Tšebeliso ea joala le kotsi ea mofets'e

Lintlha-khōlō Tsa

Litlhahlobo tsa meta tsa lithuto tse fapaneng tsa ho shebisisa li bontša hore ho noa joala ho baka litholoana tse sa rateheng joalo ka keketseho ea kotsi ea mefuta e fapaneng ea mofets'e joalo ka mofets'e oa hlooho le molala ho kenyeletsoa mofetše oa molomo le oa pharyngeal, mofetše oa esophageal, mofetše oa qoqotho le mofetše oa larynx, hammoho le kankere e mebala-bala, sebete le matsoele, leha ho le joalo, hore na joala e baka mofetše oa matšoafo le mofetše oa senya ha e tsejoe.

Kankere ke e 'ngoe ea lisosa tse ka sehloohong tsa mafu lefatšeng ka bophara. Kotsi ea ho tšoaroa ke mofetše e ipapisitse le lintlha tse ngata tse seng tlas'a taolo ea rona ho kenyelletsa liphetoho tsa liphatsa tsa lefutso, lilemo, nalane ea lelapa. tsoaroa ke kankere le mabaka a tikoloho joalo ka ho pepesetsoa mahlaseli. Leha ho le joalo, ho na le mabaka a mang a mangata a bakang / a kenyang letsoho haholo ho nts'etsopele ea mefuta e fapaneng ea mofets'e (joalo ka matsoele, matšoafo, prostate, colorectal, hlooho le molala le tse ling) empa li tlas'a taolo ea rona, joalo ka mekhoa ea lijo e kenyelletsang. ho noa joala, tšebeliso ea koae , ho ja nama e khubelu, nama e phehiloeng le lijo tse entsoeng ka morao-rao hammoho le maemo a bophelo a kang ho se ikoetlise le ho ikoetlisa le ho eketseha ha boima ba 'mele / botenya. 

Joala esale bo nkuoa e le karolo ea bohlokoa ea mekete, meketjana le boitlamo ba sechaba. Le ha ba bangata ba noa joala ka bongata bo itekanetseng e le karolo ea "ho noa sechabeng", batho ba bangata ba noa joala bo bongata khafetsa, bo qetellang bo hlahisa litholoana tse sa rateheng tse kenyeletsang mafu a sokelang bophelo le likotsi tsa mebileng. Batho ba bangata ba shoang pele ho nako (e batlang e le mathoasong a bophelo) ba ka bakoa ke tšebeliso ea joala, e lebisang ho lefu le ka bang 13.5% sehlopheng sa lilemo tse pakeng tsa 20 le 39. (Mokgatlo wa Lefatshe wa Bophelo bo Botle) 

Na tšebeliso ea joala e ka baka mofetše?

Ho ea ka Mokhatlo oa Lefatše oa Bophelo, hoo e ka bang lefu le le leng ho ba 1 (hoo e ka bang 20% ea batho ba shoang lefatšeng ka bophara) le bakoa ke ho noa joala 'me lefu le le leng ho ba 5.3 le bakiloe ke mofetše lefatšeng ka bophara. Kahoo, liphuputso tse fapaneng li 'nile tsa etsoa ke bafuputsi lefats'eng lohle ho hlahloba kamano pakeng tsa tai le tsoaroa ke kankere. Mehlala ea litlhahlobo tse ling tse ithutileng hore na joala bo ka baka mefuta e fapaneng ea mofetše (joalo ka hlooho le molala, sefuba, matšoafo, tšoelesa ea senya le colorectal) li kopantsoe blog ena. 

