Lijo bakeng sa Primary Myelofibrosis!

Selelekela

Lijo tsa Myelofibrosis ea mantlha li lokela ho ikamahanya le motho ka mong hape li tlameha ho ikamahanya le maemo ha kalafo ea mofetše kapa liphatsa tsa lefutso tsa hlahala li fetoha. Ho iketsetsa motho le ho ikamahanya le maemo ho tlameha ho nahanela metsoako eohle e sebetsang kapa li-bioactive tse fumanehang lijong tse fapaneng mabapi le baeloji ea mofetše, liphatsa tsa lefutso, kalafo, maemo a bophelo le likhetho tsa lijo. Kahoo le hoja phepo e nepahetseng e le e 'ngoe ea liqeto tsa bohlokoa haholo tseo mokuli oa mofetše le motho ea kotsing ea mofetše a lokelang ho li etsa - mokhoa oa ho khetha lijo tseo u ka li jang ha se mosebetsi o bonolo.

Bakeng sa Primary Myelofibrosis na ho na le taba hore na motho o ja meroho, litholoana, linate, lipeo life?

Potso e tloaelehileng haholo ea phepo e botsoang ke bakuli ba mofetše le batho ka bomong ba kotsing ea ho tšoaroa ke mofetše ke - bakeng sa mofetše o kang Primary Myelofibrosis na ho na le taba hore na ke ja lijo life le tseo ke sa li jeng? Kapa haeba ke latela lijo tse thehiloeng limela na hoo ho lekane bakeng sa mofetše joaloka Primary Myelofibrosis?

Mohlala, na ho na le taba hore na meroho ea Cluster Bean e jeoa haholo ha e bapisoa le Cucurbita? Na ho na le phapang e teng haeba tholoana ea Black Elderberry e ratoa ho feta Black Mulberry? Hape haeba likhetho tse tšoanang li etsoa bakeng sa linate / peo e kang Black Walnut holim'a Chestnut ea Europe le bakeng sa limela tse kang Alfalfa holim'a Catjang Pea. 'Me haeba seo ke se jang ke sa bohlokoa - joale motho o tseba joang lijo tse buelloang bakeng sa Primary Myelofibrosis le hore na ke karabo e tšoanang bakeng sa bohle ba nang le tlhahlobo e tšoanang kapa kotsi ea lefutso?

Ee! Lijo tseo u li jang li bohlokoa bakeng sa Primary Myelofibrosis!

Litlhahiso tsa lijo li ka 'na tsa se ke tsa tšoana ho bohle' me li ka fapana esita le bakeng sa tlhahlobo e tšoanang le kotsi ea lefutso.

Lijo tsohle (meroho, litholoana, linate, lipeo, li-pulses, oli joalo-joalo) le litlatsetso tsa phepo li entsoe ka metsoako e fetang e le 'ngoe e sebetsang ea molek'hule kapa bio-active ka tekanyo le bongata bo fapaneng. Sejo se seng le se seng se sebetsang se na le mokhoa o ikhethileng oa ts'ebetso - e ka bang ts'ebetso kapa ho thibela litsela tse fapaneng tsa biochemical. Lijo le li-supplement tse khothalletsoang habonolo ke tse sa bakeng keketseho ea limolek'hule tsa mofetše empa li li fokotsa. Ho seng joalo, lijo tseo ha lia lokela ho khothaletsoa. Lijo li na le metsoako e mengata e sebetsang - ka hona, ha u hlahloba lijo le li-supplement, u lokela ho nahana ka phello ea metsoako eohle e sebetsang ka bonngoe ho e-na le hore u nahane ka bonngoe.

Ka mohlala Black Elderberry e na le metsoako e sebetsang ea Linalool, Formononetin, Quercetin, Lycopene, Apigenin. 'Me Black Mulberry e na le metsoako e sebetsang ea Formononetin, Quercetin, Apigenin, Protocatechuic Acid, Phloretin le mohlomong tse ling.

