Храна за олигоастроцитом!

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Foods for Oligoastrocytoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Oligoastrocytoma, a brain tumor that contains both astrocytic and oligodendroglial components, is classified by grades, with grade 2 being less aggressive compared to grades 3 and 4. The pathology outlines and histology of oligoastrocytoma are key in determining its grade and subsequent treatment plan. Radiological imaging plays a crucial role in the diagnosis, which is categorized under the ICD-10 coding system. The survival rate and prognosis of oligoastrocytoma vary depending on its grade; grade 3 oligoastrocytoma has a lower survival rate compared to grade 2, and the life expectancy decreases further with grade 4. Treatment typically involves a combination of surgery, radiation, and chemotherapy, tailored to the tumor’s characteristics. Oligoastrocytoma can be cancerous, with its nature ranging from benign in lower grades to malignant in higher grades. Understanding the differences between oligoastrocytoma and similar tumors like glioblastoma and oligodendroglioma is essential for accurate diagnosis and effective management.

For Oligoastrocytoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Oligoastrocytoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Oligoastrocytoma?

For example does it matter if vegetable Carrot is consumed more compared to White Cabbage? Does it make any difference if fruit Abiyuch is preferred over Blackberry? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Cowpea over Common Bean. And if what I eat matters – then how does one identify foods which are recommended for Oligoastrocytoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Oligoastrocytoma!

Препоруке за храну можда нису исте за све и могу се разликовати чак и за исту дијагнозу и генетски ризик.

Сва храна (поврће, воће, орашасти плодови, семенке, махунарке, уља итд.) и додаци исхрани се састоје од више од једног активног молекуларног састојка или биоактивних састојака у различитим пропорцијама и количинама. Сваки активни састојак има јединствен механизам деловања – који може бити активација или инхибиција различитих биохемијских путева. Једноставно речено намирнице и суплементи који се препоручују су они који не изазивају повећање молекуларних покретача рака, већ их смањују. У супротном, те намирнице не би требало препоручити. Храна садржи више активних састојака – стога када процењујете храну и суплементе морате да узмете у обзир утицај свих активних састојака кумулативно, а не појединачно.

For example Abiyuch contains active ingredients Catechol, Curcumin, Apigenin, Daidzein, Caffeine. And Blackberry contains active ingredients Cinnamaldehyde, Ellagic Acid, Linalool, Myricetin, Quercetin and possibly others.

A common mistake made when deciding and choosing foods to eat for Oligoastrocytoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Oligoastrocytoma.

ДА – ИЗБОР ХРАНЕ БИТАН ЗА РАК. ОДЛУКЕ О ИСХРАНИ МОРАЈУ УЗИМАТИ У ОБЗИР СВЕ АКТИВНЕ САСТОЈКЕ ХРАНЕ.

Skills Needed for Nutrition Personalization for Oligoastrocytoma?

Personalized nutrition for cancers like Oligoastrocytoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this веза.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Oligoastrocytoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

МИНИМАЛНО ЗНАЊЕ ПОТРЕБНО ЗА ПЕРСОНАЛИЗАЦИЈУ У ИСХРАНИ ЗА РАКА СУ: БИОЛОГИЈА РАКА, НАУКА О ХРАНИ, ЛЕЧЕЊЕ РАКА И ГЕНЕТИКА.

Characteristics of cancers like Oligoastrocytoma

All cancers like Oligoastrocytoma can be characterized by a unique set of biochemical pathways – the signature pathways of Oligoastrocytoma. Biochemical pathways like Hypoxia, Notch Signaling, Oncogenic Cancer Epigenetics, Energy Metabolism are part of the signature definition of Oligoastrocytoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Oligoastrocytoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Oligoastrocytoma when taking cancer treatment Procarbazine, and some foods and supplements are not recommended.

