Selelekela
Lijo tsa Systemic Mastocytosis li lokela ho etsoa ho motho ka mong hape li tlameha ho ikamahanya le maemo ha kalafo ea mofets'e kapa liphatsa tsa lefutso tsa tumor li fetoha. Ho iketsetsa motho le ho ikamahanya le maemo ho tlameha ho nahanela metsoako eohle e sebetsang kapa li-bioactive tse fumanehang lijong tse fapaneng mabapi le baeloji ea mofetše, liphatsa tsa lefutso, kalafo, maemo a bophelo le likhetho tsa lijo. Kahoo le hoja phepo e nepahetseng e le e 'ngoe ea liqeto tsa bohlokoa haholo tseo mokuli oa mofetše le motho ea kotsing ea mofetše a lokelang ho li etsa - mokhoa oa ho khetha lijo tseo u ka li jang ha se mosebetsi o bonolo.
Bakeng sa Systemic Mastocytosis na ho na le taba hore na meroho, litholoana, linate, lipeo motho o ja eng?
Potso e atileng haholo ea phepo e botsoang ke bakuli ba mofets'e le batho ka bomong ba kotsing ea mofets'e ke - bakeng sa mofetše o kang Systemic Mastocytosis na ho na le taba hore na ke ja lijo life le tseo ke sa li jeng? Kapa haeba ke latela lijo tse thehiloeng limela na hoo ho lekane bakeng sa mofetše joaloka Systemic Mastocytosis?
Mohlala, na ho na le taba hore meroho ea Brussels Sprout e jeoa haholo ha e bapisoa le Turnip? Na ho na le phapang e teng haeba litholoana tsa feiga li ratoa ho feta Rabbiteye Blueberry? Hape haeba likhetho tse tšoanang li etsoa bakeng sa linate / peo e kang Black Walnut holim'a Chestnut le bakeng sa limela tse kang Chickpea holim'a Catjang Pea. 'Me haeba seo ke se jang se bohlokoa - joale motho o tseba joang lijo tse buelloang bakeng sa Systemic Mastocytosis mme ke karabo e tšoanang bakeng sa bohle ba nang le tlhahlobo e tšoanang kapa kotsi ea lefutso?
Ee! Lijo tseo u li jang li bohlokoa bakeng sa Systemic Mastocytosis!
Litlhahiso tsa lijo li ka 'na tsa se ke tsa tšoana ho bohle' me li ka fapana esita le bakeng sa tlhahlobo e tšoanang le kotsi ea lefutso.
Lijo tsohle (meroho, litholoana, linate, lipeo, li-pulses, oli joalo-joalo) le litlatsetso tsa phepo li entsoe ka metsoako e fetang e le 'ngoe e sebetsang ea molek'hule kapa bio-active ka tekanyo le bongata bo fapaneng. Sejo se seng le se seng se sebetsang se na le mokhoa o ikhethileng oa ts'ebetso - e ka bang ts'ebetso kapa ho thibela litsela tse fapaneng tsa biochemical. Lijo le li-supplement tse khothalletsoang habonolo ke tse sa bakeng keketseho ea limolek'hule tsa mofetše empa li li fokotsa. Ho seng joalo, lijo tseo ha lia lokela ho khothaletsoa. Lijo li na le metsoako e mengata e sebetsang - ka hona, ha u hlahloba lijo le li-supplement, u lokela ho nahana ka phello ea metsoako eohle e sebetsang ka bonngoe ho e-na le hore u nahane ka bonngoe.
Ka mohlala, feiga e na le metsoako e sebetsang ea Isoliquiritigenin, Quercetin, Kaempferol, Taxifolin, Curcumin. 'Me Rabbiteye Blueberry e na le metsoako e sebetsang ea Quercetin, Linalool, Geraniol, Gallic Acid, Ferulic Acid le mohlomong tse ling.
