Kansarkee ayaa ka faa'iidaysan doona in lagu daro 7-8-dihydroxyflavone cuntadooda?

Tilmaamaha

7-8-dihydroxyflavone waxaa si weyn loogu aqoonsaday faa'iidooyinkeeda caafimaad waxaana inta badan isticmaala bukaannada kansarka iyo kuwa halista ugu jira hidda-socodka. Hase yeeshee, badbaadada iyo waxtarka 7-8-dihydroxyflavone ee bukaannada kansarka waxay ku xiran tahay arrimo badan sida calaamadda kansarka, daaweynta kiimoterabiga, daaweynta kale, iyo hidde-sideyaasha burada. Ogaanshaha in qaar ka mid ah cuntooyinka iyo kaabisyada, sida bambeelmada iyo isbinaajka, laga yaabo inay si liidata ula falgalaan daawooyinka kansarka oo ay keenaan fal-celin xun waa muhiim.

Cuntadu waxay muhiim u tahay daaweynta kansarka sababtoo ah waxay saameyn kartaa natiijooyinka daaweynta. Bukaannada kansarku waa inay si taxadar leh u doortaan oo ku daraan cuntooyinka ku habboon iyo kaabista cuntadooda. Tusaale ahaan, 7-8-dihydroxyflavone waxay ka faa'iidaysan kartaa kuwa qaba Kansarka Unugyada Xubinta Xubinta Xubinta ee ku socota Mitomycin, laakiin waxaa laga yaabaa inaysan u fiicnayn bukaanada qaata Gemcitabine ee adenocarcinoma Primary Urachal. Intaa waxaa dheer, halka 7-8-dihydroxyflavone ay ka caawin karto shakhsiyaadka leh khatarta hidde-sidaha "CDKN2A", waxaa laga yaabaa in aan loo soo jeedin kuwa leh khatarta hidde ee kale "ASXL1". Shakhsiyeynta qorshayaasha cuntada ee ku salaysan caafimaadka, daawaynta, iyo hidaha waa lama huraan.

Fahamka in go'aan ka gaarista ku habboonaanta 7-8-dihydroxyflavone ee bukaanka kansarka u baahan yahay in la gaaryeelo waa muhiim. Qodobbada muhiimka ah sida nooca kansarka, hababka daawaynta, qurxinta hidda-socodka, khatarta hiddaha, da'da, miisaanka jidhka, iyo qaab nololeedka ayaa muhiim u ah go'aaminta haddii 7-8-dihydroxyflavone ay tahay doorashada habboon. Genetics iyo genomics, gaar ahaan, waa tixgelin muhiim ah. Maadaama arrimahan ay kobci karaan, waxaa lama huraan ah in si joogto ah dib loogu eego oo la waafajiyo doorashooyinka cuntada si loo waafajiyo isbeddelada xaaladda caafimaadka iyo daaweynta.

Gebagebadii, habka guud ee doorashada cuntada ayaa muhiim ah, iyadoo diiradda la saarayo saamaynta guud ee dhammaan qaybaha firfircoon ee cuntooyinka/kaabka sida 7-8-dihydroxyflavone halkii laga qiimayn lahaa qayb kasta oo firfircoon si gooni ah ama gebi ahaanba la iska indho-tiray. Aragtida ballaadhan waxay kobcinaysaa hab macquul ah oo cilmiyaysan oo loogu talagalay qorsheynta cuntada ee kansarka.

Dulmar Kooban

Isticmaalka cuntooyinka dhirta ku salaysan iyo waxyaalaha dheeriga ah, sida fiitamiinada, geedo yaryar, macdanta, probiotics, iyo supplements-ka gaarka ah ee kala duwan, ayaa ku soo badanaya bukaannada kansarka. Kaabayaashan waxaa loogu talagalay in lagu bixiyo uruurin sare oo ah maaddooyin firfircoon oo gaar ah, kuwaas oo qaar badan oo ka mid ah ay sidoo kale ku jiraan cuntooyin kala duwan. U fiirsashada iyo kala duwanaanta maaddooyinka firfircooni waxay ku kala duwan yihiin cuntooyinka oo dhan iyo kaabista. Cuntooyinka sida caadiga ah waxay bixiyaan noocyo kala duwan oo maaddooyin firfircoon ah laakiin xaddi hoose, halka kaabayaashu ay bixiyaan uruurin sare oo ah maaddooyin gaar ah.

