Ke mofetše ofe o ka ruang molemo ka ho kenyelletsa 7-8-dihydroxyflavone lijong tsa bona?

Lintlha-khōlō Tsa

7-8-dihydroxyflavone e tsebahala haholo ka melemo ea eona ea bophelo bo botle 'me e sebelisoa khafetsa ke bakuli ba mofetše le ba kotsing ea lefutso. Leha ho le joalo, polokeho le katleho ea 7-8-dihydroxyflavone bakeng sa bakuli ba mofetše li ipapisitse le lintlha tse ngata joalo ka sesupo sa mofets'e, chemotherapy, kalafo tse ling le liphatsa tsa lefutso tsa tumor. Ho tseba hore lijo tse ling le li-supplement, tse kang grapefruit le spinach, li ka 'na tsa sebelisana hampe le meriana ea mofetše le ho baka maikutlo a mabe ho bohlokoa.

Lijo li bohlokoa bakeng sa kalafo ea mofets'e kaha li ka ama litholoana tsa kalafo. Bakuli ba mofetše ba tlameha ho khetha ka hloko le ho kenyelletsa lijo tse loketseng le li-supplement lijong tsa bona. Ka mohlala, 7-8-dihydroxyflavone e ka thusa ba nang le Primary Penile Squamous Cell Carcinoma ba nang le Mitomycin, empa e ka 'na ea se ke ea e-ba molemo ho bakuli ba fumanang Gemcitabine bakeng sa Primary Urachal adenocarcinoma. Ho feta moo, le hoja 7-8-dihydroxyflavone e ka thusa batho ba nang le lefutso la "CDKN2A", e ka 'na ea se ke ea buelloa ho ba nang le kotsi e fapaneng ea liphatsa tsa lefutso "ASXL1". Ho iketsetsa merero ea ho ja ho latela bophelo bo botle, kalafo, le liphatsa tsa lefutso ho bohlokoa.

Ho utloisisa hore ho etsa qeto mabapi le ho lekana ha 7-8-dihydroxyflavone bakeng sa mokuli oa mofets'e ho bohlokoa hore e be motho ka mong. Lintlha tse bohlokoa joalo ka mofuta oa mofetše, mekhoa ea kalafo, liphatsa tsa lefutso, likotsi tsa lefutso, lilemo, boima ba 'mele le mokhoa oa bophelo li bohlokoa ho etsa qeto ea hore na 7-8-dihydroxyflavone ke khetho e nepahetseng. Liphatsa tsa lefutso le liphatsa tsa lefutso, haholoholo, li nahanoa haholo. Kaha lintlha tsena li ka fetoha, ho bohlokoa ho hlahloba khafetsa le ho fetola khetho ea lijo ho tsamaisana le liphetoho tsa boemo ba bophelo bo botle le kalafo.

Qetellong, mokhoa o akaretsang oa khetho ea lijo o bohlokoa, o shebane le litlamorao tse akaretsang tsa likarolo tsohle tse sebetsang lijong / litlatsetso joalo ka 7-8-dihydroxyflavone ho fapana le ho lekola motsoako o mong le o mong o sebetsang ka thoko kapa ho o hlokomoloha ka botlalo. Maikutlo ana a pharaletseng a khothalletsa mokhoa o utloahalang le oa saense oa moralo oa lijo bakeng sa mofetše.

Kakaretso e Khutšoanyane

Tšebeliso ea lijo tse thehiloeng limela le li-supplement, tse kang livithamini, litlama, liminerale, li-probiotics, le lisebelisoa tse fapaneng tse khethehileng, li ntse li eketseha har'a bakuli ba mofetše. Li-supplement tsena li etselitsoe ho fana ka metsoako e phahameng ea metsoako e sebetsang, eo bongata ba eona e leng lijong tse fapaneng. Khokahano le mefuta e fapaneng ea metsoako e sebetsang e fapana lipakeng tsa lijo tse felletseng le li-supplement. Lijo hangata li fana ka mefuta e mengata ea metsoako e sebetsang empa maemong a tlase, athe li-supplement li fana ka metsoako e phahameng ea metsoako e itseng.

