Ukutya koMhlaza weLaryngeal!

intshayelelo

Ukutya koMhlaza weLaryngeal kufuneka kulungiselelwe umntu ngamnye kwaye kufuneka kuziqhelanise xa unyango lomhlaza okanye utshintsho lwemfuza yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

NgoMhlaza weLaryngeal ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu ayityayo?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza ngowomhlaza weLaryngeal Cancer ingaba ibalulekile na into yokutya endikutyayo nendingakutyiyo? Okanye ukuba ndilandela ukutya okusekelwe kwisityalo oko kwanele umhlaza onjengeLaryngeal Cancer?

Umzekelo ingaba inomsebenzi ukuba imifuno etyheli yeZucchini ityiwa kakhulu xa kuthelekiswa nekhaphetshu loMgxobhozo? Ngaba kuyawenza umahluko xa kukhethwa isiqhamo iPitanga kuneSoursop? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane/iimbewu ezifana neButternut ngaphezu kweChestnut yaseYurophu kunye neentyatyambo ezifana neGram Bean phezu kweLima Bean. Kwaye ukuba into endiyityayo ibalulekile - umntu uchonga njani ukutya okucetyiswayo kwiLaryngeal Cancer kwaye ingaba impendulo efanayo kuye wonke umntu onoxilongo olufanayo okanye umngcipheko wemfuzo?

Ewe! Ukutya okutyayo kubalulekile kwiLaryngeal Cancer!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Umzekelo i-Pitanga iqulethe izithako ezisebenzayo i-Quercetin, i-Apigenin, i-Curcumin, i-Lycopene, i-Lupeol. Kwaye i-Soursop iqulethe izithako ezisebenzayo i-Apigenin, i-Curcumin, i-Lupeol, i-Emodin, i-Formononetin kwaye mhlawumbi nabanye.

Iphutha eliqhelekileyo elenziwe xa kuthathwa isigqibo kunye nokukhetha ukutya okutyayo kwiLaryngeal Cancer - kukuvavanya kuphela izithako ezikhethiweyo ezisebenzayo eziqulethwe kukutya kwaye ungayihoyi ezinye. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha izithako ezisebenzayo ekutyeni kunye nezongezelelo zokwenza isigqibo sesondlo seLaryngeal Cancer.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kuMhlaza weLaryngeal?

Izondlo zomntu zomhlaza ezifana neLaryngeal Cancer iquka ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubungcali kwi-Laryngeal Cancer biology, isayensi yokutya, i-genetics, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nobuthathaka obunxulumeneyo apho unyango lunokuyeka ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana neLaryngeal Cancer

Zonke ii-cancer ezifana ne-Laryngeal Cancer zingabonakaliswa ngesethi ekhethekileyo yeendlela ze-biochemical - iindlela zokutyikitya zeLaryngeal Cancer. Iindlela ze-Biochemical ezifana ne-RAS-RAF Signaling, i-NFKB Signaling, i-PI3K-AKT-MTOR yoMbonakaliso, i-Cell Cycle Checkpoints iyingxenye yenkcazo yesiginesha yeLaryngeal Cancer. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kuMhlaza weLaryngeal kufuneka luthathele ingqalelo utyikityo olunxulumene neendlela zebhayokhemikhali kwisigulana ngasinye somhlaza kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto ezinye ukutya kunye nezongezo zicetyiswayo kwiLaryngeal Cancer xa uthatha unyango lomhlaza iDocetaxel, kwaye ezinye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-TP53, NOTCH1, CDKN2A, KMT2D kunye ne-NFE2L2 zezona ziphezulu iigenes ezixeliweyo zeLaryngeal Cancer. I-TP53 ixelwe kwi-40.7% yezigulane ezimele kuzo zonke iimvavanyo zekliniki. Kwaye i-NOCH1 ixelwe kwi-18.5%. I-data edityanisiweyo yesigulane igubungela iminyaka yobudala ukusuka kuma-52 ukuya kuma-67. I-84.7 % yedatha yezigulane ichongwe njengamadoda. Ibhayoloji yoMhlaza weLaryngeal kunye nemfuzo exeliweyo kunye zichaza inani labantu elimele utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenziwa kwesondlo.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezelelo zeLaryngeal Cancer

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha iVegetable YELLOW ZUCCHINI okanye IKHABHAGEJI EXWAMPAYO?