Iyadoo la tixgalinayo shaqooyinka kala duwan ee sayniska iyo bayooloji ee walax kasta oo firfircoon heerka molecular, waxaa muhiim ah in lagu xisaabtamo saamaynta isku dhafan ee qaybahan marka la go'aaminayo cuntooyinka iyo kaabayaasha in la cuno iyo in kale.

Su'aasha muhiimka ah ayaa soo baxaysa: Ma ku daraa 7-8-dihydroxyflavone cuntadaada cunto ahaan ama kabitaan ahaan? Ma lagugula talinayaa inaad isticmaasho 7-8-dihydroxyflavone haddii aad leedahay cudurka kansarka ee la xidhiidha hidde-sidayaasha CDKN2A? Maxaa dhacaya haddii taa beddelkeeda khatartaada hidde-sidaha ay ka timid hidda-wadaha ASXL1? Faa'iido ma u leedahay in lagu daro 7-8-dihydroxyflavone cuntadaada haddii lagaa helo cudurka Urachal adenocarcinoma Primary, ama haddii cilad-sheegashadaadu tahay Kansarka Xubinta Xubinta Xubinta Xubinta Taranka? Waxaa intaa dheer, sidee loo hagaajin karaa isticmaalkaaga 7-8-dihydroxyflavone haddii lagugu daweynayo Mitomycin ama haddii qorshahaaga daawaynta uu ka wareego Mitomycin una wareego Gemcitabine? Waa lagama maarmaan in la aqoonsado in sheegashada fudud sida '7-8-dihydroxyflavone' ay tahay mid dabiici ah, markaa had iyo jeer waa faa'iido' ama '7-8-dihydroxyflavone waxay kordhisaa difaaca' kuma filna doorashada cuntada/kabka.

Intaa waxaa dheer, waa lagama maarmaan in dib loo qiimeeyo ku habboonaanta in lagu daro 7-8-dihydroxyflavone ee cuntadaada haddii ay jiraan isbeddelo ku yimaada habka daaweyntaada. Marka la soo koobo, marka aad go'aan ka gaadhayso ku darida cuntooyinka ama kaabayaasha sida 7-8-dihydroxyflavone ee cuntadaada faa'iidooyinkeeda, waa inaad tixgelisaa saamaynta guud ee bayoolaji ee dhammaan maaddooyinka, adoo tixgelinaya arrimo ay ka mid yihiin nooca kansarka, daawaynta gaarka ah ee aad tahay marada, saadaalin hidde, iyo doorashooyin hab nololeed.

Kansarka

Kansarka ayaa weli ah caqabad weyn oo dhanka caafimaadka ah, isagoo inta badan keena walaac baahsan. Si kastaba ha ahaatee, horumarradii ugu dambeeyay ayaa hagaajiyay natiijooyinka daaweynta, gaar ahaan iyada oo loo marayo hababka daawaynta shakhsi ahaaneed, hababka kormeerka aan fiicneyn ee dhiigga iyo shaybaarada candhuufta, iyo horumarinta immunotherapy. Ogaanshaha hore iyo ka-hortagga wakhtiga ayaa ahaa mid muhiim u ah si wax ku ool ah u saameeya natiijooyinka guud ee daaweynta.

Tijaabada hidde-sidaha waxay bixisaa ballan-qaad muhiim ah oo lagu qiimeeyo khatarta kansarka iyo u nuglaanta goor hore. Si kastaba ha ahaatee, shakhsiyaad badan oo qaba qoyska iyo hidde-sidaha kansarka, fursadaha faragelinta daweynta, xitaa la socodka joogtada ah, badanaa waa xaddidan yihiin ama midna. Marka lagu ogaado nooc gaar ah oo kansar ah, sida Kansarka xubinta taranka ee xubinta taranka ama Primary Urachal adenocarcinoma, xeeladaha daawaynta waxay u baahan yihiin in la habeeyo iyadoo lagu saleynayo hidda-wadaha qofka, heerka cudurka, iyo sidoo kale arrimaha sida da'da iyo jinsiga. "

Daawaynta ka dib, la socodka joogtada ahi waa lama huraan si loo ogaado calaamad kasta oo ah soo noqoshada kansarka iyo in lagu wargeliyo go'aamada xiga. Bukaanno badan oo kansar ah iyo kuwa halista ku jira ayaa inta badan raadsada talo ku saabsan ku daridda cuntooyinka qaarkood iyo kaabisyada cuntadooda, taas oo door muhiim ah ka ciyaarta guud ahaan habka go'aan qaadashada ee ku saabsan maaraynta caafimaadka.

