Lijo tsa Acral Melanoma!

Selelekela 

Lijo tsa Acral Melanoma li lokela ho etsoa ka bomong bakeng sa motho ka mong hape li tlameha ho ikamahanya le maemo ha kalafo ea mofetše kapa liphatsa tsa lefutso tsa hlahala li fetoha. Ho iketsetsa motho le ho ikamahanya le maemo ho tlameha ho nahanela metsoako eohle e sebetsang kapa li-bioactive tse fumanehang lijong tse fapaneng mabapi le baeloji ea mofetše, liphatsa tsa lefutso, kalafo, maemo a bophelo le likhetho tsa lijo. Kahoo le hoja phepo e nepahetseng e le e 'ngoe ea liqeto tsa bohlokoa haholo tseo mokuli oa mofetše le motho ea kotsing ea mofetše a lokelang ho li etsa - mokhoa oa ho khetha lijo tseo u ka li jang ha se mosebetsi o bonolo. 

Acral Melanoma, mofuta o ikhethang oa melanoma, hangata e iponahatsa matsohong, maotong le ka tlas'a manala, e hlahisa matšoao a ikhethileng joalo ka liphetoho tsa 'mala oa manala kapa maqeba a letlalo. Mofuta ona oa melanoma o ka hlahlojoa ka dermoscopy, ka acral lentiginous melanoma hangata e bonoang leotong, 'me litšoantšo tsa lipontšo tsena li thusa kutloisisong ea pono. Litlhaloso tsa pathology tsa acral melanoma, ho kenyeletsoa le liforomo tsa situ, li bohlokoa bakeng sa tlhahlobo e nepahetseng, 'me ICD-10 coding system e fana ka likarolo tsa eona. Kalafo e fapana ho ipapisitsoe le boemo le mofuta oa phetoho ea liphatsa tsa lefutso, ho latela maemo le maemo a ho pholoha ho itšetlehile ka lintlha tse kang hore na melanoma e nama ka potlako hakae le bohale ba eona ka kakaretso. Li-platform tsa Marang-rang tse kang Reddit li fana ka lipuisano tsa sechaba mabapi le liphihlelo tsa motho le tlhahisoleseling. Ho utloisisa hore na acral melanoma e shebahala joang le hore na e bakoa ke eng, ho bohlokoa bakeng sa ho lemoha kapele le taolo e sebetsang, kaha mofuta ona oa melanoma o ka hlaha libakeng tseo hangata li sa pepesetsoeng ke letsatsi.

Bakeng sa Acral Melanoma, na ho na le taba hore na motho o ja meroho, litholoana, linate, lipeo life?

Potso e atileng haholo ea phepo e botsoang ke bakuli ba mofets'e le batho ka bomong ba kotsing ea mofets'e ke - bakeng sa mofetše o kang Acral Melanoma, na ho na le taba hore na ke ja lijo life le tseo ke sa li jeng? Kapa haeba ke latela lijo tse thehiloeng limela na hoo ho lekane bakeng sa mofetše joalo ka Acral Melanoma?

Ka mohlala, na ho na le taba hore Cabbage ea meroho e jeoa haholo ha e bapisoa le Chinese Broccoli? Na ho na le phapang e teng haeba litholoana tsa Malus (crab Apple) li ratoa ho feta Black Mulberry? Hape haeba ho etsoa khetho e tšoanang bakeng sa linate/peo e kang Common Hazelnut holim'a Chestnut ea Europe le bakeng sa limela tse kang Gram Bean holim'a Moth Bean. 'Me haeba seo ke se jang se le bohlokoa - joale motho o tseba joang lijo tse buelloang bakeng sa Acral Melanoma 'me na ke karabo e tšoanang ho bohle ba nang le tlhahlobo e tšoanang kapa kotsi ea lefutso? 

Ee! Lijo tseo u li jang li bohlokoa bakeng sa Acral Melanoma!

Litlhahiso tsa lijo li ka 'na tsa se ke tsa tšoana ho bohle' me li ka fapana esita le bakeng sa tlhahlobo e tšoanang le kotsi ea lefutso.  

