Ke mofetše ofe o ka ruang molemo ka ho kenyelletsa Andrographis lijong tsa bona?

Lintlha-khōlō Tsa

Andrographis e tsebahala haholo ka melemo ea eona ea bophelo bo botle 'me e sebelisoa khafetsa ke bakuli ba mofetše le ba kotsing ea lefutso. Leha ho le joalo, polokeho le katleho ea Andrographis bakeng sa bakuli ba mofets'e e ipapisitse le lintlha tse ngata joalo ka sesupo sa mofets'e, chemotherapy, liphekolo tse ling le liphatsa tsa lefutso tsa hlahala. Ho tseba hore lijo tse ling le li-supplement, tse kang grapefruit le spinach, li ka 'na tsa sebelisana hampe le meriana ea mofetše le ho baka maikutlo a mabe ho bohlokoa.

Lijo li bohlokoa bakeng sa kalafo ea mofets'e kaha li ka ama litholoana tsa kalafo. Bakuli ba mofetše ba tlameha ho khetha ka hloko le ho kenyelletsa lijo tse loketseng le li-supplement lijong tsa bona. Ka mohlala, Andrographis e ka tsoela ba nang le Primary Glioblastoma ea Temozolomide molemo, empa e ka 'na ea se ke ea thusa bakuli ba fumanang Carmustine bakeng sa Primary Pineoblastoma. Ho feta moo, leha Andrographis e ka thusa batho ba nang le lefutso la "CDKN2A", e kanna ea se khothaletsoe ho ba nang le kotsi e fapaneng ea lefutso. Ho iketsetsa merero ea ho ja ho latela bophelo bo botle, kalafo, le liphatsa tsa lefutso ho bohlokoa.

Ho utloisisa hore ho etsa qeto mabapi le ho lekana ha Andrographis bakeng sa mokuli oa mofets'e ho bohlokoa ho ikamahanya le motho ka mong. Lintlha tsa bohlokoa joalo ka mofuta oa mofetše, mekhoa ea kalafo, liphatsa tsa lefutso, likotsi tsa lefutso, lilemo, boima ba 'mele le mokhoa oa bophelo li bohlokoa ho etsa qeto ea hore na Andrographis ke khetho e nepahetseng. Liphatsa tsa lefutso le liphatsa tsa lefutso, haholoholo, li nahanoa haholo. Kaha lintlha tsena li ka fetoha, ho bohlokoa ho hlahloba khafetsa le ho fetola khetho ea lijo ho tsamaisana le liphetoho tsa boemo ba bophelo bo botle le kalafo.

Qetellong, mokhoa o akaretsang oa khetho ea lijo ke oa bohlokoa, o lebisa tlhokomelo liphellong tse akaretsang tsa likarolo tsohle tse sebetsang lijong / lisebelisoa tse kang Andrographis ho e-na le ho hlahloba motsoako o mong le o mong o sebetsang ka thoko kapa ho o hlokomoloha ka ho feletseng. Maikutlo ana a pharaletseng a khothalletsa mokhoa o utloahalang le oa saense oa moralo oa lijo bakeng sa mofetše.

Kakaretso e Khutšoanyane

Tšebeliso ea lijo tse thehiloeng limela le li-supplement, tse kang livithamini, litlama, liminerale, li-probiotics, le lisebelisoa tse fapaneng tse khethehileng, li ntse li eketseha har'a bakuli ba mofetše. Li-supplement tsena li etselitsoe ho fana ka metsoako e phahameng ea metsoako e sebetsang, eo bongata ba eona e leng lijong tse fapaneng. Khokahano le mefuta e fapaneng ea metsoako e sebetsang e fapana lipakeng tsa lijo tse felletseng le li-supplement. Lijo hangata li fana ka mefuta e mengata ea metsoako e sebetsang empa maemong a tlase, athe li-supplement li fana ka metsoako e phahameng ea metsoako e itseng.

Ha ho nahanoa ka mesebetsi e fapaneng ea saense le ea tlhaho ea motsoako o mong le o mong o sebetsang boemong ba limolek'hule, ho bohlokoa ho ikarabella bakeng sa litlamorao tse kopaneng tsa likarolo tsena ha u etsa qeto ea lijo le li-supplement tseo u ka li jang kapa che.

