Lijo bakeng sa Lefu la Erdheim Chester!

Selelekela

Lijo tsa lefu la Erdheim Chester li lokela ho ikamahanya le motho ka mong hape li tlameha ho ikamahanya le maemo ha kalafo ea mofets'e kapa liphatsa tsa lefutso tsa tumor li fetoha. Ho iketsetsa motho le ho ikamahanya le maemo ho tlameha ho nahanela metsoako eohle e sebetsang kapa li-bioactive tse fumanehang lijong tse fapaneng mabapi le baeloji ea mofetše, liphatsa tsa lefutso, kalafo, maemo a bophelo le likhetho tsa lijo. Kahoo le hoja phepo e nepahetseng e le e 'ngoe ea liqeto tsa bohlokoa haholo tseo mokuli oa mofetše le motho ea kotsing ea mofetše a lokelang ho li etsa - mokhoa oa ho khetha lijo tseo u ka li jang ha se mosebetsi o bonolo.

Boloetse ba Erdheim-Chester (ECD) ke lefu le sa tloaelehang, leo e seng la Langerhans cell histiocytosis, leo hangata le nkoang e le mofetše, 'me sesosa sa ona se ntse se hlahlojoa empa hangata ha se nkoe e le lefutso kapa lefutso. E khetholloa ka matšoao a ikhethileng joalo ka bohloko ba masapo le matšoao a methapo ea kutlo, tlhahlobo ea ECD e kenyelletsa motsoako oa mekhoa ea radiology, ho kenyeletsoa CT le MRI ea boko, le lintlha tse felletseng tsa pathology. Mekhoa ea kalafo ea lefu la Erdheim-Chester e lula e fetoha, ka tlhaiso-leseling e ntlafalitsoeng e fumanehang ka li-platform tse kang UpToDate le Erdheim-Chester Disease Global Alliance. Hangata ECD e kenyelletsa tsamaiso ea litho tse kang matšoafo le boko, 'me radiology e bohlokoa bakeng sa tlhahlobo ea mafu le ho beha leihlo. E khethiloe tlas'a tsamaiso ea ICD-10, tsamaiso ea ECD e khantšitsoe ka litlhahlobo le lithuto tsa linyeoe, tse totobatsang bohlokoa ba lipatlisiso tse tsoelang pele le tlhokomeliso ho sebetsana le lefu lena le rarahaneng.

Bakeng sa lefu la Erdheim Chester na ho na le taba hore na meroho, litholoana, linate, lipeo motho o ja eng?

Potso e atileng haholo ea phepo e botsoang ke bakuli ba mofets'e le batho ka bomong ba kotsing ea mofets'e ke - bakeng sa mofetše joalo ka Erdheim Chester Disease na ho na le taba hore na ke ja lijo life le tseo ke sa li jeng? Kapa haeba ke latela lijo tse thehiloeng limela na hoo ho lekane bakeng sa mofetše o kang lefu la Erdheim Chester?

Mohlala, na ho na le taba hore semela sa Eggplant se jeoa haholo ha se bapisoa le Chayote? Na ho na le phapang e teng haeba litholoana tsa Apole ea Tsoekere li ratoa ho feta Arctic Blackberry? Hape haeba ho etsoa khetho e tšoanang bakeng sa linate/lipeo tse kang Black Walnut holim'a Macadamia Nut le bakeng sa limela tse kang Green Bean holim'a Catjang Pea. 'Me haeba seo ke se jang se bohlokoa - joale motho o tseba joang lijo tse buelloang bakeng sa Lefu la Erdheim Chester mme na ke karabo e tšoanang ho bohle ba nang le tlhahlobo e tšoanang kapa kotsi ea lefutso?

Ee! Lijo tseo u li jang li bohlokoa bakeng sa Lefu la Erdheim Chester!

Litlhahiso tsa lijo li ka 'na tsa se ke tsa tšoana ho bohle' me li ka fapana esita le bakeng sa tlhahlobo e tšoanang le kotsi ea lefutso.