Lijo tsohle (meroho, litholoana, linate, lipeo, li-pulses, oli joalo-joalo) le litlatsetso tsa phepo li entsoe ka metsoako e fetang e le 'ngoe e sebetsang ea molek'hule kapa bio-active ka tekanyo le bongata bo fapaneng. Sejo se seng le se seng se sebetsang se na le mokhoa o ikhethileng oa ts'ebetso - e ka bang ts'ebetso kapa ho thibela litsela tse fapaneng tsa biochemical. Lijo le li-supplement tse khothalletsoang habonolo ke tse sa bakeng keketseho ea limolek'hule tsa mofetše empa li li fokotsa. Ho seng joalo, lijo tseo ha lia lokela ho khothaletsoa. Lijo li na le metsoako e mengata e sebetsang - ka hona, ha u hlahloba lijo le li-supplement, u lokela ho nahana ka phello ea metsoako eohle e sebetsang ka bonngoe ho e-na le hore u nahane ka bonngoe. 

Ka mohlala Malus (crab Apple) e na le metsoako e sebetsang ea Lupeol, Isoliquiritigenin, Formononetin, Catechol, Phloretin. 'Me Black Mulberry e na le metsoako e sebetsang ea Quercetin, Lupeol, Isoliquiritigenin, Formononetin, Catechol le mohlomong tse ling. 

Phoso e tloaelehileng e entsoeng ha ho etsoa qeto le ho khetha lijo tse jeoang bakeng sa Acral Melanoma - ke ho hlahloba feela metsoako e sebetsang e khethiloeng e fumanehang lijong le ho hlokomoloha tse ling kaofela. Hobane metsoako e fapaneng e sebetsang e fumanehang lijong e kanna ea ba le litlamorao tse fapaneng ho bakhanni ba mofetše - u ke ke ua khona ho khetha metsoako e sebetsang lijong le li-supplement bakeng sa ho etsa qeto ea phepo e nepahetseng bakeng sa Acral Melanoma. 

EE – LIKHETHO TSA LIJO LI BOHLOKOA BAKENG SA KANKERE. LIQETO TSA PHEPO LI TLAMEHA HO NAHANA KA LITABA TSOHLE TSA LIJO.

Tsebo e Hlokahalang Bakeng sa Phepo ea Boipheliso bakeng sa Acral Melanoma?

Phepo ea motho ka mong bakeng sa mofetše joalo ka Acral Melanoma e na le lijo tse khothaletsoang / li-supplement; lijo tse sa khothaletsoang tse nang le mohlala oa diresepe tse etelletsang pele tšebeliso ea lijo tse khothaletsoang. Mohlala oa phepo e nepahetseng o ka bonoa ho sena link tsa.

Ho etsa qeto ea hore na ke lijo life tse khothalelitsoeng kapa che ho rarahane haholo, ho hloka boiphihlelo ho biology ea Acral Melanoma, mahlale a lijo, liphatsa tsa lefutso, biochemistry hammoho le kutloisiso e ntle ea hore na kalafo ea mofets'e e sebetsa joang le bofokoli bo amanang le bona boo kalafo e ka emisang ho sebetsa.

BONYENYANE BO TSEBO BOHLOKOA BAKENG SA PHEPO MOTHO BATHO BA KANKERE KE: BOLOJI YA KANKERE, SAENSE YA DIJO, DIPHEKO LA MOFEPO LE LIFUTSO.

Litšobotsi tsa mofetše joalo ka Acral Melanoma

Lik'hemik'hale tsohle tse kang Acral Melanoma li ka khetholloa ka mokhoa o ikhethang oa litsela tsa lik'hemik'hale - litsela tsa ho saena tsa Acral Melanoma. Litsela tsa biochemical tse kang Kankere ea Oncogenic Epigenetics, Suppressive Histone Methylation, PI3K-AKT-MTOR Signaling, MAPK Signaling ke karolo ea tlhaloso ea signature ea Acral Melanoma. Liphatsa tsa lefutso tsa mofetše oa motho ka mong li ka fapana, ka hona, tekeno ea bona ea mofetše e ka ikhetha.