I-Vegetable Yellow Yellow iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Formononetin, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Hypoxia, i-NFKB yokuSayina kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Yellow Zucchini icetyiswa kwiLaryngeal Cancer xa unyango lomhlaza oluqhubekayo yiDocetaxel. Oku kungenxa yokuba iZucchini etyheli iguqula ezo ndlela zebhayomichi exelwe ngokwenzululwazi ukuze zikhuthaze isiphumo seDocetaxel.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ye-Swamp Cabbage yi-Curcumin, i-Lycopene, i-Lupeol, i-Formononetin, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Heat Stress Response kunye nezinye. Ikhaphetshu engumgxobhozo ayikhuthazwa kuMhlaza weLaryngeal xa unyango lomhlaza oluqhubekayo yiDocetaxel kuba ilungisa ezo ndlela zebhayoloji ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IZUCCHINI YOMFUNO EYELLOW IYACEBISWA NGAPHEZU KWEKHABHAGEJI YOMgxobhozo woMhlaza weLaryngeal KUNYE NONYANGO iDocetaxel.

Khetha iSiqhamo SOURSOP okanye iPITANGA?

I-Fruit Soursop iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Emodin, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-MYC Signaling, i-NFKB yokuSayina kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Soursop inconywa kwiLaryngeal Cancer xa unyango oluqhubekayo lomhlaza luyiDocetaxel. Oku kungenxa yokuba i-Soursop ilungisa ezo ndlela ze-biochemical eziye zaxelwa ngokwesayensi ukwazisa isiphumo se-Docetaxel.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo ze-Pitanga yi-Quercetin, i-Apigenin, i-Curcumin, i-Lycopene, i-Lupeol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Heat Stress Response, i-TGFB Signaling kunye ne-NFKB Signaling kunye nezinye. I-Pitanga ayikhuthazwa uMhlaza weLaryngeal xa unyango lomhlaza oluqhubekayo yiDocetaxel kuba luguqula ezo ndlela zebhayoloji ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO SOURSOP KUNCEBISWA NGAPHEZU KWEPITANGA YELaryngeal Cancer KUNYE NONYANGO Docetaxel.

Khetha Nut BUTTERNUT okanye EUROPEAN CHESTNUT?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lycopene, i-Lupeol, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK yokuSayina, i-TGFB Signaling, i-NFKB Signaling kunye ne-PI3K-AKT-MTOR yokuSayina kunye nabanye. I-Butternut iyacetyiswa kuMhlaza weLaryngeal xa unyango lomhlaza oluqhubekayo yiDocetaxel. Oku kungenxa yokuba i-Butternut ilungisa ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukwazisa isiphumo se-Docetaxel.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yaseYurophu yi-Quercetin, i-Apigenin, i-Curcumin, i-Ellagic Acid, i-Lupeol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Heat Stress Response kunye nezinye. I-Chestnut yaseYurophu ayikhuthazwa ukuba iLaryngeal Cancer xa unyango lomhlaza oluqhubekayo yiDocetaxel kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IBHUTTERNUT KUCEBISWA NGAPHEZU KWE-EUROPA CHESTNUT YELaryngeal Cancer KUNYE NONYANGO iDocetaxel.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwa ngabantu abanomngcipheko wemfuzo weLaryngeal Cancer okanye imbali yentsapho "Yintoni endimele ndiyitye ngokwahlukileyo ngaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha iVegetable CALABASH okanye i-ARROWHEAD?

ICalabash yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Beta-sitosterol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK yokuSayina, i-Oxidative Stress, i-Stem Cell Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Calabash icetyiswa kumngcipheko weLaryngeal Cancer xa ingozi yemfuzo ehambelana nayo yi-CDKN2A. Oku kungenxa yokuba iCalabash yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ye-Arrowhead yi-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Beta-sitosterol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle Checkpoints kunye ne-Oxidative Stress kunye nezinye. I-Arrowhead ayikhuthazwa xa umngcipheko weLaryngeal Cancer xa umngcipheko wezofuzo uhambelana ne-CDKN2A kuba inyusa iindlela zokutyikitya kuyo.

