Ke mofetše ofe o ka ruang molemo ka ho kenyelletsa Celandine lijong tsa bona?

Lintlha-khōlō Tsa

Celandine e tsebahala haholo ka melemo ea eona ea bophelo bo botle 'me hangata e sebelisoa ke bakuli ba mofetše le ba kotsing ea lefutso. Leha ho le joalo, polokeho le katleho ea Celandine bakeng sa bakuli ba mofetše li ipapisitse le lintlha tse ngata joalo ka sesupo sa mofetše, chemotherapy, liphekolo tse ling le liphatsa tsa lefutso tsa hlahala. Ho tseba hore lijo tse ling le li-supplement, tse kang grapefruit le spinach, li ka 'na tsa sebelisana hampe le meriana ea mofetše le ho baka maikutlo a mabe ho bohlokoa.

Lijo li bohlokoa bakeng sa kalafo ea mofets'e kaha li ka ama litholoana tsa kalafo. Bakuli ba mofetše ba tlameha ho khetha ka hloko le ho kenyelletsa lijo tse loketseng le li-supplement lijong tsa bona. Ka mohlala, Celandine e ka thusa ba nang le Primary Penile Squamous Cell Carcinoma ba nang le Mitomycin. Ho feta moo, le hoja Celandine e ka thusa batho ba nang le "CDH1" ea lefutso, e ka 'na ea se ke ea buelloa ho ba nang le kotsi e fapaneng ea liphatsa tsa lefutso "ASXL1". Ho iketsetsa merero ea ho ja ho latela bophelo bo botle, kalafo, le liphatsa tsa lefutso ho bohlokoa.

Ho utloisisa hore ho etsa qeto mabapi le ho lekana ha Celandine bakeng sa mokuli oa mofets'e ho bohlokoa ho ba motho ka mong. Lintlha tsa bohlokoa tse kang mofuta oa mofetše, mekhoa ea phekolo, liphatsa tsa lefutso, likotsi tsa lefutso, lilemo, boima ba 'mele le mokhoa oa bophelo li bohlokoa ho etsa qeto ea hore na Celandine ke khetho e nepahetseng. Liphatsa tsa lefutso le liphatsa tsa lefutso, haholoholo, li nahanoa haholo. Kaha lintlha tsena li ka fetoha, ho bohlokoa ho hlahloba khafetsa le ho fetola khetho ea lijo ho tsamaisana le liphetoho tsa boemo ba bophelo bo botle le kalafo.

Qetellong, mokhoa o akaretsang oa khetho ea lijo ke oa bohlokoa, o lebisa tlhokomelo liphellong tse akaretsang tsa likarolo tsohle tse sebetsang lijong / li-supplement tse kang Celandine ho e-na le ho hlahloba motsoako o mong le o mong o sebetsang ka thoko kapa ho o hlokomoloha ka ho feletseng. Maikutlo ana a pharaletseng a khothalletsa mokhoa o utloahalang le oa saense oa moralo oa lijo bakeng sa mofetše.

Kakaretso e Khutšoanyane

Tšebeliso ea lijo tse thehiloeng limela le li-supplement, tse kang livithamini, litlama, liminerale, li-probiotics, le lisebelisoa tse fapaneng tse khethehileng, li ntse li eketseha har'a bakuli ba mofetše. Li-supplement tsena li etselitsoe ho fana ka metsoako e phahameng ea metsoako e sebetsang, eo bongata ba eona e leng lijong tse fapaneng. Khokahano le mefuta e fapaneng ea metsoako e sebetsang e fapana lipakeng tsa lijo tse felletseng le li-supplement. Lijo hangata li fana ka mefuta e mengata ea metsoako e sebetsang empa maemong a tlase, athe li-supplement li fana ka metsoako e phahameng ea metsoako e itseng.

Ha ho nahanoa ka mesebetsi e fapaneng ea saense le ea tlhaho ea motsoako o mong le o mong o sebetsang boemong ba limolek'hule, ho bohlokoa ho ikarabella bakeng sa litlamorao tse kopaneng tsa likarolo tsena ha u etsa qeto ea lijo le li-supplement tseo u ka li jang kapa che.

