Cuntooyinka loogu talagalay Adenocarcinoma esophagogastric!

Hordhac

Cuntooyinka loogu talagalay Esophagogastric Adenocarcinoma waa in loo shakhsiyeeyo qof kasta oo waa in sidoo kale la qabsado marka daaweynta kansarka ama isbeddelka hidda-socodka burooyinka. Shakhsiyaynta iyo la qabsiga waa in ay tixgeliyaan dhammaan maaddooyinka firfircoon ama bioactives ee ku jira cuntooyinka kala duwan marka loo eego bayooloojiyada unugyada kansarka, genetics, daawaynta, xaaladaha qaab nololeedka iyo doorbidka cuntada. Sidaa darteed iyada oo nafaqadu ay tahay mid ka mid ah go'aamada aadka muhiimka u ah bukaanka kansarka iyo qofka khatarta ugu jira kansarka inuu sameeyo - sida loo doorto cuntooyinka uu cuno maaha hawl fudud.

Adenocarcinoma Esophagogastric miyay muhiim u tahay khudaarta, miraha, lawska, miraha la cuno?

Su'aasha nafaqeynta ee aadka u badan ee ay weydiiyaan bukaannada kansarka iyo shakhsiyaadka halista ugu jira hidde-sidaha kansarka waa - kansarrada sida Esophagogastric Adenocarcinoma miyay macno samaynayaan cuntooyinka aan cuno iyo kuwa aanan samayn? Mise haddii aan raaco cunto ku salaysan geedka waa taas ku filan kansarka sida Esophagogastric Adenocarcinoma?

Tusaale ahaan miyay muhiim tahay haddii khudaarta duurjoogta ah la isticmaalo in ka badan marka la barbar dhigo Lettuce? Miyay wax farqi ah samaynaysaa haddii khudaarta Malabar Plum laga doorbido Raspberry Cas? Sidoo kale haddii xulashooyin la mid ah loo sameeyo lawska/abuurka sida Hazelnut-ka Caadiga ah ee xabadka iyo garaaca sida Broad Bean oo ka sarreeya digirta cagaaran. Oo haddii waxa aan cuno ay arrintu khusayso - markaa sidee qofku u aqoonsan karaa cuntooyinka lagu taliyey ee Adenocarcinoma Esophagogastric oo ma isku mid bay u tahay qof kasta oo leh isla cudurka ama khatarta hidde-sidaha?

Haa! Cuntooyinka aad cuntid waxay u tahay Esophagogastric Adenocarcinoma!

Talooyinka cuntadu waxay noqon karaan kuwo isku mid ah qof kasta oo way ka duwanaan karaan xitaa ogaanshaha isku midka ah iyo khatarta hidda-socodka.

Dhammaan cuntooyinka ( khudaarta, miraha, lawska, iniinaha, garaaca, saliidaha iwm.) iyo kaabayaasha nafaqadu waxay ka kooban yihiin wax ka badan hal walxo molecular ama bio-actives oo qiyaas iyo tiro kala duwan leh. Walax kasta oo firfircooni waxay leedahay hab u gaar ah oo wax qabad - kaas oo noqon kara firfircooni ama xannibaadda dariiqyada biochemical ee kala duwan. Cuntooyinka si fudud loo sheegay iyo kaabisyada lagu taliyay waa kuwa aan keenin korodhka wadayaasha molecular ee kansarka laakiin la yareeyo. Haddii kale cuntooyinkaas waa inaan lagu talin. Cuntooyinka waxaa ku jira maaddooyin badan oo firfircoon - markaa marka la qiimeynayo cuntooyinka iyo kaabayaasha waxaad u baahan tahay inaad tixgeliso saameynta dhammaan maaddooyinka firfircoon si wadajir ah halkii aad ka ahaan lahayd mid gaar ah.

