Ukutya kwe-Systemic Mastocytosis!

intshayelelo

Ukutya kwe-Systemic Mastocytosis kufuneka ilungiselelwe umntu ngamnye kwaye kufuneka ilungelelanise xa unyango lomhlaza okanye utshintsho lwemfuza yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

Kwi-Systemic Mastocytosis ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu ayityayo?

Umbuzo oxhaphake kakhulu wesondlo obubuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza ngowomhlaza onje nge-Systemic Mastocytosis ingaba ibalulekile na into yokutya endikutyayo nendingakutyiyo? Okanye ukuba ndilandela ukutya okusekwe kwisityalo ngaba kwanele umhlaza onje ngeSystemic Mastocytosis?

Umzekelo ingaba iyabaluleka na into yokuba imifuno i-brussel Sprouts ityiwa kakhulu xa ithelekiswa netheniphu? Ngaba kuyawenza umahluko ukuba umkhiwane uyathandwa ngaphezu kweRabbiteye Blueberry? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane / iimbewu ezifana neWalnut emnyama phezu kweChestnut kunye neepulses ezifana neChickpea phezu kweCatjang Pea. Kwaye ukuba into endiyityayo ibalulekile - umntu uchonga njani ukutya okucetyiswayo kwi-Systemic Mastocytosis kwaye ingaba impendulo efanayo kuye wonke umntu onokuxilongwa okufanayo okanye umngcipheko wemfuza?

Ewe! Ukutya okutyayo kubalulekile kwi-Systemic Mastocytosis!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Umzekelo Umzobo uqulethe izithako ezisebenzayo Isoliquiritigenin, Quercetin, Kaempferol, Taxifolin, Curcumin. Kwaye iRabbiteye Blueberry iqulethe izithako ezisebenzayo iQuercetin, iLinalool, iGeraniol, iGallic Acid, iFerulic Acid kwaye mhlawumbi nabanye.

Iphutha eliqhelekileyo elenziwe xa kuthathwa isigqibo kunye nokukhetha ukutya okutyayo kwi-Systemic Mastocytosis - kukuvavanya kuphela izithako ezisebenzayo ezikhethiweyo eziqulethwe kukutya kwaye ungayihoyi ezinye. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha izithako ezisebenzayo ekutyeni kunye nezongezelelo zokwenza isigqibo sesondlo seSystemic Mastocytosis.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwiSystemic Mastocytosis?

Izondlo zomntu zomhlaza ezifana ne-Systemic Mastocytosis iquka ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwi-Systemic Mastocytosis biology, isayensi yokutya, imfuzo, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nokuba sesichengeni okunxulumene nonyango olunokuthi luyeke ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana ne-Systemic Mastocytosis

Zonke ii-cancer ezifana ne-Systemic Mastocytosis zinokubonakaliswa ngoluhlu olulodwa lweendlela ze-biochemical - iindlela zokutyikitya ze-Systemic Mastocytosis. Iindlela ze-Biochemical ezifana ne-JAK-STAT Signaling, i-MAPK Signaling, i-PI3K-AKT-MTOR Ukubonakaliswa, ukubonakaliswa kwe-RAS-RAF kuyingxenye yenkcazo yesignesha ye-Systemic Mastocytosis. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwi-Systemic Mastocytosis kufuneka luthathele ingqalelo utyikityo lweendlela zebhayokhemikhali kwisigulana ngasinye somhlaza kunye nomntu osengozini yemfuza. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Ke ngoko okunye ukutya kunye nezongezo ziyacetyiswa kwi-Systemic Mastocytosis xa uthatha unyango lomhlaza iMidostaurin, kwaye okunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-CNOT3, i-DNMT3A, i-FLT3, i-NPM1 kunye ne-KIT zezona ziphezulu iigenes ezixeliweyo ze-Systemic Mastocytosis. I-CNOT3 ixelwe kwi-50.0% yezigulane ezimele kuzo zonke izilingo zeklinikhi. Kwaye i-DNMT3A ixelwe kwi-50.0%. Idatha yesigulana esidityanisiweyo igubungela iminyaka ukusuka ukuya . I-100.0 % yedatha yesigulane ichongwa njengamadoda. I-Systemic Mastocytosis biology kunye ne-genetics exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenza isondlo somntu.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezo ze-Systemic Mastocytosis

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha imifuno yeBRUSSEL sprouts okanye iTURNIP?

