Ukutya kweAcute Myeloid Leukemia!

intshayelelo 

Ukutya kwe-Acute Myeloid Leukemia kufuneka ilungiselelwe umntu ngamnye kwaye kufuneka ilungelelanise xa unyango lomhlaza okanye utshintsho lwemfuzo yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha. 

I-Acute myeloid leukemia (AML) ngumhlaza ochaphazela igazi kunye nomongo wethambo. Yeyona leukemia ixhaphakileyo kubantu abadala kwaye yenza malunga nama-80% yazo zonke iimeko. Ibonakala ngokuveliswa ngokugqithisileyo kweeseli zegazi ezimhlophe ezingekavuthwa, ezibizwa ngokuba yi-myeloblasts okanye i-leukemic blasts. Ezi seli zixinanisela umongo wamathambo zize ziwuthintele ekwenzeni iiseli zegazi eziqhelekileyo. Ngenxa yokuvelisa ngokugqithisileyo, ziphalala egazini kwaye zijikeleze emzimbeni kwaye ngenxa yokungakhuli kunye nokungaqhelekanga, azikwazi ukwenza umsebenzi wazo wesiqhelo wokulwa nosulelo emzimbeni. Ukuncipha kwamanani eeseli ezibomvu zegazi kunye neeplatelet ezenziwe ngumongo kubangela i-anemia kunye nokopha okulula kunye nokugruzuka. I-Acute myeloid leukemia ihlelwa kwiintlobo ezahlukeneyo ezisekelwe kwimbonakalo yeeseli ze-leukemic phantsi kwe-microscope kunye ne-cytogenetics yokuqhuma. Umyinge weminyaka emi-5 wokusinda kwe-AML ngama-27% ngokoMbutho woMhlaza waseMelika. Unyango lwe-AML lubandakanya irejimeni yonyango lwekhemotherapy yokungenisa kakhulu enetyhefu kakhulu kumongo wethambo. Ngokumalunga ne-60-80% ye-AML esandul 'ukuxilongwa iya kufumana impendulo epheleleyo ngonyango lwe-induction. Oku kulandelwa lunyango lokudibanisa kunye ne-hematopoietic cell transplant. Ukongezelela, ukunakekelwa kwenkxaso kunye nesondlo esifanelekileyo (ukutya kunye nezongezelelo zendalo) kunokunceda ukuphucula impilo yezigulane.

Kwi-Acute Myeloid Leukemia ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, iimbewu umntu azityayo?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza kukuba - kwimihlaza efana ne-Acute Myeloid Leukemia ingaba ibalulekile into yokutya endikutyayo nendingakutyiyo? Okanye ukuba ndilandela ukutya okusekwe kwisityalo oko kwanele umhlaza ofana ne-Acute Myeloid Leukemia?

Umzekelo ingaba inomsebenzi ukuba iCauliflower yemifuno ityiwa kakhulu xa ithelekiswa ne-Welsh Onion? Ngaba kuyawenza umahluko xa kukhethwa isiqhamo iPummelo kuneMango? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane/iimbewu ezifana neButternut phezu kweChestnut kunye neepulses ezifana neBroad Bean phezu kwePigeon Pea. Kwaye ukuba into endiyityayo ibalulekile - umntu ukuchonga njani ukutya okucetyiswayo kwi-Acute Myeloid Leukemia kwaye ingaba impendulo efanayo kuye wonke umntu onoxilongo olufanayo okanye umngcipheko wemfuzo? 

Ewe! Ukutya okutyayo kubalulekile kwi-Acute Myeloid Leukemia!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.  

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye. 

Umzekelo iPummelo iqulethe izithako ezisebenzayo i-Curcumin, i-Lycopene, i-Isoliquiritigenin, i-Quercetin, i-Formononetin. Kwaye iMango iqulethe izithako ezisebenzayo i-Curcumin, i-Isoliquiritigenin, i-Quercetin, i-Formononetin, i-Phloretin kwaye mhlawumbi nabanye. 

Impazamo eqhelekileyo eyenziwa xa kusenziwa isigqibo nokukhetha ukutya okuza kutyiwa kwi-Acute Myeloid Leukemia - kukuvavanya kuphela izithako ezisebenzayo ezikhethiweyo eziqulethwe kukutya kwaye ungazihoyi ezinye. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha izithako ezisebenzayo ekutyeni kunye nezongezelelo zokwenza isigqibo sesondlo se-Acute Myeloid Leukemia. 

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwi-Acute Myeloid Leukemia?