Ha ho nahanoa ka mesebetsi e fapaneng ea saense le ea tlhaho ea motsoako o mong le o mong o sebetsang boemong ba limolek'hule, ho bohlokoa ho ikarabella bakeng sa litlamorao tse kopaneng tsa likarolo tsena ha u etsa qeto ea lijo le li-supplement tseo u ka li jang kapa che.

Ho hlaha potso ea bohlokoa: Na u lokela ho kenyelletsa 7-8-dihydroxyflavone lijong tsa hau e le ntho ea lijo kapa tlatsetso? Na ho bohlokoa ho sebelisa 7-8-dihydroxyflavone haeba u na le liphatsa tsa lefutso tsa mofets'e tse amanang le mofuta oa CDKN2A? Ho thoe'ng haeba ho e-na le hoo kotsi ea hau ea liphatsa tsa lefutso e bakoa ke lefutso la ASXL1? Na ho molemo ho kenyelletsa 7-8-dihydroxyflavone lijong tsa hau haeba u fumanoa u e-na le Primary Urachal adenocarcinoma, kapa haeba tlhahlobo ea hau e le Primary Penile Squamous Cell Carcinoma? Ho feta moo, tšebeliso ea hau ea 7-8-dihydroxyflavone e lokela ho fetoloa joang haeba u ntse u fuoa phekolo ea Mitomycin kapa haeba moralo oa hau oa phekolo o tloha Mitomycin ho ea Gemcitabine? Ho bohlokoa ho elelloa hore lipolelo tse bonolo joalo ka '7-8-dihydroxyflavone ke tsa tlhaho, ka hona li molemo kamehla' kapa '7-8-dihydroxyflavone boost immune immune' ha li lekane bakeng sa khetho ea lijo/tlatsetso.

Ho feta moo, ho bohlokoa ho hlahloba bocha ho nepahala ha ho kenyelletsa 7-8-dihydroxyflavone lijong tsa hau haeba ho na le liphetoho mokhoeng oa hau oa kalafo. Ka bokhutšoanyane, ha u etsa liqeto mabapi le ho kenyelletsa lijo kapa li-supplement tse kang 7-8-dihydroxyflavone lijong tsa hau bakeng sa melemo ea eona, u lokela ho nahana ka litlamorao tse akaretsang tsa biochemical ea lisebelisoa tsohle, ho nahanoa ka lintlha tse kang mofuta oa mofets'e, kalafo e ikhethileng eo u e fumanang. tse etsahalang, liphatsa tsa lefutso, le khetho ea mokhoa oa bophelo.

Cancer

Kankere e ntse e le phephetso e khōlō lefapheng la bongaka, hangata e bakang matšoenyeho a atileng. Leha ho le joalo, tsoelo-pele ea morao-rao e ntlafalitse liphello tsa phekolo, haholo-holo ka mekhoa ea phekolo ea motho ka mong, mekhoa ea ho hlahloba e sa hlaseleng ka ho sebelisa lisampole tsa mali le mathe, le nts'etsopele ea immunotherapy. Ho lemoha kapele le ho kenella ka nako ho bile bohlokoa ho ba le tšusumetso e ntle liphellong tsohle tsa phekolo.

Teko ea liphatsa tsa lefutso e fana ka ts'episo e kholo ea ho lekola kotsi ea mofetše le ho ba kotsing kapele. Leha ho le joalo, ho batho ba bangata ba nang le mekhoa ea malapa le ea liphatsa tsa lefutso ho kankere, mekhoa ea phekolo ea phekolo, esita le ka ho hlahloba kamehla, hangata e lekanyelitsoe kapa ha e eo. Hang ha ho fumanoa hore o na le mofuta o itseng oa mofetše, o kang Primary Penile Squamous Cell Carcinoma kapa Primary Urachal adenocarcinoma, mekhoa ea phekolo e lokela ho hlophisoa ho latela liphatsa tsa lefutso tsa hlahala, boemo ba lefu lena, hammoho le lintlha tse kang lilemo le bong.

Ka mor'a kalafo, tlhahlobo e tsoelang pele e bohlokoa ho bona matšoao leha e le afe a ho khutlela mokhoeng oa mofets'e le ho tsebisa liqeto tse latelang. Bakuli ba bangata ba mofetše le ba kotsing hangata ba batla likeletso mabapi le ho kenyelletsa lijo tse itseng le li-supplement lijong tsa bona, e leng se phethang karolo ea bohlokoa ts'ebetsong ea bona ea ho etsa liqeto ka kakaretso mabapi le tsamaiso ea bophelo bo botle.

