Ukutya kweHodgkin Lymphoma!

intshayelelo

Ukutya kweHodgkin Lymphoma kufuneka kulungiselelwe umntu ngamnye kwaye kufuneka kuhlengahlengiswe xa unyango lomhlaza okanye utshintsho lwemfuza yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

I-Hodgkin lymphoma yintlupheko ye-lymphatic system, ngakumbi ibonakala kwii-lymph nodes zomlomo wesibeleko. Inokuthi ihlelwe njenge-classical Hodgkin lymphoma kunye ne-nodular lymphocyte predominant Hodgkin lymphoma. Izehlo zehlabathi ze-Hodgkin lymphoma zaziyi-0.4% kunye neemeko ezintsha ezingama-83,087 ezixelwe ngo-2020 (Ref: GLOBOCAN database). Esona siganeko siphezulu sichazwe eYurophu, eOstreliya naseNew Zealand, ngelixa esona siganeko sisezantsi safunyanwa eMpuma nakumazantsi-mpuma eAsia. Nangona unqabile, ngowona mhlaza uxhaphakileyo phakathi kwabafikisayo kunye nabantu abadala abancinci. Ngokusekelwe kuhlalutyo lwedatha yabemi, iziganeko eziphezulu ze-Hodgkin lymphoma zifunyenwe zidibene nokuxhaphaka kokutshaya, ukukhuluphala kunye noxinzelelo lwegazi. Umyinge weminyaka emi-5 yokusinda kwizigulane ezine-Hodgkin lymphoma e-United States yi-88%. (Ref: American Cancer Society, ACS). Unyango lweChemotherapy kunye nonyango lweradiation lolona nyango luphambili lweHodgkin lymphoma, ngelixa iinketho zonyango ezinoveli ezibandakanya unyango lwe-antibody, unyango lokugonya, i-checkpoint inhibitor immunotherapy kunye nonyango lwe-cytotoxic T lymphocytes lusetyenziswe kwisifo esiphambili ukuba olunye unyango alusebenzanga. Ukongeza, ugqirha umisele unyango oluxhaswa sisondlo esifanelekileyo (ukutya kunye nezongezelelo) ezihambelana nonyango zinokunyusa ngakumbi umgangatho wobomi besigulane.

KwiHodgkin Lymphoma ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu ayityayo?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza kukuba - kwimihlaza efana neHodgkin Lymphoma ingaba ibalulekile na into yokutya endikutyayo kwaye ndingayenziyo? Okanye ukuba ndilandela ukutya okusekelwe kwisityalo oko kwanele umhlaza onjengeHodgkin Lymphoma?

Umzekelo ingaba inomsebenzi ukuba imifuno yeCelery Stalks ityiwa kakhulu xa ithelekiswa neOyster Mushroom? Ngaba kuyawenza umahluko ukuba isiqhamo {food_fruit1_nr1} siyakhethwa kuneArctic Blackberry? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane / iimbewu ezifana neChestnut phezu kwe-{food_nut1_nr1} kunye neepulses ezifana neYellow Wax Bean phezu {food_pulse1_nr1}. Kwaye ukuba into endiyityayo ibalulekile - umntu uchonga njani ukutya okucetyiswayo kwiHodgkin Lymphoma kwaye ingaba impendulo efanayo kuye wonke umntu onoxilongo olufanayo okanye umngcipheko wemfuza?

Ewe! Ukutya okutyayo kubalulekile kwiHodgkin Lymphoma!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Umzekelo {food_fruit1_nr1} iqulethe izithako ezisebenzayo {food_fruit1_nr1_ing}. Kwaye i-Arctic Blackberry iqulethe izithako ezisebenzayo i-Ellagic Acid, i-Curcumin, i-Apigenin, i-Phloretin, i-Formononetin kwaye mhlawumbi nabanye.