Lijo tsohle (meroho, litholoana, linate, lipeo, li-pulses, oli joalo-joalo) le litlatsetso tsa phepo li entsoe ka metsoako e fetang e le 'ngoe e sebetsang ea molek'hule kapa bio-active ka tekanyo le bongata bo fapaneng. Sejo se seng le se seng se sebetsang se na le mokhoa o ikhethileng oa ts'ebetso - e ka bang ts'ebetso kapa ho thibela litsela tse fapaneng tsa biochemical. Lijo le li-supplement tse khothalletsoang habonolo ke tse sa bakeng keketseho ea limolek'hule tsa mofetše empa li li fokotsa. Ho seng joalo, lijo tseo ha lia lokela ho khothaletsoa. Lijo li na le metsoako e mengata e sebetsang - ka hona, ha u hlahloba lijo le li-supplement, u lokela ho nahana ka phello ea metsoako eohle e sebetsang ka bonngoe ho e-na le hore u nahane ka bonngoe.

Ka mohlala Apple ea Tsoekere e na le metsoako e sebetsang ea Myricetin, Lycopene, Pelargonidin, Curcumin, Cinnamaldehyde. 'Me Arctic Blackberry e na le metsoako e sebetsang Ellagic Acid, Lycopene, Curcumin, Quercetin, Cinnamaldehyde le mohlomong tse ling.

Phoso e tloaelehileng e entsoeng ha ho etsoa qeto le ho khetha lijo tse jeoang bakeng sa Lefu la Erdheim Chester - ke ho hlahloba feela metsoako e sebetsang e khethiloeng e fumanehang lijong le ho hlokomoloha tse ling. Hobane metsoako e fapaneng e sebetsang e fumanehang lijong e kanna ea ba le litlamorao tse hanyetsanang ho bakhanni ba mofetše - u ke ke ua khetha metsoako e sebetsang lijong le li-supplement bakeng sa ho etsa qeto ea phepo e nepahetseng bakeng sa lefu la Erdheim Chester.

EE – LIKHETHO TSA LIJO LI BOHLOKOA BAKENG SA KANKERE. LIQETO TSA PHEPO LI TLAMEHA HO NAHANA KA LITABA TSOHLE TSA LIJO.

Tsebo e Hlokahalang Bakeng sa Phepo ea Boipheliso bakeng sa Boloetse ba Erdheim Chester?

Phepo ea motho ka mong bakeng sa mofetše joalo ka Lefu la Erdheim Chester e na le lijo tse khothaletsoang / li-supplement; lijo tse sa khothaletsoang tse nang le mohlala oa diresepe tse etelletsang pele tšebeliso ea lijo tse khothaletsoang. Mohlala oa phepo e nepahetseng o ka bonoa ho sena link tsa.

Ho etsa qeto ea hore na ke lijo life tse khothalelitsoeng kapa che ho rarahane haholo, ho hloka boiphihlelo ho baeloji ea lefu la Erdheim Chester, mahlale a lijo, liphatsa tsa lefutso, biochemistry hammoho le kutloisiso e ntle ea hore na kalafo ea mofets'e e sebetsa joang le bofokoli bo amanang le bona boo liphekolo li ka emisang ho sebetsa.

BONYENYANE BO TSEBO BOHLOKOA BAKENG SA PHEPO MOTHO BATHO BA KANKERE KE: BOLOJI YA KANKERE, SAENSE YA DIJO, DIPHEKO LA MOFEPO LE LIFUTSO.

Litšobotsi tsa mofetše joalo ka lefu la Erdheim Chester

Lik'hemik'hale tsohle tse kang Lefu la Erdheim Chester li ka khetholloa ka mokhoa o ikhethang oa litsela tsa lik'hemik'hale - litsela tsa ho saena tsa Erdheim Chester Disease. Litsela tsa lik'hemik'hale tse kang RAS-RAF Signaling, MAPK Signaling, Cytoskeletal Dynamics, Angiogenesis ke karolo ea tlhaloso ea ho saena ea Lefu la Erdheim Chester. Liphatsa tsa lefutso tsa mofetše oa motho ka mong li ka fapana, ka hona, tekeno ea bona ea mofetše e ka ikhetha.