Phoso e tloaelehileng e entsoeng ha ho etsoa qeto le ho khetha lijo tse jeoang bakeng sa Systemic Mastocytosis - ke ho hlahloba feela metsoako e sebetsang e khethiloeng e fumanehang lijong le ho hlokomoloha tse ling kaofela. Hobane metsoako e fapaneng e sebetsang e fumanehang lijong e kanna ea ba le litlamorao tse fapaneng ho bakhanni ba mofetše - u ke ke ua khetha metsoako e sebetsang lijong le li-supplement bakeng sa ho etsa qeto ea phepo e nepahetseng bakeng sa Systemic Mastocytosis.
EE – LIKHETHO TSA LIJO LI BOHLOKOA BAKENG SA KANKERE. LIQETO TSA PHEPO LI TLAMEHA HO NAHANA KA LITABA TSOHLE TSA LIJO.
Tsebo e Hlokahalang Bakeng sa Phepo ea Boipheliso bakeng sa Systemic Mastocytosis?
Phepo ea motho ka mong bakeng sa mofetše joalo ka Systemic Mastocytosis e na le lijo / li-supplement tse khothalelitsoeng; lijo tse sa khothaletsoang tse nang le mohlala oa diresepe tse etelletsang pele tšebeliso ea lijo tse khothaletsoang. Mohlala oa phepo e nepahetseng o ka bonoa ho sena link tsa.
Ho etsa qeto ea hore na ke lijo life tse khothalelitsoeng kapa che ho rarahane haholo, ho hloka boiphihlelo ho Systemic Mastocytosis biology, mahlale a lijo, liphatsa tsa lefutso, biochemistry hammoho le kutloisiso e ntle ea hore na kalafo ea mofets'e e sebetsa joang le bofokoli bo amanang le bona boo kalafo e ka emisang ho sebetsa.
BONYENYANE BO TSEBO BOHLOKOA BAKENG SA PHEPO MOTHO BATHO BA KANKERE KE: BOLOJI YA KANKERE, SAENSE YA DIJO, DIPHEKO LA MOFEPO LE LIFUTSO.
Lijo Tseo U ka li Jang Kamora Ho Khetholla Kankere!
Ha ho kankere tse peli tse tšoanang. Fetela ka n the'ane ho tataiso e tloaelehileng ea phepo bakeng sa motho e mong le e mong 'me u etse liqeto tse ikhethileng mabapi le lijo le li-supplement ka kholiseho.
Litšobotsi tsa kankere tse kang Systemic Mastocytosis
Lik'hemik'hale tsohle tse kang Systemic Mastocytosis li ka khetholloa ka mokhoa o ikhethileng oa litsela tsa lik'hemik'hale - litsela tsa ho saena tsa Systemic Mastocytosis. Litsela tsa biochemical tse kang JAK-STAT Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling ke karolo ea tlhaloso ea signature ea Systemic Mastocytosis. Liphatsa tsa lefutso tsa mofetše oa motho ka mong li ka fapana, ka hona, tekeno ea bona ea mofetše e ka ikhetha.
Liphekolo tse sebetsang hantle bakeng sa Systemic Mastocytosis li hloka ho ela hloko mekhoa ea lik'hemik'hale e amanang le eona bakeng sa mokuli e mong le e mong oa mofetše le motho ea kotsing ea lefutso. Ka hona liphekolo tse fapaneng tse nang le mekhoa e fapaneng ea liketso li sebetsa hantle ho bakuli ba fapaneng. Ka mokhoa o ts'oanang le ka mabaka a ts'oanang lijo le li-supplement li hloka ho etsoa ka bomong bakeng sa motho ka mong. Kahoo lijo tse ling le li-supplement li khothaletsoa bakeng sa Systemic Mastocytosis ha u nka kalafo ea mofetše Midostaurin, 'me lijo tse ling le li-supplement ha li khothalletsoe.
Mehloli e kang cBioPortal 'me ba bang ba bangata ba fana ka lintlha tse sa tsejoeng tse tsoang litekong tsa bongaka bakeng sa matšoao ohle a mofetše. Lintlha tsena li na le lintlha tsa boithuto ba tleliniki joalo ka boholo ba sampole / palo ea bakuli, lihlopha tsa lilemo, bong, morabe, kalafo, sebaka sa tumor le liphetoho life kapa life tsa lefutso.
