Ke mofetše ofe o ka ruang molemo ka ho kenyelletsa D-limonene lijong tsa bona?

Lintlha-khōlō Tsa

D-limonene e tsebahala haholo ka melemo ea eona ea bophelo bo botle 'me e sebelisoa khafetsa ke bakuli ba mofetše le ba kotsing ea lefutso. Leha ho le joalo, polokeho le katleho ea D-limonene bakeng sa bakuli ba mofetše li ipapisitse le lintlha tse ngata joalo ka sesupo sa mofets'e, chemotherapy, liphekolo tse ling le liphatsa tsa lefutso tsa hlahala. Ho tseba hore lijo tse ling le li-supplement, tse kang grapefruit le spinach, li ka 'na tsa sebelisana hampe le meriana ea mofetše le ho baka maikutlo a mabe ho bohlokoa.

Lijo li bohlokoa bakeng sa kalafo ea mofets'e kaha li ka ama litholoana tsa kalafo. Bakuli ba mofetše ba tlameha ho khetha ka hloko le ho kenyelletsa lijo tse loketseng le li-supplement lijong tsa bona. Ka mohlala, D-limonene e ka thusa ba nang le Primary Mucinous colorectal adenocarcinoma ba tlas'a Cetuximab, empa e ka 'na ea se ke ea thusa bakuli ba fumanang Radiation for Primary Adamantinoma. Ho feta moo, le hoja D-limonene e ka thusa batho ba nang le kotsi ea lefutso "KMT2D", e ka 'na ea se ke ea buelloa ho ba nang le kotsi e fapaneng ea lefutso. Ho iketsetsa merero ea ho ja ho latela bophelo bo botle, kalafo, le liphatsa tsa lefutso ho bohlokoa.

Ho utloisisa hore ho etsa qeto mabapi le ho tšoaneleha ha D-limonene bakeng sa mokuli oa mofets'e ho bohlokoa hore e be motho ka mong. Lintlha tsa bohlokoa tse kang mofuta oa mofetše, mekhoa ea phekolo, liphatsa tsa lefutso, likotsi tsa lefutso, lilemo, boima ba 'mele le mokhoa oa bophelo li bohlokoa ho etsa qeto ea hore na D-limonene ke khetho e nepahetseng. Liphatsa tsa lefutso le liphatsa tsa lefutso, haholoholo, li nahanoa haholo. Kaha lintlha tsena li ka fetoha, ho bohlokoa ho hlahloba khafetsa le ho fetola khetho ea lijo ho tsamaisana le liphetoho tsa boemo ba bophelo bo botle le kalafo.

Qetellong, mokhoa o akaretsang oa khetho ea lijo ke oa bohlokoa, o tsepamisitse maikutlo liphellong tse akaretsang tsa likarolo tsohle tse sebetsang lijong / lisebelisoa tse kang D-limonene ho e-na le ho hlahloba motsoako o mong le o mong o sebetsang ka thoko kapa ho o hlokomoloha ka ho feletseng. Maikutlo ana a pharaletseng a khothalletsa mokhoa o utloahalang le oa saense oa moralo oa lijo bakeng sa mofetše.

Kakaretso e Khutšoanyane

Tšebeliso ea lijo tse thehiloeng limela le li-supplement, tse kang livithamini, litlama, liminerale, li-probiotics, le lisebelisoa tse fapaneng tse khethehileng, li ntse li eketseha har'a bakuli ba mofetše. Li-supplement tsena li etselitsoe ho fana ka metsoako e phahameng ea metsoako e sebetsang, eo bongata ba eona e leng lijong tse fapaneng. Khokahano le mefuta e fapaneng ea metsoako e sebetsang e fapana lipakeng tsa lijo tse felletseng le li-supplement. Lijo hangata li fana ka mefuta e mengata ea metsoako e sebetsang empa maemong a tlase, athe li-supplement li fana ka metsoako e phahameng ea metsoako e itseng.

Ha ho nahanoa ka mesebetsi e fapaneng ea saense le ea tlhaho ea motsoako o mong le o mong o sebetsang boemong ba limolek'hule, ho bohlokoa ho ikarabella bakeng sa litlamorao tse kopaneng tsa likarolo tsena ha u etsa qeto ea lijo le li-supplement tseo u ka li jang kapa che.

