Ukutya kweAnaplastic Enkulu yeLymphoma yeSeli!

intshayelelo

Ukutya kwe-Anaplastic Large Cell Lymphoma kufuneka ilungiselelwe umntu ngamnye kwaye kufuneka ilungelelanise xa unyango lomhlaza okanye utshintsho lwemfuzo yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

I-Anaplastic big cell lymphoma (ALCL) luhlobo olunqabileyo lwe-non-Hodgkin lymphoma ebonakaliswe kubukho beeseli ezinkulu ezingabonakaliyo kwii-lymph nodes. Inokudibaniswa ne-anaplastic lymphoma kinase (ALK) ukulungiswa kwakhona kofuzo. Ichaphazela i-T lymphocytes, uhlobo lweeseli ezikhuselayo ezinceda ukukhusela umzimba kumatye anqabileyo kunye nezifo. Iindidi ezahlukeneyo ze-anaplastic cell lymphoma enkulu zibonakaliswa ngendawo yomhlaza emzimbeni. I-ALCL yenkqubo inokuba yi-ALK gene positive okanye i-ALK negative ALCL. Ezinye iintlobo ze-ALCL ziquka i-ALCL yokuqala ye-cutaneous echaphazela ulusu kwaye ibangele amaqhuma okanye i-rash eluswini; kunye nokufakelwa kwebele okunxulumene ne-ALCL eyenza malunga nokufakelwa kwebele kwaye idla ngokufumanisa iminyaka eyi-10 emva kwenkqubo yokwakhiwa kwakhona kwebele. I-ALK positive i-ALCL ichaphazela kakhulu abantu abangaphambi kweshumi elivisayo kunye nabafikisayo kunye nabaselula abakwiminyaka yabo yama-20 kunye ne-30 ngelixa i-ALCL-negative ALCL ichaphazela abantu abangaphezu kweminyaka engama-60 ubudala. Ezinye ii-ALCL esikhumbeni nasebeleni zichaphazela abantu abadala abangaphezu kweminyaka engama-40-50 ubudala. Iimpawu ziyahluka ngokuxhomekeke kuhlobo lwe-ALCL. Umkhuhlane, ukudinwa, ukubila ebusuku, ukwehla kobunzima obungachazwanga zezinye zeempawu kunye nokudumba kwee-lymph nodes, iintlungu namaqhuma kwindawo apho umhlaza ukhula khona. I-prognosis kunye namazinga okusinda kwe-ALCL ayahluka ngokuxhomekeka kwizinto ezifana nesigaba, isimo se-ALK, kunye nobungakanani besifo. Iinketho zonyango ze-ALCL zinokubandakanya iirejimeni ze-chemotherapy ezidibeneyo, unyango olujoliswe kuyo, i-stem cell transplantation, kunye nonyango lwe-radiation, ngokusekelwe kwiimpawu kunye nezikhokelo zomntu ngamnye. I-Anaplastic enkulu ye-cell lymphoma ngumhlaza onzima ofuna ukujongwa ngononophelo kunye nonyango olufanelekileyo, kungakhathaliseki ukuba luhlobo luni. Ukuxilongwa kwe-ALCL kuxhomekeke kwiminyaka yobudala, ukusasazeka komhlaza kunye nenani lee-lymph nodes ezichaphazelekayo. .

Kwi-Anaplastic Large Cell Lymphoma ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu umntu ayityayo?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza kukuba - kwimihlaza efana ne-Anaplastic Large Cell Lymphoma ingaba ayinamsebenzi ukuba kukuphi ukutya endikutyayo kwaye ndingakwenzi? Okanye ukuba ndilandela ukutya okusekwe kwisityalo ngaba kwanele umhlaza ofana ne-Anaplastic Large Cell Lymphoma?

Umzekelo ingaba inomsebenzi ukuba imifuno iRed Bell Pepper ityiwa kakhulu xa ithelekiswa neRapini? Ngaba kuyawenza umahluko ukuba isiqhamo iLongan siyakhethwa kune Evergreen Blackberry? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane/iimbewu ezifana nePistachio phezu kweAcorn kunye neepulses ezifana neCommon Bean phezu {food_pulse1_nr1}. Kwaye ukuba into endiyityayo ibalulekile - umntu ukuchonga njani ukutya okucetyiswayo kwi-Anaplastic Large Cell Lymphoma kwaye ingaba impendulo efanayo kuye wonke umntu onoxilongo olufanayo okanye umngcipheko wemfuzo?

