Ngowuphi umhlaza onokuzuza ngokubandakanya iWalnut kwisidlo sabo?

Iimbalasane

IWalnut yamkelwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweWalnut kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba okunye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, iWalnut inokuba luncedo kwabo bane-Primary Solitary Fibrous Tumor ephantsi kwe-Avastin, kodwa isenokungalungeli kwizigulana ezifumana i-Ifosfamide yePrimary Round Cell Sarcoma. Ngaphaya koko, ngelixa iWalnut inokunceda abantu abanomngcipheko wemfuza "ERBB2", ayinakucetyiswa kwabo banomngcipheko wofuzo owahlukileyo "ASXL1". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kweWalnut kwisigulana somhlaza kufuneka kube ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, umngcipheko wemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekugqibeni ukuba iWalnut lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, igxile kwiziphumo ezipheleleyo zawo onke amalungu asebenzayo ekutyeni / nezongezo ezifana neWalnut endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungahoyi ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise iWalnut kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iWalnut ukuba unemfuzo enokuthanani nomhlaza onxulumene nejini ye-ERBB2? Kuthekani ukuba endaweni yoko ingozi yakho yemfuza ivela kwi-ASXL1 gene? Ngaba kuluncedo ukuquka iWalnut ekutyeni kwakho ukuba ufunyaniswe unePrimary Round Cell Sarcoma, okanye ukuba uxilongo lwakho yiPrimary Solitary Fibrous Tumor? Ngaphezu koko, kufuneka kuhlengahlengiswe njani ukusetyenziswa kwakho kweWalnut ukuba ufumana unyango lwe-Avastin okanye ukuba isicwangciso sakho sonyango siyatshintsha ukusuka kwi-Avastin ukuya kwi-Ifosfamide? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'neWalnut yendalo, ngoko isoloko iluncedo' okanye 'iWalnut yonyusa ukhuselo lomzimba' ayonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya iWalnut kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezinje ngeWalnut kwisondlo sakho ngenxa yezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ezipheleleyo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, imfuzo. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, onje ngePrimary Solitary Fibrous Tumor okanye iPrimary Round Cell Sarcoma, iindlela zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kunokubangela imingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana neWalnut. Ngaba umngcipheko wemfuza womhlaza ovela kuguquko kwi-ERBB2 unefuthe elifanayo le-biochemical pathway njengenguqu kwi-ASXL1? Ngokwembono yesondlo, ngaba umngcipheko onxulumene ne-Primary Solitary Fibrous Tumor ulingana nePrimary Round Cell Sarcoma? Ngapha koko, ngaba uqwalaselo lokutya luhlala lufana kwabo baphantsi kwe-Ifosfamide njengakwabo bafumana i-Avastin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

IWalnut – Isongezo seSondlo

I-Walnut eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, kuquka i-Geraniin, i-Juglone, i-Thymol, i-Ellagic Acid kunye ne-Hyperioside, nganye ekhoyo kwiimpawu ezihlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-MYC Signaling, i-DNA Repair kunye ne-Oncogenic Histone Methylation, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunika le mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeWalnut, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iWalnut kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kweWalnut ayisosigqibo sehlabathi lonke esilungele zonke iicancer kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zeWalnut

Ukuphendula umbuzo othi 'Ndingayiphepha nini iWalnut kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye iinzuzo zeWalnut ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye nakuphi na ukwaliwa konke kudlala indima ekuqinisekiseni ukuba i-Walnut ifanelekile okanye kufuneka ithintelwe, igxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba izongezo zeWalnut ziyakuzinceda iZigulana zeSarcoma ezikwiSisel esiPhambili eziphantsi konyango lwe-Ifosfamide?

I-Primary Round Cell Sarcoma ibonakaliswe ngokuguqulwa kofuzo oluthile, okuyi-CIC, i-ATM kunye ne-FBXW7, ekhokelela ekuguquleni kwiindlela ze-biochemical pathways, ngokukodwa ukulungiswa kwe-DNA, i-Cell Cycle Checkpoints, i-Antigen Presentation kunye ne-Post Translation Modification. Ukusebenza konyango lomhlaza, olufana ne-Ifosfamide, kuxhomekeke kwindlela yayo yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, isongezelelo seWalnut, esichaphazela ukulungiswa kwe-DNA, isenokungabi lukhetho olufanelekileyo kwimeko ye-Primary Round Cell Sarcoma xa i-Ifosfamide. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba izongezelelo zeWalnut ziya kunceda izigulana ezikwiPrimary Solitary Fibrous Tumor eziphantsi koNyango lwe-Avastin?

I-Primary Solitary Fibrous Tumor ichongiwe ngokuguqulwa kofuzo oluthile, njenge-BRD4, i-FLI1 kunye ne-KMT2C, ebangela utshintsho kwiindlela ze-biochemical, ngokukodwa i-MYC Signaling, i-Chromatin Remodeling, i-DNA Repair, i-Oncogenic Histone Methylation kunye ne-Amino Acid Metabolism. Ukusebenza kwonyango lomhlaza, njenge-Avastin, kuchongwa ngokusebenzisana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Umzekelo, isongezelelo seWalnut lukhetho olunengqiqo kwabo banePrimary Solitary Fibrous Tumor ehamba neAvastin. Oku kungenxa yokuba iWalnut inefuthe kwiindledlana ezifana ne-MYC yokuSayina, enokuthi ithintele izinto eziqhuba iTumor yePrimary Solitary Fibrous Tumor okanye izuze ukusebenza kwe-Avastin.

3. Ngaba izongezo zeWalnut zikhuselekile kubantu abasempilweni abaneASXL1 Mutation eNxulunyaniswe neMngcipheko yeMfuzo?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-ASXL1 gene idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-ASXL1 gene kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-MYC Signaling, i-Oncogenic Cancer Epigenetics kunye ne-Suppressive Histone Methylation, ebandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga ukuguqulwa kwe-ASXL1 ehambelana nomngcipheko okhulayo we-Chronic Myelomonocytic Leukemia, ingqiqo yesayensi icebisa ukuphepha ukusetyenziswa kwe-Walnut yokuncedisa. Oku kungenxa yokuba ukongeza i-Walnut inefuthe kwiindlela ezifana ne-MYC Signaling, enokukhokelela kwimiphumo emibi kumxholo we-ASXL1 yokuguqulwa kunye neemeko zomhlaza ezinxulumene nazo.

4. Ingaba izongezo zeWalnut zikhuselekile kubantu abasempilweni abaneERBB2 Mutation Associated Genetic Risk?

I-ERBB2 idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-ERBB2 kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, ezibandakanya i-Oncogenic Histone Methylation, i-Growth Factor Signaling kunye ne-PI3K-AKT-MTOR Signaling, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-ERBB2 ehambelana ne-Esophageal Adenocarcinoma, cinga ukufaka izongezo zeWalnut kwisicwangciso sakho sesondlo. Ezi zongezelelo zinokuphembelela ngokufanelekileyo iindlela ezifana ne-Oncogenic Histone Methylation, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abanokuguqulwa kwe-ERBB2 kunye neenkxalabo zempilo ezinxulumene nazo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kubandakanya ukutya kunye nezongezo ezifana neWalnut, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.
• cBioPortal for Cancer Genomics
• cBioPortal for Cancer Genomics
• Indima ye-tumor microenvironment ekuchaseni unyango lwe-anti-angiogenic.
• Iziphumo zothintelo lwe-hyperoside kumhlaza wemiphunga kwi-vitro ngokubangela i-apoptosis kunye nokuthintela ukwanda ngeCaspase-3 kunye ne-P53 indlela yokubonisa.