Tusaale ahaan Malabar Plum waxaa ku jira walxo firfircoon Curcumin, Formononetin, Lupeol, Phloretin, Daidzein. Raspberry cas waxaa ku jira maaddooyin firfircoon Ellagic Acid, Quercetin, Curcumin, Formononetin, Lupeol iyo kuwa kale oo suurtagal ah.

Khalad caadi ah oo la sameeyo marka la go'aaminayo oo la dooranayo cuntooyinka la cuno ee Esophagogastric Adenocarcinoma - waa in la qiimeeyo oo kaliya maaddooyinka firfircoon ee la doortay ee ku jira cuntooyinka oo la iska indhatiro inta kale. Sababtoo ah maaddooyinka kala duwan ee firfircoon ee ku jira cuntooyinka ayaa laga yaabaa inay saameyn liddi ku ah ku yeeshaan darawalada kansarka - ma qaadan kartid maaddooyinka firfircoon ee cuntooyinka iyo kaabayaasha si loo gaaro go'aanka nafaqada ee Esophagogastric Adenocarcinoma.

HAA – DOORASHOOYINKA CUNTADA EE KANSARKA WAXAY U TAAGAN YAHAY. GO'AANKA NAFAQADA waa in ay tixgeliyaan dhammaan walxaha firfircoon ee CUNTADA.

Xirfadaha Loo Baahan Yahay Nafaqaynta Shakhsiyaynta ee Adenocarcinoma Esophagogastric?

Nafaqada shakhsi ahaaneed ee kansarka sida Esophagogastric Adenocarcinoma waxay ka kooban tahay cuntooyin / cuntooyin lagu taliyey; Cuntooyinka aan lagu talin/kabka tusaale ahaan cunto karinta kuwaas oo mudnaanta siiya isticmaalka cuntooyinka lagu taliyay. Tusaale nafaqeynta gaarka ah ayaa tan lagu arki karaa link.

Go'aaminta cuntooyinka lagu taliyay iyo kuwa aan lagu talin waa mid aad u adag, oo u baahan khibrad xagga Esophagogastric Adenocarcinoma biology, sayniska cuntada, genetics, biochemistry oo ay weheliso faham wanaagsan oo ku saabsan sida daawaynta kansarka u shaqeyso iyo baylahda la xidhiidha kuwaas oo daaweyntu ay joojin karto waxtarka.

Khibradda UGU YAR EE AQOONTA EE LOO BAAHAN YAHAY NAFAQADA SHAQSIYADEEDKA KANSARKA WAA: NOLOLIGA KANSARKA, CUNTADA CUNTADA, DAAWAYNTA KANSARKA IYO HIDDAHA HIDDAHA.

Astaamaha kansarka sida Esophagogastric Adenocarcinoma

Dhammaan kansarrada sida Esophagogastric Adenocarcinoma waxaa lagu sifeyn karaa nooc gaar ah oo ah dariiqyada biochemical - waddooyinka saxiixa ee Esophagogastric Adenocarcinoma. Dariiqooyin kiimikaad sida RAS-RAF Signaling, mRNA Splicing, Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling waa qayb ka mid ah qeexida saxeexa ee Adenocarcinoma Esophagogastric. Hidde-sideyaasha kansarku qof walba wuu ka duwanaan karaa sidaas darteed saxiixooda gaarka ah ee kansarku wuxuu noqon karaa mid gaar ah.

Daawaynta waxtarka u leh Esophagogastric Adenocarcinoma waxay u baahan yihiin inay ogaadaan dariiqooyinka biochemical ee la xidhiidha saxeexa bukaanka kansarka iyo shakhsiga khatarta hidde-sidaha. Sidaa darteed daawayn kala duwan oo leh habab kala duwan oo ficil ah ayaa waxtar u leh bukaanada kala duwan. Si la mid ah iyo sababo la mid ah cuntooyinka iyo kaabista waxay u baahan yihiin in shaqsi kasta loo gaaryeelo. Sidaa awgeed cuntooyinka iyo kaabista qaar ayaa lagula taliyaa Esophagogastric Adenocarcinoma marka la qaadanayo daawaynta kansarka Shucaaca, iyo cuntooyinka qaar iyo kaabista laguma talinayo.