Ho hlaha potso ea bohlokoa: Na u lokela ho kenyelletsa Celandine lijong tsa hau e le ntho ea lijo kapa tlatsetso? Na ho bohlokoa ho sebelisa Celandine haeba u na le liphatsa tsa lefutso tse amanang le mofetše oa CDH1? Ho thoe'ng haeba ho e-na le hoo kotsi ea hau ea liphatsa tsa lefutso e bakoa ke lefutso la ASXL1? Na ho molemo ho kenyelletsa Celandine lijong tsa hau haeba u fumanoa u e-na le Primary Penile Squamous Cell Carcinoma? Ho feta moo, tšebeliso ea hau ea Celandine e lokela ho fetoloa joang haeba u ntse u fuoa phekolo ea Mitomycin kapa morero oa hau oa phekolo o tloha ho Mitomycin? Ho bohlokoa ho hlokomela hore lipolelo tse bonolo tse kang 'Celandine ke ea tlhaho, kahoo e lula e le molemo' kapa 'Celandine e matlafatsa sesole sa' mele ha e lekane bakeng sa khetho ea lijo/tlatsetso.

Ho feta moo, ho bohlokoa ho hlahloba bocha ho nepahala ha ho kenyelletsa Celandine lijong tsa hau haeba ho na le liphetoho mokhoeng oa hau oa kalafo. Ka bokhutšoanyane, ha u etsa liqeto mabapi le ho kenyelletsa lijo kapa li-supplement tse kang Celandine lijong tsa hau bakeng sa melemo ea eona, u lokela ho nahana ka litlamorao tse akaretsang tsa biochemical ea metsoako eohle, ho nahanoa ka lintlha tse kang mofuta oa mofets'e, kalafo e ikhethileng eo u e fuoang, liphatsa tsa lefutso. , le khetho ea bophelo.

Cancer

Kankere e ntse e le phephetso e khōlō lefapheng la bongaka, hangata e bakang matšoenyeho a atileng. Leha ho le joalo, tsoelo-pele ea morao-rao e ntlafalitse liphello tsa phekolo, haholo-holo ka mekhoa ea phekolo ea motho ka mong, mekhoa ea ho hlahloba e sa hlaseleng ka ho sebelisa lisampole tsa mali le mathe, le nts'etsopele ea immunotherapy. Ho lemoha kapele le ho kenella ka nako ho bile bohlokoa ho ba le tšusumetso e ntle liphellong tsohle tsa phekolo.

Teko ea liphatsa tsa lefutso e fana ka ts'episo e kholo ea ho lekola kotsi ea mofetše le ho ba kotsing kapele. Leha ho le joalo, ho batho ba bangata ba nang le mekhoa ea malapa le ea liphatsa tsa lefutso ho kankere, mekhoa ea phekolo ea phekolo, esita le ka ho hlahloba kamehla, hangata e lekanyelitsoe kapa ha e eo. Hang ha ho fumanoa hore o na le mofuta o itseng oa mofetše, o kang Primary Penile Squamous Cell Carcinoma, mekhoa ea phekolo e lokela ho hlophisoa ho latela liphatsa tsa lefutso tsa hlahala, boemo ba lefu lena, hammoho le lintlha tse kang lilemo le bong.

Ka mor'a kalafo, tlhahlobo e tsoelang pele e bohlokoa ho bona matšoao leha e le afe a ho khutlela mokhoeng oa mofets'e le ho tsebisa liqeto tse latelang. Bakuli ba bangata ba mofetše le ba kotsing hangata ba batla likeletso mabapi le ho kenyelletsa lijo tse itseng le li-supplement lijong tsa bona, e leng se phethang karolo ea bohlokoa ts'ebetsong ea bona ea ho etsa liqeto ka kakaretso mabapi le tsamaiso ea bophelo bo botle.

Potso ea bohlokoa ke hore na ho ameha likotsing tsa lefutso le tlhahlobo e khethehileng ea mofetše ha u etsa qeto ea khetho ea lijo, joalo ka Celandine. Na kotsi ea liphatsa tsa lefutso bakeng sa mofets'e e bakoang ke phetoho ho CDH1 e na le litlamorao tse ts'oanang tsa biochemical tseleng ea phetoho ho ASXL1? Ho ea ka pono ea phepo e nepahetseng, na kotsi e amanang le Primary Penile Squamous Cell Carcinoma e tšoana le mefuta e meng ea kankere? Ho feta moo, na tlhokomelo ea lijo e lula e tšoana bakeng sa ba ntseng ba fuoa phekolo e 'ngoe le ea ba fumanang Mitomycin? Lintlha tsena li bohlokoa ho etsa khetho e nepahetseng ea lijo bakeng sa batho ba nang le likotsi tse fapaneng tsa lefutso le kalafo ea mofets'e.