Liphekolo tse sebetsang hantle bakeng sa Lefu la Erdheim Chester li hloka ho ela hloko mekhoa ea lik'hemik'hale e amanang le eona bakeng sa mokuli e mong le e mong oa mofetše le motho ea kotsing ea lefutso. Ka hona liphekolo tse fapaneng tse nang le mekhoa e fapaneng ea liketso li sebetsa hantle ho bakuli ba fapaneng. Ka mokhoa o ts'oanang le ka mabaka a ts'oanang lijo le li-supplement li hloka ho etsoa ka bomong bakeng sa motho ka mong. Kahoo lijo tse ling le li-supplement li khothaletsoa bakeng sa Lefu la Erdheim Chester ha u nka kalafo ea mofetše Vemurafenib, 'me lijo tse ling le li-supplement ha li khothalletsoe.

Mehloli e kang cBioPortal 'me ba bang ba bangata ba fana ka lintlha tse sa tsejoeng tse tsoang litekong tsa bongaka bakeng sa matšoao ohle a mofetše. Lintlha tsena li na le lintlha tsa boithuto ba tleliniki joalo ka boholo ba sampole / palo ea bakuli, lihlopha tsa lilemo, bong, morabe, kalafo, sebaka sa tumor le liphetoho life kapa life tsa lefutso.

MAP2K1, ARAF, ARID5B, BRAF le MYCN ke liphatsa tsa lefutso tse behiloeng maemong a holimo bakeng sa Lefu la Erdheim Chester. MAP2K1 e tlalehoa ho 25.0% ea bakuli ba baemeli ho pholletsa le liteko tsohle tsa bongaka. 'Me ARAF e tlalehoa ka 12.5%. Lintlha tse kopaneng tsa bakuli li akaretsa lilemo ho tloha ho. 61.5% ea data ea bakuli e tsejoa e le banna. Baeloji ea lefu la Erdheim Chester hammoho le liphatsa tsa lefutso tse tlalehiloeng hammoho li hlalosa palo ea batho ba emetseng mekhoa ea lik'hemik'hale bakeng sa mofetše ona. Haeba liphatsa tsa lefutso tsa kankere ea motho ka mong kapa liphatsa tsa lefutso tse kenyang kotsi le tsona li tsejoa, seo se lokela ho sebelisoa hape bakeng sa ho iketsetsa lijo.

LIKHETHO TSA PHEPO LI LOKELA HO TŠOANA LE MOTHO E MONG LE E MONG LE SAENYO EA MOTHO EA KANKERE.

Lijo le Tlatsetso bakeng sa Lefu la Erdheim Chester

Bakeng sa Bakuli ba Kankere

Bakuli ba mofetše ba nakong ea kalafo kapa ba tlhokomelong ea pholiso ba lokela ho etsa liqeto mabapi le lijo le li-supplement - bakeng sa lik'hilojule tse hlokahalang tsa lijo, ho laola litla-morao life kapa life tsa kalafo le bakeng sa taolo e ntlafetseng ea mofetše. Lijo tsohle tse thehiloeng ho limela ha li lekane, 'me ho khetha le ho etelletsa pele lijo tse ikhethileng le tse etselitsoeng kalafo e tsoelang pele ea mofets'e ho bohlokoa ebile ho rarahane. Mehlala ke ena e fanang ka litataiso bakeng sa ho etsa liqeto tsa phepo e nepahetseng.

Khetha EGGPLANT ea meroho kapa CHAYOTE?

Eggplant ea meroho e na le metsoako e mengata e sebetsang kapa bioactives tse kang Myricetin, Isorhamnetin, Gallic Acid, Curcumin, Quercetin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang WNT Beta Catenin Signaling, RAS-RAF Signaling le MAPK Signaling le tse ling. Eggplant e khothaletsoa bakeng sa Lefu la Erdheim Chester ha kalafo e tsoelang pele ea mofetše e le Vemurafenib. Sena ke hobane Eggplant e fetola litsela tseo tsa biochemical tse tlalehiloeng ka mahlale hore li hlokomelisa phello ea Vemurafenib.