Tšebeliso ea joala e ka baka mofetše oa hlooho le molala

1. Tlhatlhobo e entsoeng ho palo ea batho, mekhoa ea bophelo ba pele ho lefu le tlhaiso-leseling ea bongaka ho tsoa liphuputsong tse hlano ho International Head and Neck Cancer Epidemiology (INHANCE) Consortium, e neng e kenyelletsa bakuli ba mofets'e oa mofets'e oa hlooho le molala (HNC) 4759 ba fumane hore, joala ho noa ke sesosa sa ponelopele ea ho pholoha ka kakaretso le pholoho e ikhethileng ea HNC bakeng sa bakuli ba nang le mofetše oa larynx. (L (Giraldi et al, Ann Oncol., 2017)
2. Phuputsong e phatlalalitsoeng ka 2017, bafuputsi ba sebelisitse tlhaiso-leseling ea tšebeliso ea joala ea bakuli ba 811 ba hlooho ea mokokotlo oa hlooho le molala (HNC) le litsamaiso tse 940 tse tsoang Taiwan ho lekola botsoalle pakeng tsa joala le HNC ka libaka tse ikhethileng mme ba fumana hore ts'ebeliso ea joala ka tekano e ekelitse kotsi ea HNC ka kotsi e kholo ka ho fetisisa e hlokomeloang ke mofetše oa hypopharyngeal, e lateloang ke kankere ea oropharyngeal le laryngeal. Kotsi e boetse e fumanoe e phahame ho batho ba nang le metabolism e fokolang ea ethanol. (Cheng-Chih Huang et al, Sci Rep., 2017)
3. Tlhatlhobo ea tlhaiso-leseling ea tlhaiso-leseling e fumanoeng ho tsoa ho Patlisiso e phatlalalitsoeng ho fihlela ka Loetse 2009 e kenyelletsang taolo ea linyeoe tse 43 le lithuto tse peli tsa sehlopha ho kenyeletsoa linyeoe tse 17,085 tsa kankere ea molomo le ea pharyngeal (OPC) li fumane hore batho ba noang joala haholo ba ne ba le kotsing e kholo ea mofets'e. kotsi e eketsehile ka mokhoa o itšetlehileng ka lethal dose. Phuputso e boetse e fumane hore tekanyetso e itekanetseng ea> r = 1 seno kapa 10g ethanol / letsatsi le eona e ka amahanngoa le kotsi e eketsehileng ea OPC. (Irene Tramacere et al, Molomo Oncol., 2010)
4. Tlhatlhobo ea tlhaiso-leseling e fumanoeng ho tsoa lipatlisisong tsa lingoliloeng ho kenyeletsoa Embase, Latin American le Caribbean Health Science (LILACS), PubMed, Science Direct, le Web of Science) ho fihlela ka Phupu 2018, e neng e kenyelletsa lingoloa tsa 15, e fumane hore ts'ebeliso ea joala le koae li eketsehile ka bongata. kotsi ea lefu la molomo la squamous cell carcinoma. (Fernanda Weber Mello et al, Phuputso ea Bongaka ea Bongaka., 2019)
5. Tlhahlobo e hlophisehileng le tlhaiso-leseling ea tlhaiso-leseling e fumanoeng ho tsoa lipatlisisong tsa lingoliloeng ho li-database tsa PubMed le Embase ho fihlela ka Phupu 2012 e kenyelletsang sehlopha sa 8 / palo ea baahi le lithuto tsa taolo ea linyeoe tse 11 li fumane hore ho noa joala ho bakuli ba nang le tšebetso e kaholimo ea metsi (molomo, pharynx, kankere ea larynx, le 'metso) e amahanngoa le kotsi e kholo ea mofets'e oa bobeli oa kankere. (Nathalie Druesne-Pecollo et al, Cancer Epidemiol Biomarkers Prev. 2014)

Liphuputso tse boletsoeng ka holimo li fana ka maikutlo a hore ho noa joala haholo ho ka baka mofetše oa hlooho le molala joalo ka mofetše oa molomo / oa molomo, mofetše oa pharyngeal le mofetše oa larynx. (Harindra Jayasekara, Joala joala., 2016; V Bagnardi, Br J Cancer., 2015)

Tšebeliso ea joala e ka baka mofetše oa qoqotho

Phuputsong e phatlalalitsoeng ka 2016, bafuputsi ba tsoang Chaena ba hlahlobile tlhaiso-leseling e fumanoeng ho database tsa PubMed le EMBASE tse kenyelletsang lithuto tse 24 le 9,990 kankere ea qoqotho 'me a fumana hore tšebeliso e phahameng ea joala e ka amahanngoa le keketseho ea kotsi ea mofetše oa qoqotho. (Xiaofei Wang et al, Oncotarget. 2016)

Phuputso e fana ka maikutlo a hore ho noa joala haholo ho ka baka mofetše oa qoqotho. 