CNOT3, DNMT3A, FLT3, NPM1 le KIT ke liphatsa tsa lefutso tse tlalehiloeng ka holimo bakeng sa Systemic Mastocytosis. CNOT3 e tlalehoa ho 50.0% ea bakuli ba baemeli ho pholletsa le liteko tsohle tsa meriana. Mme DNMT3A e tlalehiloe ka 50.0%. Lintlha tse kopaneng tsa bakuli li akaretsa lilemo ho tloha ho. 100.0% ea data ea bakuli e tsejoa e le banna. The Systemic Mastocytosis biology hammoho le liphatsa tsa lefutso tse tlalehiloeng hammoho li hlalosa palo ea batho ba emelang litsela tsa lik'hemik'hale tsa mofetše. Haeba liphatsa tsa lefutso tsa mofetše kapa liphatsa tsa lefutso tse kenyang kotsi le tsona li tsejoa, seo se lokela ho sebelisoa hape bakeng sa ho ja lijo.
LIKHETHO TSA PHEPO LI LOKELA HO TŠOANA LE MOTHO E MONG LE E MONG LE SAENYO EA MOTHO EA KANKERE.
Lijo le Tlatsetso bakeng sa Systemic Mastocytosis
Bakeng sa Bakuli ba Kankere
Bakuli ba mofetše ba nakong ea kalafo kapa ba tlhokomelong ea pholiso ba lokela ho etsa liqeto mabapi le lijo le li-supplement - bakeng sa lik'hilojule tse hlokahalang tsa lijo, ho laola litla-morao life kapa life tsa kalafo le bakeng sa taolo e ntlafetseng ea mofetše. Lijo tsohle tse thehiloeng ho limela ha li lekane, 'me ho khetha le ho etelletsa pele lijo tse ikhethileng le tse etselitsoeng kalafo e tsoelang pele ea mofets'e ho bohlokoa ebile ho rarahane. Mehlala ke ena e fanang ka litataiso bakeng sa ho etsa liqeto tsa phepo e nepahetseng.
Khetha Meroho ea BRUSSEL SPOUTS kapa TURNIP?
Meroho ea Brussel Sprouts e na le lisebelisoa tse ngata tse sebetsang kapa li-bioactive tse kang Isoliquiritigenin, Taxifolin, Sulforaphane, Curcumin, Lupeol. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang PI3K-AKT-MTOR Signaling, MAPK Signaling, Oncogenic Cancer Epigenetics le MYC Signaling le tse ling. Brussel Sprouts e khothaletsoa bakeng sa Systemic Mastocytosis ha kalafo e tsoelang pele ea mofetše e le Midostaurin. Lebaka ke hobane Brussel Sprouts e fetola litsela tseo tsa biochemical tse tlalehiloeng ka mahlale ho hlokomelisa phello ea Midostaurin.
Tse ling tsa metsoako e sebetsang kapa bioactive ho Turnip ea meroho ke Isoliquiritigenin, Quercetin, Kaempferol, Taxifolin, Ellagic Acid. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang MYC Signaling, MAPK Signaling le PI3K-AKT-MTOR Signaling le tse ling. Turnip ha e khothalletsoe bakeng sa Systemic Mastocytosis ha kalafo ea mofetše e tsoelang pele e le Midostaurin hobane e fetola mekhoa ea biochemical e etsang hore kalafo ea mofets'e e se ke ea sebetsa kapa e se ke ea arabela hantle.
LITLHAKISO TSA MEROHO BRUSSEL LI KHOTHATSOA HO FETISA TURNIP BAKENG SA Systemic Mastocytosis LE KALAKO Midostaurin.
Khetha Litholoana RABBITEYE BLUEBERRY kapa FIG?