Ewe! Ukutya okutyayo kubalulekile kwi-Anaplastic Large Cell Lymphoma!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Umzekelo i-Longan iqulethe izithako ezisebenzayo i-Apigenin, i-Geraniol, i-Daidzein, i-Lupeol, i-Luteolin. Kwaye i-Evergreen Blackberry iqulethe izithako ezisebenzayo iGeraniol, i-Eugenol, i-Ellagic Acid, i-Beta-ionone, i-Linalool kunye nabanye.

Impazamo eqhelekileyo eyenziwa xa kusenziwa isigqibo kunye nokukhetha ukutya okutyayo kwi-Anaplastic Large Cell Lymphoma - kukuvavanya kuphela izithako ezisebenzayo ezikhethiweyo eziqulethwe kukutya kwaye ungazihoyi ezinye. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha izithako ezisebenzayo ekutyeni kunye nezongezelelo zokwenza isigqibo sesondlo se-Anaplastic Large Cell Lymphoma.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwi-Anaplastic Enkulu yeLymphoma yeSeli?

Isondlo somntu somhlaza esifana ne-Anaplastic Large Cell Lymphoma ibandakanya ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwi-Anaplastic Large Cell Lymphoma biology, isayensi yokutya, imfuzo, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nobuthathaka obunxulumeneyo apho unyango lunokuyeka ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana ne-Anaplastic Large Cell Lymphoma

Zonke ii-cancer ezifana ne-Anaplastic Large Cell Lymphoma zinokuphawulwa ngoluhlu olulodwa lweendlela ze-biochemical - iindlela zokutyikitya ze-Anaplastic Large Cell Lymphoma. Iindlela ze-Biochemical ezifana ne-Cell Cycle, i-Oncogenic Histone Methylation, i-Adherens junction, i-AGE-RAGE Ukubonakaliswa yinxalenye yenkcazo yesignesha ye-Anaplastic Large Cell Lymphoma. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwi-Anaplastic Large Cell Lymphoma kufuneka luthathele ingqalelo utyikityo olunxulumene neendlela zebhayokhemikhali kwisigulana ngasinye somhlaza kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto okunye ukutya kunye nezongezo zicetyiswayo kwi-Anaplastic Large Cell Lymphoma xa uthatha unyango lomhlaza i-Cyclophosphamide, kwaye okunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-CCND1, i-SETD2 kunye ne-SPEN zezona ziphezulu iigenes ezixeliweyo ze-Anaplastic Large Cell Lymphoma. I-CCND1 ixelwe kwi-100.0% yezigulane ezimele kuzo zonke izilingo zonyango. Kwaye iSETD2 inikwe ingxelo nge-100.0%. Idatha yesigulana esidityanisiweyo sigubungela iminyaka ukusuka ukuya . I-100.0 % yedatha yesigulane ichongwa njengamadoda. I-Anaplastic Large Cell Lymphoma biology kunye ne-genetics exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenziwa kwesondlo.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezo zeAnaplastic Enkulu yeLymphoma yeSeli

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha iVegetable RED BELL PEPPER okanye iRAPINI?

I-Vegetable Red Bell Pepper iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana neGeraniol, iCapsaicin, iLupeol, iDaidzein, iBeta-caryophyllene. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo zebhayoloji ezifana noMjikelo weSeli kunye nezinye. I-Red Bell Pepper icetyiswa kwi-Anaplastic Large Cell Lymphoma xa unyango lomhlaza oluqhubekayo i-Cyclophosphamide. Oku kungenxa yokuba i-Red Bell Pepper iguqula ezo ndlela ze-biochemical eziye zachazwa ngokwesayensi ukwazisa isiphumo se-Cyclophosphamide.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ye-Rapini yi-Apigenin, i-Geraniol, i-Lupeol, i-Daidzein, i-Luteolin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo zebhayoloji ezifana noMjikelo weSeli kunye nezinye. I-Rapini ayikhuthazwa kwi-Anaplastic Large Cell Lymphoma xa unyango lomhlaza oluqhubekayo yi-Cyclophosphamide kuba ilungisa ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

I-PEPPER EBOMVU YOMFUNO IYACEBISWA NGAPHEZU KWE-RAPINI YE-Anaplastic Enkulu Yeseli Lymphoma KUNYE NONYANGO I-Cyclophosphamide.