Извори попут цБиоПортал и многи други пружају анонимизоване податке о пацијентима који су репрезентативни за популацију из клиничких испитивања за све индикације рака. Ови подаци се састоје од детаља студије клиничког испитивања као што су величина узорка/број пацијената, старосне групе, пол, етничка припадност, третмани, место тумора и било које генетске мутације.

IDH1, ATRX, ABL1, ARID2 and ASXL1 are the top ranked reported genes for Oligoastrocytoma. IDH1 is reported in 100.0 % of the representative patients across all clinical trials. And ATRX is reported in 50.0 %. The combined population patient data cover ages from to . 50.0 % of the patient data are identified as men. The Oligoastrocytoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

ИЗБОР ИСХРАНА ТРЕБА ДА СЕ ПОГОДАВА СА ПОТПИСОМ ОД РАКА СВАКЕ ПОЈЕДИНЕ.

Food and Supplements for Oligoastrocytoma

За пацијенте са раком

Пацијенти са раком на лечењу или на палијативном збрињавању морају да донесу одлуке о храни и суплементима – за потребне калорије у исхрани, за управљање било којим нежељеним ефектима лечења, као и за побољшано управљање раком. Сва биљна храна није једнака, а одабир и давање приоритета намирницама које су персонализоване и прилагођене текућем лечењу рака је важно и компликовано. Ево неколико примера који пружају смернице за доношење одлука о исхрани.

Choose Vegetable CARROT or WHITE CABBAGE?

Vegetable Carrot contains many active ingredients or bioactives such as Catechol, Curcumin, Apigenin, Isorhamnetin, Daidzein. These active ingredients manipulate various biochemical pathways like Notch Signaling, Hypoxia and PI3K-AKT-MTOR Signaling and others. Carrot is recommended for Oligoastrocytoma when ongoing cancer treatment is Procarbazine. This is because Carrot modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Procarbazine.

Some of the active ingredients or bioactives in vegetable White Cabbage are Catechol, Curcumin, Daidzein, Cinnamaldehyde, Benzyl Isothiocyanate. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and others. White Cabbage is not recommended for Oligoastrocytoma when ongoing cancer treatment is Procarbazine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CARROT IS RECOMMENDED OVER WHITE CABBAGE FOR Oligoastrocytoma AND TREATMENT Procarbazine.

Choose Fruit BLACKBERRY or ABIYUCH?

Fruit Blackberry contains many active ingredients or bioactives such as Cinnamaldehyde, Ellagic Acid, Linalool, Myricetin, Quercetin. These active ingredients manipulate various biochemical pathways like Hypoxia and PI3K-AKT-MTOR Signaling and others. Blackberry is recommended for Oligoastrocytoma when ongoing cancer treatment is Procarbazine. This is because Blackberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Procarbazine.

Some of the active ingredients or bioactives in fruit Abiyuch are Catechol, Curcumin, Apigenin, Daidzein, Caffeine. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and others. Abiyuch is not recommended for Oligoastrocytoma when ongoing cancer treatment is Procarbazine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT BLACKBERRY IS RECOMMENDED OVER ABIYUCH FOR Oligoastrocytoma AND TREATMENT Procarbazine.

Изаберите НУТ БУТЕРНУТ или ЕВРОПСКИ КЕСТЕН?

Butternut contains many active ingredients or bioactives such as Catechol, Apigenin, Curcumin, Daidzein, Cinnamaldehyde. These active ingredients manipulate various biochemical pathways like Hypoxia and PI3K-AKT-MTOR Signaling and others. Butternut is recommended for Oligoastrocytoma when ongoing cancer treatment is Procarbazine. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Procarbazine.

Some of the active ingredients or bioactives in European Chestnut are Catechol, Curcumin, Apigenin, Daidzein, Cinnamaldehyde. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and others. European Chestnut is not recommended for Oligoastrocytoma when ongoing cancer treatment is Procarbazine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Oligoastrocytoma AND TREATMENT Procarbazine.