Potso ea bohlokoa ke hore na ho ameha likotsing tsa lefutso le tlhahlobo e khethehileng ea mofetše ha u etsa qeto ea khetho ea lijo, joalo ka 7-8-dihydroxyflavone. Na kotsi ea lefutso ea mofets'e e bakoang ke phetoho ho CDKN2A e na le litlamorao tse ts'oanang tsa biochemical le phetoho ho ASXL1? Ho latela pono ea phepo e nepahetseng, na kotsi e amanang le Primary Penile Squamous Cell Carcinoma e lekana le Primary Urachal adenocarcinoma? Ho feta moo, na tlhokomelo ea lijo e lula e tšoana bakeng sa ba kenang Gemcitabine le ba amohelang Mitomycin? Lintlha tsena li bohlokoa ho etsa khetho e nepahetseng ea lijo bakeng sa batho ba nang le likotsi tse fapaneng tsa lefutso le kalafo ea mofets'e.

7-8-dihydroxyflavone - Tlatsetso ea Phepo

Tlatsetso 7-8-dihydroxyflavone e akaretsa mefuta e mengata ea metsoako e sebetsang, ho kenyeletsoa 7-8-dihydroxyflavone, e 'ngoe le e' ngoe e teng ka maemo a fapaneng. Lithako tsena li susumetsa litsela tsa limolek'hule, haholo-holo Apoptosis, Oxidative Stress, Endoplasmic Reticulum Stress le Angiogenesis, tse laolang likarolo tse mahlonoko tsa mofetše maemong a lisele, joalo ka kholo ea hlahala, ho ata le lefu la lisele. Ka lebaka la tšusumetso ena ea tlhaho, ho khetha li-supplement tse nepahetseng joalo ka 7-8-dihydroxyflavone, e le 'ngoe kapa e kopane, e fetoha qeto ea bohlokoa maemong a phepo e nepahetseng ea mofets'e. Ha u nahana ho sebelisa 7-8-dihydroxyflavone bakeng sa mofetše, ho bohlokoa ho nahana ka lintlha tsena tse fapaneng le mekhoa. Lebaka ke hobane, joalo ka kalafo ea mofets'e, ts'ebeliso ea 7-8-dihydroxyflavone ha se qeto e akaretsang e loketseng mats'oafo ohle empa e hloka ho etsoa motho ka mong.

Ho khetha 7-8-dihydroxyflavone Tlatsetso

Ho araba potso e reng 'Ke lokela ho qoba neng 7-8-dihydroxyflavone tabeng ea Kankere' ho thata hobane karabo e itšetlehile haholo ka motho ka mong - e mpa feela e le 'Ho itšetlehile!'. Joalo ka ha kalafo efe kapa efe ea mofetše e kanna ea se sebetse ho mokuli e mong le e mong, bohlokoa le polokeho kapa melemo ea 7-8-dihydroxyflavone e fapana ho latela maemo a motho. Lintlha tse kang mofuta o itseng oa mofetše, liphatsa tsa lefutso, phekolo ea morao-rao, li-supplement tse ling tse nkiloeng, mekhoa ea bophelo, BMI, le lintho tse ling tse amanang le ho kula kaofela li phetha karolo ea ho tseba hore na 7-8-dihydroxyflavone e nepahetse kapa e lokela ho qojoa, e totobatsa bohlokoa. ea ho nahanela motho ka mong liqetong tse joalo.

1. Na Li-Supplement tsa 7-8-dihydroxyflavone li tla thusa Bakuli ba Pele ba Urachal adenocarcinoma ba etsoang kalafo ea Gemcitabine?