Ho hlaha potso ea bohlokoa: Na u lokela ho kenyelletsa D-limonene lijong tsa hau e le ntho ea lijo kapa tlatsetso? Na ho bohlokoa ho sebelisa D-limonene haeba u na le liphatsa tsa lefutso tse amanang le mofetše o amanang le mofuta oa KMT2D? Ho thoe'ng haeba ho e-na le hoo kotsi ea hau ea lefutso e bakoa ke lefutso? Na ho molemo ho kenyelletsa D-limonene lijong tsa hau haeba u fumanoa u e-na le Primary Adamantinoma, kapa haeba tlhahlobo ea hau e le Primary Mucinous colorectal adenocarcinoma? Ho feta moo, tšebeliso ea hau ea D-limonene e lokela ho fetoloa joang haeba u ntse u le kalafo ea Cetuximab kapa morero oa hau oa kalafo o tloha ho Cetuximab ho ea ho Radiation? Ho bohlokoa ho hlokomela hore lipolelo tse bonolo tse kang 'D-limonene ke ntho ea tlhaho, kahoo e molemo ka linako tsohle' kapa 'D-limonene e matlafatsa tšireletso ea' mele ea 'mele' ha e lekane bakeng sa khetho ea lijo/tlatsetso.

Ho feta moo, ho bohlokoa ho hlahloba bocha ho nepahala ha ho kenyelletsa D-limonene lijong tsa hau haeba ho na le liphetoho mokhoeng oa hau oa kalafo. Ka bokhutšoanyane, ha u etsa liqeto mabapi le ho kenyelletsa lijo kapa li-supplement tse kang D-limonene lijong tsa hau bakeng sa melemo ea eona, u lokela ho nahana ka liphello tsa biochemical tsa metsoako eohle, ho nahana ka lintlha tse kang mofuta oa kankere, phekolo e khethehileng eo u ntseng u e etsa. liphatsa tsa lefutso, le khetho ea mokhoa oa bophelo.

Cancer

Kankere e ntse e le phephetso e khōlō lefapheng la bongaka, hangata e bakang matšoenyeho a atileng. Leha ho le joalo, tsoelo-pele ea morao-rao e ntlafalitse liphello tsa phekolo, haholo-holo ka mekhoa ea phekolo ea motho ka mong, mekhoa ea ho hlahloba e sa hlaseleng ka ho sebelisa lisampole tsa mali le mathe, le nts'etsopele ea immunotherapy. Ho lemoha kapele le ho kenella ka nako ho bile bohlokoa ho ba le tšusumetso e ntle liphellong tsohle tsa phekolo.

Teko ea liphatsa tsa lefutso e fana ka ts'episo e kholo ea ho lekola kotsi ea mofetše le ho ba kotsing kapele. Leha ho le joalo, ho batho ba bangata ba nang le mekhoa ea malapa le ea liphatsa tsa lefutso ho kankere, mekhoa ea phekolo ea phekolo, esita le ka ho hlahloba kamehla, hangata e lekanyelitsoe kapa ha e eo. Hang ha ho fumanoa hore o na le mofuta o itseng oa mofetše, o kang Primary Mucinous colorectal adenocarcinoma kapa Primary Adamantinoma, mekhoa ea phekolo e lokela ho hlophisoa ho latela liphatsa tsa lefutso tsa hlahala, boemo ba lefu lena, hammoho le lintlha tse kang lilemo le bong.

Ka mor'a kalafo, tlhahlobo e tsoelang pele e bohlokoa ho bona matšoao leha e le afe a ho khutlela mokhoeng oa mofets'e le ho tsebisa liqeto tse latelang. Bakuli ba bangata ba mofetše le ba kotsing hangata ba batla likeletso mabapi le ho kenyelletsa lijo tse itseng le li-supplement lijong tsa bona, e leng se phethang karolo ea bohlokoa ts'ebetsong ea bona ea ho etsa liqeto ka kakaretso mabapi le tsamaiso ea bophelo bo botle.

Potso ea bohlokoa ke hore na ho ameha likotsing tsa lefutso le tlhahlobo e khethehileng ea mofets'e ha u etsa qeto ea khetho ea lijo, joalo ka D-limonene. Na kotsi ea lefutso bakeng sa mofets'e e bakoang ke phetoho e teng ho KMT2D e na le litlamorao tse ts'oanang tsa biochemical le phetoho ea mofuta o mong? Ho latela pono ea phepo e nepahetseng, na kotsi e amanang le Primary Mucinous colorectal adenocarcinoma e lekana le Primary Adamantinoma? Ho feta moo, na tlhokomeliso ea lijo e lula e tšoana ho ba nang le Radiation joalo ka ba amohelang Cetuximab? Lintlha tsena li bohlokoa ho etsa khetho e nepahetseng ea lijo bakeng sa batho ba nang le likotsi tse fapaneng tsa lefutso le kalafo ea mofets'e.