Ho hlaha potso ea bohlokoa: Na u lokela ho kenyelletsa Andrographis lijong tsa hau e le ntho ea lijo kapa tlatsetso? Na ho bohlokoa ho sebelisa Andrographis haeba u na le liphatsa tsa lefutso tse amanang le mofetše oa CDKN2A? Ho thoe'ng haeba ho e-na le hoo kotsi ea hau ea lefutso e bakoa ke lefutso le leng? Na ho molemo ho kenyelletsa Andrographis lijong tsa hau haeba u fumanoa u e-na le Primary Pineoblastoma, kapa haeba tlhahlobo ea hau e le Primary Glioblastoma? Ho feta moo, tšebeliso ea hau ea Andrographis e lokela ho fetoloa joang haeba u ntse u le kalafo ea Temozolomide kapa haeba moralo oa hau oa phekolo o tloha Temozolomide ho ea Carmustine? Ho bohlokoa ho hlokomela hore lipolelo tse bonolo tse kang 'Andrographis ke ntho ea tlhaho, kahoo e molemo ka linako tsohle' kapa 'Andrographis boost immune immune' ha li lekane bakeng sa khetho ea lijo/tlatsetso.

Ho feta moo, ho bohlokoa ho hlahloba bocha ho nepahala ha ho kenyelletsa Andrographis lijong tsa hau haeba ho na le liphetoho mokhoeng oa hau oa kalafo. Ka bokhutšoanyane, ha u etsa liqeto mabapi le ho kenyelletsa lijo kapa li-supplement tse kang Andrographis lijong tsa hau bakeng sa melemo ea tsona, u lokela ho nahana ka litlamorao tse akaretsang tsa biochemical ea metsoako eohle, u nahanne ka lintlha tse kang mofuta oa mofets'e, kalafo e ikhethileng eo u e fuoang, liphatsa tsa lefutso. , le khetho ea bophelo.

Cancer

Kankere e ntse e le phephetso e khōlō lefapheng la bongaka, hangata e bakang matšoenyeho a atileng. Leha ho le joalo, tsoelo-pele ea morao-rao e ntlafalitse liphello tsa phekolo, haholo-holo ka mekhoa ea phekolo ea motho ka mong, mekhoa ea ho hlahloba e sa hlaseleng ka ho sebelisa lisampole tsa mali le mathe, le nts'etsopele ea immunotherapy. Ho lemoha kapele le ho kenella ka nako ho bile bohlokoa ho ba le tšusumetso e ntle liphellong tsohle tsa phekolo.

Teko ea liphatsa tsa lefutso e fana ka ts'episo e kholo ea ho lekola kotsi ea mofetše le ho ba kotsing kapele. Leha ho le joalo, ho batho ba bangata ba nang le mekhoa ea malapa le liphatsa tsa lefutso ho kankere, mekhoa ea phekolo ea phekolo, esita le ka ho hlahloba kamehla, hangata e lekanyelitsoe kapa ha e eo. Hang ha ho fumanoa hore o na le mofuta o itseng oa mofetše, o kang Primary Glioblastoma kapa Primary Pineoblastoma, mekhoa ea phekolo e lokela ho hlophisoa ho latela liphatsa tsa lefutso tsa hlahala, boemo ba lefu lena, hammoho le lintlha tse kang lilemo le bong.

Ka mor'a kalafo, tlhahlobo e tsoelang pele e bohlokoa ho bona matšoao leha e le afe a ho khutlela mokhoeng oa mofets'e le ho tsebisa liqeto tse latelang. Bakuli ba bangata ba mofetše le ba kotsing hangata ba batla likeletso mabapi le ho kenyelletsa lijo tse itseng le li-supplement lijong tsa bona, e leng se phethang karolo ea bohlokoa ts'ebetsong ea bona ea ho etsa liqeto ka kakaretso mabapi le tsamaiso ea bophelo bo botle.

Potso ea bohlokoa ke hore na ho ameha likotsing tsa lefutso le tlhahlobo e khethehileng ea mofetše ha u etsa qeto ea khetho ea lijo, joalo ka Andrographis. Na kotsi ea lefutso bakeng sa mofets'e e bakoang ke phetoho ho CDKN2A e na le litlamorao tse ts'oanang tsa biochemical joalo ka phetoho ea lefutso? Ho latela pono ea phepo e nepahetseng, na kotsi e amanang le Primary Glioblastoma e lekana le Primary Pineoblastoma? Ho feta moo, na ho hlahlojoa ha lijo ho lula ho tšoana le ho ba nang le Carmustine le ba fumanang Temozolomide? Lintlha tsena li bohlokoa ho etsa khetho e nepahetseng ea lijo bakeng sa batho ba nang le likotsi tse fapaneng tsa lefutso le kalafo ea mofets'e.