I-CALABASH YOMFUNO ICEBISWA NGENXA YE-ARROWHEAD YE-CDKN2A UMNGCIPHEKO WOMFUZO WOMHLAZA.

Khetha iSiqhamo se-NANCE okanye i-MUSCADINE GRAPE?

I-Fruit Nance iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Beta-sitosterol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK yokuSayina, i-Oxidative Stress, i-Stem Cell Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Nance icetyiswa kumngcipheko weLaryngeal Cancer xa umngcipheko wemfuza ohambelana ne-CDKN2A. Oku kungenxa yokuba i-Nance yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo ze-Muscadine Grape yi-Apigenin, i-Curcumin, i-Lupeol, i-Ellagic Acid, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo zebhayochemicals ezifana neCell Cycle Checkpoints kunye neStem Cell Signaling kunye nezinye. IMuscadine Grape ayikhuthazwa xa umngcipheko weLaryngeal Cancer xa umngcipheko wemfuzo uhambelana neCDKN2A kuba yonyusa iindlela zokutyikitya.

ISIQHAMO NANCE KUCEBISWA NGAPHEZU KWEMIDILIYA YOMUSCADINE NGE-CDKN2A GENETIC RISK YOMHLAZA.

Khetha i Nut COMMON HAZELNUT okanye iFLXSEED?

I-Hazelnut eqhelekileyo iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Lupeol, i-Daidzein, i-Quercetin, i-Beta-sitosterol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-PI3K-AKT-MTOR yokuSayina, i-Stem Cell Signaling kunye ne-Oxidative Stress kunye nabanye. IHazelnut eqhelekileyo icetyiswa kumngcipheko weLaryngeal Cancer xa umngcipheko wemfuzo ohambelana neCDKN2A. Oku kungenxa yokuba iHazelnut eqhelekileyo yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Flaxseed yi-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Beta-sitosterol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-PI3K-AKT-MTOR Umqondiso kunye noxinzelelo lwe-Oxidative kunye nabanye. I-Flaxseed ayikhuthazwa xa umngcipheko weLaryngeal Cancer xa umngcipheko wezofuzo uhambelana ne-CDKN2A kuba inyusa iindlela zokutyikitya kuyo.

I-HAZELNUT EQHELEKILEYO IYANCEBISWA NGAPHEZU KWE-FLAXSEED YE-CDKN2A GENETIC RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezelelo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana neLaryngeal Cancer. Izigulana zoMhlaza weLaryngeal kunye nabantu abasengozini yemfuza bahlala benombuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye zingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezinje ngoMhlaza weLaryngeal, nganye ineemfuza ezahlukeneyo zethumba kunye nokwahluka kwe-genomic ngakumbi kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okufana neZucchini emthubi iqulethe izinto ezahlukeneyo zebhayoloji kwimiyinge eyahlukeneyo, enempembelelo kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo somntu we-addon wesondlo senza ukuba isigqibo sibe lula kwaye sisuse yonke ingqikelelo ekuphenduleni umbuzo othi, "Kukuphi ukutya endimele ndikhethe okanye ndingakhethi kwiLaryngeal Cancer?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Hnc Mskcc 2016
• I-Molecular Landscape ye-Recurrent and Metastatic Head and Neck Cancers: Iingcamango ezivela kwi-Platform yokuSekelana kwe-Oncology echanekileyo.
• I-L-Ascorbic Acid Inqanda Ukukhula koMhlaza Webele ngokuNxibisa i-IRE/JNK/CHOP-Enxulumene ne-Endoplasmic Reticulum Stress-Mediated p62/SQSTM1 Ukuqokelela kwi-Nucleus.
• Ulawulo olubi lwe-transducer yesignali kunye ne-activator ye-transcription-3 yokubonisa i-cascade yi-lupeol inqanda ukukhula kwaye yenza i-apoptosis kwiiseli ze-hepatocellular carcinoma.
• Iingcamango ezintsha kwi-phospholipase D ebonisa ukuvuvukala kunye nomhlaza.