Phoso e tloaelehileng e entsoeng ha ho etsoa qeto le ho khetha lijo tse jeoang bakeng sa Primary Myelofibrosis - ke ho hlahloba feela metsoako e sebetsang e khethiloeng e fumanehang lijong le ho hlokomoloha tse ling. Hobane metsoako e fapaneng e sebetsang e fumanehang lijong e kanna ea ba le litlamorao tse fapaneng ho bakhanni ba mofetše - u ke ke ua khetha metsoako e sebetsang lijong le li-supplement bakeng sa ho etsa qeto ea phepo bakeng sa Primary Myelofibrosis.

EE – LIKHETHO TSA LIJO LI BOHLOKOA BAKENG SA KANKERE. LIQETO TSA PHEPO LI TLAMEHA HO NAHANA KA LITABA TSOHLE TSA LIJO.

Tsebo e Hlokahalang Bakeng sa ho Itloaetsa Phepo ea Motheo bakeng sa Primary Myelofibrosis?

Phepo e ikhethileng bakeng sa mofets'e joalo ka Myelofibrosis ea mantlha e na le lijo / li-supplement tse khothalelitsoeng; lijo tse sa khothaletsoang tse nang le mohlala oa diresepe tse etelletsang pele tšebeliso ea lijo tse khothaletsoang. Mohlala oa phepo e nepahetseng o ka bonoa ho sena link tsa.

Ho etsa qeto ea hore na ke lijo life tse khothalelitsoeng kapa che ho rarahane haholo, ho hloka boiphihlelo ho baeloji ea mantlha ea Myelofibrosis, mahlale a lijo, liphatsa tsa lefutso, biochemistry hammoho le kutloisiso e ntle ea hore na kalafo ea mofets'e e sebetsa joang le bofokoli bo amanang le bona boo liphekolo li ka emisang ho sebetsa.

BONYENYANE BO TSEBO BOHLOKOA BAKENG SA PHEPO MOTHO BATHO BA KANKERE KE: BOLOJI YA KANKERE, SAENSE YA DIJO, DIPHEKO LA MOFEPO LE LIFUTSO.

Litšobotsi tsa mofets'e joalo ka Primary Myelofibrosis

Lik'hemik'hale tsohle tse kang Primary Myelofibrosis li ka khetholloa ka mokhoa o ikhethang oa litsela tsa lik'hemik'hale - litsela tsa ho saena tsa Primary Myelofibrosis. Litsela tsa biochemical tse kang RAS-RAF Signaling, Cytokine Signaling, Oncogenic Cancer Epigenetics, JAK-STAT Signaling ke karolo ea tlhaloso ea signature ea Primary Myelofibrosis. Liphatsa tsa lefutso tsa mofetše oa motho ka mong li ka fapana, ka hona, tekeno ea bona ea mofetše e ka ikhetha.

Liphekolo tse sebetsang hantle bakeng sa Primary Myelofibrosis li hloka ho ela hloko mekhoa e amanang le ho saena ea biochemical bakeng sa mokuli e mong le e mong oa mofetše le motho ea kotsing ea lefutso. Ka hona liphekolo tse fapaneng tse nang le mekhoa e fapaneng ea liketso li sebetsa hantle ho bakuli ba fapaneng. Ka mokhoa o ts'oanang le ka mabaka a ts'oanang lijo le li-supplement li hloka ho etsoa ka bomong bakeng sa motho ka mong. Kahoo lijo tse ling le li-supplement li khothaletsoa bakeng sa Primary Myelofibrosis ha u nka kalafo ea mofetše Ruxolitinib, 'me lijo tse ling le li-supplement ha li khothalletsoe.