Tšebeliso ea joala e ka baka mofetše oa Esophageal

1. Phuputsong e phatlalalitsoeng ka 2014, bafuputsi ba tsoang Sekolong sa Bongaka sa Univesithi ea Michigan, Michigan ba hlahlobile tlhaiso-leseling e fumanoeng ho tsoa lipatlisisong tsa lingoliloeng ho kenyeletsoa MEDLINE, litlhahlobo tsa EBM, EMBASE, ISI Web of Knowledge le BIOSIS tse kenyelletsang litemana tse 5 mme ba fumana hore joala le koae ho ja ka tsela e lumellanang ho ile ha eketsa menyetla ea ho Kankere ea 'metso. (Anoop Prabhu le al, Am J Gastroenterol., 2014)
2. Tlhatlhobo e hlophisehileng le tlhatlhobo ea meta e sebelisang taolo ea linyeoe tsa 40 le lithuto tsa sehlopha sa batho ba 13 tse kenyeletsang lithuto tse 17 tse tsoang Amerika, 22 ho tsoa Asia, 1 e tsoang Australia le 13 e tsoang Europe, e fumane hore ho noa joala bo itekanetseng le bo phahameng ho ka amahanngoa le keketseho kotsi ea ho tšoaroa ke kankere ea 'metso. Phuputso e boetse e fumane hore ho noa joala hanyane le hona ho ka amahanngoa le mofetše oa esophageal Asia, ho fana ka maikutlo a karolo e ka bang teng ea lisosa tsa ho ba le liphatsa tsa lefutso. (Farhad Islami et al, Kankere ea Int J. 2011)

Liphuputso tsena li bonts'a hore ho noa joala haholo ho ka baka mofets'e oa 'metso. (V Bagnardi, Br J Cancer., 2015)

Tšebeliso ea joala e ka baka mofetše oa matsoele

1. Tlhatlhobo ea meta e entsoeng ke bafuputsi ba Yunivesithi ea Lanzhou, Chaena ba sebelisa lithuto tse 25 tsa sehlopha e fumane hore ho na le kamano ea karabelo ea tekano lipakeng tsa ts'ebeliso ea joala le lefu la mofets'e oa matsoele le ho ipheta. Ba boetse ba fumane hore ts'ebeliso ea joala e fetang 20 g / ka letsatsi e ka amahanngoa le kotsi e eketsehileng ea lefu la mofetše oa matsoele. (Yun-Jiu Gou et al, Pele ea Kankere ea Pac Pac ea Asia, 2013)
2. Tlhatlhobo ea meta e kenyellelitseng tlhaiso-leseling ea lipotso tsa maqhubu a lijo ho tsoa liphuputsong tse 6 tse lebelletsoeng le linyeoe tse 200 tsa kankere ea matsoele tse tsoang Canada, Netherlands, Sweden le United States li fumane hore tšebeliso ea joala e kanna ea amahanngoa le keketseho e lekanang ea kankere ea matsoele. basali. Phuputso e boetse e khothalelitse hore har'a basali ba noang joala khafetsa, ho fokotsa tšebeliso ea joala ho ka thusa ho fokotsa kotsi ea mofetše oa matsoele. (SA Smith-Warner le al, JAMA, 1998)

Liphuputso tsena li bontša hore ho noa joala haholo ho ka baka mofetše oa matsoele. (V Bagnardi, Br J Cancer., 2015)

Tšebeliso ea joala e ka baka mofetše oa Colorectal 

1. Tlhatlhobo ea meta e entsoeng ke bafuputsi ba Zhejiang University School of Public Health, China ba sebelisa tlhaiso-leseling e fumanoeng lipatlisisong tsa lingoliloeng ho PubMed le Web of Science ho tloha ka Pherekhong 1966 ho isa ka Phuptjane 2013 e neng e kenyelletsa lithuto tse 9 tsa sehlopha se fumane hore ho noa joala haholo ho tsamaellanang le ~ 50 g / letsatsi la ethanol le ka eketsa menyetla ea ho bolaoa ke mofets'e ka 'mala. (Shaofang Cai et al, Prev Cancer Prev., 2014)
2. Tlhatlhobo e ngoe e ts'oanang ea tlhaiso-leseling e tsoang ho sehlopha sa 27 le lithuto tsa taolo ea linyeoe tse 34 tse fumanoeng ka patlo ea lingoliloeng tse hatisitsoeng li fumane hore ho noa joala> seno sa 1 / letsatsi ho ka amahanngoa le kotsi e kholo ea mofetše oa 'mala. (V Fedirko et al, Ann Oncol., 2011)
3. Tlhatlhobo ea meta ea lithuto tse 16 tse kenyelletsang linyeoe tsa mofets'e tse 14,276 tse hlakileng le taolo ea 15,802 ho tsoa ho li-5 tsa taolo ea linyeoe le lithuto tse 11 tsa taolo ea linyeoe li fumane hore ho noa haholo (ho feta lino tse tharo / letsatsi) ho ka amahanngoa le keketseho e kholo ea kotsi ea kankere e khanyang. (Sarah McNabb, Kankere ea Int J., 2020)