Khetha iSiqhamo EVERGREEN BLACKBERRY okanye LONGAN?

Isiqhamo i-Evergreen Blackberry iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana neGeraniol, i-Eugenol, i-Ellagic Acid, i-Beta-ionone, i-Linalool. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo zebhayoloji ezifana noMjikelo weSeli kunye nezinye. I-Evergreen Blackberry iyacetyiswa kwi-Anaplastic Large Cell Lymphoma xa unyango lomhlaza oluqhubekayo yi-Cyclophosphamide. Oku kungenxa yokuba i-Evergreen Blackberry ilungisa ezo ndlela zebhayomichimi ekuye kwaxelwa ngokwenzululwazi ukuba zinike impembelelo ye-Cyclophosphamide.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo zeLongan yi-Apigenin, iGeraniol, iDaidzein, iLupeol, iLuteolin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo zebhayoloji ezifana noMjikelo weSeli kunye nezinye. I-Longan ayikhuthazwa kwi-Anaplastic Large Cell Lymphoma xa unyango lomhlaza oluqhubekayo yi-Cyclophosphamide kuba lulungisa ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO EVERGREEN BLACKBERRY KUNCEBISWA NGEXESHA ELIDE NGE-Anaplastic Enkulu yeLymphoma yeSeli KUNYE NONYANGO ICyclophosphamide.

Khetha Nut PISTACHIO okanye ACORN?

I-Pistachio iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana neGeraniol, iLupeol, iDaidzein, iPhloretin, iBergapten. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo zebhayoloji ezifana noMjikelo weSeli kunye nezinye. I-Pistachio iyacetyiswa kwi-Anaplastic Large Cell Lymphoma xa unyango lomhlaza oluqhubekayo yi-Cyclophosphamide. Oku kungenxa yokuba i-Pistachio iguqula ezo ndlela ze-biochemical eziye zaxelwa ngokwesayensi ukuze zikhuthaze umphumo we-Cyclophosphamide.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Acorn yi-Apigenin, i-Geraniol, i-Daidzein, i-Lupeol, i-Luteolin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo zebhayoloji ezifana noMjikelo weSeli kunye nezinye. I-Acorn ayikhuthazwa kwi-Anaplastic Large Cell Lymphoma xa unyango lomhlaza oluqhubekayo yi-Cyclophosphamide kuba lulungisa ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

I-PISTACHIO INCEBISWA NGAPHEZU KWE-ACORN YE-Anaplastic Large Cell Lymphoma KUNYE NONYANGO I-Cyclophosphamide.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwa ngabantu abasengozini yemfuzo ye-Anaplastic Large Cell Lymphoma okanye imbali yosapho "Yintoni endimele ndiyitye ngokwahlukileyo kunangaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha imifuno ye-WILD CARROT okanye i-OSTRICH FERN?

I-Vegetable Wild Carrot iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Vitamin D3. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MYC Signaling, i-Apoptosis, i-Cell Cycle kunye ne-Growth Factor Signaling kunye nezinye. I-Wild Carrot inconywa kumngcipheko we-Anaplastic Large Cell Lymphoma xa ingozi yemfuzo ehambelana nayo yi-CCND1. Oku kungenxa yokuba i-Wild Carrot yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno Inciniba iFern yi-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-WNT Beta Catenin Signaling kunye neCell Cycle Checkpoints kunye nezinye. Inciniba iFern ayikhuthazwa xa umngcipheko we-Anaplastic Large Cell Lymphoma xa umngcipheko wezofuzo uhambelana ne-CCND1 kuba yonyusa iindlela zokutyikitya.

UMNQATHA WASEMHLANENI UYA KUCEBISWA PHEZU KWENXIBA YE-CCND1 UMNGCIPHEKO WEMFUZO YOMHLAZA.

Khetha iSiqhamo se-NANCE okanye iFIG?