Mehloli e kang cBioPortal 'me ba bang ba bangata ba fana ka lintlha tse sa tsejoeng tse tsoang litekong tsa bongaka bakeng sa matšoao ohle a mofetše. Lintlha tsena li na le lintlha tsa boithuto ba tleliniki joalo ka boholo ba sampole / palo ea bakuli, lihlopha tsa lilemo, bong, morabe, kalafo, sebaka sa tumor le liphetoho life kapa life tsa lefutso.

JAK2, ASXL1, TET2, DNMT3A le CALR ke mefuta e kaholimo-limo e tlalehiloeng bakeng sa Primary Myelofibrosis. JAK2 e tlalehiloe ho 58.3% ea bakuli ba baemeli ho pholletsa le liteko tsohle tsa bongaka. 'Me ASXL1 e tlalehiloe ho 31.7%. Lintlha tse kopaneng tsa bakuli li akaretsa lilemo ho tloha ho. 0.0% ea lintlha tsa mokuli li khetholloa e le banna. Biology ea mantlha ea Myelofibrosis hammoho le liphatsa tsa lefutso tse tlalehiloeng hammoho li hlalosa palo ea batho ba emelang litsela tse saenneng tsa biochemical bakeng sa mofetše ona. Haeba liphatsa tsa lefutso tsa kankere ea motho ka mong kapa liphatsa tsa lefutso tse kenyang kotsi le tsona li tsejoa, seo se lokela ho sebelisoa hape bakeng sa ho iketsetsa lijo.

LIKHETHO TSA PHEPO LI LOKELA HO TŠOANA LE MOTHO E MONG LE E MONG LE SAENYO EA MOTHO EA KANKERE.

Lijo le Tlatsetso bakeng sa Primary Myelofibrosis

Bakeng sa Bakuli ba Kankere

Bakuli ba mofetše ba nakong ea kalafo kapa ba tlhokomelong ea pholiso ba lokela ho etsa liqeto mabapi le lijo le li-supplement - bakeng sa lik'hilojule tse hlokahalang tsa lijo, ho laola litla-morao life kapa life tsa kalafo le bakeng sa taolo e ntlafetseng ea mofetše. Lijo tsohle tse thehiloeng ho limela ha li lekane, 'me ho khetha le ho etelletsa pele lijo tse ikhethileng le tse etselitsoeng kalafo e tsoelang pele ea mofets'e ho bohlokoa ebile ho rarahane. Mehlala ke ena e fanang ka litataiso bakeng sa ho etsa liqeto tsa phepo e nepahetseng.

Khetha Meroho CLUSTER BEAN kapa CUCURBITA?

Meroho ea Cluster Bean e na le metsoako e mengata e sebetsang kapa li-bioactives tse kang Stigmasterol, Vithamine C, Beta-sitosterol, Linolenic Acid, Oleic Acid. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang DNA Repair, Hypoxia, RAS-RAF Signaling le MAPK Signaling le tse ling. Cluster Bean e khothaletsoa bakeng sa Primary Myelofibrosis ha kalafo ea mofetše e tsoelang pele e le Ruxolitinib. Sena ke hobane Cluster Bean e fetola litsela tseo tsa biochemical tse tlalehiloeng ka mahlale ho hlokomelisa phello ea Ruxolitinib.

Tse ling tsa metsoako e sebetsang kapa li-bioactive tsa meroho Cucurbita ke Formononetin, Protocatechuic Acid, Phloretin, Curcumin, Bergapten. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka PI3K-AKT-MTOR Signaling le MYC Signaling le tse ling. Cucurbita ha e khothalletsoe bakeng sa Primary Myelofibrosis ha kalafo ea mofetše e tsoelang pele e le Ruxolitinib hobane e fetola mekhoa ea biochemical e etsang hore kalafo ea mofets'e e se ke ea sebetsa kapa e se ke ea arabela hantle.

INAWA YA MEROGO E KHOTHATSWA HO FETISISA CUCURBITA BAKENG SA Primary Myelofibrosis LE PHEKO Ruxolitinib.

Khetha Litholoana BLACK MULBERRY kapa BLACK ELDERBERRY?