Fruit Rabbiteye Blueberry e na le metsoako e mengata e sebetsang kapa bioactives tse kang Quercetin, Linalool, Geraniol, Gallic Acid, Ferulic Acid. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka MAPK Signaling le PI3K-AKT-MTOR Signaling le tse ling. Rabbiteye Blueberry e khothaletsoa bakeng sa Systemic Mastocytosis ha kalafo ea mofetše e tsoelang pele e le Midostaurin. Lebaka ke hobane Rabbiteye Blueberry e fetola litsela tseo tsa biochemical tse tlalehiloeng ka mahlale ho hlokomelisa phello ea Midostaurin.
Tse ling tsa metsoako e sebetsang kapa li-bioactive ka litholoana Fig ke Isoliquiritigenin, Quercetin, Kaempferol, Taxifolin, Curcumin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka MAPK Signaling le PI3K-AKT-MTOR Signaling le tse ling. Fig ha e khothalletsoe bakeng sa Systemic Mastocytosis ha kalafo ea mofets'e e ntse e tsoela pele e le Midostaurin hobane e fetola mekhoa ea biochemical e etsang hore kalafo ea mofets'e e hane kapa e se ke ea arabela hantle.
THOLOANA RABBITEYE BLUEBERRY E KHOTHATSOA HO FETISISA FIG BAKENG SA Systemic Mastocytosis LE KAlafo Midostaurin.
Khetha Nut BLACK WALNUT kapa CHESTNUT?
Black Walnut e na le metsoako e mengata e sebetsang kapa bioactives tse kang Apigenin, Isoliquiritigenin, Myricetin, Quercetin, Kaempferol. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang RAS-RAF Signaling, PI3K-AKT-MTOR Signaling le MYC Signaling le tse ling. Black Walnut e khothaletsoa bakeng sa Systemic Mastocytosis ha kalafo ea mofetše e tsoelang pele e le Midostaurin. Lebaka ke hobane Walnut e Ntšo e fetola litsela tseo tsa biochemical tse tlalehiloeng ka mahlale ho hlokomelisa phello ea Midostaurin.
Tse ling tsa metsoako e sebetsang kapa bioactives ka Chestnut ke Apigenin, Isoliquiritigenin, Myricetin, Kaempferol, Luteolin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics le MYC Signaling le tse ling. Chestnut ha e khothalletsoe bakeng sa Systemic Mastocytosis ha kalafo ea mofetše e tsoelang pele e le Midostaurin hobane e fetola mekhoa ea biochemical e etsang hore kalafo ea mofets'e e se ke ea sebetsa kapa e se ke ea arabela hantle.
WALNUT E TŠO E KHOTHATSOE HO FETISISA CHESTNUT BAKENG SA Systemic Mastocytosis LE PHEKO Midostaurin.
Bakeng sa Batho ba nang le Kotsi ea Liphatsa tsa Kankere
Potso e botsoang ke batho ba nang le kotsi ea liphatsa tsa lefutso ea Systemic Mastocytosis kapa nalane ea lelapa ke "Ke Lokela ho Ja Eng e sa Tšoaneng le Pele?" le kamoo ba lokelang ho khetha lijo le li-supplement bakeng sa ho laola likotsi tsa lefu lena. Kaha bakeng sa kotsi ea mofets'e ha ho letho le ka etsoang mabapi le kalafo - liqeto tsa lijo le li-supplement li fetoha tsa bohlokoa 'me e le e' ngoe ea lintho tse fokolang haholo tse ka etsoang. Lijo tsohle tse thehiloeng ho limela ha li lekane 'me li ipapisitse le liphatsa tsa lefutso le mokhoa oa ho saena - khetho ea lijo le li-supplement li lokela ho etsoa ke motho ka mong.
Khetha Meroho CAULIFLOWER kapa ARROWHEAD?
Cauliflower ea meroho e na le metsoako e mengata e sebetsang kapa bioactives tse kang Isoliquiritigenin, Curcumin, Catechol, Vithamine C, Lupeol. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang PI3K-AKT-MTOR Signaling, RAS-RAF Signaling, MAPK Signaling le MYC Signaling le tse ling. Cauliflower e buelloa bakeng sa kotsi ea Systemic Mastocytosis ha kotsi ea lefutso e amanang le CNOT3. Sena ke hobane Cauliflower e eketsa litsela tsa biochemical tse hanyetsanang le bakhanni ba eona.