Liphekolo tse sebetsang hantle bakeng sa Acral Melanoma li hloka ho ela hloko mekhoa ea lik'hemik'hale e amanang le eona bakeng sa mokuli e mong le e mong oa mofetše le motho ea kotsing ea lefutso. Ka hona liphekolo tse fapaneng tse nang le mekhoa e fapaneng ea liketso li sebetsa hantle ho bakuli ba fapaneng. Ka mokhoa o ts'oanang le ka mabaka a ts'oanang lijo le li-supplement li hloka ho etsoa ka bomong bakeng sa motho ka mong. Ka hona, lijo tse ling le li-supplement li khothaletsoa bakeng sa Acral Melanoma ha u nka kalafo ea mofetše Checkpoint Pdl1, 'me lijo tse ling le li-supplement ha li khothalletsoe.

Mehloli e kang cBioPortal 'me ba bang ba bangata ba fana ka lintlha tse sa tsejoeng tse tsoang litekong tsa bongaka bakeng sa matšoao ohle a mofetše. Lintlha tsena li na le lintlha tsa boithuto ba tleliniki joalo ka boholo ba sampole / palo ea bakuli, lihlopha tsa lilemo, bong, morabe, kalafo, sebaka sa tumor le liphetoho life kapa life tsa lefutso. 

DNMT3A, TET2, PPM1D, ASXL1 le ATM ke liphatsa tsa lefutso tse behiloeng ka holimo tse tlalehiloeng bakeng sa Acral Melanoma. DNMT3A e tlalehoa ho 31.6% ea bakuli ba baemeli ho pholletsa le liteko tsohle tsa bongaka. Mme TET2 e tlalehile ka 11.8%. Lintlha tse kopaneng tsa bakuli li akaretsa lilemo ho tloha ho 5 ho isa ho 96. 60.8 % ea lintlha tsa bakuli li khetholloa e le banna. Biology ea Acral Melanoma hammoho le liphatsa tsa lefutso tse tlalehiloeng hammoho li hlalosa palo ea batho ba emelang litsela tsa lik'hemik'hale tsa mofetše. Haeba liphatsa tsa lefutso tsa mofetše kapa liphatsa tsa lefutso tse kenyang kotsi le tsona li tsejoa, seo se lokela ho sebelisoa hape bakeng sa ho ja lijo.

LIKHETHO TSA PHEPO LI LOKELA HO TŠOANA LE MOTHO E MONG LE E MONG LE SAENYO EA MOTHO EA KANKERE.

Lijo le Lisebelisoa tsa Acral Melanoma

Bakeng sa Bakuli ba Kankere

Bakuli ba mofetše ba nakong ea kalafo kapa ba tlhokomelong ea pholiso ba lokela ho etsa liqeto mabapi le lijo le li-supplement - bakeng sa lik'hilojule tse hlokahalang tsa lijo, ho laola litla-morao life kapa life tsa kalafo le bakeng sa taolo e ntlafetseng ea mofetše. Lijo tsohle tse thehiloeng ho limela ha li lekane, 'me ho khetha le ho etelletsa pele lijo tse ikhethileng le tse etselitsoeng kalafo e tsoelang pele ea mofets'e ho bohlokoa ebile ho rarahane. Mehlala ke ena e fanang ka litataiso bakeng sa ho etsa liqeto tsa phepo e nepahetseng.  

Khetha K'habeche ea Meroho kapa BROCCOLI ea CHINESE?

Hop ea meroho e na le metsoako e mengata e sebetsang kapa bioactives tse kang Quercetin, Lupeol, Isoliquiritigenin, Formononetin, Catechol. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang Angiogenesis, WNT Beta Catenin Signaling, Natural Killer Cell Activation le Interferon Signaling le tse ling. Khabeche e khothaletsoa bakeng sa Acral Melanoma ha kalafo ea mofetše e tsoelang pele e le Checkpoint Pdl1. Lebaka ke hobane Khabeche e fetola litsela tseo tsa biochemical tse tlalehiloeng ka mahlale ho hlokomelisa phello ea Checkpoint Pdl1.

Tse ling tsa metsoako e sebetsang kapa li-bioactive tsa meroho ea Chinese Broccoli ke Lupeol, Isoliquiritigenin, Formononetin, Catechol, Phloretin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang Dendritic Cell Maturation, CD8 T-cell Activation le Antigen Presentation le tse ling. Chinese Broccoli ha e khothalletsoe bakeng sa Acral Melanoma ha kalafo ea mofets'e e ntse e tsoela pele e le Checkpoint Pdl1 hobane e fetola mekhoa ea biochemical e etsang hore kalafo ea mofets'e e hane kapa e se ke ea arabela hantle.