Fruit Black Mulberry e na le metsoako e mengata e sebetsang kapa bioactives tse kang Formononetin, Quercetin, Apigenin, Protocatechuic Acid, Phloretin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang JAK-STAT Signaling, Hypoxia, MAPK Signaling le MYC Signaling le tse ling. Black Mulberry e khothaletsoa bakeng sa Primary Myelofibrosis ha kalafo ea mofetše e tsoelang pele e le Ruxolitinib. Sena ke hobane Black Mulberry e fetola mekhoa ea biochemical eo ho tlalehiloeng ka mahlale ho hlokomelisa phello ea Ruxolitinib.

Tse ling tsa metsoako e sebetsang kapa li-bioactive tsa litholoana Black Elderberry ke Linalool, Formononetin, Quercetin, Lycopene, Apigenin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka JAK-STAT Signaling le Oncogenic Cancer Epigenetics le tse ling. Black Elderberry ha e khothalletsoe bakeng sa Primary Myelofibrosis ha kalafo ea mofets'e e tsoelang pele e le Ruxolitinib hobane e fetola litsela tsa biochemical tse etsang hore kalafo ea mofets'e e se ke ea sebetsa kapa e se ke ea arabela.

FRUIT BLACK MulBERRY E COMPOTSOE HO PHETHA BLACK ELDERBERRY BAKENG SA Primary Myelofibrosis LE PHEKO Ruxolitinib.

Khetha Nut BLACK WALNUT kapa EUROPEAN CHESTNUT?

Black Walnut e na le metsoako e mengata e sebetsang kapa bioactives tse kang Formononetin, Quercetin, Apigenin, Protocatechuic Acid, Phloretin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang RAS-RAF Signaling, PI3K-AKT-MTOR Signaling le MYC Signaling le tse ling. Black Walnut e buelloa bakeng sa Primary Myelofibrosis ha phekolo ea kankere e tsoelang pele e le Ruxolitinib. Lebaka ke hobane Walnut e Ntšo e fetola litsela tseo tsa biochemical tse tlalehiloeng ka mahlale ho hlokomelisa phello ea Ruxolitinib.

Tse ling tsa metsoako e sebetsang kapa bioactives ka Chestnut ea Europe ke Formononetin, Quercetin, Apigenin, Protocatechuic Acid, Phloretin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka PI3K-AKT-MTOR Signaling le Oncogenic Cancer Epigenetics le tse ling. Chestnut ea Europe ha e khothalletsoe bakeng sa Primary Myelofibrosis ha kalafo ea mofets'e e tsoelang pele e le Ruxolitinib hobane e fetola mekhoa ea biochemical e etsang hore kalafo ea mofets'e e hane kapa e se ke ea arabela hantle.

WALNUT E TŠO E KHOTHATSOE HO FETA CHESTNUT EA EUROPE BAKENG SA Myelofibrosis ea mantlha LE PHEKO Ruxolitinib.

Bakeng sa Batho ba nang le Kotsi ea Liphatsa tsa Kankere

Potso e botsoang ke batho ba nang le kotsi ea lefutso ea Primary Myelofibrosis kapa histori ea lelapa ke "Ke Lokela ho Ja Eng e sa Tšoaneng le Pele?" le kamoo ba lokelang ho khetha lijo le li-supplement bakeng sa ho laola likotsi tsa lefu lena. Kaha bakeng sa kotsi ea mofets'e ha ho letho le ka etsoang mabapi le kalafo - liqeto tsa lijo le li-supplement li fetoha tsa bohlokoa 'me e le e' ngoe ea lintho tse fokolang haholo tse ka etsoang. Lijo tsohle tse thehiloeng ho limela ha li lekane 'me li ipapisitse le liphatsa tsa lefutso le mokhoa oa ho saena - khetho ea lijo le li-supplement li lokela ho etsoa ke motho ka mong.