Iphutha eliqhelekileyo elenziwe xa uthatha isigqibo kunye nokukhetha ukutya okutyayo kwiHodgkin Lymphoma - kukuvavanya kuphela izithako ezikhethiweyo ezisebenzayo eziqulethwe kukutya kwaye ungayihoyi ezinye. Kuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha izithako ezisebenzayo ekutyeni kunye nezongezelelo zokwenza isigqibo sesondlo seHodgkin Lymphoma.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwiHodgkin Lymphoma?

Izondlo zomntu zomhlaza ezifana neHodgkin Lymphoma zibandakanya ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwi-Hodgkin Lymphoma biology, isayensi yokutya, imfuzo, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nobuthathaka obunxulumeneyo apho unyango lunokuyeka ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana neHodgkin Lymphoma

Zonke ii-cancer ezifana ne-Hodgkin Lymphoma zinokubonakaliswa ngoluhlu olulodwa lweendlela ze-biochemical - iindlela zokutyikitya zeHodgkin Lymphoma. Iindlela ze-Biochemical ezifana ne-Apoptosis, i-Chromatin Remodeling, ii-Checkpoints ze-Cell Cycle, i-Epithelial ukuya kwi-Mesenchymal Transition ziyingxenye yenkcazo yesiginesha ye-Hodgkin Lymphoma. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwi-Hodgkin Lymphoma kufuneka luthathele ingqalelo utyikityo lweendlela zebhayokhemikhali kwisigulana ngasinye somhlaza kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto okunye ukutya kunye nezongezo zicetyiswayo kwiHodgkin Lymphoma xa uthatha unyango lomhlaza iVinblastine, kwaye okunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-ARID1A, i-ARID5B, i-B2M, i-CD79A kunye ne-CTCF zezona ziphezulu iiseli zemfuza ezixeliweyo ze-Hodgkin Lymphoma. I-ARID1A ixelwe kwi-25.0% yezigulane ezimele kuzo zonke izilingo zeklinikhi. Kwaye i-ARID5B ixelwe kwi-25.0%. Idatha yesigulana esidityanisiweyo sigubungela iminyaka ukusuka ukuya . I-60.0% yedatha yesigulane ichongwa njengamadoda. Ibhayoloji yeHodgkin Lymphoma kunye nemfuzo exeliweyo kunye zichaza inani labantu elimele utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenziwa kwesondlo.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezo zeHodgkin Lymphoma

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha IZIDLA zeCelery zeVegetable okanye i-OYSTER MUSHROOM

Imifuno ye-Celery Stalks iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Apigenin, i-Phloretin, i-Formononetin, i-Rosmarinic Acid. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo zebhayoloji njengeApoptosis kunye nokusinda kweSeli kunye nezinye. I-Celery Stalks iyacetyiswa kwiHodgkin Lymphoma xa unyango lomhlaza oluqhubekayo yiVinblastine. Oku kungenxa yokuba i-Celery Stalks iguqula ezo ndlela ze-biochemical eziye zaxelwa ngokwesayensi ukuze zikhuthaze isiphumo seVinblastine.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Oyster Mushroom yemifuno yi-Curcumin, i-Apigenin, i-Phloretin, i-Formononetin, i-Rosmarinic Acid. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Apoptosis kunye nezinye. I-Oyster Mushroom ayikhuthazwa kwiHodgkin Lymphoma xa unyango lomhlaza oluqhubekayo iVinblastine kuba luguqula ezo ndlela zebhayoloji ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IZIDLA ZEMIFUNO YECEREY IYAKUNCEBISWA NGAPHEZU KWE-OYSTER MUSHROOM YEHodgkin Lymphoma KUNYE NONYANGO iVinblastine.