Isondlo esilungiselelwe wena somhlaza njenge-Acute Myeloid Leukemia ibandakanya ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwi-Acute Myeloid Leukemia biology, isayensi yokutya, imfuzo, i-biochemistry kunye nokuqonda kakuhle ukuba lusebenza njani unyango lomhlaza kunye nokuba sesichengeni okunxulumene nonyango olunokuthi luyeke ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana ne-Acute Myeloid Leukemia

Yonke imihlaza efana ne-Acute Myeloid Leukemia inokuphawulwa ngoluhlu olulodwa lweendlela ze-biochemical - iindlela zokutyikitya ze-Acute Myeloid Leukemia. Iindlela ze-Biochemical ezifana ne-Angiogenesis, i-PI3K-AKT-MTOR Ukubonakaliswa, i-Oncogenic Cancer Epigenetics, i-MAPK Ukubonakaliswa yinxalenye yenkcazo yesiginesha ye-Acute Myeloid Leukemia. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwi-Acute Myeloid Leukemia kufuneka luthathele ingqalelo utyikityo lweendlela zebhayoloji kwisigulane ngasinye somhlaza kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Kungoko okunye ukutya kunye nezongezo zicetyiswayo kwi-Acute Myeloid Leukemia xa uthatha unyango lomhlaza i-Idarubicin, kwaye okunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza. 

I-NPM1, i-IDH2, i-CEBPA, i-WT1 kunye ne-PTPN11 zezona zixeliweyo zofuzo ze-Acute Myeloid Leukemia. I-NPM1 ixelwe kwi-13.0 % yezigulane ezimele kuwo onke amalingo onyango. Kwaye i-IDH2 ichazwe kwi-5.1%. Idatha yezigulane ezidityanisiweyo zigubungela iminyaka yobudala ukusuka ku-1 ukuya kuma-88. I-53.5 % yedatha yesigulane ichongwa njengamadoda. I-Acute Myeloid Leukemia biology kunye ne-genetics exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenziwa kwesondlo.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezo ze-Acute Myeloid Leukemia

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.  

Khetha iVegetable CAULIFLOWER okanye WELSH anyanisi?

I-Cauliflower yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Isoliquiritigenin, i-Formononetin, i-Phloretin, i-Lupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-JAK-STAT Signaling, i-WNT Beta yeCatenin Signaling kunye ne-Amino Acid Metabolism kunye nabanye. ICauliflower iyacetyiswa kwi-Acute Myeloid Leukemia xa unyango lomhlaza oluqhubekayo i-Idarubicin. Oku kungenxa yokuba iCauliflower ilungisa ezo ndlela zebhayochemicals ekuye kwaxelwa ngazo ngokwenzululwazi ukwazisa isiphumo se-Idarubicin.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ye-Welsh Onion yi-Curcumin, i-Lycopene, i-Isoliquiritigenin, i-Formononetin, i-Phloretin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-NFKB Signaling, i-WNT Beta Catenin Signaling kunye ne-Amino Acid Metabolism kunye nabanye. Itswele le-Welsh alikhuthazwa kwi-Acute Myeloid Leukemia xa unyango lomhlaza oluqhubekayo i-Idarubicin kuba lulungisa ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

I-CAULIFLOWER YOMFUNO INCEBISWA NGAPHEZU KWE-WELSH anyanisi kwi-Acute Myeloid Leukemia KUNYE NONYANGO Idarubicin.

Khetha iFruit MANGO okanye iPUMMELO?

I-Fruit Mango iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Isoliquiritigenin, i-Quercetin, i-Formononetin, i-Phloretin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-Angiogenesis, i-Amino Acid Metabolism kunye ne-Hypoxia kunye nabanye. IMango icetyiswa kwi-Acute Myeloid Leukemia xa unyango lomhlaza oluqhubekayo i-Idarubicin. Oku kungenxa yokuba i-Mango iguqula ezo ndlela ze-biochemical eziye zaxelwa ngokwesayensi ukwazisa isiphumo se-Idarubicin.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo iPummelo yiCurcumin, iLycopene, i-Isoliquiritigenin, i-Quercetin, i-Formononetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-NFKB Signaling kunye ne-WNT Beta Catenin Signaling kunye nezinye. IPummelo ayikhuthazwa kwi-Acute Myeloid Leukemia xa unyango lomhlaza oluqhubekayo i-Idarubicin kuba luguqula ezo ndlela zebhayoloji ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli ngokukhawuleza.

I-FRUIT MANGO IYANIKEZISWA NGAPHEZU KWE-PUMMELO YE-Acute Myeloid Leukemia KUNYE NONYANGO I-Idarubicin.