Imifuno ye-Brussel Sprouts iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Isoliquiritigenin, i-Taxifolin, i-Sulforaphane, i-Curcumin, i-Lupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Ukubonakalisa, ukubonakaliswa kwe-MAPK, i-Oncogenic Cancer Epigenetics kunye ne-MYC Signaling kunye nabanye. I-Brussel Sprouts icetyiswa kwi-Systemic Mastocytosis xa unyango lomhlaza oluqhubekayo yi-Midostaurin. Oku kungenxa yokuba i-Brussel Sprouts ilungisa ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukuze zikhuthaze isiphumo seMidostaurin.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Tunip yemifuno yi-Isoliquiritigenin, i-Quercetin, i-Kaempferol, i-Taxifolin, i-Ellagic Acid. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MYC Signaling, i-MAPK yokuSayina kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. Itheniphu ayikhuthazwa kwi-Systemic Mastocytosis xa unyango lomhlaza oluqhubekayo i-Midostaurin kuba lulungisa ezo ndlela zebhayoloji ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IMIFUNO YEBRUSSEL IYAKUNQITSHISWA NGAPHEZU KWEJIKO KWISystemic Mastocytosis KUNYE NONYANGO iMidostaurin.

Khetha iSiqhamo RABBITEYE BLUEBERRY okanye iFIG?

I-Fruit Rabbiteye Blueberry iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Quercetin, i-Linalool, i-Geraniol, i-Gallic Acid, i-Ferulic Acid. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Rabbiteye Blueberry icetyiswa kwi-Systemic Mastocytosis xa unyango lomhlaza oluqhubekayo yi-Midostaurin. Oku kungenxa yokuba iRabbiteye Blueberry ilungisa ezo ndlela zebhayoloji eziye zaxelwa ngokwesayensi ukwazisa isiphumo seMidostaurin.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo Umzobo yi-Isoliquiritigenin, i-Quercetin, i-Kaempferol, i-Taxifolin, i-Curcumin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. Umzobo awukhuthazwa kwi-Systemic Mastocytosis xa unyango lomhlaza oluqhubekayo yi-Midostaurin kuba luguqula ezo ndlela zebhayoloji ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO RABBITEYE BLUEBERRY KUNCEBISWA NGAPHEZU KWEFIGI YESystemic Mastocytosis KUNYE NONYANGO iMidostaurin.

Khetha i-Nutt EMNYAMA WALNUT okanye i-CHESTNUT?

I-Walnut emnyama iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Isoliquiritigenin, i-Myricetin, i-Quercetin, i-Kaempferol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-RAS-RAF Signaling, i-PI3K-AKT-MTOR Umqondiso kunye ne-MYC Signaling kunye nabanye. IWalnut emnyama icetyiswa kwi-Systemic Mastocytosis xa unyango lomhlaza oluqhubekayo yiMidostaurin. Oku kungenxa yokuba iWalnut emnyama ilungisa ezo ndlela zebhayoloji eziye zaxelwa ngokwesayensi ukwazisa isiphumo seMidostaurin.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yi-Apigenin, i-Isoliquiritigenin, i-Myricetin, i-Kaempferol, i-Luteolin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Ukubonakaliswa, i-Oncogenic Cancer Epigenetics kunye ne-MYC Signaling kunye nabanye. I-Chestnut ayikhuthazwa kwi-Systemic Mastocytosis xa unyango lomhlaza oluqhubekayo yi-Midostaurin kuba luguqula ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IWALNUT EMNYAMA KUNCEBISWA NGAPHEZU KWE-CHESTNUT YE-Systemic Mastocytosis KUNYE NONYANGO iMidostaurin.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwe ngabantu abasengozini yemfuza ye-Systemic Mastocytosis okanye imbali yentsapho ithi "Yintoni endimele ndiyitye ngokwahlukileyo kunangaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenziwa malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nesignesha yendlela - ukhetho lokutya kunye nezongezelelo kufuneka lube lomntu.

Khetha iVegetable CAULIFLOWER okanye i-ARROWHEAD?

