Ke mofetše ofe o ka ruang molemo ka ho kenyelletsa Resveratrol lijong tsa bona?

Lintlha-khōlō Tsa

Resveratrol e tsebahala haholo ka melemo ea eona ea bophelo bo botle mme e sebelisoa khafetsa ke bakuli ba mofetše le ba kotsing ea lefutso. Leha ho le joalo, polokeho le katleho ea Resveratrol bakeng sa bakuli ba mofets'e e ipapisitse le lintlha tse ngata joalo ka sesupo sa mofets'e, chemotherapy, liphekolo tse ling le liphatsa tsa lefutso tsa tumor. Ho tseba hore lijo tse ling le li-supplement, tse kang grapefruit le spinach, li ka 'na tsa sebelisana hampe le meriana ea mofetše le ho baka maikutlo a mabe ho bohlokoa.

Lijo li bohlokoa bakeng sa kalafo ea mofets'e kaha li ka ama litholoana tsa kalafo. Bakuli ba mofetše ba tlameha ho khetha ka hloko le ho kenyelletsa lijo tse loketseng le li-supplement lijong tsa bona. Ka mohlala, Resveratrol e ka thusa ba nang le Primary Penile Squamous Cell Carcinoma ba nang le Mitomycin, empa e ka 'na ea se ke ea e-ba molemo ho bakuli ba fumanang Fluorouracil bakeng sa Primary Pediatric Hepatoblastoma. Ho feta moo, le hoja Resveratrol e ka thusa batho ba nang le "KMT2D" ea kotsi ea lefutso, e ka 'na ea se ke ea buelloa ho ba nang le kotsi e fapaneng ea liphatsa tsa lefutso "ASXL1". Ho iketsetsa merero ea ho ja ho latela bophelo bo botle, kalafo, le liphatsa tsa lefutso ho bohlokoa.

Ho utloisisa hore ho etsa qeto mabapi le ho lekana ha Resveratrol bakeng sa mokuli oa mofets'e ho bohlokoa ho ba motho ka mong. Lintlha tsa bohlokoa joalo ka mofuta oa mofetše, mekhoa ea kalafo, liphatsa tsa lefutso, likotsi tsa lefutso, lilemo, boima ba 'mele le mokhoa oa bophelo li bohlokoa ho etsa qeto ea hore na Resveratrol ke khetho e nepahetseng. Liphatsa tsa lefutso le liphatsa tsa lefutso, haholoholo, li nahanoa haholo. Kaha lintlha tsena li ka fetoha, ho bohlokoa ho hlahloba khafetsa le ho fetola khetho ea lijo ho tsamaisana le liphetoho tsa boemo ba bophelo bo botle le kalafo.

Qetellong, mokhoa o akaretsang oa khetho ea lijo ke oa bohlokoa, o lebisa tlhokomelo liphellong tse akaretsang tsa likarolo tsohle tse sebetsang lijong / lisebelisoa tse kang Resveratrol ho e-na le ho hlahloba motsoako o mong le o mong o sebetsang ka thoko kapa ho o hlokomoloha ka ho feletseng. Maikutlo ana a pharaletseng a khothalletsa mokhoa o utloahalang le oa saense oa moralo oa lijo bakeng sa mofetše.

Kakaretso e Khutšoanyane

Tšebeliso ea lijo tse thehiloeng limela le li-supplement, tse kang livithamini, litlama, liminerale, li-probiotics, le lisebelisoa tse fapaneng tse khethehileng, li ntse li eketseha har'a bakuli ba mofetše. Li-supplement tsena li etselitsoe ho fana ka metsoako e phahameng ea metsoako e sebetsang, eo bongata ba eona e leng lijong tse fapaneng. Khokahano le mefuta e fapaneng ea metsoako e sebetsang e fapana lipakeng tsa lijo tse felletseng le li-supplement. Lijo hangata li fana ka mefuta e mengata ea metsoako e sebetsang empa maemong a tlase, athe li-supplement li fana ka metsoako e phahameng ea metsoako e itseng.

