Ukutya kweNasopharyngeal Cancer!

intshayelelo

Ukutya koMhlaza weNasopharyngeal kufuneka kulungiselelwe umntu ngamnye kwaye kufuneka kuhlengahlengiswe xa unyango lomhlaza okanye utshintsho lwemfuza yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

KwiCancer yeNasopharyngeal ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu ayityayo?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza kukuba - kwimihlaza efana neNasopharyngeal Cancer ingaba ayinamsebenzi ukuba kukutya ntoni na endikutyayo kwaye ndingakwenzi? Okanye ukuba ndilandela ukutya okusekelwe kwisityalo oko kwanele umhlaza onjengeNasopharyngeal Cancer?

Umzekelo ingaba inomsebenzi ukuba imifuno ye-Giant Butterbur ityiwa kakhulu xa ithelekiswa neMalabar Spinatshi? Ngaba kuyawenza umahluko ukuba iziqhamo zeBilberry zikhethwa ngaphezu kweRaspberry eliBomvu? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane/iimbewu ezifana neHazelnut eqhelekileyo ngaphezu kweChestnut yaseYurophu kunye nezityalo ezifana ne-Pea enamehlo aMnyama ngaphezu kwe-Common Bean. Kwaye ukuba into endiyidlayo ibalulekile - ngoko umntu uchonga njani ukutya okucetyiswayo kwi-Cancer ye-Nasopharyngeal kwaye ingaba impendulo efanayo kumntu wonke onokuxilongwa okufanayo okanye umngcipheko wemfuza?

Ewe! Ukutya okutyayo imicimbi yeNasopharyngeal Cancer!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Ngokomzekelo iBilberry iqukethe izithako ezisebenzayo i-Curcumin, i-Resveratrol, i-Apigenin, i-Lycopene, i-Isoliquiritigenin. Kwaye i-Red Raspberry iqulethe izithako ezisebenzayo i-Curcumin, i-Ellagic Acid, i-Isoliquiritigenin, i-Quercetin, i-Daidzein kwaye mhlawumbi nabanye.

Iphutha eliqhelekileyo elenziwe xa uthatha isigqibo kunye nokukhetha ukutya okutyayo kwi-Cancer ye-Nasopharyngeal - kukuvavanya kuphela izithako ezikhethiweyo ezisebenzayo eziqulethwe kukutya kwaye ungayihoyi yonke into. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha i-cherry izithako ezisebenzayo ekutyeni kunye nezongezelelo zokwenza isigqibo sesondlo seNasopharyngeal Cancer.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kwiSondlo soMntu kuMhlaza weNasopharyngeal?

Izondlo zomntu zomhlaza ezifana neNasopharyngeal Cancer iquka ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwi-Nasopharyngeal Cancer biology, isayensi yokutya, imfuzo, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nobuthathaka obunxulumeneyo apho unyango lunokuyeka ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana neNasopharyngeal Cancer

Zonke ii-cancer ezifana ne-Nasopharyngeal Cancer zingabonakaliswa yinkqubo ekhethekileyo yeendlela ze-biochemical - iindlela zokutyikitya ze-Nasopharyngeal Cancer. Iindlela ze-Biochemical ezifana ne-Cytoskeletal Dynamics, i-MAPK Signaling, i-PI3K-AKT-MTOR Ukubonakaliswa, i-G-protein-coupled Receptor Signaling iyingxenye yenkcazo yesignesha ye-Nasopharyngeal Cancer. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kuMhlaza weNasopharyngeal kufuneka luthathele ingqalelo utyikityo olunxulumene neendlela zebhayochemicals kumguli ngamnye womhlaza kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto ezinye ukutya kunye nezongezelelo ziyacetyiswa kuMhlaza weNasopharyngeal xa uthatha unyango lomhlaza iVincristine, kwaye ezinye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-KMT2D, i-CDKN2A, i-TP53, i-RYR2 kunye ne-NSD1 zezona ziphezulu iijene ezichazwe kwi-Nasopharyngeal Cancer. I-KMT2D ixelwe kwi-5.5% yezigulane ezimele kuzo zonke izilingo zonyango. Kwaye i-CDKN2A ichazwe kwi-4.4%. Idatha yezigulane ezidityanisiweyo igubungela iminyaka yobudala ukusuka kuma-36 ukuya kuma-80. I-74.0 % yedatha yezigulane ichongwe njengamadoda. Ibhayoloji yoMhlaza weNasopharyngeal kunye nemfuzo exeliweyo kunye zichaza inani labantu elimele utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenza isondlo somntu.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezelelo zoMhlaza weNasopharyngeal

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha iVegetable GIANT BUTTERBUR or MALABAR SPINACH?