Su'aasha muhiimka ah ayaa ah in la falanqeeyo khatarta hidda-socodka iyo ogaanshaha kansarka gaarka ah marka la go'aaminayo doorashooyinka cuntada, sida 7-8-dihydroxyflavone. Khatarta hidde-sidaha kansarka ee ka imanaysa isbeddelka CDKN2A ma leedahay saameyn la mid ah dariiqa kiimikaad ee isbeddelka ASXL1? Marka laga eego dhinaca nafaqeynta, khatarta la xiriirta kansarka xubinta taranka ee xubinta taranka ee xubinta taranka miyay la mid tahay adenocarcinoma Primary Urachal? Intaa waxaa dheer, tixgelinta cuntadu miyay la mid tahay kuwa qaata Gemcitabine iyo kuwa qaata Mitomycin? Tixgelintan ayaa muhiim u ah samaynta doorashooyin cunto oo xog-ogaal ah oo loogu talagalay shakhsiyaadka leh khataraha hidde-sidaha ee kala duwan iyo daaweynta kansarka.

7-8-dihydroxyflavone - Kaab nafaqo

Kaabista 7-8-dihydroxyflavone waxay ka kooban tahay noocyo kala duwan oo maaddooyin firfircoon ah, oo ay ku jiraan 7-8-dihydroxyflavone, mid kastaa wuxuu joogaa tirooyin kala duwan. Maaddooyinkaani waxay saameeyaan dariiqyada molecular, gaar ahaan Apoptosis, Cadaadiska Oxidative, Cadaadiska Endoplasmic Reticulum iyo Angiogenesis, kuwaas oo nidaamiya dhinacyada muhiimka ah ee kansarka ee heerka gacanta, sida koritaanka burada, faafidda, iyo dhimashada unugyada. Marka la eego saameyntan bayoolojiga ah, doorashada dheellitirka ku habboon sida 7-8-dihydroxyflavone, kaligii ama isku darka, waxay noqotaa go'aan muhiim ah marka la eego macnaha nafaqeynta kansarka. Markaad ka fekereyso isticmaalka 7-8-dihydroxyflavone kansarka, waa lagama maarmaan in la tixgeliyo arrimahan iyo hababka kala duwan. Tani waa sababta oo ah, oo la mid ah daaweynta kansarka, isticmaalka 7-8-dihydroxyflavone maaha go'aan caalami ah oo ku habboon dhammaan kansarrada laakiin wuxuu u baahan yahay in la shakhsiyeeyo.

Doorashada 7-8-dihydroxyflavone Supplements

Wax ka qabashada su'aasha 'Goorma ayaan iska ilaalinayaa 7-8-dihydroxyflavone marka la eego macnaha Kansarka' waa caqabad sababtoo ah jawaabtu waa mid si gaar ah loo gaar yeelay - waxay si fudud 'Ku xiran tahay!'. Si la mid ah sida daawaynta kansarku aanay waxtar ugu yeelan bukaan kasta, ku habboonaanta iyo badbaadada ama faa'iidooyinka 7-8-dihydroxyflavone way kala duwan yihiin iyadoo ku xidhan duruufaha shakhsi ahaaneed. Waxyaabaha ay ka midka yihiin nooca kansarka ee gaarka ah, saadaalinta hidde-sideyaasha, daawaynta hadda jirta, kaabisyada kale ee la qaato, hab-nololeedka, BMI, iyo xasaasiyad kasta ayaa dhammaantood door ka ciyaara go'aaminta in 7-8-dihydroxyflavone ay ku habboon tahay ama ay tahay in laga fogaado, iyada oo hoosta ka xariiqaysa muhiimadda. ee tixgelinta shakhsi ahaaneed ee go'aamadan oo kale.

1. Kaabayaasha 7-8-dihydroxyflavone ma ka faa'iidaysan doonaan Aasaaska Urachal adenocarcinoma Bukaan-socodka lagu daweynayo Gemcitabine?