Tse ling tsa metsoako e sebetsang kapa li-bioactives tsa Chayote ea meroho ke Myricetin, Pelargonidin, Curcumin, Cinnamaldehyde, Isoliquiritigenin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka WNT Beta Catenin Signaling le MAPK Signaling le tse ling. Chayote ha e khothalletsoe bakeng sa Lefu la Erdheim Chester ha kalafo ea mofets'e e ntse e tsoela pele e le Vemurafenib hobane e fetola litsela tseo tsa biochemical tse etsang hore kalafo ea mofets'e e hane kapa e se ke ea arabela hantle.

EMAHE A MERO E KHOTHATSOENG HO FETISISA CHAYOTE BAKENG SA Lefu la Erdheim Chester LE PHEKO Vemurafenib.

Khetha Litholoana ARCTIC BLACKBERRY kapa SUGAR APPLE?

Litholoana tsa Arctic Blackberry li na le metsoako e mengata e sebetsang kapa bioactives tse kang Ellagic Acid, Lycopene, Curcumin, Quercetin, Cinnamaldehyde. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang WNT Beta Catenin Signaling, RAS-RAF Signaling le MAPK Signaling le tse ling. Arctic Blackberry e khothaletsoa bakeng sa Lefu la Erdheim Chester ha kalafo e tsoelang pele ea mofetše e le Vemurafenib. Sena ke hobane Arctic Blackberry e fetola litsela tseo tsa biochemical tse tlalehiloeng ka mahlale ho hlokomelisa phello ea Vemurafenib.

Tse ling tsa metsoako e sebetsang kapa li-bioactive tsa litholoana tsa Sugar Apple ke Myricetin, Lycopene, Pelargonidin, Curcumin, Cinnamaldehyde. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka WNT Beta Catenin Signaling le tse ling. Tsoekere Apple ha e khothalletsoe bakeng sa Lefu la Erdheim Chester ha kalafo ea mofets'e e ntse e tsoela pele e le Vemurafenib hobane e fetola litsela tseo tsa biochemical tse etsang hore kalafo ea mofets'e e hane kapa e se ke ea arabela hantle.

LITHOLOANA ARCTIC BLACKBERRY E KHOTHATSOA HO PHAHAMA APOLE EA SEKERE BAKENG SA Erdheim Chester Lefu LE KAlafi Vemurafenib.

Khetha Nut BLACK WALNUT kapa MACADAMIA NUT?

Black Walnut e na le metsoako e mengata e sebetsang kapa bioactives tse kang Myricetin, Ellagic Acid, Pelargonidin, Gallic Acid, Curcumin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka RAS-RAF Signaling le MAPK Signaling le tse ling. Black Walnut e khothaletsoa bakeng sa Lefu la Erdheim Chester ha kalafo e tsoelang pele ea mofetše e le Vemurafenib. Lebaka ke hobane Walnut e Ntšo e fetola litsela tseo tsa biochemical tse tlalehiloeng ka mahlale ho hlokomelisa phello ea Vemurafenib.

Tse ling tsa metsoako e sebetsang kapa bioactives ho Macadamia Nut ke Myricetin, Pelargonidin, Curcumin, Cinnamaldehyde, Isoliquiritigenin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka WNT Beta Catenin Signaling le MAPK Signaling le tse ling. Macadamia Nut ha e khothalletsoe bakeng sa Lefu la Erdheim Chester ha kalafo ea mofets'e e ntse e tsoela pele e le Vemurafenib hobane e fetola litsela tsa biochemical tse etsang hore kalafo ea mofets'e e se ke ea sebetsa kapa e se ke ea arabela hantle.

WALNUT E TŠO E KHOTHATSOE HO FETISISA MACADAMIA NUT BAKENG SA Lefu la Erdheim Chester LE KAlafo Vemurafenib.