Tse ling tsa metsoako e sebetsang kapa li-bioactive tsa meroho Arrowhead ke Apigenin, Myricetin, Isoliquiritigenin, Kaempferol, Luteolin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka Stem Cell Signaling le Oncogenic Cancer Epigenetics le tse ling. Arrowhead ha e khothalletsoe ha kotsi ea Systemic Mastocytosis ha kotsi ea liphatsa tsa lefutso e amanang le CNOT3 hobane e eketsa litsela tsa ho saena.
CAULIFLOWER EA MERO E KHOTHATSOA HO ARROWHEAD BAKENG SA CNOT3 GENETIC RISK EA KANKERE.
Khetha Litholoana LEMON kapa PUMMELO?
Fruit Lemon e na le metsoako e mengata e sebetsang kapa bioactives tse kang Isoliquiritigenin, D-limonene, Luteolin, Linalool, Curcumin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang Suppressive Histone Methylation, RAS-RAF Signaling, PI3K-AKT-MTOR Signaling le MYC Signaling le tse ling. Lemon e buelloa bakeng sa kotsi ea Systemic Mastocytosis ha kotsi ea lefutso e amanang le CNOT3. Lebaka ke hobane Lemon e eketsa litsela tsa biochemical tse hanyetsanang le bakhanni ba eona ba saenneng.
Tse ling tsa metsoako e sebetsang kapa li-bioactive tsa litholoana Pummelo ke Apigenin, Quercetin, Isoliquiritigenin, Curcumin, Lycopene. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka PI3K-AKT-MTOR Signaling le MYC Signaling le tse ling. Pummelo ha e khothalletsoe ha kotsi ea Systemic Mastocytosis ha kotsi ea lefutso e amanang le CNOT3 hobane e eketsa litsela tsa ho saena.
LEMONE THOLOANA E KHOTHATSOA HO FETISISA PUMMELO BAKENG SA CNOT3 GENETIC RISK EA KANKERE.
Khetha Nut BUTTERNUT kapa EUROPEAN CHESTNUT?
Butternut e na le metsoako e mengata e sebetsang kapa bioactives tse kang Apigenin, Myricetin, Isoliquiritigenin, Kaempferol, Luteolin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang JAK-STAT Signaling, RAS-RAF Signaling, MAPK Signaling le MYC Signaling le tse ling. Butternut e buelloa bakeng sa kotsi ea Systemic Mastocytosis ha kotsi ea lefutso e amanang le CNOT3. Lebaka ke hobane Butternut e eketsa litsela tsa biochemical tse khahlano le bakhanni ba eona ba saenneng.
Tse ling tsa metsoako e sebetsang kapa li-bioactive tsa Chestnut ea Europe ke Apigenin, Quercetin, Myricetin, Isoliquiritigenin, Kaempferol. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka Stem Cell Signaling le Oncogenic Cancer Epigenetics le tse ling. Chestnut ea Europe ha e khothalletsoe ha kotsi ea Systemic Mastocytosis e amahanngoa le kotsi ea liphatsa tsa lefutso ke CNOT3 hobane e eketsa litsela tsa ho saena.
BUTTERNUT E KHOTHATSOE HO FETA CHESTNUT EA EUROPE BAKENG SA CNOT3 genetic RISK OF KANKERE.
Ha re phethela
Lijo le Lisebelisoa tse khethiloeng ke liqeto tsa bohlokoa bakeng sa mofetše joalo ka Systemic Mastocytosis. Bakuli ba Systemic Mastocytosis le batho ba nang le kotsi ea lefutso ba lula ba e-na le potso ena: "Ke lijo life le li-supplement tsa phepo tse khothalletsoang ho 'na le tse sa buelloang?" Ho na le tumelo e tloaelehileng eo e leng maikutlo a fosahetseng a hore lijo tsohle tse thehiloeng limela li ka ba molemo kapa che empa li ke ke tsa e-ba kotsi. Lijo tse ling le li-supplement li ka kena-kenana le phekolo ea mofetše kapa tsa khothalletsa bakhanni ba limolek'hule tsa mofetše.