I-Fruit Nance iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MYC Signaling, i-Apoptosis, i-Cell Cycle kunye ne-Growth Factor Signaling kunye nezinye. I-Nance icetyiswa kumngcipheko we-Anaplastic Large Cell Lymphoma xa umngcipheko wezofuzo ohambelana ne-CCND1. Oku kungenxa yokuba i-Nance yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo Umzobo yiCurcumin, Lupeol, Daidzein, Formononetin, Phloretin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Umqondiso, i-WNT Beta Catenin Signaling kunye ne-MYC Signaling kunye nabanye. Umzobo awukhuthazwa xa umngcipheko we-Anaplastic Large Cell Lymphoma xa umngcipheko wezofuzo uhambelana ne-CCND1 kuba yonyusa iindlela zokutyikitya.

ISIQHAMO NANCE KUCEBISWA NGAPHEZU KWEFIG YECCND1 GENETIC RISK YOMHLAZA.

Khetha Nut BUTTERNUT okanye CHESTNUT?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Growth Factor Signaling, i-WNT Beta Catenin Signaling, i-Cell Cycle kunye ne-P53 Signaling kunye nabanye. I-Butternut icetyiswa kumngcipheko we-Anaplastic Large Cell Lymphoma xa umngcipheko wemfuzo ohambelana ne-CCND1. Oku kungenxa yokuba i-Butternut yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yi-Apigenin, i-Curcumin, i-Lupeol, i-Ellagic Acid, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-WNT Beta Catenin Signaling kunye neCell Cycle Checkpoints kunye nezinye. I-Chestnut ayikhuthazwa xa umngcipheko we-Anaplastic Large Cell Lymphoma xa umngcipheko wezofuzo uhambelana ne-CCND1 kuba yonyusa iindlela zokutyikitya kuyo.

IBHUTTERNUT KUCEBISWA NGAPHEZU KWE-CHESTNUT NGE-CCND1 GENETIC RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezelelo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana ne-Anaplastic Large Cell Lymphoma. Izigulana ze-Anaplastic Large Cell Lymphoma kunye nabantu abasengozini yemfuza bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye ezingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana ne-Anaplastic Large Cell Lymphoma, nganye ine-tumor genetics eyahlukeneyo kunye nokwahluka kwe-genomic kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okunje ngeRed Bell Pepper kuqulethe izinto ezahlukeneyo zebhayoloji kwimiyinge eyahlukeneyo, enempembelelo kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo se-addon yesondlo somntu senza ukuba isigqibo sibe lula kwaye sisuse yonke into eqikelelwayo ekuphenduleni umbuzo, "Kukuphi ukutya endimele ndikukhethe okanye ndingakhethi kwi-Anaplastic Large Cell Lymphoma?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Msk Impact 2017
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.
• I-asidi ye-Shikimic ikhuthaza i-estrogen receptor (ER) -iiseli zomhlaza webele ezintle zikhula ngokusebenza kwe-NF-κB yokubonisa.
• I-Curcumin inqanda ukukhula ngendlela ye-Wnt / β-catenin kwiiseli zomhlaza wemiphunga ezingezizo ezincinci.
• I-Paederia foetida yenza umsebenzi we-anticancer ngokumodareyitha i-chromatin modification enzymes kunye nokuguqula i-pro-inflammatory cytokine gene expression kwiiseli zomhlaza we-prostate.
• I-Vitamin C iphucula ukuguqulwa kwe-epigenetic eyenziwa yi-5-azacytidine kunye nokubanjwa komjikelo weseli kwi-hepatocellular carcinoma celllines HLE kunye ne-Huh7.
• I-Eugenol inamandla okwenza umsebenzi we-cisplatin wokuchasana nomhlaza ngokuvinjelwa kwe-ALDH-positive breast cancer cells kunye ne-NF-κB indlela yokubonisa.
• Ukhuseleko oluchasene nempembelelo yentengiso yeti emhlophe kunye necaffeine kwi-PhIP-induced tumorigenesis kunye ne-beta-catenin expression kwi-rat.
• https://my.clevelandclinic.org/health/diseases/24029-anaplastic-large-cell-lymphoma
• https://lymphoma.org/understanding-lymphoma/aboutlymphoma/nhl/anaplastic-large-cell-lymphoma
• https://www.ncbi.nlm.nih.gov/books/NBK537150/#:~:text=ALCL%20(ALK%2Dpositive)%20is%20a%20moderately%20aggressive%20T%20cell,80%25%20compared%20to%2048%25.