Bakeng sa Batho ba nang le Kotsi ea Liphatsa tsa Kankere

Potso e botsoang ke batho ba nang le kotsi ea lefutso ea lefu la Erdheim Chester kapa nalane ea lelapa ke "Ke Lokela ho Ja Eng e sa Tšoaneng le Pele?" le kamoo ba lokelang ho khetha lijo le li-supplement bakeng sa ho laola likotsi tsa lefu lena. Kaha bakeng sa kotsi ea mofets'e ha ho letho le ka etsoang mabapi le kalafo - liqeto tsa lijo le li-supplement li fetoha tsa bohlokoa 'me e le e' ngoe ea lintho tse fokolang haholo tse ka etsoang. Lijo tsohle tse thehiloeng ho limela ha li lekane 'me li ipapisitse le liphatsa tsa lefutso le mokhoa oa ho saena - khetho ea lijo le li-supplement li lokela ho etsoa ke motho ka mong.

Khetha Vegetable GIANT BUTTERBUR kapa GARLAND CHRYSANTHEMUM?

Butterbur ea Vegetable Giant e na le metsoako e mengata e sebetsang kapa bioactives tse kang Apigenin, Curcumin, Myricetin, Lycopene, Lupeol. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang Angiogenesis, RAS-RAF Signaling, Cell Cycle le PI3K-AKT-MTOR Signaling le tse ling. Giant Butterbur e khothaletsoa kotsing ea lefu la Erdheim Chester ha kotsi ea lefutso e amanang le ARAF. Sena ke hobane Giant Butterbur e eketsa litsela tsa biochemical tse hanyetsanang le bakhanni ba eona.

Tse ling tsa metsoako e sebetsang kapa li-bioactive tsa meroho ea Garland Chrysanthemum ke Apigenin, Curcumin, Myricetin, Lupeol, Daidzein. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka WNT Beta Catenin Signaling le MAPK Signaling le tse ling. Garland Chrysanthemum ha e khothalletsoe ha kotsi ea lefu la Erdheim Chester e amahanngoa le kotsi ea lefutso e le ARAF hobane e eketsa litsela tsa eona.

BUTTERBUR E KHOLO EA MERO E KHOTHATSOE HO PHAHAMA GARLAND CHRYSANTHEMUM BAKENG SA ARAF genetic KOTSI EA KANKERE.

Khetha Tholoana NANCE kapa PUMMELO?

Litholoana tsa Nance li na le lisebelisoa tse ngata tse sebetsang kapa li-bioactive tse kang Apigenin, Curcumin, Myricetin, Lupeol, Daidzein. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang Angiogenesis, RAS-RAF Signaling, Cell Cycle le PI3K-AKT-MTOR Signaling le tse ling. Nance e khothaletsoa bakeng sa kotsi ea lefu la Erdheim Chester ha kotsi ea lefutso e amanang le ARAF. Lebaka ke hore Nance e eketsa litsela tsa biochemical tse hanyetsanang le bakhanni ba eona ba saenneng.

Tse ling tsa metsoako e sebetsang kapa bioactives litholoana Pummelo ke Apigenin, Curcumin, Quercetin, Lycopene, Lupeol. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka WNT Beta Catenin Signaling le Cell Cycle Checkpoints le tse ling. Pummelo ha e khothalletsoe ha kotsi ea lefu la Erdheim Chester e amahanngoa le kotsi ea lefutso e le ARAF hobane e eketsa litsela tsa eona.

THOLOANA NANCE E KHOTHATSOE HO FETA PUMMELO BAKENG SA ARAF genetic RISK EA KANSERE.

Khetha Nut COMMON HAZELNUT kapa EUROPEAN CHESTNUT?