D-limonene – Tlatsetso ya Phepo

Tlatsetso ea D-limonene e kenyelletsa mefuta e mengata ea metsoako e sebetsang, ho kenyeletsoa D-limonene, e 'ngoe le e' ngoe e teng ka mefuta e sa tšoaneng. Lithako tsena li susumetsa litsela tsa limolek'hule, haholoholo MAPK Signaling le Oxidative Stress, e laolang likarolo tsa bohlokoa tsa mofets'e maemong a lisele, joalo ka kholo ea tumor, ho ata le lefu la lisele. Ho fanoe ka tšusumetso ena ea likokoana-hloko, ho khetha li-supplement tse loketseng tse kang D-limonene, li le mong kapa li kopane, e fetoha qeto ea bohlokoa tabeng ea phepo ea kankere. Ha u nahana ka ho sebelisa D-limonene bakeng sa mofetše, ho bohlokoa ho nahana ka lintlha tsena le mekhoa e fapaneng. Lebaka ke hobane, joalo ka kalafo ea mofets'e, ts'ebeliso ea D-limonene ha se qeto e akaretsang e loketseng mafu a mofetše, empa e hloka ho etsoa ke motho ka mong.

Ho khetha Lisebelisoa tsa D-limonene

Ho araba potso e reng 'Ke lokela ho qoba D-limonene neng maemong a Kankere' ho thata hobane karabo e itšetlehile haholo ka motho ka mong - e mpa feela e le 'Ho ipapisitse le!'. Joalo ka ha kalafo efe kapa efe ea mofetše e kanna ea se sebetse ho mokuli e mong le e mong, bohlokoa le polokeho kapa melemo ea D-limonene e fapana ho latela maemo a motho. Lintlha tse kang mofuta o itseng oa mofetše, liphatsa tsa lefutso, phekolo ea morao-rao, li-supplement tse ling tse nkiloeng, mekhoa ea bophelo, BMI, le ho kula hofe kapa hofe ho phetha karolo ea ho tseba hore na D-limonene e nepahetse kapa e lokela ho qojoa, e totobatsa bohlokoa ba ho iketsetsa motho ka mong. ho nahanela liqetong tse joalo.

1. Na Li-Supplement tsa D-limonene li tla tsoela Bakuli ba Pele ba Adamantinoma ba ntseng ba le tlas'a kalafo ea Radiation?

Adamantinoma ea mantlha e tšoauoa ka liphetoho tse itseng tsa liphatsa tsa lefutso, e leng ARHGAP45, PI4KB le SDSL, e lebisang phetohong ea litsela tsa biochemical, haholo-holo Oxidative Stress le Inositol Phosphate Signaling. Katleho ea kalafo ea mofetše, joalo ka Radiation, e ipapisitse le mokhoa oa eona oa ts'ebetso litseleng tsena tse ikhethileng. Leano le nepahetseng le kenyelletsa ho hokahanya ts'ebetso ea kalafo le litsela tse tsamaisang mofets'e, ka hona ho netefatsa mokhoa oa motho ka mong le o sebetsang. Maemong a joalo, ho bohlokoa ho qoba lijo kapa lisebelisoa tsa phepo e nepahetseng tse ka hananang le litlamorao tsa kalafo kapa tsa fokotsa tumellano ena. Ka mohlala, tlatsetso ea D-limonene, e amang Khatello ea Oxidative, e ka 'na ea se ke ea e-ba khetho e nepahetseng tabeng ea Primary Adamantinoma ha e etsoa ke Radiation. Lebaka ke hobane e ka 'na ea mpefatsa tsoelo-pele ea lefu lena kapa ea kena-kenana le katleho ea phekolo. Ha u khetha moralo oa phepo e nepahetseng, ho bohlokoa ho nahana ka lintlha tse kang mofuta oa mofets'e, kalafo e tsoelang pele, lilemo, bong, BMI, mokhoa oa bophelo le liphetoho life kapa life tse tsebahalang tsa lefutso.

2. Na Li-Supplement tsa D-limonene li tla tsoela bakuli molemo oa Primary Mucinous colorectal adenocarcinoma ba ntseng ba tsoela pele ka Kalafo ea Cetuximab?