Ilaha sida cBioPortal iyo qaar kale oo badan ayaa bixiya xogta bukaan-socodka ee aan la magacaabin ee laga helay tijaabooyinka bukaan-socodka ee dhammaan calaamadaha kansarka. Xogtan waxay ka kooban tahay tafaasiisha daraasadda tijaabada caafimaad sida cabbirka saamiga / tirada bukaannada, kooxaha da'da, jinsiga, qowmiyadda, daawaynta, goobta burooyinka iyo isbeddellada hidde-sidaha.

DNMT3A, PPM1D, CDKN2A, SMAD4 iyo TET2 waa hiddo-wadaha ugu sarreeya ee la soo sheegay ee Esophagogastric Adenocarcinoma. DNMT3A waxaa lagu soo warramey 11.0% bukaanada mataleysa dhamaan tijaabooyinka caafimaad. Iyo PPM1D waxaa lagu soo warramey 3.2 %. Isku darka xogta bukaan-socodka ee dadweynaha ayaa daboolaya da'da 23 ilaa 89. 75.2 % xogta bukaan-socodka waxaa loo aqoonsaday inay yihiin rag. Biology-ga Esophagogastric Adenocarcinoma oo ay weheliso genetics-ka la soo sheegay ayaa si wada jir ah u qeexaya dariiqooyinka biochemical ee saxeexa dadweynaha ee kansarkan. Haddii genetics-ka burada kansarka shakhsi ahaaneed ama hiddo-wadaha ka qaybqaata khatarta sidoo kale waa la yaqaan markaa waa in sidoo kale loo isticmaalo shakhsiyaynta nafaqada.

Dookhyada nafaqeynta waa in ay iswaafaqaan shaqsi walba saxiixiisa.

Cuntada iyo Kaabayaasha loogu talagalay Adenocarcinoma hunguriga

Bukaanka Kansarka

Bukaanjiifka kansarka ee ku jira daawaynta ama daryeelka palliative waxay u baahan yihiin inay go'aan ka gaadhaan cuntada iyo kaabista - kaloriinta cuntada ee loo baahan yahay, maaraynta waxyeellooyin kasta oo daawaynta iyo sidoo kale hagaajinta maaraynta kansarka. Dhammaan cuntooyinka dhirta ku salaysan maaha kuwo siman oo doorashada iyo kala horraysiinta cuntooyinka kuwaas oo shakhsi ahaan loo habeeyey oo loo habeeyey daawaynta kansarka ee socota waa muhiim oo dhib badan. Waa kuwan tusaalayaal siinaya tilmaamo lagu samaynayo go'aannada nafaqada.

Dooro LEEK duurjoogta khudaar ama salaar?

Leek duurjoogta ah waxaa ku jira waxyaabo badan oo firfircoon ama bioactives sida Curcumin, Formononetin, Lupeol, Phloretin, Daidzein. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida MAPK Signaling, Signaling TGFB, NFKB Signaling iyo Oxidative Stress iyo kuwa kale. Leek duurjoogta ah ayaa lagula talinayaa Adenocarcinoma Esophagogastric marka daawaynta kansarka ee socota ay tahay Shucaac. Tani waa sababta oo ah Wild Leek waxay wax ka beddeshaa dariiqyada biochemical ee si cilmiyeysan loo soo sheegay si loo dareemo saameynta shucaaca.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee ku jira lettuce khudradda waa Quercetin, Curcumin, Formononetin, Vitamin D3, Lupeol. Maaddooyinkan firfircooni waxay wax ka qabtaan dariiqooyin kiimikaad oo kala duwan sida Cadaadiska Oxidative iyo kuwa kale. Salaar laguma talinayo Esophagogastric Adenocarcinoma marka daawaynta kansarka ee socota ay tahay Shucaac sababtoo ah waxay wax ka beddeshaa dariiqyada biochemical ee ka dhigaya daaweynta kansarku mid adkaysi u leh ama aan ka jawaabin.

