Ke mofetše ofe o ka ruang molemo ka ho kenyelletsa Pterostilbene lijong tsa bona?

Lintlha-khōlō Tsa

Pterostilbene e tsebahala haholo ka melemo ea eona ea bophelo bo botle mme e sebelisoa khafetsa ke bakuli ba mofetše le ba kotsing ea lefutso. Leha ho le joalo, polokeho le katleho ea Pterostilbene bakeng sa bakuli ba mofetše li ipapisitse le lintlha tse ngata joalo ka sesupo sa mofetše, chemotherapy, kalafo e meng le lefutso la tumor. Ho tseba hore lijo tse ling le li-supplement, tse kang grapefruit le spinach, li ka 'na tsa sebelisana hampe le meriana ea mofetše le ho baka maikutlo a mabe ho bohlokoa.

Lijo li bohlokoa bakeng sa kalafo ea mofets'e kaha li ka ama litholoana tsa kalafo. Bakuli ba mofetše ba tlameha ho khetha ka hloko le ho kenyelletsa lijo tse loketseng le li-supplement lijong tsa bona. Mohlala, Pterostilbene e ka thusa ba nang le Primary Mucinous colorectal adenocarcinoma ba tšoaroang ke Cetuximab, empa e kanna ea se be molemo ho bakuli ba fumanang Radiation bakeng sa Primary Sinonasal Adenocarcinoma. Ntle le moo, leha Pterostilbene e ka thusa batho ba nang le "TERT" ea kotsi ea lefutso, e kanna ea se khothaletsoe bakeng sa ba nang le kotsi e fapaneng ea lefutso. Ho iketsetsa merero ea ho ja ho latela bophelo bo botle, kalafo, le liphatsa tsa lefutso ho bohlokoa.

Ho utloisisa hore ho etsa qeto mabapi le ho lekana ha Pterostilbene bakeng sa mokuli oa mofets'e ho bohlokoa ho ba motho ka mong. Lintlha tse bohlokoa joalo ka mofuta oa mofetše, mekhoa ea kalafo, liphatsa tsa lefutso, likotsi tsa lefutso, lilemo, boima ba 'mele le mokhoa oa bophelo li bohlokoa ho etsa qeto ea hore na Pterostilbene ke khetho e nepahetseng. Liphatsa tsa lefutso le liphatsa tsa lefutso, haholoholo, li nahanoa haholo. Kaha lintlha tsena li ka fetoha, ho bohlokoa ho hlahloba khafetsa le ho fetola khetho ea lijo ho tsamaisana le liphetoho tsa boemo ba bophelo bo botle le kalafo.

Qetellong, mokhoa o akaretsang oa khetho ea lijo o bohlokoa, o shebane le litlamorao tse akaretsang tsa likarolo tsohle tse sebetsang lijong / litlatsetso tse joalo ka Pterostilbene sebakeng sa ho lekola motsoako o mong le o mong o sebetsang ka thoko kapa ho o hlokomoloha ka botlalo. Maikutlo ana a pharaletseng a khothalletsa mokhoa o utloahalang le oa saense oa moralo oa lijo bakeng sa mofetše.

Kakaretso e Khutšoanyane

Tšebeliso ea lijo tse thehiloeng limela le li-supplement, tse kang livithamini, litlama, liminerale, li-probiotics, le lisebelisoa tse fapaneng tse khethehileng, li ntse li eketseha har'a bakuli ba mofetše. Li-supplement tsena li etselitsoe ho fana ka metsoako e phahameng ea metsoako e sebetsang, eo bongata ba eona e leng lijong tse fapaneng. Khokahano le mefuta e fapaneng ea metsoako e sebetsang e fapana lipakeng tsa lijo tse felletseng le li-supplement. Lijo hangata li fana ka mefuta e mengata ea metsoako e sebetsang empa maemong a tlase, athe li-supplement li fana ka metsoako e phahameng ea metsoako e itseng.

Ha ho nahanoa ka mesebetsi e fapaneng ea saense le ea tlhaho ea motsoako o mong le o mong o sebetsang boemong ba limolek'hule, ho bohlokoa ho ikarabella bakeng sa litlamorao tse kopaneng tsa likarolo tsena ha u etsa qeto ea lijo le li-supplement tseo u ka li jang kapa che.