Liphuputso tsena li fana ka maikutlo a hore ho noa joala haholo ho ka baka mofetše oa mebala. (Harindra Jayasekara, Joala joala. 2016; V Bagnardi, Br J Cancer., 2015)

Tšebeliso ea joala e ka baka mofetše oa sebete 

1. Tlhatlhobo ea meta e sebelisitsoeng ho sebelisoa lintlha tse fumanoeng lipatlisisong tsa lingoliloeng ho PubMed ho fihlela ka Mots'eanong 2014 e kenyelletsang lingoliloeng tse 112 tse fumanoeng hore seno se le seng sa joala ka letsatsi (~ 12 g / ka letsatsi) se ka amahanngoa le kotsi e kholo ea makhetlo a 1.1 ea mofets'e oa sebete. Tlhahlobo e boetse e fana ka maikutlo a litlamorao tsa tšebeliso ea joala le lefu la sebete le lefu la tsoekere le kotsing ea mofetše oa sebete, leha ho le joalo, ba khothalelitse lithuto tse ling ho theha se tšoanang. (Shu-Chun Chuang et al, Cancer Causes Control., 2015)
2. Tlhatlhobo e tšoanang ea meta e sebelisitsoeng ho sebelisoa lintlha tse fumanoeng lipatlisisong tsa lingoliloeng ho PubMed le EMBASE ho fihlela ka Mmesa 2013 e kenyelletsang lingoloa tse 16 (li-cohorts tse 19) tse nang le linyeoe tsa liketsahalo tsa 4445 le lefu la 5550 ho tsoa mofetseng oa sebete, li fumane 46% e hakantsoeng e le kotsi ea kankere ea sebete bakeng sa 50 g ea ethanol ka letsatsi le 66% bakeng sa 100 g ka letsatsi. Tlhatlhobo ena e khothalelitse karolo e kotsi ea ho noa haholo (ho noa lino tse tahang tse tharo kapa ho feta ka letsatsi) mofetseng oa sebete le ho se kopane le ho noa ho itekanetseng.

Leha ho le joalo, lithuto tsena li boetse li fana ka maikutlo a hore ho noa joala haholo ho ka baka mofetše oa sebete. (V Bagnardi, Br J Kankere., 2015)

Tšebeliso ea joala e ka baka mofetše oa Gastric 

1. Tlhatlhobo e hlophisehileng ea meta e sebelisitsoeng ho sebelisoa lintlha tse fumanoeng ho tsoa lipatlisisong tsa Medline ho kenyelletsa le lithuto tse 10 tse fumanoeng hore tšebeliso e phahameng ea joala e kanna ea amahanngoa le kotsi e phahameng ea mofetše oa mpeng. Phuputso e boetse e netefalitse hore ho noa joala ka mokhoa o itekanetseng le ho noa joala haholo ho ka amahanngoa le kotsi e kholo ea mofetše oa mpeng. (Ke Ma et al, Med Sci Monit., 2017)
2. Tlhatlhobo ea meta ea lithuto tse 11 tsa sehlopha se fumanoeng ho tsoa lipatlisisong tsa database tsa PUBMED le Ichushi hammoho le patlo e entsoeng ka letsoho ho baahi ba Japane e fumane hore lithutong tse 9 ho tse 11 ho ne ho se na kamano lipakeng tsa ho noa joala le mofetše oa mpeng, leha ho le joalo, phuputso e le 'ngoe e bontšitse kotsi e kholo ea gastric mofets'e ho banna ba nang le joala bo bongata. Bafuputsi ba khothalelitse lithuto tse ling ka baahi ba Majapane ho netefatsa se tšoanang. (Taichi Shimazu et al, Jpn J Clin Oncol., 2008)

Ho noa haholo ho kenyelletsa ho noa lino tse tahang tse tharo kapa ho feta ka letsatsi ho ka baka mofetše oa ka mpeng.