Adenocarcinoma asaasiga ah ee Urachal waxaa lagu gartaa isbeddellada hidde-sidaha ee gaarka ah, kuwaas oo ah NFE2L2, TP53 iyo GNAS, kuwaas oo horseeda isbeddel ku yimaada dariiqyada biochemical, gaar ahaan Cadaadiska Oxidative, Isbaarooyinka difaaca jirka, Isbaarada wareegga unugyada, Apoptosis, G-protein-ku-xidhan yahay calaamadaynta Hormone. Waxtarka daaweynta kansarka, sida Gemcitabine, waxay ku xiran tahay habkeeda ficil ee waddooyinkan gaarka ah. Istaraatiijiyadda ugu habboon waxay ku lug leedahay in la waafajiyo ficilka daawaynta iyo waddooyinka kansarka, si loo hubiyo hab shakhsiyeed oo waxtar leh. Xaaladahan oo kale, ka fogaanshaha cuntooyinka ama dheellitirka nafaqeynta ee laga yaabo inay ka hortagaan saameynta daaweynta ama hoos u dhigta isku-habayntan ayaa muhiim ah. Tusaale ahaan, 7-8-dihydroxyflavone supplement, kaas oo saameeya Cadaadiska Oxidative, ma noqon karo doorashada saxda ah ee kiiska adenocarcinoma Primary Urachal marka la marinayo Gemcitabine. Tani waa sababta oo ah waxay ka sii dari kartaa horumarka cudurka ama waxay faragelin kartaa waxtarka daaweynta. Markaad dooranayso qorshaha nafaqeynta, waxaa muhiim ah in la tixgeliyo arrimo ay ka mid yihiin nooca kansarka, daawaynta socota, da'da, jinsiga, BMI, qaab nololeedka, iyo isbeddellada hidde-sidaha ee la yaqaan.

2. Kaabayaasha 7-8-dihydroxyflavone ma ka faa'iidaysan doonaan Bukaannada Kansarka Unugyada Squamous Cell ee Guska Aasaasiga ah

Kansarka xubinta taranka ee xubinta taranka waxaa lagu gartaa isbeddellada hidde-sidaha gaarka ah, sida ABRAXAS1, PIK3CB iyo NUP93, taas oo keenta isbeddel ku yimaada dariiqyada biochemical, gaar ahaan Apoptosis, Hematopoiesis iyo Inositol Fosfate Signaling. Waxtarka daaweynta kansarka, sida Mitomycin, waxaa lagu go'aamiyaa la falgalka waddooyinkan. Ujeeddadu waa in la hubiyo in daawadu ay si fiican ula jaanqaado dariiqooyinka keena kansarka, taasoo awood u siinaysa hab daawaynta shakhsi ahaaneed. Xaaladdan oo kale, cuntooyinka ama kaabeyaasha ku habboon daawaynta ama kor u qaadaysa isku-habayntan waa in la tixgeliyo. Tusaale ahaan, kabka 7-8-dihydroxyflavone waa ikhtiyaar macquul ah oo loogu talagalay kuwa qaba kansarka xubinta taranka ee aasaasiga ah ee loo maro Mitomycin. Tani waa sababta oo ah 7-8-dihydroxyflavone waxay saameyn ku yeelataa waddooyinka sida Apoptosis, taas oo joojin karta arrimaha keenaya Kansarka Unugyada Xubinta Xubinta Hore ama faa'iido u leh waxtarka Mitomycin.

3. Kaabayaasha 7-8-dihydroxyflavone ma yihiin kuwo badbaado u ah Shakhsiyaadka Caafimaadka qaba ee leh ASXL1 Mutation Associated Khatarta Hiddaha?

Shirkado kala duwan ayaa bixiya unugyada hidde-sidaha si ay u qiimeeyaan halista hidde-sidaha ee noocyada kala duwan ee kansarrada. Qaybahaan waxaa ka mid ah hidde-sideyaasha ku xiran naaska, ugxan-sidaha, uterineine-ka, qanjirka 'prostate', iyo kansarka mindhicirka. Tijaabinta hidde-sideyaashan waxay xaqiijin kartaa ogaanshaha cudurka waxayna ku wargelin kartaa daaweynta iyo xeeladaha maaraynta. Aqoonsiga kala duwanaanshaha sababa cudurku waxa uu sii caawin karaa baadhista iyo ogaanshaha qaraabada khatarta ku jira. Hidde-sidaha ASXL1 waxa caadi ahaan lagu daraa qaybahan si loo qiimeeyo khatarta kansarka.