Khetha Meroho GREEN BELL PEPPER kapa COMMON BEET?

Pepere e tala ea meroho e na le metsoako e mengata e sebetsang kapa bioactives tse kang Quercetin, Resveratrol, Bergapten, Formononetin, Luteolin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang Suppressive Histone Methylation, Cytokine Signaling, Oncogenic Cancer Epigenetics le Hematopoiesis le tse ling. Green Bell Pepper e buelloa bakeng sa kotsi ea Primary Myelofibrosis ha kotsi ea liphatsa tsa lefutso e amanang le ASXL1. Sena ke hobane Green Bell Pepper e eketsa litsela tsa biochemical tse hanyetsanang le bakhanni ba eona ba saenneng.

Tse ling tsa metsoako e sebetsang kapa li-bioactive tsa meroho ea Common Beet ke Bergapten, Formononetin, Stigmasterol, Phloretin, Myricetin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka Cytokine Signaling le Oncogenic Cancer Epigenetics le tse ling. Beet e tloaelehileng ha e khothalletsoe ha kotsi ea Primary Myelofibrosis ha e amahanngoa le kotsi ea liphatsa tsa lefutso ke ASXL1 hobane e eketsa litsela tsa ho saena.

PIRIPI YA MOROO E TLANG E KHOTHATSOE HO FETA BEET E TLOAELEHANG BAKENG SA ASXL1 KOTSI EA LITŠOANTŠISO EA KANKERE.

Khetha FIG ea Litholoana kapa PUMMELO?

Fruit Fig e na le metsoako e mengata e sebetsang kapa bioactives tse kang Quercetin, Bergapten, Formononetin, Phloretin, Stigmasterol. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang JAK-STAT Signaling, Suppressive Histone Methylation, AGE-RAGE Signaling le Cytokine Signaling le tse ling. Fig e buelloa bakeng sa kotsi ea Primary Myelofibrosis ha kotsi ea lefutso e amanang le ASXL1. Sena ke hobane Fig e eketsa litsela tsa biochemical tse hanyetsanang le bakhanni ba eona ba saenneng.

Tse ling tsa metsoako e sebetsang kapa bioactives litholoana Pummelo ke Quercetin, Bergapten, Formononetin, Naringin, Phloretin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka Post Translation Modification le Cytokine Signaling le tse ling. Pummelo ha e khothalletsoe ha kotsi ea Primary Myelofibrosis ha e amahanngoa le kotsi ea liphatsa tsa lefutso ke ASXL1 hobane e eketsa litsela tsa ho saena.

THOLOANA FIG E KHOTHATSOA HO FETISISA PUMMELO BAKENG SA ASXL1 Genese RISK EA KANKERE.

Khetha Nut PEO EA MOKOPU kapa ALMOND?

Peo ea Mokopu e na le metsoako e mengata e sebetsang kapa bioactives tse kang Cucurbitacin I, Stigmasterol, Linolenic Acid, Salicylic Acid, Beta-sitosterol. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang JAK-STAT Signaling, AGE-RAGE Signaling, Cytokine Signaling le Hematopoiesis le tse ling. Peo ea Mokopu e khothaletsoa bakeng sa kotsi ea Primary Myelofibrosis ha kotsi ea lefutso e amanang le ASXL1. Lebaka ke hobane Peo ea Mokopu e eketsa litsela tsa biochemical tse hanyetsanang le bakhanni ba eona ba saenneng.

Tse ling tsa metsoako e sebetsang kapa bioactives ho Almond ke Bergapten, Formononetin, Phloretin, Stigmasterol, Isorhamnetin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang Cytokine Signaling le IL27 Signaling le tse ling. Almond ha e khothalletsoe ha kotsi ea Primary Myelofibrosis ha kotsi ea lefutso e amahanngoa le ASXL1 hobane e eketsa litsela tsa ho saena.

LIPEO TSA MOKOPU LI KHOTHATSOA HO FETISISA ALMOND BAKENG SA ASXL1 Genese RISK EA KANKERE.