Leek duurjoogta ah ee khudaarta ah ayaa lagula talinayaa salaadda loogu talagalay Adenocarcinoma hunguriga iyo shucaaca daawaynta.

Dooro midhaha cas raspberry ama MALABAR Plum?

Khudradu waxay ka kooban tahay waxyaabo badan oo firfircoon ama bioactives sida Ellagic Acid, Quercetin, Curcumin, Formononetin, Lupeol. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida MAPK Signaling, Dayactirka DNA, PI3K-AKT-MTOR Signaling iyo Oxidative Stress iyo kuwa kale. Raspberry cas ayaa lagula talinayaa Adenocarcinoma Esophagogastric marka daawaynta kansarka ee socota ay tahay Shucaac. Tani waa sababta oo ah Raspberry Cas ayaa wax ka beddelaya dariiqyada biochemical ee si cilmiyeysan loo soo sheegay si loo dareemo saameynta shucaaca.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee ku jira khudaarta Malabar Plum waa Curcumin, Formononetin, Lupeol, Phloretin, Daidzein. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida Epithelial ilaa Mesenchymal Transition iyo Oxidative Stress iyo kuwa kale. Malabar Plum laguma talinayo Esophagogastric Adenocarcinoma marka daawaynta kansarka ee socota ay tahay Shucaac sababtoo ah waxay wax ka beddeshaa dariiqyada biochemical ee ka dhigaya daawaynta kansarku mid adkaysi u leh ama aan ka jawaabin.

Raspberryry cas miro ayaa lagula taliyaa PLUMKA MALABAR ee loogu talagalay Adenocarcinoma hunguriga iyo shucaaca daawaynta.

Dooro Nut COMMON HAZELNUT ama LAABKA?

Hazelnut-ka caadiga ah waxa ku jira maaddooyin badan oo firfircoon ama bioactives sida Quercetin, Curcumin, Formononetin, Lupeol, Phloretin. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida MAPK Signaling, Dayactirka DNA, Calaamadaynta NFKB iyo Cadaadiska Oxidative iyo kuwa kale. Hazelnut-ka caadiga ah ayaa lagula talinayaa Adenocarcinoma Esophagogastric marka daawaynta kansarka ee socota ay tahay Shucaac. Tani waa sababta oo ah Hazelnut Common waxay wax ka beddeshaa dariiqyada biochemical ee si cilmiyeysan loo soo sheegay si loo dareemo saameynta shucaaca.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee ku jira Chestnut waa Ellagic Acid, Curcumin, Formononetin, Lupeol, Phloretin. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida Epithelial ilaa Mesenchymal Transition iyo Oxidative Stress iyo kuwa kale. Chestnut laguma talinayo Esophagogastric Adenocarcinoma marka daawaynta kansarka ee socota ay tahay Shucaac sababtoo ah waxay wax ka beddeshaa dariiqyada biochemical ee ka dhigaya daaweynta kansarku mid adkaysi u leh ama aan ka jawaabin.

HAZELNUT caam ah ayaa lagula taliyaa laabta laabta oo loogu talagalay Adenocarcinoma hunguriga iyo shucaaca daawaynta.

Shakhsiyaadka leh Khatarta Hidde ee Kansarka

Su'aasha ay weydiiyaan shakhsiyaadka leh khatarta hidde-sidaha ee Adenocarcinoma Esophagogastric Adenocarcinoma ama taariikhda qoysku waa "Maxaan Cunnaa si ka duwan kii hore?" iyo sida ay tahay inay doortaan cuntooyinka iyo kaabista si loo maareeyo khatarta cudurka. Maadaama khatarta kansarku aanay jirin wax la qaban karo marka la eego daawaynta - go'aannada cuntooyinka iyo kaabista ayaa noqda mid muhiim ah iyo mid ka mid ah wax yaabaha yar ee la qaban karo ee la samayn karo. Dhammaan cuntooyinka dhirta ku salaysan maaha kuwo siman oo ku salaysan hidde-sideyaasha la aqoonsaday iyo saxiixa dariiqa - doorashooyinka cuntada iyo kaabista waa in la shakhsiyeeyo.