Celandine - Tlatsetso ea Phepo

Tlatsetso ea Celandine e kenyelletsa mefuta e mengata ea metsoako e sebetsang, ho akarelletsa Chelidonine le Chelerythrine, e 'ngoe le e' ngoe e teng ka mefuta e sa tšoaneng. Lithako tsena li susumetsa litsela tsa limolek'hule, haholo-holo NFKB Signaling, DNA Repair le Adherens junction, e laolang likarolo tse mahlonoko tsa mofets'e maemong a cellular, joalo ka kholo ea tumor, ho ata le lefu la lisele. Ka lebaka la tšusumetso ena ea tlhaho, ho khetha li-supplement tse loketseng joalo ka Celandine, e le 'ngoe kapa e kopane, e fetoha qeto e boima molemong oa phepo ea mofets'e. Ha u nahana ho sebelisa Celandine bakeng sa mofetše, ho bohlokoa ho nahana ka lintlha tsena tse fapaneng le mekhoa. Lebaka ke hobane, joalo ka kalafo ea mofets'e, ts'ebeliso ea Celandine ha se qeto e akaretsang e loketseng mefets'e eohle empa e hloka ho etsoa motho ka mong.

Ho khetha lisebelisoa tsa Celandine

Ho araba potso e reng 'Ke lokela ho qoba Celandine neng maemong a Kankere' ho thata hobane karabo e itšetlehile haholo ka motho ka mong - e mpa feela e le 'Ho itšetlehile!'. Joalo ka ha kalafo efe kapa efe ea mofetše e kanna ea se sebetse ho mokuli e mong le e mong, bohlokoa le polokeho kapa melemo ea Celandine e fapana ho latela maemo a motho. Lintlha tse joalo ka mofuta o itseng oa mofets'e, liphatsa tsa lefutso, liphekolo tsa morao-rao, litlatsetso tse ling tse nkuoang, mekhoa ea bophelo, BMI, le lintho tse ling tse amanang le ho kula, kaofela li na le karolo ho bona hore na Celandine e nepahetse kapa e lokela ho qojoa, e totobatsa bohlokoa ba ho nahanela motho ka mong. liqeto tse joalo.

1. Na Li-Supplement tsa Celandine li tla thusa bakuli ba Primary Penile Squamous Cell Carcinoma ba ntseng ba etsoa ka Kalafo ea Mitomycin?

Penile Squamous Cell Carcinoma e khetholloa ka liphetoho tse itseng tsa lefutso, tse kang ABRAXAS1, PIK3CB le NUP93, tse hlahisang liphetoho litseleng tsa biochemical, haholo-holo NFKB Signaling, Hematopoiesis le Inositol Phosphate Signaling. Katleho ea kalafo ea mofetše, joalo ka Mitomycin, e khethoa ke tšebelisano ea eona le litsela tsena. Sepheo ke ho netefatsa hore phekolo e lumellana hantle le litsela tse tsamaisang mofetše, e leng ho nolofalletsang mokhoa oa phekolo ea motho ka mong. Tabeng ena, ho lokela ho nahanoa ka lijo kapa li-supplement tse tsamaellanang le kalafo kapa tse matlafatsang tekano ena. Ka mohlala, tlatsetso ea Celandine ke khetho e utloahalang bakeng sa ba nang le Primary Penile Squamous Cell Carcinoma ba nang le Mitomycin. Lebaka ke hobane Celandine e susumetsa litsela tse kang NFKB Signaling, e ka thibelang mabaka a khanna Primary Penile Squamous Cell Carcinoma kapa ea rua molemo katlehong ea Mitomycin.

2. Na li-Supplement tsa Celandine li Sireletsehile ho Batho ba Phelang ba nang le ASXL1 Mutation Associated Genetic Risk?