Tšebeliso ea joala le liphio, Kotsi ea Kankere ea Prostate le ea Lung

Kankere ea Liphio

1. Tlhatlhobo ea tlhaiso-leseling ea tlhaiso-leseling e fumanoeng ho tsoa lipapatsong tsa PubMed, EMBASE, le MEDLINE ho fihlela ka Phato 2011 e kenyelletsang lithuto tse 20 tsa taolo ea linyeoe, lithuto tsa sehlopha sa 3, le tlhahlobo e kopaneng ea lithuto tsa sehlopha e fumane hore, ho makatsang ke hore ho noa joala ho ka amahanngoa le kotsi e tlase Kankere ea renal ea sele, ka tšebeliso e itekanetseng e fanang ka ts'ireletso le ts'ebeliso e phahameng ha e fane ka melemo e meng. (DY Song et al, Br J Cancer. 1) Phuputso e khothalelitse hore ho noa joala ka mokhoa o itekanetseng ho ka thusa ho fokotsa kotsi ea mofetše oa lisele tsa renal.

2. Leha ho le joalo, tlhaiso-leseling e ngoe ea tlhaiso-leseling e neng e kenyelletsa lithuto tse 20 tsa ho shebella (4 cohort, 1 pooled and 15 case-control) e fumanoeng lipatlisisong tsa lingoliloeng ho database tsa PubMed le EMBASE ho fihlela ka Pulungoana 2010 e fumane hore ho noa joala ka mokhoa o itekanetseng le ho tlola ho ka amahanngoa le kotsi e kholo ea mofetše oa sele ea renal.  

Ka kakaretso, kamano lipakeng tsa tšebeliso ea joala le mofetše oa liphio ha e tsejoe.

Kankere ea Prostate

Liphuputso tse ngata li boetse li hlahlobile kamano lipakeng tsa joala le kotsi ea mofetše oa senya. Leha ho le joalo, likhanyetsano tse tšoanang le tsona li fumanoe liphuputsong tsena tse amanang le kamano lipakeng tsa tšebeliso ea joala le kotsi ea mofetše oa senya. J Kankere Pele, 2016). 

Kankere ea Lung

Hore na ho noa joala ho baka kotsi e eketsehileng ea mofetše oa matšoafo le hona ha ho na bonnete. Le hoja phuputso e ’ngoe e ile ea fana ka maikutlo a hore “kotsi e khōloanyane ea matšoafo tsoaroa ke kankere e ne e amahanngoa le ho noa > kapa = 30 g joala / letsatsi ha ho bapisoa le ho se noe joala "(Jo L Freudenheim et al, Am J Clin Nutr., 2005), phuputso ea bobeli e bontšitse hore ha ho na kamano pakeng tsa ho noa joala le kotsi ea kankere ea matšoafo “le ka mohla” batsubi. (V Bagnardi et al, Ann Oncol., 2011)

Ho hlokahala lithuto tse ling ho etsa qeto ea hore na ts'ebeliso ea joala e baka mofetše oa matšoafo.

Tšebeliso ea joala le kotsi ea li-Cancer tsa Endometrial le Ovarian

Lithuto tse ngata tsa tlhahlobo ea meta li hlahlobile kamano lipakeng tsa tšebeliso ea joala le endometrial tsoaroa ke kankere. Leha ho le joalo, liphuputso ha lia ka tsa fumana likamano tsa bohlokoa pakeng tsa tse peli. Tse ngata tsa liphuputso tsena li boetse li fana ka maikutlo a hore liphello li ne li tšoana ho sa tsotellehe mofuta oa seno se tahang. (Quan Zhou et al, Arch Gynecol Obstet., 2017; Qingmin Sun et al, Asia Pac J Clin Nutr. 2011)