Urachal adenocarcinoma ea mantlha e tšoauoa ka liphetoho tse itseng tsa liphatsa tsa lefutso, e leng NFE2L2, TP53 le GNAS, tse lebisang liphetohong litseleng tsa biochemical, haholo-holo khatello ea kelello ea oxidative, li-immune Checkpoints, Cell Cycle Checkpoints, Apoptosis, G-protein-coupled Receptor Signaling and Reproductive Hormone Signaling. Katleho ea kalafo ea mofetše, joalo ka Gemcitabine, e ipapisitse le mokhoa oa eona oa ts'ebetso litseleng tsena tse ikhethileng. Leano le nepahetseng le kenyelletsa ho hokahanya ts'ebetso ea kalafo le litsela tse tsamaisang mofets'e, ka hona ho netefatsa mokhoa oa motho ka mong le o sebetsang. Maemong a joalo, ho bohlokoa ho qoba lijo kapa lisebelisoa tsa phepo e nepahetseng tse ka hananang le litlamorao tsa kalafo kapa tsa fokotsa tumellano ena. Ka mohlala, tlatsetso ea 7-8-dihydroxyflavone, e amang Khatello ea Oxidative, e ka 'na ea se ke ea e-ba khetho e nepahetseng tabeng ea Primary Urachal adenocarcinoma ha e etsoa Gemcitabine. Lebaka ke hobane e ka 'na ea mpefatsa tsoelo-pele ea lefu lena kapa ea kena-kenana le katleho ea phekolo. Ha u khetha moralo oa phepo e nepahetseng, ho bohlokoa ho nahana ka lintlha tse kang mofuta oa mofets'e, kalafo e tsoelang pele, lilemo, bong, BMI, mokhoa oa bophelo le liphetoho life kapa life tse tsebahalang tsa lefutso.

2. Na Li-Supplement tsa 7-8-dihydroxyflavone li tla ruisa Bakuli ba Pele ba Penile Squamous Cell Carcinoma ba ntseng ba etsoa ka Kalafo ea Mitomycin?

Penile Squamous Cell Carcinoma e khetholloa ka liphetoho tse itseng tsa lefutso, tse kang ABRAXAS1, PIK3CB le NUP93, tse hlahisang liphetoho litseleng tsa biochemical, haholo-holo Apoptosis, Hematopoiesis le Inositol Phosphate Signaling. Katleho ea kalafo ea mofetše, joalo ka Mitomycin, e khethoa ke tšebelisano ea eona le litsela tsena. Sepheo ke ho netefatsa hore phekolo e lumellana hantle le litsela tse tsamaisang mofetše, e leng ho nolofalletsang mokhoa oa phekolo ea motho ka mong. Tabeng ena, ho lokela ho nahanoa ka lijo kapa li-supplement tse tsamaellanang le kalafo kapa tse matlafatsang tekano ena. Ka mohlala, tlatsetso ea 7-8-dihydroxyflavone ke khetho e utloahalang bakeng sa ba nang le Primary Penile Squamous Cell Carcinoma ba nang le Mitomycin. Sena ke hobane 7-8-dihydroxyflavone e susumetsa litsela tse kang Apoptosis, e ka thibelang mabaka a khanna Primary Penile Squamous Cell Carcinoma kapa ea rua molemo katlehong ea Mitomycin.

3. Na li-Supplement tsa 7-8-dihydroxyflavone li Sireletsehile ho Batho ba Phelang ba nang le ASXL1 Mutation Associated Genetic Kotsi?

Likhamphani tse fapaneng li fana ka liphanele tsa lefutso bakeng sa ho lekola kotsi ea lefutso ea mefuta e fapaneng ea mofets'e. Liphanele tsena li kenyelletsa liphatsa tsa lefutso tse amanang le kankere ea matsoele, ea mahe a bomme, ea popelo, ea senya le ea mala. Ho lekola liphatsa tsa lefutso tsena ho ka netefatsa tlhahlobo le ho tsebisa mekhoa ea kalafo le taolo. Ho tseba phapang e bakang mafu ho ka thusa ho ea pele tlhahlobong le tlhahlobong ea beng ka bona ba ka bang kotsing. Mofuta oa ASXL1 hangata o kenyeletsoa liphanele tsena bakeng sa tlhahlobo ea kotsi ea mofetše.

Phetoho ho mofuta oa ASXL1 e ama litsela kapa lits'ebetso tsa biochemical, joalo ka Endoplasmic Reticulum Stress, Oncogenic Cancer Epigenetics le Suppressive Histone Methylation, tse amehang ka kotloloho kapa ka tsela e sa tobang ho khanna mofetše boemong ba limolek'hule. Ha phanele ea liphatsa tsa lefutso e supa phetoho ho ASXL1 e amanang le kotsi e eketsehileng ea Chronic Myelomonocytic Leukemia, mabaka a saense a fana ka maikutlo a ho qoba tšebeliso ea tlatsetso 7-8-dihydroxyflavone. Lebaka ke hobane tlatsetso ea 7-8-dihydroxyflavone e susumetsa litsela tse kang Endoplasmic Reticulum Stress, e ka lebisang litlamorao tse mpe maemong a phetoho ea ASXL1 le maemo a amanang le mofetše.