Isbeddelka hiddasidaha ASXL1 wuxuu saameeyaa dariiqyada biochemical ama hababka, sida Cadaadiska Endoplasmic Reticulum Stress, Kansarka Oncogenic Epigenetics iyo Suppressive Histone Methylation, kuwaas oo si toos ah ama si dadban ugu lug leh wadista kansarka heerka molecular. Marka guddiga hidde-sidaha ay aqoonsadaan isbeddelka ASXL1 ee la xidhiidha khatarta sii kordheysa ee Myelomonocytic Leukemia, fikradda sayniska ayaa soo jeedinaysa ka fogaanshaha isticmaalka dheeriga ah ee 7-8-dihydroxyflavone. Tani waa sababta oo ah kaabista 7-8-dihydroxyflavone waxay saameyn ku yeelataa waddooyinka sida Endoplasmic Reticulum Stress, taas oo u horseedi karta saameyn xun marka la eego macnaha isbeddelka ASXL1 iyo xaaladaha kansarka ee la xiriira.

4. Kaabayaasha 7-8-dihydroxyflavone ma yihiin kuwo badbaado u ah Shakhsiyaadka Caafimaadka qaba ee leh CDKN2A Mutation Associated Khatarta Hiddaha?

CDKN2A waxay door muhiim ah ka ciyaartaa qiimaynta halista kansarka. Isbeddellada ku jira CDKN2A waxay carqaladayn karaan dariiqyada biochemical ee muhiimka ah, oo ay ku jiraan Angiogenesis, Isbaarada wareegga unugyada iyo wareegga unugyada, kuwaas oo saameeya horumarka kansarka. Haddii guddigaaga hidde-sidaha uu muujiyo isbeddellada CDKN2A ee la xidhiidha Kansarka Maqaarka, tixgeli inaad ku darto 7-8-dihydroxyflavone supplements qorshahaaga nafaqeynta. Kaabayaashan waxay si togan u saameyn karaan waddooyinka sida Angiogenesis, ka faa'iideysiga iyagoo siinaya taageero ku habboon shakhsiyaadka leh isbeddellada CDKN2A iyo welwelka caafimaadka ee la xiriira.

In Gabagabo

Labada shay ee ugu muhiimsan in la xasuusto waa in daawaynta kansarka iyo nafaqeynta aysan weligood isku mid ahayn qof walba. Nafaqada, oo ay ku jiraan cuntada iyo kaabisyada sida 7-8-dihydroxyflavone, waa qalab wax ku ool ah oo lagu xakameyn karo adiga markaad wajaheyso kansarka.

"Maxaan cunaa?" waa su'aasha ugu badan ee ay weydiiyaan bukaannada kansarka iyo kuwa halista ugu jira kansarka. Jawaabta saxda ah waa in ay ku xiran tahay arrimo ay ka mid yihiin nooca kansarka, hidde-sideyaasha burada, daawaynta hadda, xasaasiyadda, qaab nololeedka, iyo BMI.

Ka hel shakhsiyayntaada nafaqada ee kansarka addon adiga oo gujinaya xidhiidhka hoose oo ka jawaabaya su'aalaha ku saabsan nooca kansarka, daawaynta, qaab nololeedkaaga, xasaasiyadahaaga, da'da, iyo jinsigaaga.

tixraacyada

• Apoptosis induction ee unugyada leukemia bini'aadamka U937 by 7,8-dihydroxyflavone hydrate iyada oo loo marayo habaynta qoyska Bcl-2 ee borotiinka iyo dariiqa calaamadaynta MAPKs.
• 7,8-DHF daawaynta waxay keentaa muujinta Cyr61 si loo xakameeyo Cadaadiska ER ee Hypoxia ee Unugyada HK-2.
• cBioPortal ee Kansarka Genomics
• Sahaminta Isdhexgalka Molecular ee 7,8-Dihydroxyflavone iyo Ka-soo-saarkeeda oo leh TrkB iyo VEGFR2 Proteins.
• Daaweynta kansarku waxay qaabaysaa muuqaalka fayow ee hematopoiesis ee clonal.
• 7,8-Dihydroxyflavone waxay dhaqaajisaa Nrf2/HO-1 dariiqyada calaamadaha waxayna ka ilaalisaa osteoarthritis.
• Mitomycin C waxay xoojisaa apoptosis-ka TRAIL iyada oo loo marayo p53-ku-habaynta madax-bannaanida ee soo-dhoweynta dhimashada: caddaynta doorka c-Jun N-terminal kinase activation.
• Hababka looga gudbo iska caabbinta gudaha ee Gemcitabine ee Adenocarcinoma Ductal Pancreatic iyada oo loo marayo Modulation Redox.
• Muuqaalka is-beddelka ee kansarka dheef-shiid kiimikaadka ayaa shaaca ka qaaday isku xigxiga mustaqbalka ee bukaan-socodka ee 10,000 bukaan.