Ho hlaha potso ea bohlokoa: Na u lokela ho kenyelletsa Pterostilbene lijong tsa hau e le ntho ea lijo kapa tlatsetso? Na ho bohlokoa ho sebelisa Pterostilbene haeba u na le liphatsa tsa lefutso tsa mofetše tse amanang le mofuta oa TERT? Ho thoe'ng haeba ho e-na le hoo kotsi ea hau ea lefutso e bakoa ke lefutso? Na ho molemo ho kenyelletsa Pterostilbene lijong tsa hau haeba u fumanoa u e-na le Primary Sinonasal Adenocarcinoma, kapa haeba tlhahlobo ea hau e le Primary Mucinous colorectal adenocarcinoma? Ho feta moo, tšebeliso ea hau ea Pterostilbene e lokela ho fetoloa joang haeba u ntse u le kalafo ea Cetuximab kapa haeba leano la hau la kalafo le tloha ho Cetuximab ho ea ho Radiation? Ho bohlokoa ho hlokomela hore lipolelo tse bonolo tse kang 'Pterostilbene ke tsa tlhaho, kahoo e lula e le molemo' kapa 'Pterostilbene e matlafatsa boits'ireletso ba mmele' ha e lekane bakeng sa khetho ea lijo / tlatsetso.

Ho feta moo, ho bohlokoa ho hlahloba bocha ho nepahala ha ho kenyelletsa Pterostilbene lijong tsa hau haeba ho na le liphetoho mokhoeng oa hau oa kalafo. Ka bokhutšoanyane, ha u etsa liqeto mabapi le ho kenyelletsa lijo kapa li-supplement tse kang Pterostilbene lijong tsa hau bakeng sa melemo ea eona, u lokela ho nahana ka litlamorao tse akaretsang tsa biochemical ea metsoako eohle, u nahanne ka lintlha tse joalo ka mofuta oa mofets'e, kalafo e ikhethileng eo u ntseng u e fuoa, liphatsa tsa lefutso. , le khetho ea bophelo.

Cancer

Kankere e ntse e le phephetso e khōlō lefapheng la bongaka, hangata e bakang matšoenyeho a atileng. Leha ho le joalo, tsoelo-pele ea morao-rao e ntlafalitse liphello tsa phekolo, haholo-holo ka mekhoa ea phekolo ea motho ka mong, mekhoa ea ho hlahloba e sa hlaseleng ka ho sebelisa lisampole tsa mali le mathe, le nts'etsopele ea immunotherapy. Ho lemoha kapele le ho kenella ka nako ho bile bohlokoa ho ba le tšusumetso e ntle liphellong tsohle tsa phekolo.

Teko ea liphatsa tsa lefutso e fana ka ts'episo e kholo ea ho lekola kotsi ea mofetše le ho ba kotsing kapele. Leha ho le joalo, ho batho ba bangata ba nang le mekhoa ea malapa le ea liphatsa tsa lefutso ho kankere, mekhoa ea phekolo ea phekolo, esita le ka ho hlahloba kamehla, hangata e lekanyelitsoe kapa ha e eo. Hang ha ho fumanoa hore o na le mofuta o itseng oa mofetše, o kang Primary Mucinous colorectal adenocarcinoma kapa Primary Sinonasal Adenocarcinoma, mekhoa ea phekolo e lokela ho hlophisoa ho latela liphatsa tsa lefutso tsa hlahala, boemo ba lefu lena, hammoho le lintlha tse kang lilemo le bong.”

Ka mor'a kalafo, tlhahlobo e tsoelang pele e bohlokoa ho bona matšoao leha e le afe a ho khutlela mokhoeng oa mofets'e le ho tsebisa liqeto tse latelang. Bakuli ba bangata ba mofetše le ba kotsing hangata ba batla likeletso mabapi le ho kenyelletsa lijo tse itseng le li-supplement lijong tsa bona, e leng se phethang karolo ea bohlokoa ts'ebetsong ea bona ea ho etsa liqeto ka kakaretso mabapi le tsamaiso ea bophelo bo botle.

Potso ea bohlokoa ke hore na ho ameha likotsing tsa lefutso le tlhahlobo e khethehileng ea mofetše ha u etsa qeto mabapi le khetho ea lijo, joalo ka Pterostilbene. Na kotsi ea lefutso bakeng sa mofets'e e bakoang ke phetoho e teng ho TERT e na le litlamorao tse ts'oanang tsa lik'hemik'hale tsa biochemical joalo ka phetoho ea mofuta o mong? Ho latela pono ea phepo e nepahetseng, na kotsi e amanang le Primary Mucinous colorectal adenocarcinoma e lekana le Primary Sinonasal Adenocarcinoma? Ho feta moo, na tlhokomelo ea lijo e lula e tšoana bakeng sa ba nang le Radiation joalo ka ba amohelang Cetuximab? Lintlha tsena li bohlokoa ho etsa khetho e nepahetseng ea lijo bakeng sa batho ba nang le likotsi tse fapaneng tsa lefutso le kalafo ea mofets'e.