Khetha Nut BUTTERNUT okanye CHESTNUT?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Lycopene, i-Isoliquiritigenin, i-Formononetin, i-Phloretin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-Angiogenesis, i-WNT Beta yeCatenin Signaling kunye ne-Amino Acid Metabolism kunye nabanye. I-Butternut icetyiswa kwi-Acute Myeloid Leukemia xa unyango lomhlaza oluqhubekayo i-Idarubicin. Oku kungenxa yokuba i-Butternut ilungisa ezo ndlela zebhayochemicals ezixelwe ngokwenzululwazi ukwazisa isiphumo se-Idarubicin.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yi-Curcumin, i-Lycopene, i-Isoliquiritigenin, i-Formononetin, i-Phloretin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-WNT Beta Catenin Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Chestnut ayikhuthazwa kwi-Acute Myeloid Leukemia xa unyango lomhlaza oluqhubekayo i-Idarubicin kuba luguqula ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli ngokukhawuleza.

IBHUTTERNUT IYAYINGCEBISWA NGAPHEZU KWE-CHESTNUT YE-Acute Myeloid Leukemia KUNYE NONYANGO I-Idarubicin.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwe ngabantu abasengozini yemfuzo ye-Acute Myeloid Leukemia okanye imbali yosapho ithi "Yintoni endifanele nditye ngokwahlukileyo kunangaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye ne-Acute Myeloid Leukemia pathway signature - ukhetho lokutya kunye nezongezelelo kufuneka lube lomntu. 

Khetha iVegetable GIANT BUTTERBUR or RED BELL PEPPER?

I-Butterbur enkulu yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Myricetin, i-Isoliquiritigenin, i-Kaempferol, i-Curcumin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-Angiogenesis, i-JAK-STAT Signaling kunye ne-Hypoxia kunye nabanye. I-Giant Butterbur icetyiswa kumngcipheko we-Acute Myeloid Leukemia xa umngcipheko wemfuzo ohambelana ne-CEBPA. Oku kungenxa yokuba i-Giant Butterbur yonyusa ezo pathways zebhayoloji ezichasa utyikityo lwabaqhubi be-Acute Myeloid Leukemia.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ebomvu i-Bell Pepper yi-Quercetin, i-Isoliquiritigenin, i-Curcumin, i-Luteolin, i-Lycopene. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokuSayina kwe-MAPK kunye ne-Stem Cell Signaling kunye nabanye. I-Red Bell Pepper ayikhuthazwa xa umngcipheko we-Acute Myeloid Leukemia xa umngcipheko wemfuzo uhambelana ne-CEBPA kuba yonyusa iindlela zokutyikitya ze-Acute Myeloid Leukemia.

IBHUTTERBUR YEMIZI YEZIGIDI IYACEBISWA NGAPHEZU KWE-RED BELL PEPPER NGE-CEBPA genetic RISK OF CANCER.

Khetha iSiqhamo se-NANCE okanye i-MALABAR PLUM?

I-Fruit Nance iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Myricetin, i-Isoliquiritigenin, i-Kaempferol, i-Curcumin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-Angiogenesis kunye ne-Hypoxia kunye nabanye. UNance ucetyiswa kumngcipheko we-Acute Myeloid Leukemia xa umngcipheko wemfuzo ohambelana ne-CEBPA. Oku kungenxa yokuba i-Nance yonyusa ezo ndlela zebhayoloji ezichasa utyikityo lwabaqhubi be-Acute Myeloid Leukemia.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwisiqhamo i-Malabar Plum yi-Apigenin, i-Myricetin, i-Isoliquiritigenin, i-Kaempferol, i-Curcumin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Oncogenic Cancer Epigenetics kunye ne-Stem Cell Signaling kunye nezinye. I-Malabar Plum ayikhuthazwa xa umngcipheko we-Acute Myeloid Leukemia xa umngcipheko wemfuzo uhambelana ne-CEBPA kuba yonyusa iindlela zokutyikitya ze-Acute Myeloid Leukemia.

ISIQHAMO NANCE KUCEBISWA NGAPHEZU KWE-MALABAR PLUM YE-CEBPA genetic RISK YOMHLAZA.

Khetha Nut WALNUT EQHELEKILEYO okanye i-EUROPEAN CHESTNUT?