KHABECHE EA MERO E E KHOTHATSOENG HO PHETHA BROCCOLI EA CHINESE BAKENG SA Acral Melanoma LE Checkpoint Pdl1 ea PHEKO.

Khetha Tholoana BLACK MULBERRY kapa MALUS (CRAB APPLE)?

Litholoana tse ntšo tsa Mulberry li na le metsoako e mengata e sebetsang kapa bioactives tse kang Quercetin, Lupeol, Isoliquiritigenin, Formononetin, Catechol. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang Macrophage M2, JAK-STAT Signaling, Natural Killer Cell Activation le Angiogenesis le tse ling. Black Mulberry e khothaletsoa bakeng sa Acral Melanoma ha kalafo ea mofetše e tsoelang pele e le Checkpoint Pdl1. Lebaka ke hobane Black Mulberry e fetola litsela tseo tsa biochemical tse tlalehiloeng ka mahlale ho hlokomelisa phello ea Checkpoint Pdl1.

Tse ling tsa metsoako e sebetsang kapa bioactives litholoana Malus (crab Apple) ke Lupeol, Isoliquiritigenin, Formononetin, Catechol, Phloretin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang Dendritic Cell Maturation, CD8 T-cell Activation le Antigen Presentation le tse ling. Malus (crab Apple) ha e khothalletsoe bakeng sa Acral Melanoma ha kalafo e tsoelang pele ea mofets'e e le Checkpoint Pdl1 hobane e fetola litsela tsa biochemical tse etsang hore kalafo ea mofets'e e se ke ea sebetsa kapa e se ke ea arabela hantle.

LITHOLOANA TSE TŠOANA TSA KHALA E KHOTHATSOE HO HOLA MALUS (CRAB APPLE) BAKENG SA Acral Melanoma LE Checkpoint Pdl1 ea PHEKO.

Khetha Nut COMMON HAZELNUT kapa EUROPEAN CHESTNUT?

Hazelnut e tloaelehileng e na le metsoako e mengata e sebetsang kapa bioactives tse kang Quercetin, Lupeol, Isoliquiritigenin, Formononetin, Catechol. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang JAK-STAT Signaling, Angiogenesis, Antigen Presentation le T-Regulatory Cell Differentiation le tse ling. Hazelnut e tloaelehileng e buelloa bakeng sa Acral Melanoma ha phekolo ea kankere e tsoelang pele e le Checkpoint Pdl1. Lebaka ke hobane Koetliso e Tloaelehileng e fetola litsela tsa biochemical tse tlalehiloeng ka mahlale ho hlokomelisa phello ea Checkpoint Pdl1.

Tse ling tsa metsoako e sebetsang kapa bioactives ka Chestnut ea Europe ke Quercetin, Ellagic Acid, Lupeol, Isoliquiritigenin, Formononetin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang Dendritic Cell Maturation, CD8 T-cell Activation le G-protein-coupled Receptor Signaling le tse ling. Chestnut ea Europe ha e khothalletsoe bakeng sa Acral Melanoma ha kalafo ea mofets'e e ntse e tsoela pele e le Checkpoint Pdl1 hobane e fetola litsela tseo tsa biochemical tse etsang hore kalafo ea mofets'e e hane kapa e se ke ea arabela hantle.

HAZELNUT E TLOAELEHANG E KHOTHATSOA HO FETISISA CHESTNUT EA EUROPE BAKENG SA Acral Melanoma LE Checkpoint Pdl1 ea PHEKO.