Pterostilbene - Tlatsetso ea Phepo

Tlatsetso ea Pterostilbene e kenyelletsa mefuta e mengata ea metsoako e sebetsang, ho kenyeletsoa Pterostilbene, e 'ngoe le e' ngoe e teng ka maemo a fapaneng. Lithako tsena li susumetsa litsela tsa limolek'hule, haholo-holo MYC Signaling, Notch Signaling, Chromatin Remodeling le Cell Cycle, e laolang likarolo tse mahlonoko tsa mofets'e maemong a cellular, joalo ka kholo ea tumor, ho ata le lefu la lisele. Ka lebaka la tšusumetso ena ea tlhaho, ho khetha li-supplement tse nepahetseng joalo ka Pterostilbene, e le 'ngoe kapa e kopane, e fetoha qeto ea bohlokoa molemong oa phepo e nepahetseng ea mofets'e. Ha u nahana ho sebelisa Pterostilbene bakeng sa mofetše, ho bohlokoa ho nahana ka lintlha le mekhoa ena e fapaneng. Lebaka ke hobane, joalo ka kalafo ea mofets'e, ts'ebeliso ea Pterostilbene ha se qeto e akaretsang e loketseng mefetše eohle empa e hloka ho etsoa motho ka mong.

Ho khetha Lisebelisoa tsa Pterostilbene

Ho araba potso e reng 'Ke lokela ho qoba Pterostilbene neng maemong a Kankere' ho thata hobane karabo ke ea motho ka mong - e mpa feela e le 'Ho ipapisitse!'. Joalo ka ha kalafo efe kapa efe ea mofetše e kanna ea se sebetse ho mokuli e mong le e mong, bohlokoa le polokeho kapa melemo ea Pterostilbene e fapana ho latela maemo a motho. Lintlha tse joalo ka mofuta o ikhethileng oa mofetše, liphatsa tsa lefutso, kalafo ea hajoale, li-supplement tse ling tse nkuoang, mekhoa ea bophelo, BMI, le lintho tse ling tse amanang le ho kula kaofela li na le karolo ho bona hore na Pterostilbene e nepahetse kapa e lokela ho qojoa, e totobatsa bohlokoa ba ho nahanela motho ka mong. liqeto tse joalo.

1. Na Pterostilbene Supplements e tla thusa bakuli ba Primary Sinonasal Adenocarcinoma ba ntseng ba etsoa kalafo ea Radiation?

Primary Sinonasal Adenocarcinoma e tšoauoa ka liphetoho tse itseng tsa liphatsa tsa lefutso, e leng ATRX, NOTCH1 le PTPRD, tse lebisang ho liphetoho litseleng tsa biochemical, haholo-holo Notch Signaling le RUNX Signaling. Katleho ea kalafo ea mofetše, joalo ka Radiation, e ipapisitse le mokhoa oa eona oa ts'ebetso litseleng tsena tse ikhethileng. Leano le nepahetseng le kenyelletsa ho hokahanya ts'ebetso ea kalafo le litsela tse tsamaisang mofets'e, ka hona ho netefatsa mokhoa oa motho ka mong le o sebetsang. Maemong a joalo, ho bohlokoa ho qoba lijo kapa lisebelisoa tsa phepo e nepahetseng tse ka hananang le litlamorao tsa kalafo kapa tsa fokotsa tumellano ena. Mohlala, tlatsetso ea Pterostilbene, e amang Notch Signaling, e kanna ea se be khetho e nepahetseng molemong oa Primary Sinonasal Adenocarcinoma ha o ntse o le Radiation. Lebaka ke hobane e ka 'na ea mpefatsa tsoelo-pele ea lefu lena kapa ea kena-kenana le katleho ea phekolo. Ha u khetha moralo oa phepo e nepahetseng, ho bohlokoa ho nahana ka lintlha tse kang mofuta oa mofets'e, kalafo e tsoelang pele, lilemo, bong, BMI, mokhoa oa bophelo le liphetoho life kapa life tse tsebahalang tsa lefutso.

2. Na Pterostilbene Supplements e tla tsoela bakuli molemo oa Primary Mucinous colorectal adenocarcinoma ba ntseng ba tsoela pele ka Kalafo ea Cetuximab?

