Ukutya koMhlaza woMlomo weSibeleko!

intshayelelo

Ukutya koMhlaza woMlomo weSibeleko kufuneka kulungiselelwe umntu ngamnye kwaye kufuneka kulungiswe xa unyango lomhlaza okanye utshintsho lwemfuzo yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

KuMhlaza woMlomo weSibeleko ingaba inomsebenzi ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu umntu ayityayo?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza ngowomhlaza - kwimihlaza efana neMucinous Cervical Cancer ingaba ibalulekile na into yokutya endikutyayo nendingakutyiyo? Okanye ukuba ndilandela ukutya okusekelwe kwisityalo oko kwanele umhlaza ofana noMhlaza weSibeleko seMucinous?

Umzekelo ingaba inomsebenzi ukuba imifuno yaseBrussels Sprouts ityiwa kakhulu xa ithelekiswa neMalabar Spinatshi? Ngaba kuyawenza umahluko xa kukhethwa isiqhamo iPummelo kuneLamuni? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane / iimbewu ezifana neWalnut emnyama phezu kweChestnut kunye neepulses ezifana ne-Black-eyed Pea phezu {food_pulse1_nr1}. Kwaye ukuba into endiyityayo ibalulekile - ke umntu uchonga njani ukutya okucetyiswayo kwi-Mucinous Cervical Cancer kwaye ingaba impendulo efanayo kuye wonke umntu onoxilongo olufanayo okanye umngcipheko wemfuzo?

Ewe! Ukutya okutyayo kubalulekile kuMhlaza woMlomo weSibeleko!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Umzekelo iPummelo iqulethe izithako ezisebenzayo i-Curcumin, i-Apigenin, i-Protocatechuic Acid, i-Lycopene, i-Lupeol. Kwaye iLemon iqulethe izithako ezisebenzayo i-D-limonene, i-Linalool, i-Curcumin, i-Protocatechuic Acid, i-Glucaric Acid kunye nabanye.

Impazamo eqhelekileyo eyenziwa xa kusenziwa isigqibo nokukhetha ukutya okuza kutyiwa kuMhlaza woMlomo weSibeleko we-Mucinous Cervical Cancer - kukuvavanya kuphela izithako ezisebenzayo ezikhethiweyo eziqulethwe kukutya kwaye ungazihoyi ezinye. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichaseneyo kubaqhubi bomhlaza - awukwazi ukukhetha izithako ezisebenzayo ekutyeni kunye nezongezelelo ukwenza isigqibo sesondlo soMhlaza woMlomo weSibeleko.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kuMhlaza woMlomo weSibeleko?

Isondlo esilungiselelwe wena somhlaza onjengoMhlaza woMlomo weSibeleko weMucinous siquka ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubungcali kwi-Mucinous Cervical Cancer biology, isayensi yokutya, i-genetics, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nobuthathaka obunxulumeneyo apho unyango lunokuyeka ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana noMhlaza woMlomo weSibeleko

Yonke imihlaza efana noMhlaza woMlomo weSibeleko weMucinous inokuphawulwa ngeseti eyodwa yeendlela ze-biochemical - iindlela zokutyikitywa koMhlaza woMlomo weSibeleko. Iindlela ze-Biochemical ezifana ne-RAS-RAF Signaling, i-MAPK Signaling, i-PI3K-AKT-MTOR yoMbonakaliso, i-Cell Cycle Checkpoints iyingxenye yenkcazo yesiginesha ye-Mucinous Cervical Cancer. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kuMhlaza woMlomo weSibeleko we-Mucinous Cervical Cancer kufuneka luthathele ingqalelo utyikityo olunxulumene neendlela zebhayokhemikhali kwisigulana ngasinye somhlaza kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto okunye ukutya kunye nezongezo zicetyiswayo kwi-Mucinous Cervical Cancer xa uthatha unyango lomhlaza IRadiation, kunye nokunye ukutya kunye nezongezelelo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-KRAS, i-NSD1, i-PTCH1, i-RB1 kunye ne-STK11 zezona ntlobo zemfuza zibekwe phezulu kuMhlaza woMlomo weSibeleko. I-KRAS ixelwe kwi-50.0% yezigulane ezimele kuzo zonke iimvavanyo zeklinikhi. Kwaye i-NSD1 ixelwe kwi-50.0%. Idatha yesigulana esidityanisiweyo igubungela iminyaka ukusuka ukuya . I-0.0% yedatha yesigulane ichongwa njengamadoda. Ibhayoloji yoMhlaza woMlomo weSibeleko kunye nofuzo oluxeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenza isondlo somntu.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezo zoMhlaza woMlomo weSibeleko

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha imifuno ye-BRUSSEL sprouts okanye i-MALABAR SPINACH?

