Храна за аднексални карцином коже!

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Foods for Skin Adnexal Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Skin Adnexal Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Skin Adnexal Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Skin Adnexal Carcinoma?

For example does it matter if vegetable New Zealand Spinach is consumed more compared to Garland Chrysanthemum? Does it make any difference if fruit Plains Prickly Pear is preferred over Bilberry? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Adzuki Bean over Lima Bean. And if what I eat matters – then how does one identify foods which are recommended for Skin Adnexal Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Skin Adnexal Carcinoma!

Препоруке за храну можда нису исте за све и могу се разликовати чак и за исту дијагнозу и генетски ризик.

Сва храна (поврће, воће, орашасти плодови, семенке, махунарке, уља итд.) и додаци исхрани се састоје од више од једног активног молекуларног састојка или биоактивних састојака у различитим пропорцијама и количинама. Сваки активни састојак има јединствен механизам деловања – који може бити активација или инхибиција различитих биохемијских путева. Једноставно речено намирнице и суплементи који се препоручују су они који не изазивају повећање молекуларних покретача рака, већ их смањују. У супротном, те намирнице не би требало препоручити. Храна садржи више активних састојака – стога када процењујете храну и суплементе морате да узмете у обзир утицај свих активних састојака кумулативно, а не појединачно.

For example Plains Prickly Pear contains active ingredients Curcumin, Formononetin, Delphinidin, Phloretin, Caffeine. And Bilberry contains active ingredients Quercetin, Curcumin, Resveratrol, Formononetin, Delphinidin and possibly others.

A common mistake made when deciding and choosing foods to eat for Skin Adnexal Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Skin Adnexal Carcinoma.

ДА – ИЗБОР ХРАНЕ БИТАН ЗА РАК. ОДЛУКЕ О ИСХРАНИ МОРАЈУ УЗИМАТИ У ОБЗИР СВЕ АКТИВНЕ САСТОЈКЕ ХРАНЕ.

Skills Needed for Nutrition Personalization for Skin Adnexal Carcinoma?

Personalized nutrition for cancers like Skin Adnexal Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this веза.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Skin Adnexal Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

МИНИМАЛНО ЗНАЊЕ ПОТРЕБНО ЗА ПЕРСОНАЛИЗАЦИЈУ У ИСХРАНИ ЗА РАКА СУ: БИОЛОГИЈА РАКА, НАУКА О ХРАНИ, ЛЕЧЕЊЕ РАКА И ГЕНЕТИКА.

Characteristics of cancers like Skin Adnexal Carcinoma

All cancers like Skin Adnexal Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Skin Adnexal Carcinoma. Biochemical pathways like RAS-RAF Signaling, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Skin Adnexal Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Skin Adnexal Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Skin Adnexal Carcinoma when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Извори попут цБиоПортал и многи други пружају анонимизоване податке о пацијентима који су репрезентативни за популацију из клиничких испитивања за све индикације рака. Ови подаци се састоје од детаља студије клиничког испитивања као што су величина узорка/број пацијената, старосне групе, пол, етничка припадност, третмани, место тумора и било које генетске мутације.

CARD11, TERT, KIT, IGF1R and AXL are the top ranked reported genes for Skin Adnexal Carcinoma. CARD11 is reported in 50.0 % of the representative patients across all clinical trials. And TERT is reported in 50.0 %. The combined population patient data cover ages from to . 33.3 % of the patient data are identified as men. The Skin Adnexal Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

ИЗБОР ИСХРАНА ТРЕБА ДА СЕ ПОГОДАВА СА ПОТПИСОМ ОД РАКА СВАКЕ ПОЈЕДИНЕ.

Food and Supplements for Skin Adnexal Carcinoma

За пацијенте са раком

Пацијенти са раком на лечењу или на палијативном збрињавању морају да донесу одлуке о храни и суплементима – за потребне калорије у исхрани, за управљање било којим нежељеним ефектима лечења, као и за побољшано управљање раком. Сва биљна храна није једнака, а одабир и давање приоритета намирницама које су персонализоване и прилагођене текућем лечењу рака је важно и компликовано. Ево неколико примера који пружају смернице за доношење одлука о исхрани.

Изаберите поврће НОВОЗЕЛАНДСКИ ШПАНАТ или ХРИЗАНТЕМУ ВЕНЦА?

Vegetable New Zealand Spinach contains many active ingredients or bioactives such as Quercetin, Curcumin, Formononetin, Delphinidin, Phloretin. These active ingredients manipulate various biochemical pathways like DNA Repair, Angiogenesis, Microtubule Dynamics and MYC Signaling and others. New Zealand Spinach is recommended for Skin Adnexal Carcinoma when ongoing cancer treatment is Radiation. This is because New Zealand Spinach modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Garland Chrysanthemum are Curcumin, Formononetin, Delphinidin, Phloretin, Catechol. These active ingredients manipulate various biochemical pathways like Notch Signaling and NFKB Signaling and others. Garland Chrysanthemum is not recommended for Skin Adnexal Carcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE NEW ZEALAND SPINACH IS RECOMMENDED OVER GARLAND CHRYSANTHEMUM FOR Skin Adnexal Carcinoma AND TREATMENT Radiation.

Choose Fruit BILBERRY or PLAINS PRICKLY PEAR?