Primary Mucinous colorectal adenocarcinoma e khetholloa ka liphetoho tse khethehileng tsa lefutso, tse kang TTN, APC le KRAS, tse hlahisang liphetoho litseleng tsa lik'hemik'hale, haholo-holo MYC Signaling, Angiogenesis, G-protein-coupled Receptor Signaling le Growth Factor Signaling. Katleho ea kalafo ea mofetše, joalo ka Cetuximab, e khethoa ke tšebelisano ea eona le litsela tsena. Sepheo ke ho netefatsa hore phekolo e lumellana hantle le litsela tse tsamaisang mofetše, e leng ho nolofalletsang mokhoa oa phekolo ea motho ka mong. Tabeng ena, ho lokela ho nahanoa ka lijo kapa li-supplement tse tsamaellanang le kalafo kapa tse matlafatsang tekano ena. Mohlala, tlatsetso ea Pterostilbene ke khetho e bohlale bakeng sa ba nang le Primary Mucinous colorectal adenocarcinoma ba fetang Cetuximab. Lebaka ke hore Pterostilbene e susumetsa litsela tse kang MYC Signaling, e ka thibelang lintlha tse khannang Primary Mucinous colorectal adenocarcinoma kapa ea thusa katleho ea Cetuximab.

3. Na Lisebelisoa tsa Pterostilbene li Sireletsehile ho Batho ba Phelang ba nang le Kotsi ea TERT Mutation Associated Genetic Risk?

TERT e bapala karolo ea bohlokoa tlhahlobong ea kotsi ea mofetše. Liphetoho ho TERT li ka sitisa litsela tsa bohlokoa tsa biochemical, ho kenyelletsa Cell Cycle le DNA Repair, tse susumetsang nts'etsopele ea mofetše. Haeba phanele ea hau ea liphatsa tsa lefutso e senola liphetoho ho TERT e amanang le Kankere ea Hematological, nahana ka ho kenyelletsa li-supplement tsa Pterostilbene moralong oa hau oa phepo. Li-supplement tsena li ka susumetsa mekhoa e kang Cell Cycle, ho rua molemo ka ho fana ka ts'ehetso e nepahetseng bakeng sa batho ba nang le liphetoho tsa TERT le mathata a amanang le bophelo bo botle.

Ha re phethela

Lintho tse peli tsa bohlokoa ka ho fetisisa tseo u lokelang ho li hopola ke hore phekolo ea kankere le phepo e nepahetseng ha ho mohla li tšoanang ho bohle. Phepo e nepahetseng, ho kenyelletsa lijo le li-supplement joalo ka Pterostilbene, ke sesebelisoa se sebetsang se ka laoloang ke uena ha u ntse u tobane le mofetše.

“Ke lokela ho ja eng?” ke potso e atisang ho botsoa ke bakuli ba mofetše le ba kotsing ea ho tšoaroa ke mofetše. Karabo e nepahetseng ke hore e ipapisitse le lintlha tse kang mofuta oa mofets'e, liphatsa tsa lefutso tsa hlahala, kalafo ea hajoale, ho kula, mokhoa oa bophelo le BMI.

Fumana phepo ea hau ea phepo e nepahetseng bakeng sa mofets'e ho tsoa ho addon ka ho tobetsa sehokelo se ka tlase le ho araba lipotso mabapi le mofuta oa mofets'e oa hau, kalafo, mokhoa oa bophelo, ho kula, lilemo le bong.

References

• Papiso ea lihlopha ha liphetho li le ka tekanyo e laetsoeng.
• cBioPortal bakeng sa Cancer Genomics
• Ho lebisa Notch ho hlola khanyetso ea mahlaseli.
• Ho ja lijo tsa pterostilbene, e leng karolo ea blueberries, ho thibela beta-catenin/p65 tsela ea pontšo e tlase le colon carcinogenesis ho likhoto.
• Pterostilbene e fana ka ts'ebetso ea antitumor ka tsela ea pontšo ea Notch1 liseleng tsa motho tsa matšoafo adenocarcinoma.
• Pterostilbene e laola hTERT maemong a 'mele ka har'a lisele tsa mofetše oa matsoele: Ho ka etsahala ka ho thibela cMyc.
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• cBioPortal bakeng sa Cancer Genomics
• Boemo bo feto-fetohang ba mofetše oa metastatic bo senotsoe ho tsoa ho tatellano ea kliniki ea bakuli ba 10,000.