I-Cauliflower yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Isoliquiritigenin, i-Curcumin, iCatechol, i-Vitamin C, i-Lupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Umqondiso, umqondiso we-RAS-RAF, umqondiso we-MAPK kunye ne-MYC Signaling kunye nabanye. I-Cauliflower icetyiswa kumngcipheko we-Systemic Mastocytosis xa umngcipheko wemfuzo ohambelana ne-CNOT3. Oku kungenxa yokuba iCauliflower yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ye-Arrowhead yi-Apigenin, i-Myricetin, i-Isoliquiritigenin, i-Kaempferol, i-Luteolin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Stem Cell Signaling kunye ne-Oncogenic Cancer Epigenetics kunye nezinye. I-Arrowhead ayikhuthazwa xa umngcipheko we-Systemic Mastocytosis xa umngcipheko wezofuzo uhambelana ne-CNOT3 kuba yonyusa iindlela zokutyikitya.

I-CAULIFLOWER YOMFUNO ICEBISWA NGE-ARROWHEAD NGE-CNOT3 GENETIC RISK YOMHLAZA.

Khetha iSiqhamo ILAMONI okanye iPUMMELO?

I-Fruit Lemon iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Isoliquiritigenin, i-D-limonene, i-Luteolin, i-Linalool, i-Curcumin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Suppressive Histone Methylation, i-RAS-RAF Signaling, i-PI3K-AKT-MTOR Umqondiso kunye ne-MYC Signaling kunye nabanye. I-Lemon icetyiswa kumngcipheko we-Systemic Mastocytosis xa umngcipheko wemfuza ohambelana ne-CNOT3. Oku kungenxa yokuba iLamuni yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezithako ezisebenzayo okanye i-bioactives kwisiqhamo iPummelo yi-Apigenin, i-Quercetin, i-Isoliquiritigenin, i-Curcumin, i-Lycopene. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Umqondiso kunye ne-MYC Signaling kunye nabanye. IPummelo ayikhuthazwa xa umngcipheko we-Systemic Mastocytosis xa umngcipheko wofuzo uhambelana ne-CNOT3 kuba yonyusa iindlela zokutyikitya.

I-LEMON YESIQHAMO IYANCEBISWA PHEZU KWE-PUMMELO NGE-CNOT3 GENETIC RISK YOMHLAZA.

Khetha Nut BUTTERNUT okanye EUROPEAN CHESTNUT?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Myricetin, i-Isoliquiritigenin, i-Kaempferol, i-Luteolin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-JAK-STAT Signaling, i-RAS-RAF Signaling, i-MAPK Signaling kunye ne-MYC Signaling kunye nabanye. I-Butternut iyacetyiswa kumngcipheko we-Systemic Mastocytosis xa umngcipheko wemfuzo ohambelana ne-CNOT3. Oku kungenxa yokuba i-Butternut yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yaseYurophu yi-Apigenin, i-Quercetin, i-Myricetin, i-Isoliquiritigenin, i-Kaempferol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Stem Cell Signaling kunye ne-Oncogenic Cancer Epigenetics kunye nezinye. I-Chestnut yaseYurophu ayikhuthazwa xa umngcipheko we-Systemic Mastocytosis xa umngcipheko wemfuza uhambelana ne-CNOT3 kuba yonyusa iindlela zokutyikitya.

IBHUTTERNUT KUCEBISWA NGAPHEZU KWE-EUROPA CHESTNUT NGE-CNOT3 GENETIC RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezelelo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana ne-Systemic Mastocytosis. Izigulana ze-Systemic Mastocytosis kunye nabantu abasengozini yemfuza bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye ezingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana ne-Systemic Mastocytosis, nganye inemfuza eyahlukileyo ye-tumor enolunye utshintsho lwe-genomic kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okufana ne-Brussels Sprouts kuqulethe iintlobo ngeentlobo ze-bioactives ngokwemiyinge eyahlukeneyo, enempembelelo kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela ze-biochemical. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo somntu we-addon wesondlo senza ukuba isigqibo sibe lula kwaye sisuse yonke into eqikelelwayo ekuphenduleni umbuzo othi, "Kukuphi ukutya endimele ndikhethe okanye ndingakhethi kwi-Systemic Mastocytosis?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Aml Ohsu 2018
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• I-Gallic acid indanone kunye ne-mangiferin xanthone zizigqibo ezinamandla ze-immunosuppressive anti-tumour effects of Mangifera indica L. bark kwi-MDA-MB231 iiseli zomhlaza webele.
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