Hazelnut e tloaelehileng e na le metsoako e mengata e sebetsang kapa bioactives tse kang Curcumin, Quercetin, Myricetin, Lycopene, Lupeol. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang Angiogenesis, RAS-RAF Signaling, Cell Cycle le PI3K-AKT-MTOR Signaling le tse ling. Hazelnut e tloaelehileng e khothaletsoa kotsing ea lefu la Erdheim Chester ha kotsi ea lefutso e amanang le ARAF. Lebaka ke hobane Koetliso e Tloaelehileng e eketsa litsela tsa biochemical tse hanyetsanang le bakhanni ba eona.

Tse ling tsa metsoako e sebetsang kapa li-bioactive tsa Chestnut ea Europe ke Apigenin, Ellagic Acid, Curcumin, Quercetin, Myricetin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang WNT Beta Catenin Signaling, PI3K-AKT-MTOR Signaling le MYC Signaling le tse ling. Chestnut ea Europe ha e khothalletsoe ha kotsi ea lefu la Erdheim Chester e amahanngoa le kotsi ea lefutso ke ARAF hobane e eketsa litsela tsa eona.

HAZELNUT E TLOAELEHANG E KHOTHATSOA HO FETISISA CHESTNUT EA EUROPE BAKENG SA ARAF genetic RISK EA KANKERE.

Ha re phethela

Lijo le li-Supplement tse khethiloeng ke liqeto tsa bohlokoa bakeng sa mofets'e joalo ka lefu la Erdheim Chester. Bakuli ba lefu la Erdheim Chester le batho ba nang le kotsi ea lefutso ba lula ba e-na le potso ena: "Ke lijo life le li-supplement tsa phepo tse khothalletsoang ho 'na le tse seng joalo?" Ho na le tumelo e tloaelehileng eo e leng maikutlo a fosahetseng a hore lijo tsohle tse thehiloeng limela li ka ba molemo kapa che empa li ke ke tsa e-ba kotsi. Lijo tse ling le li-supplement li ka kena-kenana le phekolo ea mofetše kapa tsa khothalletsa bakhanni ba limolek'hule tsa mofetše.

Ho na le mefuta e fapaneng ea matšoao a mofets'e joalo ka Lefu la Erdheim Chester, e 'ngoe le e' ngoe e na le liphatsa tsa lefutso tse fapaneng tsa tumor tse nang le mefuta e fapaneng ea genomic ho motho ka mong. Ho feta moo kalafo e 'ngoe le e' ngoe ea mofetše le chemotherapy e na le mokhoa o ikhethileng oa ts'ebetso. Sejo se seng le se seng joalo ka Eggplant se na le li-bioactive tse fapaneng ka bongata bo fapaneng, tse nang le tšusumetso litseleng tse fapaneng le tse ikhethileng tsa biochemical. Tlhaloso ea phepo e nepahetseng ke likhothaletso tsa motho ka mong bakeng sa sesupo sa mofetše, kalafo, liphatsa tsa lefutso, mokhoa oa bophelo le lintlha tse ling. Liqeto tsa phepo e nepahetseng bakeng sa mofetše li hloka tsebo ea biology ea mofets'e, mahlale a lijo le kutloisiso ea liphekolo tse fapaneng tsa chemotherapy. Qetellong ha ho e-na le liphetoho tsa phekolo kapa li-genomics tse ncha li khetholloa - phepo e nepahetseng e hloka ho hlahlojoa bocha.

Tharollo ea motho ka mong ea phepo e nepahetseng ea addon e etsa hore ho etsa liqeto ho be bonolo 'me e tlose mehopolo eohle ho araba potso e reng, "Ke lijo life tseo ke lokelang ho li khetha kapa ho se khethe bakeng sa Lefu la Erdheim Chester?". Sehlopha sa li-addon tse nang le taeo e mengata se kenyelletsa lingaka tsa mofetše, bo-ramahlale ba bongaka, baenjiniere ba mananeo le bo-ramahlale ba data.

References

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• https://medlineplus.gov/genetics/condition/erdheim-chester-disease/#resources
• https://rarediseases.org/rare-diseases/erdheim-chester-disease
• https://histio.org/histiocytic-disorders/erdheim-chester-disease
• https://www.lls.org/sites/default/files/2022-07/FS37_Erdheim_Chester_2022.pdf