Primary Mucinous colorectal adenocarcinoma e khetholloa ka liphetoho tse khethehileng tsa liphatsa tsa lefutso, tse kang TTN, APC le KRAS, tse hlahisang liphetoho litseleng tsa lik'hemik'hale, haholo-holo MAPK Signaling, Angiogenesis, G-protein-coupled Receptor Signaling le Growth Factor Signaling. Katleho ea kalafo ea mofetše, joalo ka Cetuximab, e khethoa ke tšebelisano ea eona le litsela tsena. Sepheo ke ho netefatsa hore phekolo e lumellana hantle le litsela tse tsamaisang mofetše, e leng ho nolofalletsang mokhoa oa phekolo ea motho ka mong. Tabeng ena, ho lokela ho nahanoa ka lijo kapa li-supplement tse tsamaellanang le kalafo kapa tse matlafatsang tekano ena. Ka mohlala, tlatsetso ea D-limonene ke khetho e utloahalang bakeng sa ba nang le Primary Mucinous colorectal adenocarcinoma ba fetang Cetuximab. Sena ke hobane D-limonene e susumetsa litsela tse kang MAPK Signaling, e ka thibelang lintlha tse tsamaisang Primary Mucinous colorectal adenocarcinoma kapa ea ruisa katleho ea Cetuximab.

3. Na Li-Supplement tsa D-limonene li Sireletsehile ho Batho ba Phelang ba nang le Kotsi ea KMT2D Phetoho e Amanang le Liphatsa tsa lefutso?

KMT2D e bapala karolo ea bohlokoa tlhahlobong ea kotsi ea mofetše. Liphetoho ho KMT2D li ka sitisa litsela tsa bohlokoa tsa biochemical, ho kenyelletsa le MAPK Signaling le Oncogenic Histone Methylation, tse susumetsang nts'etsopele ea mofetše. Haeba phanele ea liphatsa tsa lefutso tsa hau e senola liphetoho tsa KMT2D tse amanang le Bladder Urothelial Carcinoma, nahana ka ho kenyelletsa D-limonene leano la phepo ea hau. Li-supplement tsena li ka susumetsa litsela tse kang MAPK Signaling, molemo ka ho fana ka tšehetso e nepahetseng bakeng sa batho ba nang le liphetoho tsa KMT2D le mathata a amanang le bophelo bo botle.

Ha re phethela

Lintho tse peli tsa bohlokoa ka ho fetisisa tseo u lokelang ho li hopola ke hore phekolo ea kankere le phepo e nepahetseng ha ho mohla li tšoanang ho bohle. Phepo e nepahetseng, ho kenyelletsa lijo le li-supplement joalo ka D-limonene, ke sesebelisoa se sebetsang se ka laoloang ke uena ha u ntse u tobane le mofetše.

“Ke lokela ho ja eng?” ke potso e atisang ho botsoa ke bakuli ba mofetše le ba kotsing ea ho tšoaroa ke mofetše. Karabo e nepahetseng ke hore e ipapisitse le lintlha tse kang mofuta oa mofets'e, liphatsa tsa lefutso tsa hlahala, kalafo ea hajoale, ho kula, mokhoa oa bophelo le BMI.

Fumana phepo ea hau ea phepo e nepahetseng bakeng sa mofets'e ho tsoa ho addon ka ho tobetsa sehokelo se ka tlase le ho araba lipotso mabapi le mofuta oa mofets'e oa hau, kalafo, mokhoa oa bophelo, ho kula, lilemo le bong.

References

• Karolo ea KEAP1/NRF2 le TP53 Liphetoho ho Lung Squamous Cell Carcinoma Development le Radiation Resistance.
• cBioPortal bakeng sa Cancer Genomics
• Tšireletso ea Tšireletso ea D-Limonene Khahlanong le Tšenyo ea Cell e Bakiloeng ke Oxidative-Induced Cell in Human Lens Epithelial Cells ka P38 Pathway.
• D-Limonene e fetola ho ruruha, khatello ea oxidative le tsela ea Ras-ERK ho thibela tumorigenesis ea letlalo la murine.
• Tlhahlobo ea kankere ea kankere ea liphatsa tsa lefutso tse feletseng.
• Mosebetsi oa Antitumor oa ZD6474, vascular endothelial growth factor receptor tyrosine kinase inhibitor, liseleng tsa mofetše oa motho tse nang le khanyetso ea antiepidermal growth factor receptor therapy.
• cBioPortal bakeng sa Cancer Genomics