Andrographis - Tlatsetso ea Phepo

Tlatsetso Andrographis e kenyelletsa mefuta e mengata ea metsoako e sebetsang, ho kenyelletsa le Andrographolide, e 'ngoe le e' ngoe e teng ka maemo a fapaneng. Lithako tsena li susumetsa litsela tsa limolek'hule, haholo-holo Cell Cycle le Oncogenic Cancer Epigenetics, e laolang likarolo tsa bohlokoa tsa mofets'e maemong a lisele, joalo ka kholo ea tumor, ho ata le lefu la lisele. Ka lebaka la tšusumetso ena ea tlhaho, ho khetha li-supplement tse loketseng joalo ka Andrographis, e le 'ngoe kapa e kopane, e fetoha qeto ea bohlokoa maemong a phepo e nepahetseng ea mofets'e. Ha u nahana ka ho sebelisa Andrographis bakeng sa mofetše, ho bohlokoa ho nahana ka lintlha tsena tse fapaneng le mekhoa. Lebaka ke hobane, joalo ka kalafo ea mofets'e, ts'ebeliso ea Andrographis ha se qeto e akaretsang e loketseng mafu a mofetše empa e hloka ho etsoa motho ka mong.

Ho khetha Lisebelisoa tsa Andrographis

Ho araba potso e reng 'Ke lokela ho qoba Andrographis neng maemong a Kankere' ho thata hobane karabo e itšetlehile haholo ka motho ka mong - e mpa feela e le 'Ho itšetlehile!'. Joalo ka ha kalafo efe kapa efe ea mofetše e kanna ea se sebetse ho mokuli e mong le e mong, bohlokoa le polokeho kapa melemo ea Andrographis e fapana ho latela maemo a motho. Lintlha tse joalo ka mofuta o itseng oa mofetše, liphatsa tsa lefutso, kalafo ea hajoale, li-supplement tse ling tse nkuoang, mekhoa ea bophelo, BMI, le lintho tse ling tse amanang le ho kula, kaofela li na le karolo ho bona hore na Andrographis e nepahetse kapa e lokela ho qojoa, e totobatsa bohlokoa ba ho nahanela motho ka mong. liqeto tse joalo.

1. Na Andrographis Supplements e tla thusa bakuli ba Primary Pineoblastoma ba ntseng ba etsoa kalafo ea Carmustine?

Pineoblastoma ea mantlha e tšoauoa ka liphetoho tse itseng tsa liphatsa tsa lefutso, e leng ATR, ATM le CREBBP, tse lebisang phetohong ea litsela tsa biochemical, haholo-holo Oncogenic Cancer Epigenetics, DNA Repair, Cell Cycle Checkpoints, G-protein-coupled Receptor Signaling le Immune Evasion Signaling. Katleho ea kalafo ea mofetše, joalo ka Carmustine, e ipapisitse le mokhoa oa eona oa ts'ebetso litseleng tsena tse ikhethileng. Leano le nepahetseng le kenyelletsa ho hokahanya ts'ebetso ea kalafo le litsela tse tsamaisang mofets'e, ka hona ho netefatsa mokhoa oa motho ka mong le o sebetsang. Maemong a joalo, ho bohlokoa ho qoba lijo kapa lisebelisoa tsa phepo e nepahetseng tse ka hananang le litlamorao tsa kalafo kapa tsa fokotsa tumellano ena. Ka mohlala, tlatsetso ea Andrographis, e amang Kankere ea Oncogenic Epigenetics, e ka 'na ea se ke ea e-ba khetho e nepahetseng tabeng ea Primary Pineoblastoma ha u ntse u le Carmustine. Lebaka ke hobane e ka 'na ea mpefatsa tsoelo-pele ea lefu lena kapa ea kena-kenana le katleho ea phekolo. Ha u khetha moralo oa phepo e nepahetseng, ho bohlokoa ho nahana ka lintlha tse kang mofuta oa mofets'e, kalafo e tsoelang pele, lilemo, bong, BMI, mokhoa oa bophelo le liphetoho life kapa life tse tsebahalang tsa lefutso.

2. Na Li-Supplement tsa Andrographis li tla tsoela Bakuli ba Pele ba Glioblastoma ba ntseng ba tsoela pele ho Phekolo ea Temozolomide?