Ha ho nahanoa ka mesebetsi e fapaneng ea saense le ea tlhaho ea motsoako o mong le o mong o sebetsang boemong ba limolek'hule, ho bohlokoa ho ikarabella bakeng sa litlamorao tse kopaneng tsa likarolo tsena ha u etsa qeto ea lijo le li-supplement tseo u ka li jang kapa che.

Ho hlaha potso ea bohlokoa: Na u lokela ho kenyelletsa Resveratrol lijong tsa hau e le ntho ea lijo kapa tlatsetso? Na ho bohlokoa ho sebelisa Resveratrol haeba u na le liphatsa tsa lefutso tse amanang le mofetše oa KMT2D? Ho thoe'ng haeba ho e-na le hoo kotsi ea hau ea liphatsa tsa lefutso e bakoa ke lefutso la ASXL1? Na ho molemo ho kenyelletsa Resveratrol lijong tsa hau haeba u fumanoa u e-na le Primary Pediatric Hepatoblastoma, kapa haeba tlhahlobo ea hau ke Primary Penile Squamous Cell Carcinoma? Ho feta moo, tšebeliso ea hau ea Resveratrol e lokela ho fetoloa joang haeba u ntse u fuoa phekolo ea Mitomycin kapa morero oa hau oa phekolo o tloha ho Mitomycin ho ea Fluorouracil? Ho bohlokoa ho hlokomela hore lipolelo tse bonolo tse kang 'Resveratrol ke ea tlhaho, kahoo e lula e le molemo' kapa 'Resveratrol e matlafatsa sesole sa' mele' ha e lekane bakeng sa khetho ea lijo / tlatsetso.

Ho feta moo, ho bohlokoa ho hlahloba bocha ho nepahala ha ho kenyelletsa Resveratrol lijong tsa hau haeba ho na le liphetoho mokhoeng oa hau oa kalafo. Ka bokhutšoanyane, ha u etsa liqeto mabapi le ho kenyelletsa lijo kapa li-supplement tse kang Resveratrol lijong tsa hau bakeng sa melemo ea eona, u lokela ho nahana ka litlamorao tse akaretsang tsa biochemical ea lisebelisoa tsohle, u nahane ka lintlha tse kang mofuta oa mofets'e, kalafo e ikhethileng eo u e fuoang, liphatsa tsa lefutso. , le khetho ea bophelo.

Cancer

Kankere e ntse e le phephetso e khōlō lefapheng la bongaka, hangata e bakang matšoenyeho a atileng. Leha ho le joalo, tsoelo-pele ea morao-rao e ntlafalitse liphello tsa phekolo, haholo-holo ka mekhoa ea phekolo ea motho ka mong, mekhoa ea ho hlahloba e sa hlaseleng ka ho sebelisa lisampole tsa mali le mathe, le nts'etsopele ea immunotherapy. Ho lemoha kapele le ho kenella ka nako ho bile bohlokoa ho ba le tšusumetso e ntle liphellong tsohle tsa phekolo.

Teko ea liphatsa tsa lefutso e fana ka ts'episo e kholo ea ho lekola kotsi ea mofetše le ho ba kotsing kapele. Leha ho le joalo, ho batho ba bangata ba nang le mekhoa ea malapa le ea liphatsa tsa lefutso ho kankere, mekhoa ea phekolo ea phekolo, esita le ka ho hlahloba kamehla, hangata e lekanyelitsoe kapa ha e eo. Hang ha ho fumanoa hore o na le mofuta o itseng oa mofetše, o kang Primary Penile Squamous Cell Carcinoma kapa Primary Pediatric Hepatoblastoma, mekhoa ea phekolo e lokela ho etsoa ho latela liphatsa tsa lefutso tsa hlahala, boemo ba lefu lena, hammoho le lintlha tse kang lilemo le bong.