Imifuno ye-Brussel Sprouts iqulethe ezininzi izithako ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Protocatechuic Acid, i-Glucaric Acid, i-Lupeol, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-MYC Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Brussel Sprouts yenza isincomo kwi-Mucinous Cervical Cancer xa unyango lomhlaza oluqhubekayo luyiRadiation. Oku kungenxa yokuba i-Brussel Sprouts ilungisa ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukuze zikhuthaze impembelelo yeRadiation.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno yeMalabar Isipinashi yi-Apigenin, i-Curcumin, i-Protocatechuic Acid, i-Lycopene, i-Lupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Malabar Spinach ayinconywa kuMhlaza woMlomo weSibeleko xa unyango lomhlaza oluqhubekayo luyiRadiation kuba iguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli ngokukhawuleza.

IMIFUNO YEBRUSSEL IYAKUCEBISWA NGAPHEZU KWE-MALABAR SPINACH kuMhlaza woMlomo weSibeleko kunye noNyango lweRadi.

Khetha iSiqhamo ILAMONI okanye iPUMMELO?

I-Fruit Lemon iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-D-limonene, i-Linalool, i-Curcumin, i-Protocatechuic Acid, i-Glucaric Acid. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-MYC Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. Ilamuni iyacetyiswa kuMhlaza woMlomo weSibeleko xa unyango lomhlaza oluqhubekayo luyiRadiation. Oku kungenxa yokuba iLamuni ilungisa ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukwazisa isiphumo seRadi.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo iPummelo yiCurcumin, i-Apigenin, i-Protocatechuic Acid, i-Lycopene, i-Lupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MYC Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. IPummelo ayikhuthazwa ngoMhlaza woMlomo weSibeleko xa unyango lomhlaza oluqhubekayo luyiRadiation kuba iguqula ezo ndlela zamachiza ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli ngokukhawuleza.

I-LEMON YESIQHAMO IYAKUNIKEZISWA NGAPHEZU KWE-PUMMELO KUMhlaza woMlomo weSibeleko kunye noNyango lweRadiation.

Khetha i-Nutt EMNYAMA WALNUT okanye i-CHESTNUT?

I-Walnut emnyama iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Apigenin, i-Protocatechuic Acid, i-Ellagic Acid, i-Lupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-RAS-RAF Signaling kunye ne-PI3K-AKT-MTOR Ukubonakaliswa kunye nabanye. IWalnut emnyama icetyiswa kuMhlaza woMlomo weSibeleko xa unyango lomhlaza oluqhubekayo yiRadiation. Oku kungenxa yokuba iWalnut Emnyama ilungisa ezo ndlela zebhayomichi exelwe ngokwenzululwazi ukwazisa isiphumo seRadi.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yi-Apigenin, i-Curcumin, i-Protocatechuic Acid, i-Lycopene, i-Ellagic Acid. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MYC Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Chestnut ayikhuthazwa ngoMhlaza woMlomo weSibeleko xa unyango lomhlaza oluqhubekayo luyiRadiation kuba iguqula ezo ndlela zamachiza ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli ngokukhawuleza.

IWALNUT EMNYAMA KUNCEBISWA NGAPHEZU KWE-CHESTNUT YOMHLAZA woMlomo weSibeleko kunye noNyango lweRadi.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwe ngabantu abasengozini yemfuzo ye-Mucinous Cervical Cancer okanye imbali yentsapho "Yintoni endimele ndiyitye ngokwahlukileyo kunangaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha iVegetable GIANT BUTTERBUR or ITATO?

I-Vegetable Giant Butterbur iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Apigenin, i-Delphinidin, i-Lupeol, i-Myricetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-PI3K-AKT-MTOR yokuSayina, i-RAS-RAF yokubonisa kunye noxinzelelo lwe-Oxidative kunye nabanye. I-Giant Butterbur iyacetyiswa kumngcipheko woMhlaza woMlomo weSibeleko xa ingozi yemfuzo eyayanyaniswa nayo yi-KRAS. Oku kungenxa yokuba i-Giant Butterbur yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno yePotato yi-Quercetin, i-Curcumin, i-Delphinidin, i-Lupeol, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Oxidative Stress kunye nezinye. Iitapile ayikhuthazwa xa umngcipheko woMhlaza woMlomo weSibeleko xa umngcipheko wemfuzo unxulunyaniswa ne-KRAS kuba yonyusa iindlela zokutyikitywa kwayo.