Ho na le mefuta e fapaneng ea matšoao a mofets'e joalo ka Systemic Mastocytosis, e 'ngoe le e' ngoe e na le liphatsa tsa lefutso tse fapaneng tsa tumor tse nang le mefuta e meng ea genomic ho motho ka mong. Ho feta moo kalafo e 'ngoe le e' ngoe ea mofetše le chemotherapy e na le mokhoa o ikhethileng oa ts'ebetso. Sejo se seng le se seng joalo ka Brussel Sprouts se na le li-bioactive tse fapaneng ka bongata bo fapaneng, tse nang le tšusumetso litseleng tse fapaneng le tse ikhethileng tsa lik'hemik'hale tsa biochemical. Tlhaloso ea phepo e nepahetseng ke likhothaletso tsa motho ka mong bakeng sa sesupo sa mofetše, kalafo, liphatsa tsa lefutso, mokhoa oa bophelo le lintlha tse ling. Liqeto tsa phepo e nepahetseng bakeng sa mofetše li hloka tsebo ea baeloji ea mofetše, mahlale a lijo le kutloisiso ea liphekolo tse fapaneng tsa chemotherapy. Qetellong ha ho e-na le liphetoho tsa phekolo kapa li-genomics tse ncha li khetholloa - phepo e nepahetseng e hloka ho hlahlojoa bocha.
Tharollo ea motho ka mong ea phepo e nepahetseng ea addon e etsa hore ho be bonolo ho etsa liqeto mme e tlose mehopolo eohle ea ho araba potso e reng, "Ke lijo life tseo ke lokelang ho li khetha kapa ho se khethe bakeng sa Systemic Mastocytosis?". Sehlopha sa li-addon tse nang le taeo e mengata se kenyelletsa lingaka tsa mofetše, bo-ramahlale ba bongaka, baenjiniere ba mananeo le bo-ramahlale ba data.
Phepo e ikhethileng bakeng sa Kankere!
Kankere e fetoha ha nako e ntse e ea. Iketsetse 'me u fetole phepo ea hau ho latela sesupo sa mofets'e, kalafo, mokhoa oa bophelo, khetho ea lijo, lintho tse allergy le lintlha tse ling.
References
- Aml Ohsu 2018
- Liphello tsa isoliquiritigenin liseleng tsa mofetše oa mahe a bomme.
- Gallic acid indanone le mangiferin xanthone ke li-determinants tse matla tsa immunosuppressive anti-tumor effects of Mangifera indica L. bark ho MDA-MB231 lisele tsa kankere ea matsoele.
- Sulforaphane e baka khatello ea epigenetic ea polelo ea hTERT meleng ea lisele tsa mofetše oa matsoele.
- Kholiso ea kholo ea lisele tsa pulmonary adenocarcinoma le lisele tse nyane tsa epithelial tsa moea ka beta-carotene ka ts'ebetso ea cAMP, PKA, CREB le ERK1/2.
- Geraniol, e leng karolo ea oli ea bohlokoa ea semela, e hlokomelisa lisele tsa mofetše oa colonic ho kalafo ea 5-Fluorouracil.
- Lilipidomics tse sebetsang: asiti ea Palmitic e sitisa nts'etsopele ea kankere ea sebete ea hepatocellular ka ho fetola mokelikeli oa membrane le metabolism ea tsoekere.
- D-Limonene e fetola ho ruruha, khatello ea oxidative le tsela ea Ras-ERK ho thibela tumorigenesis ea letlalo la murine.
- Liphello tse thibelang tsa butyric acid, nicotinamide, calcium glucarate li le mong kapa li kopane nakong ea 7, 12-dimethylbenz (a) anthracene e kentse mouse ea letlalo tumorigenesis ka modulation ea K-Ras-PI3K-AKTpathway le li-RNA tse nyenyane tse amanang le tsona.