Glioblastoma e ka sehloohong e khetholloa ka liphetoho tse khethehileng tsa lefutso, tse kang TRBV7-7, TAS2R46 le TP53, tse hlahisang liphetoho litseleng tsa biochemical, haholo-holo Cell Cycle, Cell Cycle Checkpoints le Apoptosis. Katleho ea kalafo ea mofets'e, joalo ka Temozolomide, e khethoa ke tšebelisano ea eona le litsela tsena. Sepheo ke ho netefatsa hore phekolo e lumellana hantle le litsela tse tsamaisang mofetše, e leng ho nolofalletsang mokhoa oa phekolo ea motho ka mong. Tabeng ena, ho lokela ho nahanoa ka lijo kapa li-supplement tse tsamaellanang le kalafo kapa tse matlafatsang tekano ena. Ka mohlala, tlatsetso ea Andrographis ke khetho e utloahalang bakeng sa ba nang le Primary Glioblastoma ba nang le Temozolomide. Lebaka ke hore Andrographis e susumetsa litsela tse kang Cell Cycle, e ka thibelang lintlha tse khanna Primary Glioblastoma kapa ea rua molemo ka katleho ea Temozolomide.

3. Na Andrographis Supplements e Sireletsehile ho Batho ba Phelang ba nang le CDKN2A Mutation Associated Genetic Risk?

CDKN2A e bapala karolo ea bohlokoa tlhahlobong ea kotsi ea mofetše. Liphetoho tsa liphatsa tsa lefutso ho CDKN2A li ka sitisa litsela tsa bohlokoa tsa lik'hemik'hale, ho kenyelletsa le Cell Cycle Checkpoints le Cell Cycle, tse susumetsang nts'etsopele ea mofetše. Haeba phanele ea liphatsa tsa lefutso tsa hau e senola liphetoho tsa CDKN2A tse amanang le Kankere ea Letlalo, nahana ka ho kenyelletsa Andrographis leano la phepo ea hau. Li-supplement tsena li ka susumetsa litsela tse kang Cell Cycle, ho rua molemo ka ho fana ka ts'ehetso e nepahetseng bakeng sa batho ba nang le liphetoho tsa CDKN2A le mathata a amanang le bophelo bo botle.

Ha re phethela

Lintho tse peli tsa bohlokoa ka ho fetisisa tseo u lokelang ho li hopola ke hore phekolo ea kankere le phepo e nepahetseng ha ho mohla li tšoanang ho bohle. Phepo e nepahetseng, ho kenyelletsa lijo le li-supplement joalo ka Andrographis, ke sesebelisoa se sebetsang se ka laoloang ke uena ha u ntse u tobane le mofetše.

“Ke lokela ho ja eng?” ke potso e atisang ho botsoa ke bakuli ba mofetše le ba kotsing ea ho tšoaroa ke mofetše. Karabo e nepahetseng ke hore e ipapisitse le lintlha tse kang mofuta oa mofets'e, liphatsa tsa lefutso tsa hlahala, kalafo ea hajoale, ho kula, mokhoa oa bophelo le BMI.

Fumana phepo ea hau ea phepo e nepahetseng bakeng sa mofets'e ho tsoa ho addon ka ho tobetsa sehokelo se ka tlase le ho araba lipotso mabapi le mofuta oa mofets'e oa hau, kalafo, mokhoa oa bophelo, ho kula, lilemo le bong.

References

• Khatiso ea menoana ea mefuta e fapaneng e nang le lisebelisoa tsa DNA tse hlahisoang ho tsoa ho litempele tsa DNA tse sa sebetseng tsa khoele e le 'ngoe.
• cBioPortal bakeng sa Cancer Genomics
• Andrographolide e hanyetsa phetoho ea epithelial-mesenchymal e bakoang ke mosi oa sakerete le ho se sebetse hantle ha matšoafo ka ho thibela ho ruruha ho thibela HOTAIR.
• Phetoho ea IDH1/2 ke lets'oao la ho pholoha 'me e bolela esale pele karabelo ho chemotherapy bakeng sa li-glioma tsa sehlopha sa II tse phekolehang ka kalafo ea radiation.
• cBioPortal bakeng sa Cancer Genomics
• Kalafo ea mofets'e e theha sebopeho sa boikoetliso ba clonal hematopoiesis.
• MGMT-inhibitor hammoho le TGF-βRI inhibitor kapa CDK 4/6 inhibitor e eketsa kutloisiso ea temozolomide liseleng tsa temozolomide tse hanyetsanang le glioblastoma.
• Sebaka sa somatic genomic landscape ea glioblastoma.