Ka mor'a kalafo, tlhahlobo e tsoelang pele e bohlokoa ho bona matšoao leha e le afe a ho khutlela mokhoeng oa mofets'e le ho tsebisa liqeto tse latelang. Bakuli ba bangata ba mofetše le ba kotsing hangata ba batla likeletso mabapi le ho kenyelletsa lijo tse itseng le li-supplement lijong tsa bona, e leng se phethang karolo ea bohlokoa ts'ebetsong ea bona ea ho etsa liqeto ka kakaretso mabapi le tsamaiso ea bophelo bo botle.

Potso ea bohlokoa ke hore na ho ameha likotsing tsa lefutso le tlhahlobo e khethehileng ea mofetše ha u etsa qeto ea khetho ea lijo, joalo ka Resveratrol. Na kotsi ea lefutso bakeng sa mofets'e e bakoang ke phetoho ho KMT2D e na le litlamorao tse ts'oanang tsa tsela ea biochemical joalo ka phetoho ho ASXL1? Ho latela pono ea phepo e nepahetseng, na kotsi e amanang le Primary Penile Squamous Cell Carcinoma e lekana le Primary Pediatric Hepatoblastoma? Ho feta moo, na tlhokomelo ea lijo e lula e tšoana bakeng sa ba nang le Fluorouracil le ba fumanang Mitomycin? Lintlha tsena li bohlokoa ho etsa khetho e nepahetseng ea lijo bakeng sa batho ba nang le likotsi tse fapaneng tsa lefutso le kalafo ea mofets'e.

Resveratrol - Tlatsetso ea phepo e nepahetseng

Resveratrol ea tlatsetso e kenyelletsa mefuta e mengata ea metsoako e sebetsang, ho kenyeletsoa Resveratrol, e 'ngoe le e' ngoe e teng ka maemo a fapaneng. Lithako tsena li susumetsa litsela tsa limolek'hule, haholo-holo Lipid Metabolism, Oncogenic Cancer Epigenetics, P53 Signaling le DAP12 Signaling, e laolang likarolo tse mahlonoko tsa mofets'e maemong a lisele, joalo ka kholo ea tumor, ho ata le lefu la lisele. Ka lebaka la tšusumetso ena ea tlhaho, ho khetha li-supplement tse nepahetseng joalo ka Resveratrol, e le 'ngoe kapa e kopane, e fetoha qeto ea bohlokoa molemong oa phepo e nepahetseng ea mofets'e. Ha o nahana ka ho sebelisa Resveratrol bakeng sa mofetše, ho bohlokoa ho nahana ka lintlha tsena tse fapaneng le mekhoa. Lebaka ke hobane, joalo ka kalafo ea mofets'e, ts'ebeliso ea Resveratrol ha se qeto e akaretsang e loketseng batho bohle ba mofetše empa e hloka ho etsoa motho ka mong.

Ho khetha lisebelisoa tsa Resveratrol

Ho araba potso e reng 'Ke lokela ho qoba Resveratrol neng maemong a Kankere' ho thata hobane karabo e itšetlehile haholo ka motho ka mong - e mpa feela e le 'Ho itšetlehile!'. Joalo ka ha kalafo efe kapa efe ea mofetše e kanna ea se sebetse ho mokuli e mong le e mong, bohlokoa le polokeho kapa melemo ea Resveratrol e fapana ho latela maemo a motho. Lintlha tse kang mofuta o itseng oa mofetše, liphatsa tsa lefutso, phekolo ea morao-rao, li-supplement tse ling tse nkiloeng, mekhoa ea bophelo, BMI, le ntho leha e le efe ea ho kula kaofela li phetha karolo ea ho tseba hore na Resveratrol e nepahetse kapa e lokela ho qojoa, e totobatsa bohlokoa ba ho nahanela motho ka mong. liqeto tse joalo.