4. Na Li-Supplement tsa 7-8-dihydroxyflavone li Sireletsehile ho Batho ba Phelang ba nang le CDKN2A Mutation Associated Genetic Kotsi?

CDKN2A e bapala karolo ea bohlokoa tlhahlobong ea kotsi ea mofetše. Liphetoho ho CDKN2A li ka sitisa litsela tsa bohlokoa tsa biochemical, ho kenyelletsa Angiogenesis, Cell Cycle Checkpoints le Cell Cycle, tse susumetsang nts'etsopele ea mofetše. Haeba phanele ea liphatsa tsa lefutso ea hau e senola liphetoho tsa CDKN2A tse amanang le Kankere ea Letlalo, nahana ka ho kenyelletsa 7-8-dihydroxyflavone leanong la hau la phepo. Li-supplement tsena li ka susumetsa mekhoa e kang Angiogenesis, ho rua molemo ka ho fana ka ts'ehetso e nepahetseng bakeng sa batho ba nang le liphetoho tsa CDKN2A le mathata a amanang le bophelo bo botle.

Ha re phethela

Lintho tse peli tsa bohlokoa ka ho fetisisa tseo u lokelang ho li hopola ke hore phekolo ea kankere le phepo e nepahetseng ha ho mohla li tšoanang ho bohle. Phepo e nepahetseng, ho kenyelletsa lijo le li-supplement joalo ka 7-8-dihydroxyflavone, ke sesebelisoa se sebetsang se ka laoloang ke uena ha u ntse u tobane le mofetše.

“Ke lokela ho ja eng?” ke potso e atisang ho botsoa ke bakuli ba mofetše le ba kotsing ea ho tšoaroa ke mofetše. Karabo e nepahetseng ke hore e ipapisitse le lintlha tse kang mofuta oa mofets'e, liphatsa tsa lefutso tsa hlahala, kalafo ea hajoale, ho kula, mokhoa oa bophelo le BMI.

Fumana phepo ea hau ea phepo e nepahetseng bakeng sa mofets'e ho tsoa ho addon ka ho tobetsa sehokelo se ka tlase le ho araba lipotso mabapi le mofuta oa mofets'e oa hau, kalafo, mokhoa oa bophelo, ho kula, lilemo le bong.

References

• Apoptosis induction ea human leukemia U937 cell by 7,8-dihydroxyflavone hydrate ka ho feto-fetoha ha lelapa la Bcl-2 la liprotheine le tsela ea pontšo ea MAPKs.
• Kalafo ea 7,8-DHF e Etsa Hore Pontšo ea Cyr61 e Hatelle Hypoxia e Bakiloeng ke ER Stress ho Lisele tsa HK-2.
• cBioPortal bakeng sa Cancer Genomics
• Ho Hlahloba Litšebelisano Tsa Limolek'hule tsa 7,8-Dihydroxyflavone le Li-Derivatives tsa Tsona le Liprotheine tsa TrkB le VEGFR2.
• Kalafo ea mofets'e e theha sebopeho sa boikoetliso ba clonal hematopoiesis.
• 7,8-Dihydroxyflavone e kenya tšebetsong litsela tsa lipontšo tsa Nrf2 / HO-1 mme e sireletsa khahlanong le lefu la osteoarthritis.
• Mitomycin C e khona ho hlahisa apoptosis e bakoang ke TRAIL ka p53-e ikemetseng e ikemetseng ea li-receptors tsa lefu: bopaki ba karolo ea c-Jun N-terminal kinase activation.
• Mekhoa ea ho Hlōla Khanyetso ea Intrinsic ho Gemcitabine ho Pancreatic Ductal Adenocarcinoma ka Redox Modulation.
• Boemo bo feto-fetohang ba mofetše oa metastatic bo senotsoe ho tsoa ho tatellano ea kliniki ea bakuli ba 10,000.