Fruit Bilberry contains many active ingredients or bioactives such as Quercetin, Curcumin, Resveratrol, Formononetin, Delphinidin. These active ingredients manipulate various biochemical pathways like DNA Repair, Epithelial to Mesenchymal Transition, Angiogenesis and Microtubule Dynamics and others. Bilberry is recommended for Skin Adnexal Carcinoma when ongoing cancer treatment is Radiation. This is because Bilberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Plains Prickly Pear are Curcumin, Formononetin, Delphinidin, Phloretin, Caffeine. These active ingredients manipulate various biochemical pathways like DNA Repair, Epithelial to Mesenchymal Transition and NFKB Signaling and others. Plains Prickly Pear is not recommended for Skin Adnexal Carcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT BILBERRY IS RECOMMENDED OVER PLAINS PRICKLY PEAR FOR Skin Adnexal Carcinoma AND TREATMENT Radiation.

Изаберите НУТ БУТЕРНУТ или ЕВРОПСКИ КЕСТЕН?

Butternut contains many active ingredients or bioactives such as Curcumin, Formononetin, Delphinidin, Phloretin, Caffeine. These active ingredients manipulate various biochemical pathways like DNA Repair, Angiogenesis, Microtubule Dynamics and MYC Signaling and others. Butternut is recommended for Skin Adnexal Carcinoma when ongoing cancer treatment is Radiation. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in European Chestnut are Quercetin, Ellagic Acid, Curcumin, Formononetin, Delphinidin. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition and NFKB Signaling and others. European Chestnut is not recommended for Skin Adnexal Carcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Skin Adnexal Carcinoma AND TREATMENT Radiation.

За појединце са генетским ризиком од рака

The question asked by individuals who have genetic risk of Skin Adnexal Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Изаберите поврће КАРФИОЛ или ЦАРДООН?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Formononetin, Lupeol, Isoliquiritigenin, Daidzein. These active ingredients manipulate various biochemical pathways like Apoptosis, P53 Signaling, MAPK Signaling and Cell Cycle Checkpoints and others. Cauliflower is recommended for risk of Skin Adnexal Carcinoma when associated genetic risk is AXL. This is because Cauliflower increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Cardoon are Apigenin, Curcumin, Formononetin, Myricetin, Lycopene. These active ingredients manipulate various biochemical pathways like NFKB Signaling, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics and others. Cardoon is not recommended when risk of Skin Adnexal Carcinoma when associated genetic risk is AXL because it increases the signature pathways of it.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER CARDOON FOR AXL GENETIC RISK OF CANCER.

Изаберите воће ЦРВЕНУ МАЛИНУ или ПУММЕЛО?

Fruit Red Raspberry contains many active ingredients or bioactives such as Ellagic Acid, Quercetin, Curcumin, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like P53 Signaling, EPHRIN Signaling, MAPK Signaling and Cell Cycle Checkpoints and others. Red Raspberry is recommended for risk of Skin Adnexal Carcinoma when associated genetic risk is AXL. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Quercetin, Curcumin, Formononetin, Lycopene. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and NFKB Signaling and others. Pummelo is not recommended when risk of Skin Adnexal Carcinoma when associated genetic risk is AXL because it increases the signature pathways of it.

ВОЋЕ ЦРВЕНЕ МАЛИНЕ ПРЕПОРУЧУЈЕ СЕ ПРЕКО ПУММЕЛА ЗА АКСЛ ГЕНЕТСКИ РИЗИК ОД РАКА.

Изаберите ЦРНИ ОРАХ или индијски орах?

Black Walnut contains many active ingredients or bioactives such as Apigenin, Ellagic Acid, Quercetin, Curcumin, Formononetin. These active ingredients manipulate various biochemical pathways like P53 Signaling, MAPK Signaling, Cell Cycle Checkpoints and MYC Signaling and others. Black Walnut is recommended for risk of Skin Adnexal Carcinoma when associated genetic risk is AXL. This is because Black Walnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Cashew Nut are Quercetin, Curcumin, Formononetin, Myricetin, Lupeol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics and others. Cashew Nut is not recommended when risk of Skin Adnexal Carcinoma when associated genetic risk is AXL because it increases the signature pathways of it.

BLACK WALNUT IS RECOMMENDED OVER CASHEW NUT FOR AXL GENETIC RISK OF CANCER.

У закључку

Foods and Supplements chosen are important decisions for cancers like Skin Adnexal Carcinoma. Skin Adnexal Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Skin Adnexal Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like New Zealand Spinach contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Skin Adnexal Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

Референце

• Мск Импацт 2017
• Мутацијски пејзаж метастатског рака откривен из проспективног клиничког секвенцирања 10,000 пацијената.
• Превентивни ефекти бутирне киселине, никотинамида, калцијум глукарата сами или у комбинацији током туморигенезе коже миша изазване 7-диметилбенз (а) антраценом путем модулације К-Рас-ПИ12К-АКТ пута и повезаних микро РНК.
• Хлорогена киселина инхибира пролиферацију и индукује апоптозу у А498 људским ћелијама рака бубрега путем инактивације ПИ3К/Акт/мТОР сигналног пута.
• Рецептор ретиноичне киселине β је побољшао ефекат β-каротена матичних ћелија против рака тако што је смањио експресију делта-лике 1 хомолога у ћелијама хуманог неуробластома.
• Ефекти и значај формононетина на нивое експресије ХИФ-1α и ВЕГФ у ткиву рака грлића материце код миша.
• Паедериа фоетида индукује антиканцерогену активност модулацијом ензима за модификацију хроматина и мењањем експресије гена проинфламаторног цитокина у људским ћелијама рака простате.
• Брасинин инхибира СТАТ3 сигнални пут кроз модулацију експресије ПИАС-3 и СОЦС-3 и сензибилизира ксенотрансплантат хуманог рака плућа код голих мишева на паклитаксел.
• Гераниол, компонента биљних етеричних уља, сензибилизира људске ћелије рака дебелог црева на третман са 5-флуороурацилом.