Bakeng sa Batho ba nang le Kotsi ea Liphatsa tsa Kankere

Potso e botsoang ke batho ba nang le kotsi ea lefutso ea Acral Melanoma kapa histori ea lelapa ke "Ke Lokela ho Ja Eng e sa Tšoaneng le Pele?" le kamoo ba lokelang ho khetha lijo le li-supplement bakeng sa ho laola likotsi tsa lefu lena. Kaha bakeng sa kotsi ea mofets'e ha ho letho le ka etsoang mabapi le kalafo - liqeto tsa lijo le li-supplement li fetoha tsa bohlokoa 'me e le e' ngoe ea lintho tse fokolang haholo tse ka etsoang. Lijo tsohle tse thehiloeng ho limela ha li lekane 'me li ipapisitse le liphatsa tsa lefutso le Acral Melanoma tsela signature - khetho ea lijo le li-supplement li lokela ho etsoa ke motho ka mong. 

Khetha Meroho CELERY STALKS kapa ROMINE LETTUCE?

Meroho ea Celery Stalks e na le metsoako e mengata e sebetsang kapa bioactives tse kang Apigenin, Curcumin, Linalool, Lupeol, Lycopene. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang Oncogenic Cancer Epigenetics, RAS-RAF Signaling, Cell Cycle Checkpoints le Apoptosis le tse ling. Celery Stalks e khothalletsoa kotsi ea Acral Melanoma ha kotsi ea lefutso e amanang le ASXL1. Sena ke hobane Celery Stalks e eketsa litsela tsa biochemical tse hanyetsanang le bakhanni ba eona ba saenneng.

Tse ling tsa metsoako e sebetsang kapa li-bioactive tsa meroho ea Romaine Lettuce ke Apigenin, Curcumin, Lupeol, Resveratrol, Protocatechuic Acid. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang P53 Signaling le DNA Repair le tse ling. Romaine Lettuce ha e khothalletsoe ha kotsi ea Acral Melanoma ha kotsi ea lefutso e amanang le ASXL1 hobane e eketsa litsela tsa ho saena tsa Acral Melanoma.

LITABA TSA MOROO TSA CELERY LI COMPOTSOA HO FETISISA LETTUCE YA ROMAINE BAKENG SA ASXL1 KOTSI EA LITŠOANTŠISO EA KANKERE.

Khetha Litholoana NANCE kapa GRAPEFRUIT?

Litholoana tsa Nance li na le lisebelisoa tse ngata tse sebetsang kapa li-bioactive tse kang Apigenin, Curcumin, Lupeol, Protocatechuic Acid, Daidzein. Lithako tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang DNA Repair, RAS-RAF Signaling, MYC Signaling le Cell Cycle Checkpoints le tse ling. Nance e buelloa bakeng sa kotsi ea Acral Melanoma ha kotsi ea lefutso e amanang le ASXL1. Lebaka ke hore Nance e eketsa litsela tsa biochemical tse hanyetsanang le bakhanni ba eona ba saenneng.

Tse ling tsa metsoako e sebetsang kapa li-bioactive tsa litholoana tsa Grapefruit ke Curcumin, Lupeol, Lycopene, Daidzein, Beta-sitosterol. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka DNA Repair le tse ling. Grapefruit ha e khothalletsoe ha kotsi ea Acral Melanoma e amahanngoa le kotsi ea lefutso e le ASXL1 hobane e eketsa mekhoa ea ho saena ea Acral Melanoma.

THOLOANA NANCE E KHOTHATSOA HO FETISISA GRAPEFRUIT BAKENG SA ASXL1 genetic RISK EA KANKERE.

Khetha Nut BUTTERNUT kapa CHESTNUT?

Butternut e na le metsoako e mengata e sebetsang kapa bioactives tse kang Apigenin, Curcumin, Juglone, Lupeol, Lycopene. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang Oncogenic Cancer Epigenetics, RAS-RAF Signaling, MYC Signaling le Cell Cycle Checkpoints le tse ling. Butternut e khothaletsoa bakeng sa kotsi ea Acral Melanoma ha kotsi ea lefutso e amanang le ASXL1. Lebaka ke hobane Butternut e eketsa litsela tsa biochemical tse khahlano le bakhanni ba eona ba saenneng.

Tse ling tsa metsoako e sebetsang kapa bioactives ka Chestnut ke Apigenin, Curcumin, Lupeol, Lycopene, Ellagic Acid. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka DNA Repair le tse ling. Chestnut ha e khothalletsoe ha kotsi ea Acral Melanoma e amahanngoa le kotsi ea liphatsa tsa lefutso ke ASXL1 hobane e eketsa litsela tsa ho saena tsa Acral Melanoma.