Tlhatlhobo ea litlhahlobo tsa tlhaiso-leseling e fumanoeng lipatlisisong tsa lingoliloeng ho PubMed ho fihlela ka Loetse 2011 e kenyelletsang lithuto tse 27 tsa ho shebella, tseo 23 e neng e le lithuto tsa taolo ea linyeoe, lithuto tsa sehlopha sa 3 le tlhahlobo e le 'ngoe e kopaneng ea lithuto tsa sehlopha sa sehlopha, ho kenyeletsoa kakaretso ea linyeoe tsa mofets'e tsa mahe a bomme a 16,554. , ha ea ka ea fumana kamano lipakeng tsa tšebeliso ea joala le kotsi ea mofetše oa mahe a bomme.

fihlela qeto e

Liphuputso tse ngata le litlhahlobo tsa meta li bontša hore ho noa joala ho phahamisa kotsi ea mefuta e sa tšoaneng ea kankere e kang kankere ea hlooho le molala ho akarelletsa le mofetše oa molomo le oa pharyngeal, kankere ea 'metso, kankere ea qoqotho, kankere ea larynx; kankere ea mala; kankere ea sebete le kankere ea matsoele. Leha ho le joalo, tlhahlobo ea meta ea lithuto tse fapaneng e bontšitse hore tšebeliso ea joala e kanna ea se amahane le kankere joalo ka mofets'e oa endometrial le ovary, empa bakeng sa mefuta e meng ea mofetše joalo ka mofetše oa matšoafo le oa tšoelesa ea senya, liphuputso ha li na bonnete. Leha ho le joalo, le hoja ho sa hlaka hore na joala bo baka kankere ea matšoafo, ho molemo ho qoba tai e le hore u lule u phetse hantle.

Kaholimo ho lithuto le bopaki ba mahlale bo bontša ka ho hlaka tlhoko ea ho fokotsa kapa ha ho khonahala, emisa / qoba tšebeliso ea joala ho fokotsa kotsi ea mofetše. Ha re noa joala bo fokolang, re tla ba le bokamoso bo botle!

Lijo tseo u li jang le tse u tlatsetsang ke qeto eo u e etsang. Qeto ea hau e lokela ho kenyelletsa ho nahanisisa ka liphetoho tsa liphatsa tsa lefutso tsa mofetše, e leng mofetše, kalafo e tsoelang pele le litlatsetso, ho kula hohle, leseli la bophelo, boima, bolelele le litloaelo.

Morero oa phepo e nepahetseng bakeng sa mofets'e ho tsoa addon ha o ea ipapisa le lipatlisiso tsa inthanete. E iketsetsa liqeto bakeng sa hau e ipapisitse le mahlale a limolek'hule a kentsoeng tšebetsong ke bo-rasaense ba rona le lienjineri tsa software. Ho sa tsotelehe hore na o tsotella ho utloisisa metheo ea limolek'hule kapa che - bakeng sa moralo oa phepo ea mofets'e kutloisiso ea hlokahala.

Qala hona joale ka moralo oa hau oa phepo e nepahetseng ka ho araba lipotso lebitsong la mofetše, phetoho ea lefutso, kalafo e tsoelang pele le litlatsetso, ho kula hohle, litloaelo, mokhoa oa bophelo, sehlopha sa lilemo le bong.

Bakuli ba mofets'e hangata ba tlameha ho sebetsana le tse fapaneng litla-morao tsa chemotherapy tse amang boleng ba bona ba bophelo le ho batla mekhoa e meng ea kalafo ea mofets'e. Ho nka phepo e nepahetseng le litlatsetso ho latela maikutlo a mahlale (ho qoba ho inahanela le ho khetha ka mokhoa o sa reroang) ke pheko ea tlholeho bakeng sa mofets'e le litla-morao tse amanang le kalafo

• Lijo tsa Tlhaho / Lisebelisoa tse ka bakang / tsa senya Kankere
• Meroho ea Cruciferous Inake & Kotsi ea Kankere
• Na Tšebeliso ea Tee e ka Eketsa Kotsi ea Kankere e Colorectal?
• Hobaneng ho le kotsi hore bakuli ba mofets'e ba noe lihlahisoa tsa litlama ka mokhoa o lumellanang le chemotherapy ea bona?
• Ho noa kofi le ho pholoha ho bakuli ba nang le mofetše o hlakileng