I-Walnut eqhelekileyo iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Quercetin, i-Ellagic Acid, i-Myricetin, i-Isoliquiritigenin, i-Kaempferol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-Angiogenesis, i-RAS-RAF Signaling kunye ne-Hypoxia kunye nabanye. IWalnut eqhelekileyo icetyiswa kumngcipheko we-Acute Myeloid Leukemia xa umngcipheko wemfuzo ohambelana ne-CEBPA. Oku kungenxa yokuba iWalnut eqhelekileyo yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi beAcute Myeloid Leukemia.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yaseYurophu yi-Quercetin, i-Apigenin, i-Ellagic Acid, i-Myricetin, i-Isoliquiritigenin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana neStem Cell Signaling kunye nezinye. I-Chestnut yaseYurophu ayikhuthazwa xa umngcipheko we-Acute Myeloid Leukemia xa umngcipheko wemfuzo uhambelana ne-CEBPA kuba yonyusa iindlela zokutyikitya ze-Acute Myeloid Leukemia.

IWALNUT EQHELEKILEYO INCEBISWA KWI-CHESTNUT YAseYurophu NGE-CEBPA genetic RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana ne-Acute Myeloid Leukemia. Izigulana ze-Acute Myeloid Leukemia kunye nabantu abasengozini yemfuza bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye ezingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana ne-Acute Myeloid Leukemia, nganye ineemfuza ezahlukeneyo zethumba ezinolunye ulwahlulo lwe-genomic kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okufana neCauliflower kuqulethe izinto ezahlukeneyo zebhayoloji kwimithamo eyahlukeneyo, enefuthe kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo somhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo se-addon sesondlo somntu senza ukuba isigqibo sibe lula kwaye sisuse yonke into eqikelelwayo ekuphenduleni umbuzo, "Kukuphi ukutya endimele ndikukhethe okanye ndingakhethi kwi-Acute Myeloid Leukemia?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha. 

Ucaphulo

1) Aml Ohsu 2018

2) Iipateni zeCell-of-Origin ziLawula uHlelo lweMolekyuli ye-10,000 ye-Tumors ukusuka kwiintlobo ze-33 ze-Cancer.

3) Indlela yeNzululwazi eVulekileyo eScalable yokuBiza uTshintsho lweTumor exomes kusetyenziswa iiMibhobho ezininzi zeGenomic.

4) Iindlela zeGenomic kunye neziSebenzayo zokuqonda iCancer Aneuploidy.

5) I-Driver Fusion kunye neziphumo zabo kuPhuhliso kunye noNyango lwe-Cancer yoLuntu.

6) Isixhobo esiDityanisiweyo se-TCGA yePan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics.

7) Iindlela zoMbonakaliso ze-Oncogenic kwi-Cancer Genome Atlas.

8) Uhlalutyo lweMicrobiome lwegazi kunye nezicubu lucebisa indlela yokuxilonga umhlaza.

9) Umbono kwiiNkqubo ze-Oncogenic ekupheleni kokuQala kweCancer Genomics.

10) Ubume beMicrosatellite Ukungazinzi kuzo zonke iintlobo zeCancer ezingama-39.

11) Iziphumo ze-isoliquiritigenin kwiiseli zomhlaza we-ovarian.

12) I-Gallic acid, i-phenolic compound, yenza i-anti-angiogenic effects ngokusebenzisa i-PTEN/AKT/HIF-1α/VEGF indlela yokubonisa kwiiseli zomhlaza we-ovarian.

13) I-Brassinin inqanda indlela yokubonisa i-STAT3 ngokumodareyithwa kwe-PIAS-3 kunye ne-SOCS-3 intetho kwaye inike amandla i-xenograft yomhlaza wemiphunga yabantu kwiimpuku ezinqunu ukuya kwi-paclitaxel.

14) Ukhuseleko oluchasene nempembelelo yentengiso yeti emhlophe kunye necaffeine kwi-PhIP-induced tumorigenesis kunye ne-beta-catenin expression kwi-rat.

15) I-Lycopene ngokwahlukileyo idala i-quiescence kunye ne-apoptosis kwi-androgen-esabelayo kunye ne-independent ye-prostate cancer celllines.

16) Impembelelo ye-Daidzein kumhlaza we-prostate refractory kwi-vitro kunye ne-vivo xa kuthelekiswa ne-genistein kunye ne-soy extract: amandla onyango lwe-radiotherapy.

17) I-Triggering of transient receptor potential potential vanilloid type 1 (TRPV1) yi-capsaicin induces i-Fas/CD95-mediated apoptosis yeeseli zomhlaza we-urothelial ngendlela exhomekeke kwi-ATM.

https://www.leukaemia.org.au/blood-cancer-information/types-of-blood-cancer/leukaemia/acute-myeloid-leukemia

https://www.ncbi.nlm.nih.gov/books/NBK507875

https://www.cancer.net/cancer-types/leukemia-acute-myeloid-aml/statistics#:~:text=The%205%2Dyear%20survival%20rate%20for%20people%2020%20and%20older,see%20Subtypes%20for%20more%20information