1. Na Li-Supplement tsa Resveratrol li tla thusa Bakuli ba Pele ba Hepatoblastoma ba nang le phekolo ea Fluorouracil?

Hepatoblastoma ea Bana ea Mantlha e khetholloa ka liphetoho tse itseng tsa liphatsa tsa lefutso, e leng CTNNB1, HUWE1 le NFE2L2, tse lebisang liphetohong tsa litsela tsa lik'hemik'hale, haholo-holo Oncogenic Cancer Epigenetics, Adherens junction, Androgen Signaling, Oxidative Stress le Immune Checkpoints. Katleho ea kalafo ea mofetše, joalo ka Fluorouracil, e ipapisitse le mokhoa oa eona oa ts'ebetso litseleng tsena tse ikhethileng. Leano le nepahetseng le kenyelletsa ho hokahanya ts'ebetso ea kalafo le litsela tse tsamaisang mofets'e, ka hona ho netefatsa mokhoa oa motho ka mong le o sebetsang. Maemong a joalo, ho bohlokoa ho qoba lijo kapa lisebelisoa tsa phepo e nepahetseng tse ka hananang le litlamorao tsa kalafo kapa tsa fokotsa tumellano ena. Ka mohlala, tlatsetso ea Resveratrol, e amang Oncogenic Cancer Epigenetics, e ka 'na ea se ke ea e-ba khetho e nepahetseng tabeng ea Primary Pediatric Hepatoblastoma ha e etsoa Fluorouracil. Lebaka ke hobane e ka 'na ea mpefatsa tsoelo-pele ea lefu lena kapa ea kena-kenana le katleho ea phekolo. Ha u khetha moralo oa phepo e nepahetseng, ho bohlokoa ho nahana ka lintlha tse kang mofuta oa mofets'e, kalafo e tsoelang pele, lilemo, bong, BMI, mokhoa oa bophelo le liphetoho life kapa life tse tsebahalang tsa lefutso.

2. Na Li-Supplement tsa Resveratrol li tla thusa bakuli ba Primary Penile Squamous Cell Carcinoma ba ntseng ba le ka kalafo ea Mitomycin?

Penile Squamous Cell Carcinoma e khetholloa ka liphetoho tse khethehileng tsa lefutso, tse kang ABRAXAS1, PIK3CB le NUP93, tse hlahisang liphetoho litseleng tsa lik'hemik'hale, haholo-holo Lipid Metabolism, Hematopoiesis le Inositol Phosphate Signaling. Katleho ea kalafo ea mofetše, joalo ka Mitomycin, e khethoa ke tšebelisano ea eona le litsela tsena. Sepheo ke ho netefatsa hore phekolo e lumellana hantle le litsela tse tsamaisang mofetše, e leng ho nolofalletsang mokhoa oa phekolo ea motho ka mong. Tabeng ena, lijo kapa li-supplement tse tsamaellanang le kalafo kapa tse matlafatsang tekano ena li lokela ho nahanoa. Ka mohlala, tlatsetso ea Resveratrol ke khetho e utloahalang bakeng sa ba nang le Primary Penile Squamous Cell Carcinoma ba nang le Mitomycin. Sena ke hobane Resveratrol e susumetsa litsela tse kang Lipid Metabolism, e ka thibelang lintlha tse khanna Primary Penile Squamous Cell Carcinoma kapa ea rua molemo katlehong ea Mitomycin.

3. Na Li-Supplement tsa Resveratrol li Sireletsehile ho Batho ba Phelang ba nang le ASXL1 Mutation Associated Genetic Risk?

Likhamphani tse fapaneng li fana ka liphanele tsa lefutso bakeng sa ho lekola kotsi ea lefutso ea mefuta e fapaneng ea mofets'e. Liphanele tsena li kenyelletsa liphatsa tsa lefutso tse amanang le kankere ea matsoele, ea mahe a bomme, ea popelo, ea senya le ea mala. Ho lekola liphatsa tsa lefutso tsena ho ka netefatsa tlhahlobo le ho tsebisa mekhoa ea kalafo le taolo. Ho tseba phapang e bakang mafu ho ka thusa ho ea pele tlhahlobong le tlhahlobong ea beng ka bona ba ka bang kotsing. Mofuta oa ASXL1 hangata o kenyeletsoa liphanele tsena bakeng sa tlhahlobo ea kotsi ea mofetše.