I-Butterbur enkulu yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Apigenin, i-Lycopene, i-Isoliquiritigenin, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-Carbohydrate Metabolism, i-Microtubule Dynamics kunye ne-Chemokine Signaling kunye nabanye. I-Giant Butterbur iyacetyiswa kuMhlaza weNasopharyngeal xa unyango lomhlaza oluqhubekayo yiVincristine. Oku kungenxa yokuba i-Giant Butterbur ilungisa ezo ndlela ze-biochemical eziye zaxelwa ngokwesayensi ukwazisa isiphumo seVincristine.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno iMalabar Isipinashi yi-Curcumin, i-Apigenin, i-Lycopene, i-Isoliquiritigenin, i-Quercetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Ceramide Signaling, i-PI3K-AKT-MTOR Umqondiso kunye noxinzelelo lwe-Oxidative kunye nabanye. I-Malabar Spinach ayikhuthazwa ukuba i-Cancer ye-Nasopharyngeal xa unyango lomhlaza oluqhubekayo yi-Vincristine kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IBHUTTERBURE EYINGXAKI YOMFUNO IYINGQINISWA NGAPHEZU KWE-MALABAR SPINACH KUMhlaza weNasopharyngeal KUNYE NONYANGO iVincristine.

Khetha iSiqhamo RED RASPBERRY okanye BILBERRY?

Isiqhamo esiBomvu iRaspberry iqukethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Ellagic Acid, i-Isoliquiritigenin, i-Quercetin, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-MAPK Signaling, i-Microtubule Dynamics kunye ne-MYC Signaling kunye nabanye. I-Red Raspberry inconywa kwiCancer yeNasopharyngeal xa unyango oluqhubekayo lomhlaza yiVincristine. Oku kungenxa yokuba i-Red raspberry iguqula ezo ndlela ze-biochemical eziye zaxelwa ngokwesayensi ukwazisa isiphumo seVincristine.

Ezinye zezithako ezisebenzayo okanye i-bioactives kwisiqhamo iBilberry yiCurcumin, i-Resveratrol, i-Apigenin, i-Lycopene, i-Isoliquiritigenin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana neCeramide Signaling kunye ne-Oxidative Stress kunye nezinye. I-Bilberry ayikhuthazwa ukuba i-Cancer Nasopharyngeal xa unyango lomhlaza oluqhubekayo yi-Vincristine kuba iguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO ERED RASPBERRY KUNCEBISWA NGAPHEZU KWEBILBERRY YENasopharyngeal Cancer KUNYE NONYANGO iVincristine.

Khetha i-Nutt EQHELEKILEYO IHAZELNUT okanye i-EUROPEAN CHESTNUT?

I-Hazelnut eqhelekileyo iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Lycopene, i-Isoliquiritigenin, i-Quercetin, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-MYC Signaling, i-Microtubule Dynamics kunye ne-Chemokine Signaling kunye nabanye. I-Hazelnut eqhelekileyo inconywa kwiCancer yeNasopharyngeal xa unyango oluqhubekayo lomhlaza yiVincristine. Oku kungenxa yokuba i-Hazelnut eqhelekileyo iguqula ezo ndlela ze-biochemical ezixelwe ngokwenzululwazi ukuze zikhuthaze isiphumo seVincristine.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yaseYurophu yi-Curcumin, i-Ellagic Acid, i-Apigenin, i-Isoliquiritigenin, i-Quercetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Ceramide Signaling, i-PI3K-AKT-MTOR Umqondiso kunye noxinzelelo lwe-Oxidative kunye nabanye. I-Chestnut yaseYurophu ayikhuthazwa ukuba i-Cancer Nasopharyngeal xa unyango lomhlaza oluqhubekayo yi-Vincristine kuba iguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

I-HAZELNUT EQHELEKILEYO KUNCEBISWA NGAPHEZU KWE-EUROPEY CHESTNUT YOMhlaza weNasopharyngeal KUNYE NONYANGO iVincristine.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwa ngabantu abanomngcipheko wemfuzo we-Nasopharyngeal Cancer okanye imbali yentsapho "Yintoni endimele ndiyitye ngokwahlukileyo ngaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha iVegetable CALABASH okanye iRADISH?

ICalabash yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-Amino Acid Metabolism, i-P53 Signaling kunye ne-Angiogenesis kunye nabanye. I-Calabash icetyiswa kumngcipheko we-Nasopharyngeal Cancer xa ingozi yemfuzo ehambelana nayo yi-CDKN2A. Oku kungenxa yokuba iCalabash yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno yeRadish yi-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Quercetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-Stem Cell Signaling kunye ne-PI3K-AKT-MTOR Ukubonisana kunye nabanye. IRadish ayikhuthazwa xa umngcipheko weNasopharyngeal Cancer xa umngcipheko wofuzo unxulumene neCDKN2A kuba inyusa iindlela zokutyikitya kuyo.