BUTTERNUT E KHOTHATSOE HO FETA CHESTNUT BAKENG SA ASXL1 genetic RISK EA KANSERE.

Ha re phethela

Lijo le Lisebelisoa tse khethiloeng ke liqeto tsa bohlokoa bakeng sa mofetše o kang Acral Melanoma. Bakuli ba Acral Melanoma le batho ba nang le kotsi ea lefutso ba lula ba e-na le potso ena: "Ke lijo life le li-supplement tsa phepo tse khothalletsoang ho 'na le tse sa buelloang?" Ho na le tumelo e tloaelehileng eo e leng maikutlo a fosahetseng a hore lijo tsohle tse thehiloeng limela li ka ba molemo kapa che empa li ke ke tsa e-ba kotsi. Lijo tse ling le li-supplement li ka kena-kenana le phekolo ea mofetše kapa tsa khothalletsa bakhanni ba limolek'hule tsa mofetše.

Ho na le mefuta e fapaneng ea matšoao a mofets'e joalo ka Acral Melanoma, e 'ngoe le e' ngoe e na le liphatsa tsa lefutso tse fapaneng tse nang le mefuta e fapaneng ea genomic ho motho ka mong. Ho feta moo kalafo e 'ngoe le e' ngoe ea mofetše le chemotherapy e na le mokhoa o ikhethileng oa ts'ebetso. Sejo se seng le se seng joalo ka Khabeche se na le li-bioactive tse fapaneng ka bongata bo fapaneng, tse nang le tšusumetso mekhoeng e fapaneng ea lik'hemik'hale. Tlhaloso ea phepo e nepahetseng ke likhothaletso tsa motho ka mong bakeng sa sesupo sa mofetše, kalafo, liphatsa tsa lefutso, mokhoa oa bophelo le lintlha tse ling. Liqeto tsa phepo e nepahetseng bakeng sa mofetše li hloka tsebo ea baeloji ea mofetše, mahlale a lijo le kutloisiso ea liphekolo tse fapaneng tsa chemotherapy. Qetellong ha ho e-na le liphetoho tsa phekolo kapa li-genomics tse ncha li khetholloa - phepo e nepahetseng e hloka ho hlahlojoa bocha.

Tharollo ea motho ka mong ea phepo e nepahetseng ea addon e etsa hore ho be bonolo ho etsa liqeto 'me e tlose mehopolo eohle ho araba potso e reng, "Ke lijo life tseo ke lokelang ho li khetha bakeng sa Acral Melanoma?". Sehlopha sa li-addon tse nang le taeo e mengata se kenyelletsa lingaka tsa mofetše, bo-ramahlale ba bongaka, baenjiniere ba mananeo le bo-ramahlale ba data. 

References

1) Msk Impact 2017

2) Tumor mutational load e bolela esale pele ho pholoha ka mor'a immunotherapy ho mefuta e mengata ea mofetše.

3) Taolo e mpe ea transducer ea matšoao le activator ea transcription-3 signing cascade ke lupeol e thibela kholo mme e etsa hore apoptosis e be liseleng tsa hepatocellular carcinoma.

4) Liphello tsa isoliquiritigenin liseleng tsa mofetše oa mahe a bomme.

5) Litlamorao tsa lijo tsa D-glucarate ho li-biomarker tsa ho ruruha nakong ea mekhahlelo ea pele ea ho qala ha benzo[a]pyrene-induced lung tumorigenesis ho litoeba tsa A/J.

6) Luteolin e khothalletsa lefu la apoptotic ka ho phahamisoa ha polelo ea Nrf2 ka DNA demethylase le tšebelisano ea Nrf2 le p53 liseleng tsa mofetše oa mala.

7) Asiti ea Gallic e baka tšenyo ea DNA mme e hatella tlhahiso ea liphatsa tsa lefutso tsa DNA ho mofetše oa tšoelesa ea senya ea PC-3.

https://www.ncbi.nlm.nih.gov/books/NBK559113

https://www.cancercenter.com/cancer-types/melanoma/types/acral-lentiginous-melanoma

https://www.healthline.com/health/acral-lentiginous-melanoma