За појединце са генетским ризиком од рака

The question asked by individuals who have genetic risk of Oligoastrocytoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable CELERY STALKS or CHICORY?

Vegetable Celery Stalks contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like DNA Repair, Hypoxia, P53 Signaling and Glutathione Metabolism and others. Celery Stalks is recommended for risk of Oligoastrocytoma when associated genetic risk is ABL1. This is because Celery Stalks increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Chicory are Curcumin, Lupeol, Daidzein, Beta-sitosterol, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair and Glutathione Metabolism and others. Chicory is not recommended when risk of Oligoastrocytoma when associated genetic risk is ABL1 because it increases the signature pathways of it.

VEGETABLE CELERY STALKS IS RECOMMENDED OVER CHICORY FOR ABL1 GENETIC RISK OF CANCER.

Изаберите Фруит БАЕЛ или ГРЕЈПФРУИТ?

Fruit Bael contains many active ingredients or bioactives such as Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Auraptene. These active ingredients manipulate various biochemical pathways like Apoptosis, Hypoxia, P53 Signaling and MYC Signaling and others. Bael is recommended for risk of Oligoastrocytoma when associated genetic risk is ABL1. This is because Bael increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Grapefruit are Curcumin, Lupeol, Daidzein, Beta-sitosterol, Lycopene. These active ingredients manipulate various biochemical pathways like DNA Repair and Glutathione Metabolism and others. Grapefruit is not recommended when risk of Oligoastrocytoma when associated genetic risk is ABL1 because it increases the signature pathways of it.

FRUIT BAEL IS RECOMMENDED OVER GRAPEFRUIT FOR ABL1 GENETIC RISK OF CANCER.

Choose Nut COLORADO PINYON or JAPANESE CHESTNUT?

Colorado Pinyon contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like DNA Repair, Apoptosis, P53 Signaling and Cell Cycle Checkpoints and others. Colorado Pinyon is recommended for risk of Oligoastrocytoma when associated genetic risk is ABL1. This is because Colorado Pinyon increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Japanese Chestnut are Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like DNA Repair and Glutathione Metabolism and others. Japanese Chestnut is not recommended when risk of Oligoastrocytoma when associated genetic risk is ABL1 because it increases the signature pathways of it.

COLORADO PINYON IS RECOMMENDED OVER JAPANESE CHESTNUT FOR ABL1 GENETIC RISK OF CANCER.

У закључку

Foods and Supplements chosen are important decisions for cancers like Oligoastrocytoma. Oligoastrocytoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Oligoastrocytoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Carrot contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Oligoastrocytoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

Референце

• Мск Импацт 2017
• Мутацијски пејзаж метастатског рака откривен из проспективног клиничког секвенцирања 10,000 пацијената.
• Делфинидин инхибира ангиогенезу супресијом експресије ХИФ-1α и ВЕГФ у А549 ћелијама рака плућа.
• Шикимична киселина промовише пролиферацију ћелија рака дојке позитивних на естрогенски рецептор(ЕР) путем активације НФ-κБ сигнализације.
• Молекуларна доцкинг анализа цианиданола из Гинкго билобе са циљем рака дојке ХЕР2+.
• Еугенол ограничава популацију матичних ћелија рака деградацијом β-катенина путем фосфорилације Сер37 на Н-терминалном нивоу – експерименталном проценом ин виво и ин витро.
• Паедериа фоетида индукује антиканцерогену активност модулацијом ензима за модификацију хроматина и мењањем експресије гена проинфламаторног цитокина у људским ћелијама рака простате.
• Функционална липидомика: Палмитинска киселина омета развој хепатоцелуларног карцинома модулацијом флуидности мембране и метаболизма глукозе.
• Лутеолин промовише апоптотичку ћелијску смрт преко регулације експресије Нрф2 помоћу ДНК деметилазе и интеракције Нрф2 са п53 у људским ћелијама рака дебелог црева.