Khetha Isiqhamo ARCTIC BLACKBERRY

Iziqhamo zeArctic Blackberry ziqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Ellagic Acid, i-Curcumin, i-Apigenin, i-Phloretin, i-Formononetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo zebhayoloji njengeApoptosis kunye nokusinda kweSeli kunye nezinye. IArctic Blackberry iyacetyiswa kwiHodgkin Lymphoma xa unyango lomhlaza oluqhubekayo yiVinblastine. Oku kungenxa yokuba iArctic Blackberry ilungisa ezo ndlela zebhayomichi exelwe ngokwenzululwazi ukuze zikhuthaze isiphumo seVinblastine.

ISIQHAMO I-ARCTIC BLACKBERRY IYANCEBISWA NGEHodgkin Lymphoma KUNYE NONYANGO iVinblastine.

Khetha Nut CHESTNUT

I-Chestnut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Ellagic Acid, i-Curcumin, i-Apigenin, i-Phloretin, i-Formononetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo zebhayoloji njengeApoptosis kunye nokusinda kweSeli kunye nezinye. I-Chestnut iyacetyiswa kwi-Hodgkin Lymphoma xa unyango lomhlaza oluqhubekayo i-Vinblastine. Oku kungenxa yokuba i-Chestnut ilungisa ezo ndlela ze-biochemical eziye zaxelwa ngokwenzululwazi ukuze zikhuthaze isiphumo seVinblastine.

I-CHESTNUT INCEBISELWE iHodgkin Lymphoma KUNYE NONYANGO iVinblastine.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwa ngabantu abasengozini yemfuza ye-Hodgkin Lymphoma okanye imbali yentsapho "Yintoni endimele ndiyitye ngokwahlukileyo ngaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha iVegetable GIANT BUTTERBUR or MOUNTAIN YAM

I-Butterbur enkulu yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Apigenin, i-Lupeol, i-Beta-sitosterol, i-Phloretin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle Checkpoints, i-Cell Cycle, i-Apoptosis kunye ne-PI3K-AKT-MTOR Ukubonakaliswa kunye nabanye. I-Giant Butterbur iyacetyiswa kumngcipheko we-Hodgkin Lymphoma xa ingozi yemfuzo eyayanyaniswa nayo yi-ARID1A. Oku kungenxa yokuba i-Giant Butterbur yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ye-Mountain Yam yi-Curcumin, i-Apigenin, i-Lupeol, i-Beta-sitosterol, i-Phloretin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle Checkpoints, ukulungiswa kwe-DNA kunye ne-WNT Beta Catenin Signaling kunye nezinye. I-Mountain Yam ayikhuthazwa xa umngcipheko we-Hodgkin Lymphoma xa umngcipheko wemfuzo uhambelana ne-ARID1A kuba yonyusa iindlela zokutyikitya kuyo.

IBHUTTERBURE EYISINXIBA YOMFUNO IYAKUCEBISWA PHEZU KWENTABA YAM NGE-ARID1A UMNGCIPHEKO WEMFUZO YOMHLAZA.

Khetha iFruit JAVA PLUM okanye iHALF-HIGHBUSH BLUEBERRY

Iziqhamo zeJava Plum ziqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana neCurcumin, i-Apigenin, i-Lupeol, i-Beta-sitosterol, i-Phloretin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle Checkpoints, i-Cell Cycle, i-Apoptosis kunye ne-PI3K-AKT-MTOR Ukubonakaliswa kunye nabanye. I-Java Plum iyacetyiswa kumngcipheko we-Hodgkin Lymphoma xa umngcipheko wemfuzo ohambelana ne-ARID1A. Oku kungenxa yokuba iJava Plum yonyusa ezo ndlela zebhayokhemikhali ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo I-Half-highbush Blueberry yi-Curcumin, i-Apigenin, i-Lupeol, i-Beta-sitosterol, i-Phloretin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye ne-Suppressive Histone Methylation kunye nezinye. I-Half-highbush Blueberry ayikhuthazwa xa umngcipheko we-Hodgkin Lymphoma xa umngcipheko wemfuzo uhambelana ne-ARID1A kuba yonyusa iindlela zokutyikitya kuyo.