Dooro Qudaar GIANT BUTTERBUR ama YAM?

Khudaarta Giant Butterbur waxay ka kooban tahay waxyaabo badan oo firfircoon ama bioactives sida Apigenin, Curcumin, Lupeol, Daidzein, Lycopene. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida MAPK Signaling, Dayactirka DNA, Calaamadaynta Unugyada stem iyo PI3K-AKT-MTOR Signaling iyo kuwa kale. Giant Butterbur waxaa lagula talinayaa halista Esophagogastric Adenocarcinoma marka khatarta hidde-sidaha la xiriirta ay tahay CDKN2A. Tani waa sababta oo ah Giant Butterbur waxay kordhisaa dariiqyada biochemical ee ka soo horjeeda wadayaasha saxeexa.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee ku jira Yam khudradda waa Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida Dayactirka DNA-ga iyo Calaamadaynta Unugyada stem iyo kuwa kale. Yam laguma talinayo marka halista Esophagogastric Adenocarcinoma marka khatarta hidde-sidaha la xiriirta ay tahay CDKN2A sababtoo ah waxay kordhisaa dariiqyada saxiixa.

BUTTERBUR WAYN OO khudaar ah ayaa lagula talinayaa YAMKA khatarta hidda-socodka CDKN2A ee kansarka.

Dooro Miraha NANCE ama PUMMELO?

Miraha Nance waxaa ku jira waxyaabo badan oo firfircoon ama bioactives sida Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida MAPK Signaling, Dayactirka DNA, Calaamadaynta Unugyada stem iyo PI3K-AKT-MTOR Signaling iyo kuwa kale. Nance waxaa lagula talinayaa halista Esophagogastric Adenocarcinoma marka khatarta hidde-sidaha la xiriirta ay tahay CDKN2A. Tani waa sababta oo ah Nance waxay kordhisaa dariiqyada biochemical ee ka soo horjeeda darawaliinta saxeexa.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee ku jira miro Pummelo waa Apigenin, Curcumin, Lupeol, Quercetin, Daidzein. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida Dayactirka DNA-ga iyo Calaamadaynta Unugyada stem iyo kuwa kale. Pummelo laguma talinayo marka halista Esophagogastric Adenocarcinoma marka khatarta hidde-sidaha la xidhiidha ay tahay CDKN2A sababtoo ah waxay kordhisaa dariiqyada saxiixa.

FRUIT NANCE waxaa lagula talinayaa PUMMELO oo loogu talagalay khatarta hidda-socodka CDKN2A ee kansarka.

Dooro basbaaska lowska ama XABADAHA YURUB?

Butternut wuxuu ka kooban yahay waxyaabo badan oo firfircoon ama bioactives sida Apigenin, Curcumin, Lupeol, Daidzein, Lycopene. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida MAPK Signaling, Dayactirka DNA, Calaamadaynta Unugyada Jirka iyo Isbaarooyinka Wareegga Unugyada iyo kuwa kale. Butternut ayaa lagula talinayaa halista Esophagogastric Adenocarcinoma marka khatarta hidde-sidaha la xiriirta ay tahay CDKN2A. Tani waa sababta oo ah Butternut waxay kordhisaa dariiqyada biochemical ee ka soo horjeeda wadayaasha saxiixa.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee Chestnut Yurub waa Apigenin, Curcumin, Ellagic Acid, Lupeol, Quercetin. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida Dayactirka DNA-ga iyo Calaamadaynta Unugyada stem iyo kuwa kale. Chestnut Yurub laguma talinayo marka halista Esophagogastric Adenocarcinoma marka khatarta hidde-sidaha la xiriirta ay tahay CDKN2A sababtoo ah waxay kordhisaa dariiqyada saxiixa.