I-CALABASH YOMFUNO INCEBISIWE NGAPHEZU KWERADISHI YE-CDKN2A GENETIC RISK YOMHLAZA.

Khetha iSiqhamo sePAPAYA okanye iPUMMELO?

I-Fruit Papaya iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin, i-Linalool. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-Stem Cell Signaling, i-P53 Signaling kunye ne-MYC Signaling kunye nabanye. I-Papaya icetyiswa kumngcipheko we-Nasopharyngeal Cancer xa ingozi yemfuza ehambelana nayo yi-CDKN2A. Oku kungenxa yokuba i-Papaya yonyusa ezo ndlela ze-biochemical ezichasene nabaqhubi besignesha kuyo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo iPummelo yi-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Quercetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana neStem Cell Signaling kunye neCell Cycle Checkpoints kunye nezinye. IPummelo ayikhuthazwa xa umngcipheko weNasopharyngeal Cancer xa umngcipheko wemfuza uhambelana ne-CDKN2A kuba inyusa iindlela zokutyikitya kuyo.

I-PAPAYA YESIQHAMO IYACEBISWA PHEZU KWE-PUMMELO YE-CDKN2A GENETIC RISK YOMHLAZA.

Khetha i-Nutt BUTTERNUT okanye i-CASHEW NUT?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-Amino Acid Metabolism, i-P53 Signaling kunye ne-Angiogenesis kunye nabanye. I-Butternut icetyiswa kumngcipheko we-Nasopharyngeal Cancer xa ingozi yemfuzo ehambelana nayo yi-CDKN2A. Oku kungenxa yokuba i-Butternut yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Cashew Nut yi-Curcumin, i-Lupeol, i-Daidzein, i-Quercetin, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Cashew Nut ayikhuthazwa xa umngcipheko weNasopharyngeal Cancer xa umngcipheko wemfuza uhambelana ne-CDKN2A kuba inyusa iindlela zokutyikitya kuyo.

IBHUTTERNUT KUCEBISWA NGAPHEZU KWE-CASHEW NUT YE-CDKN2A GENETIC RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezelelo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana neNasopharyngeal Cancer. Izigulana zoMhlaza weNasopharyngeal kunye nabantu abanomngcipheko wemfuza bahlala benombuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye zingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezinje ngoMhlaza weNasopharyngeal, nganye ineemfuza ezahlukeneyo zethumba kunye nokwahluka kwe-genomic ngakumbi kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okufana neGiant Butterbur kuqulethe izinto ezahlukeneyo zebhayoloji kwimiyinge eyahlukeneyo, enefuthe kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo somntu we-addon wesondlo senza ukuba isigqibo sibe lula kwaye sisuse yonke ingqikelelo ekuphenduleni umbuzo othi, "Kukuphi ukutya endimele ndikhethe okanye ndingakhethi kwiCancer yeNasopharyngeal?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Hnc Mskcc 2016
• I-Molecular Landscape ye-Recurrent and Metastatic Head and Neck Cancers: Iingcamango ezivela kwi-Platform yokuSekelana kwe-Oncology echanekileyo.
• Impembelelo ye-Daidzein kumhlaza we-prostate refractory kwi-vitro kunye ne-vivo xa kuthelekiswa ne-genistein kunye ne-soy extract: amandla onyango lwe-radiotherapy.
• I-Vitamin C iphucula ukuguqulwa kwe-epigenetic eyenziwa yi-5-azacytidine kunye nokubanjwa komjikelo weseli kwi-hepatocellular carcinoma celllines HLE kunye ne-Huh7.
• Iinxalenye ezithile zejusi yerharnati njengezithinteli ezinokubakho kwi-prostate cancer metastasis.
• I-Lycopene ngokwahlukileyo idala i-quiescence kunye ne-apoptosis kwi-androgen-esabelayo kunye ne-independent ye-prostate cancer celllines.
• Ulawulo olubi lwe-transducer yesignali kunye ne-activator ye-transcription-3 yokubonisa i-cascade yi-lupeol inqanda ukukhula kwaye yenza i-apoptosis kwiiseli ze-hepatocellular carcinoma.
• Ukukhula okukhuthazwayo kweeseli ze-pulmonary adenocarcinoma yabantu kunye neeseli ezincinci ze-epithelial zomoya nge-beta-carotene ngokusebenza kwe-cAMP, i-PKA, i-CREB kunye ne-ERK1/2.