IBHUTTERBURE EYISINQIZI YOMFUNO IYAKUNQINABISWA PHEZU KWEITAPATO YE-KRAS genetic RISK YOMHLAZA.

Khetha iSiqhamo se-NANCE okanye i-ACEROLA?

I-Fruit Nance iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Apigenin, i-Delphinidin, i-Lupeol, i-Myricetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-PI3K-AKT-MTOR yokuSayina, i-RAS-RAF yokubonisa kunye noxinzelelo lwe-Oxidative kunye nabanye. UNance ucetyiswa kumngcipheko woMhlaza woMlomo weSibeleko xa umngcipheko wemfuzo onxulumeneyo yi-KRAS. Oku kungenxa yokuba i-Nance yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo ze-Acerola yi-Quercetin, i-Curcumin, i-Apigenin, i-Delphinidin, i-Lupeol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana neStem Cell Signaling kunye ne-Oxidative Stress kunye nezinye. I-Acerola ayikhuthazwa xa umngcipheko woMhlaza woMlomo weSibeleko xa umngcipheko wemfuzo unxulunyaniswa ne-KRAS kuba yonyusa iindlela zokutyikitywa kwayo.

ISIQHAMO NANCE KUCEBISWA NGE-ACEROLA YE-KRAS genetic RISK YOMHLAZA.

Khetha Nut BUTTERNUT okanye EUROPEAN CHESTNUT?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Apigenin, i-Delphinidin, i-Lupeol, i-Myricetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-PI3K-AKT-MTOR yokuSayina, i-RAS-RAF yokubonisa kunye noxinzelelo lwe-Oxidative kunye nabanye. I-Butternut iyacetyiswa kumngcipheko woMhlaza woMlomo weSibeleko xa ingozi yemfuzo eyayanyaniswa nayo yi-KRAS. Oku kungenxa yokuba i-Butternut yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yaseYurophu yi-Ellagic Acid, i-Quercetin, i-Curcumin, i-Apigenin, i-Delphinidin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana neStem Cell Signaling kunye ne-Oxidative Stress kunye nezinye. I-Chestnut yaseYurophu ayikhuthazwa xa umngcipheko we-Mucinous Cervical Cancer xa umngcipheko wezofuzo uhambelana ne-KRAS kuba yonyusa iindlela zokutyikitya.

IBHUTTERNUT KUCEBISWA NGAPHEZU KWE-EUROPEY CHESTNUT YE-KRAS genetic RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezelelo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana noMhlaza woMlomo weSibeleko. Izigulana zoMhlaza weSibeleko seMucinous kunye nabantu abasengozini yemfuza bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye zingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana noMhlaza woMlomo weSibeleko, nganye ineemfuza ezahlukeneyo zethumba ezinokwahluka kwe-genomic ngakumbi kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okufana ne-Brussels Sprouts kuqulethe iintlobo ngeentlobo ze-bioactives ngokwemiyinge eyahlukeneyo, enempembelelo kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela ze-biochemical. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo somntu we-addon wesondlo senza ukuba isigqibo sibe lula kwaye sisuse yonke ingqikelelo ekuphenduleni umbuzo othi, "Kukuphi ukutya endimele ndikhethe okanye ndingakhethi kwi-Mucinous Cervical Cancer?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Msk Impact 2017
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.
• I-Daidzein icinezela i-tumor necrosis factor-α ebangela ukufuduka kunye nokuhlasela ngokuthintela i-hedgehog / i-Gli1 ukubonakaliswa kwiiseli zomhlaza webele lomntu.
• I-D-Limonene imodareyitha ukuvuvukala, uxinzelelo lwe-oxidative kunye ne-Ras-ERK indlela yokuvimbela i-tumorigenesis yesikhumba se-murine.
• Iziphumo zokuthintela i-butyric acid, i-nicotinamide, i-calcium glucarate yodwa okanye idibene ngexesha le-7, i-12-dimethylbenz (a) i-anthracene ibangele i-tumorigenesis yesikhumba semouse ngokumodareyitha kwe-K-Ras-PI3K-AKTpathway kunye ne-RNAs ezincinci ezinxulumene nazo.
• Ukukhula okukhuthazwayo kweeseli ze-pulmonary adenocarcinoma yabantu kunye neeseli ezincinci ze-epithelial zomoya nge-beta-carotene ngokusebenza kwe-cAMP, i-PKA, i-CREB kunye ne-ERK1/2.
• Ulawulo olubi lwe-transducer yesignali kunye ne-activator ye-transcription-3 yokubonisa i-cascade yi-lupeol inqanda ukukhula kwaye yenza i-apoptosis kwiiseli ze-hepatocellular carcinoma.