Phetoho ea liphatsa tsa lefutso tsa ASXL1 e ama litsela kapa mekhoa ea lik'hemik'hale, tse kang P53 Signaling, Oncogenic Cancer Epigenetics le Suppressive Histone Methylation, tse amehang ka ho toba kapa ka tsela e sa tobang ho khanna kankere boemong ba limolek'hule. Ha phanele ea liphatsa tsa lefutso e supa phetoho ho ASXL1 e amanang le kotsi e eketsehileng ea Chronic Myelomonocytic Leukemia, mabaka a saense a fana ka maikutlo a ho qoba tšebeliso ea tlatsetso ea Resveratrol. Sena ke hobane tlatsetso ea Resveratrol e susumetsa litsela tse kang P53 Signaling, e ka lebisang litlamorao tse mpe molemong oa phetoho ea ASXL1 le maemo a amanang le mofets'e.

4. Na Li-Supplement tsa Resveratrol li Sireletsehile ho Batho ba Phelang ba nang le KMT2D Mutation Associated Genetic Kotsi?

KMT2D e bapala karolo ea bohlokoa tlhahlobong ea kotsi ea mofetše. Liphetoho ho KMT2D li ka sitisa litsela tsa bohlokoa tsa lik'hemik'hale, ho kenyelletsa le DAP12 Signaling le Oncogenic Histone Methylation, e susumetsang nts'etsopele ea kankere. Haeba phanele ea hau ea lefutso e senola liphetoho tsa KMT2D tse amanang le Bladder Urothelial Carcinoma, nahana ka ho kenyelletsa li-supplement tsa Resveratrol moralong oa hau oa phepo. Li-supplement tsena li ka susumetsa mekhoa e kang DAP12 Signaling, molemo ka ho fana ka ts'ehetso e nepahetseng bakeng sa batho ba nang le liphetoho tsa KMT2D le mathata a amanang le bophelo bo botle.

Ha re phethela

Lintho tse peli tsa bohlokoa ka ho fetisisa tseo u lokelang ho li hopola ke hore phekolo ea kankere le phepo e nepahetseng ha ho mohla li tšoanang ho bohle. Phepo e nepahetseng, ho kenyelletsa lijo le li-supplement joalo ka Resveratrol, ke sesebelisoa se sebetsang se ka laoloang ke uena ha u ntse u tobane le mofetše.

“Ke lokela ho ja eng?” ke potso e atisang ho botsoa ke bakuli ba mofetše le ba kotsing ea ho tšoaroa ke mofetše. Karabo e nepahetseng ke hore e ipapisitse le lintlha tse kang mofuta oa mofets'e, liphatsa tsa lefutso tsa hlahala, kalafo ea hajoale, ho kula, mokhoa oa bophelo le BMI.

Fumana phepo ea hau ea phepo e nepahetseng bakeng sa mofets'e ho tsoa ho addon ka ho tobetsa sehokelo se ka tlase le ho araba lipotso mabapi le mofuta oa mofets'e oa hau, kalafo, mokhoa oa bophelo, ho kula, lilemo le bong.

References

• cBioPortal bakeng sa Cancer Genomics
• Khetho e ikhethileng le tlhahlobo ea bioloji ea sulfate-conjugated resveratrol metabolites.
• Kalafo ea mofets'e e theha sebopeho sa boikoetliso ba clonal hematopoiesis.
• Vorinostat E na le Matla a 5-Fluorouracil / Cisplatin Combination ka Ho thibela Chemotherapy-Induced EGFR Nuclear Translocation le Keketseho ea Cisplatin.
• Resveratrol, inhibitor e tsotehang ea ribonucleotide reductase.
• Boemo bo feto-fetohang ba mofetše oa metastatic bo senotsoe ho tsoa ho tatellano ea kliniki ea bakuli ba 10,000.
• [Tlhaloso ea Cyclooxygenase-2 liseleng tsa mofetše oa esophageal le ho kenngoa ke mitomycin C].