Ha re phethela

Lijo le li-Supplement tse khethiloeng ke liqeto tsa bohlokoa bakeng sa mofetše o kang Primary Myelofibrosis. Bakuli ba mantlha ba Myelofibrosis le batho ba nang le kotsi ea liphatsa tsa lefutso ba lula ba e-na le potso ena: "Ke lijo life le li-supplement tsa phepo tse khothalletsoang ho 'na le tse seng joalo?" Ho na le tumelo e tloaelehileng eo e leng maikutlo a fosahetseng a hore lijo tsohle tse thehiloeng limela li ka ba molemo kapa che empa li ke ke tsa e-ba kotsi. Lijo tse ling le li-supplement li ka kena-kenana le phekolo ea mofetše kapa tsa khothalletsa bakhanni ba limolek'hule tsa mofetše.

Ho na le mefuta e fapaneng ea matšoao a mofets'e joalo ka Myelofibrosis ea mantlha, e 'ngoe le e' ngoe e na le liphatsa tsa lefutso tse fapaneng tse nang le mefuta e fapaneng ea genomic ho motho ka mong. Ho feta moo kalafo e 'ngoe le e' ngoe ea mofetše le chemotherapy e na le mokhoa o ikhethileng oa ts'ebetso. Sejo se seng le se seng joalo ka Cluster Bean se na le li-bioactive tse fapaneng ka bongata bo fapaneng, tse nang le tšusumetso litseleng tse fapaneng le tse ikhethileng tsa lik'hemik'hale tsa biochemical. Tlhaloso ea phepo e nepahetseng ke likhothaletso tsa motho ka mong bakeng sa sesupo sa mofetše, kalafo, liphatsa tsa lefutso, mokhoa oa bophelo le lintlha tse ling. Liqeto tsa phepo e nepahetseng bakeng sa mofetše li hloka tsebo ea biology ea mofets'e, mahlale a lijo le kutloisiso ea liphekolo tse fapaneng tsa chemotherapy. Qetellong ha ho e-na le liphetoho tsa phekolo kapa li-genomics tse ncha li khetholloa - phepo e nepahetseng e hloka ho hlahlojoa bocha.

Tharollo ea motho ka mong ea phepo e nepahetseng ea addon e etsa hore ho be bonolo ho etsa liqeto 'me e tlose maikutlo ohle ho araba potso e reng, "Ke lijo life tseo ke lokelang ho li khetha kapa ho se khethe bakeng sa Primary Myelofibrosis?". Sehlopha sa li-addon tse nang le taeo e mengata se kenyelletsa lingaka tsa mofetše, bo-ramahlale ba bongaka, baenjiniere ba mananeo le bo-ramahlale ba data.

References

• Aml Ohsu 2018
• Liphello tse thibelang tsa butyric acid, nicotinamide, calcium glucarate li le mong kapa li kopane nakong ea 7, 12-dimethylbenz (a) anthracene e kentse mouse ea letlalo tumorigenesis ka modulation ea K-Ras-PI3K-AKTpathway le li-RNA tse nyenyane tse amanang le tsona.
• Tsoelo-pele ea lipatlisiso mabapi le litlamorao tsa anticancer tsa vithamine K2.
• Formononetin-induced oxidative stress e hlakola ts'ebetso ea STAT3/5 axis signing mme e hatella kholo ea hlahala ka har'a mefuta e mengata ea myeloma preclinical.
• Stigmasterol e bonts'a litlamorao tse matla tsa antitumor liseleng tsa mofetše oa mala oa motho tse kenelletseng ka ho thibela ho falla ha lisele, ho ts'oaroa ha cell cycle, mitochondrial mediated apoptosis le ho thibela tsela ea JAK/STAT.
• Isorhamnetin e hatella mofetše oa letlalo ka ho thibela ka ho toba MEK1 le PI3-K.