BUTTERNUT ayaa lagula talinayaa laabta Yurub si loogula taliyo halista hiddesidaha CDKN2A ee kansarka.

In Gabagabo

Cuntooyinka iyo Kaabayaasha la doortay ayaa ah go'aamo muhiim u ah kansarka sida Esophagogastric Adenocarcinoma. Bukaannada Adenocarcinoma Esophagogastric iyo shakhsiyaadka leh khatarta hidde-sidaha waxay had iyo jeer qabaan su'aashan: "Waa maxay cuntooyinka iyo nafaqooyinka nafaqada ee lagu taliyey aniga iyo kuwa aan ahayn?" Waxaa jira aaminsanaan guud oo ah fikrad khaldan oo ah in dhammaan cuntooyinka dhirta ku salaysan ay faa'iido yeelan karaan ama aysan ahayn laakiin aan waxyeello lahayn. Cuntooyinka qaarkood iyo kaabisyada qaarkood waxay faragelin karaan daawaynta kansarka ama waxay kor u qaadi karaan wadayaasha dariiqyada molecular ee kansarka.

Waxaa jira noocyo kala duwan oo tilmaamayaasha kansarka sida Esophagogastric Adenocarcinoma, mid kasta oo leh hidde-sidaha burooyinka kala duwan oo leh kala duwanaansho genomic oo dheeraad ah oo qof kasta ah. Intaa waxaa dheer daawaynta kansar kasta iyo kiimoterabi kasta waxay leeyihiin hab wax-qabad oo gaar ah. Cunto kasta sida Leek duurjoogta ah waxay ka kooban tahay nooleyaal kala duwan oo tirooyin kala duwan leh, kuwaas oo saameyn ku leh noocyo kala duwan oo kala duwan oo ah dariiqyada biochemical. Qeexida nafaqeynta shakhsi ahaaneed waa talooyinka cuntada ee gaarka ah ee tilmaamaya kansarka, daawaynta, genetics, qaab nololeedka iyo arrimo kale. Go'aannada shakhsiyaynta nafaqada ee kansarka waxay u baahan yihiin aqoonta bayoolajiga kansarka, sayniska cuntada iyo fahamka daaweynta kemotherabi ee kala duwan. Ugu dambeyntii marka ay jiraan isbeddel daaweyn ama genomics cusub ayaa la aqoonsaday - shakhsiyeynta nafaqeynta waxay u baahan tahay dib-u-qiimeyn.

Xalka shakhsiyaynta nafaqeynta ee addon ayaa ka dhigaysa go'aan qaadashada mid fudud oo meesha ka saaraysa dhammaan malo-awaalka ka jawaabaya su'aasha, "Cunto noocee ah ayaan dooran karaa ama ma dooran karaa Esophagogastric Adenocarcinoma?". Kooxda edbinta badan ee addon waxaa ka mid ah dhakhaatiirta kansarka, saynisyahano caafimaad, injineerada software iyo saynisyahano xogta.

tixraacyada

• Helitaanka Msk 2021
• Xakamaynta kinase HER ee bukaanada qaba HER2-iyo HER3-kaansarka mutant.
• Saamaynta iyo muhiimada formononetin ee heerarka muujinta HIF-1a iyo VEGF ee unugyada kansarka ilmo-galeenka.
• Retinol wuxuu hoos u dhigaa heerarka borotiinka beta-catenin ee khadadka unugyada kansarka mindhicirka ee retinoic acid u adkaysta.
• Saamaynta Daidzein ee hoormoonka kansarka qanjirka 'prostate' ee vitro iyo in vivo marka la barbar dhigo genistein iyo soosaarka soy: awoodda shucaaca.
• Xeer-beegtida xun-xun ee gudbiyaha calaamadaha iyo firfircoonida qoraalka-3 calaamadaynta cascade ee lupeol waxay joojisaa koritaanka waxayna keentaa apoptosis unugyada kansarka hepatocellular.