Likhamphani tse fapaneng li fana ka liphanele tsa lefutso bakeng sa ho lekola kotsi ea lefutso ea mefuta e fapaneng ea mofets'e. Liphanele tsena li kenyelletsa liphatsa tsa lefutso tse amanang le kankere ea matsoele, ea mahe a bomme, ea popelo, ea senya le ea mala. Ho lekola liphatsa tsa lefutso tsena ho ka netefatsa tlhahlobo le ho tsebisa mekhoa ea kalafo le taolo. Ho tseba phapang e bakang mafu ho ka thusa ho ea pele tlhahlobong le tlhahlobong ea beng ka bona ba ka bang kotsing. Mofuta oa ASXL1 hangata o kenyeletsoa liphanele tsena bakeng sa tlhahlobo ea kotsi ea mofetše.

Phetoho ea mofuta oa ASXL1 e ama litsela kapa mekhoa ea lik'hemik'hale, tse kang DNA Repair, Oncogenic Cancer Epigenetics le Suppressive Histone Methylation, tse amehang ka ho toba kapa ka tsela e sa tobang ho khanna mofetše boemong ba limolek'hule. Ha phanele ea liphatsa tsa lefutso e supa phetoho ho ASXL1 e amanang le kotsi e eketsehileng ea Chronic Myelomonocytic Leukemia, mabaka a saense a fana ka maikutlo a ho qoba tšebeliso ea tlatsetso ea Celandine. Lebaka ke hobane tlatsetso ea Celandine e susumetsa litsela tse kang Tokiso ea DNA, e ka lebisang litlamorao tse mpe molemong oa phetoho ea ASXL1 le maemo a amanang le mofets'e.

3. Na Li-Supplement tsa Celandine li Sireletsehile ho Batho ba Phelang ba nang le CDH1 Mutation Associated Genetic Risk?

CDH1 e bapala karolo ea bohlokoa tlhahlobong ea kotsi ea mofetše. Liphetoho tsa CDH1 li ka sitisa litsela tsa bohlokoa tsa lik'hemik'hale tsa biochemical, ho kenyelletsa le Adherens junction le Epithelial to Mesenchymal Transition, tse susumetsang nts'etsopele ea mofetše. Haeba phanele ea hau ea lefutso e senola liphetoho tsa CDH1 tse amanang le Kankere ea Gastric, nahana ka ho kenyelletsa li-supplement tsa Celandine moralong oa hau oa phepo. Li-supplement tsena li ka susumetsa litsela tse kang Adherens junction, ho rua molemo ka ho fana ka ts'ehetso e nepahetseng bakeng sa batho ba nang le liphetoho tsa CDH1 le mathata a amanang le bophelo bo botle.

Ha re phethela

Lintho tse peli tsa bohlokoa ka ho fetisisa tseo u lokelang ho li hopola ke hore phekolo ea kankere le phepo e nepahetseng ha ho mohla li tšoanang ho bohle. Phepo e nepahetseng, ho kenyelletsa lijo le li-supplement joalo ka Celandine bakeng sa melemo ea eona, ke sesebelisoa se sebetsang se ka laoloang ke uena ha u ntse u tobane le mofetše.

“Ke lokela ho ja eng?” ke potso e atisang ho botsoa ke bakuli ba mofetše le ba kotsing ea ho tšoaroa ke mofetše. Karabo e nepahetseng ke hore e ipapisitse le lintlha tse kang mofuta oa mofets'e, liphatsa tsa lefutso tsa hlahala, kalafo ea hajoale, ho kula, mokhoa oa bophelo le BMI.

Fumana phepo ea hau ea phepo e nepahetseng bakeng sa mofets'e ho tsoa ho addon ka ho tobetsa sehokelo se ka tlase le ho araba lipotso mabapi le mofuta oa mofets'e oa hau, kalafo, mokhoa oa bophelo, ho kula, lilemo le bong.

References

• cBioPortal bakeng sa Cancer Genomics
• Kalafo ea mofets'e e theha sebopeho sa boikoetliso ba clonal hematopoiesis.
• Chelidonine e hatella tlhahiso ea LPS-E hlahisitsoeng ke bahlaseli ba ho ruruha ka ho thibela tsela ea TLR4 / NF-κB ho RAW264.7 macrophages.
• Chelidonine e ntlafatsa phello ea antitumor ea lenvatinib liseleng tsa hepatocellular carcinoma.
• Piperine (PP) e ntlafalitse phekolo ea mitomycin-C (MMC) ea kankere ea molomo oa motho ka ho hatella tsela ea pontšo ea Bcl-2 ka ho thibela STAT3 / NF-κB.