ISIQHAMO I-JAVA PLUM IYANCEBISWA NGAPHEZU KWEHAlf-HIGHBUSH BLUEBERRY NGE-ARID1A genetic RISK OF CANCER.

Khetha i-Nutt BUTTERNUT okanye iWALNUT YASEJAPANE

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Apigenin, i-Lupeol, i-Beta-sitosterol, i-Phloretin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokuLungiswa kwe-DNA, i-Cell Cycle, i-MYC Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Butternut iyacetyiswa kumngcipheko we-Hodgkin Lymphoma xa ingozi yemfuzo enxulumeneyo yi-ARID1A. Oku kungenxa yokuba i-Butternut yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Walnut yaseJapan yi-Curcumin, i-Apigenin, i-Lupeol, i-Beta-sitosterol, i-Phloretin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle Checkpoints, ukulungiswa kwe-DNA kunye ne-Suppressive Histone Methylation kunye nezinye. IWalnut yaseJapan ayikhuthazwa xa umngcipheko weHodgkin Lymphoma xa umngcipheko wemfuzo uhambelana ne-ARID1A kuba yonyusa iindlela zokutyikitya kuyo.

IBHUTTERNUT UYCEBISWA NGAPHEZU KWEWALNUT YASEJAPANE NGE-ARID1A UMNGCIPHEKO WEMFUZO YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezelelo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana neHodgkin Lymphoma. Izigulana zeHodgkin Lymphoma kunye nabantu abasengozini yemfuza bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye zingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana neHodgkin Lymphoma, nganye ineemfuza ezahlukeneyo zethumba kunye nokwahluka kwe-genomic kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okunje ngeCelery Stalks kuqulethe izinto ezahlukeneyo zebhayoloji kwimiyinge eyahlukeneyo, enempembelelo kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela ze-biochemical. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo somntu we-addon wesondlo senza ukuba isigqibo sibe lula kwaye sisuse yonke into eqikelelwayo ekuphenduleni umbuzo othi, "Kukuphi ukutya endimele ndikukhethe okanye ndingakhethi kwiHodgkin Lymphoma?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Msk Impact 2017
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.
• Ukufunyanwa kwee-flavones ezincinci ezingaziwa njenge-inhibitors ye-NF-κB yokubonisa kwi-MDA-MB-231 iiseli zomhlaza webele-Isifundo se-SAR.
• Indlela yemolekyuli ye-luteolin-induced apoptosis inokunxulumana nokuthintelwa kwe-angiogenesis kwiiseli ze-pancreatic carcinoma zabantu.
• I-acids egcweleyo yamafutha imodareyitha impendulo yeseli kumonakalo we-DNA: impembelelo yendima yabo kwi-tumorigenesis.
• I-Betulinyl Sulfamates njengeeAgents ze-Anticancer kunye ne-Radiosensitizers kwiiSeli zoMhlaza woMbele woMntu.
• I-β-Sitosterol kunye neGemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity ngokuModulating i-Apoptosis kunye ne-Inhibiting Epithelial-Mesenchymal Transition ngo-Deactivating Akt / GSK-3β Signaling.
• I-Betulinic Acid iNxinzelela iMetastasis yoMhlaza wamabele ngokuJonga i-GRP78-Mediated Glycolysis kunye ne-ER Stress Apoptotic Pathway.
• I-Vitamin C iphucula ukuguqulwa kwe-epigenetic eyenziwa yi-5-azacytidine kunye nokubanjwa komjikelo weseli kwi-hepatocellular carcinoma celllines HLE kunye ne-Huh7.
• Ukhuseleko oluchasene nempembelelo yentengiso yeti emhlophe kunye necaffeine kwi-PhIP-induced tumorigenesis kunye ne-beta-catenin expression kwi-rat.
• Huang J et al, J Hematol. kunye ne-Oncol., 2022