoloji ezixelwe ngokwesayensi ukuze zikhuthaze isiphumo seCarboplatin.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yaseYurophu yi-Quercetin, i-Apigenin, i-Curcumin, i-Myricetin, i-Luteolin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-WNT Beta Catenin Signaling kunye ne-Oxidative Stress kunye nezinye. I-Chestnut yaseYurophu ayikhuthazwa kwi-Prostate Neuroendocrine Carcinoma xa unyango lomhlaza oluqhubekayo yiCarboplatin kuba luguqula ezo ndlela zebhayoloji ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IHAZELNUT EQHELEKILEYO IYANCEBISWA NGE-CHESTNUT YAseYurophu YE-Prostate Neuroendocrine Carcinoma KUNYE NONYANGO I-Carboplatin.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwe ngabantu abasengozini yemfuzo ye-Prostate Neuroendocrine Carcinoma okanye imbali yentsapho ithi "Yintoni endimele ndiyitye ngokwahlukileyo kunangaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha iVegetable CAULIFLOWER okanye iCUCURBITA?

I-Cauliflower yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin, i-Beta-sitosterol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-P53 Signaling, i-Angiogenesis, i-Cell Cycle Checkpoints kunye ne-MYC Signaling kunye nezinye. ICauliflower iyacetyiswa kumngcipheko weProstate Neuroendocrine Carcinoma xa umngcipheko wemfuzo ohambelana nawo yi-CACNA1B. Oku kungenxa yokuba iCauliflower yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Cucurbita yemifuno yi-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin, i-Beta-sitosterol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Umqondiso kunye ne-MYC Signaling kunye nabanye. I-Cucurbita ayikhuthazwa xa umngcipheko we-Prostate Neuroendocrine Carcinoma xa umngcipheko wezofuzo uhambelana ne-CACNA1B kuba yonyusa iindlela zokutyikitya kuyo.

I-CAULIFLOWER YOMFUNO INCEBISWA NGE-CUCURBITA YE-CACNA1B GENETIC RISK YOMHLAZA.

Khetha iFruit NANCE okanye iPUMMELO?

I-Fruit Nance iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Stem Cell Signaling, i-P53 Signaling, i-Angiogenesis kunye ne-MYC Signaling kunye nabanye. UNance ucetyiswa kumngcipheko we-Prostate Neuroendocrine Carcinoma xa umngcipheko wemfuzo ohambelana ne-CACNA1B. Oku kungenxa yokuba i-Nance yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo zePummelo yi-Apigenin, i-Curcumin, i-Quercetin, i-Lupeol, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokuLungiswa kwe-DNA kunye ne-Stem Cell Signaling kunye nezinye. IPummelo ayikhuthazwa xa umngcipheko we-Prostate Neuroendocrine Carcinoma xa umngcipheko wofuzo uhambelana ne-CACNA1B kuba yonyusa iindlela zokutyikitya kuyo.

ISIQHAMO NANCE KUCEBISWA NGAPHEZU KWE-PUMMELO NGE-CACNA1B genetic RISK YOMHLAZA.

Khetha i-Nutt BUTTERNUT okanye i-CASHEW NUT?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Stem Cell Signaling, i-P53 Signaling, i-MAPK Signaling kunye ne-MYC Signaling kunye nabanye. I-Butternut iyacetyiswa kumngcipheko we-Prostate Neuroendocrine Carcinoma xa ingozi yemfuzo ehambelana nayo yi-CACNA1B. Oku kungenxa yokuba i-Butternut yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Cashew Nut yi-Curcumin, i-Quercetin, i-Lupeol, i-Daidzein, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, ukulungiswa kwe-DNA kunye ne-PI3K-AKT-MTOR Ukubonakaliswa kunye nabanye. I-Cashew Nut ayikhuthazwa xa umngcipheko we-Prostate Neuroendocrine Carcinoma xa umngcipheko wemfuzo uhambelana ne-CACNA1B kuba yonyusa iindlela zokutyikitya kuyo.

IBHUTTERNUT KUCEBISWA NGAPHEZU KWE-CASHEW NUT YE-CACNA1B genetic RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezelelo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana ne-Prostate Neuroendocrine Carcinoma. Izigulane ze-Prostate Neuroendocrine Carcinoma kunye nabantu abasengozini yemfuza bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye ezingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana ne-Prostate Neuroendocrine Carcinoma, nganye ineemfuza ezahlukeneyo zethumba ezinolunye utshintsho lwe-genomic kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okufana neGiant Butterbur kuqulethe izinto ezahlukeneyo zebhayoloji kwimiyinge eyahlukeneyo, enefuthe kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo somntu we-addon wesondlo senza ukuba isigqibo sibe lula kwaye sisuse yonke ingqikelelo ekuphenduleni umbuzo othi, "Yintoni ukutya endimele ndiyikhethe okanye ndingakhethi kwi-Prostate Neuroendocrine Carcinoma?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Nepc Wcm 2016
• Iprofayili elindelekileyo yeGenomic yoMhlaza wedlala lobudoda kuwo onke amazwe eZifo ityhila iiNtsholongwane zeNtsholongwane kunye neeNguquko zeSomatic ezinokuchaphazela ukwenziwa kweZigqibo zoNyango.
• I-Betulinic Acid iNxinzelela iMetastasis yoMhlaza wamabele ngokuJonga i-GRP78-Mediated Glycolysis kunye ne-ER Stress Apoptotic Pathway.
• I-Brassinin inqanda indlela yokubonisa i-STAT3 ngokumodareyithwa kwe-PIAS-3 kunye ne-SOCS-3 intetho kwaye inike amandla i-xenograft yomhlaza wemiphunga yabantu kwiimpuku ezinqunu ukuya kwi-paclitaxel.
• Ulawulo olubi lwe-transducer yesignali kunye ne-activator ye-transcription-3 yokubonisa i-cascade yi-lupeol inqanda ukukhula kwaye yenza i-apoptosis kwiiseli ze-hepatocellular carcinoma.