Cuntooyinka loogu talagalay Kansarka Sambabada Unugyada Aan Yarayn!

Hordhac

Cuntooyinka Kansarka Sambabada Unugyada Aan Yarayn waa in loo shakhsiyeeyaa qof kasta waana in uu la qabsado marka daawaynta kansarka ama hidde-sidaha buro ay isbeddelaan. Shakhsiyaynta iyo la qabsiga waa in ay tixgelisaa dhammaan maaddooyinka firfircoon ama bioactives ee ku jira cuntooyinka kala duwan marka loo eego bayooloojiyada unugyada kansarka, genetics, daawaynta, xaaladaha qaab nololeedka iyo doorbidka cuntada. Sidaa darteed iyadoo nafaqadu ay tahay mid ka mid ah go'aamada aadka muhiimka u ah bukaanka kansarka iyo qofka halista ugu jira kansarka inuu sameeyo - sida loo doorto cuntooyinka uu cuno maaha hawl fudud.

Kansarka sambabada unug aan yareyn miyay muhiim u tahay khudaarta, miraha, lawska, miraha uu qofku cuno?

Su'aal nafaqeyn oo aad u caan ah oo ay weydiiyaan bukaannada kansarka iyo shakhsiyaadka khatarta hidde-sidaha ee kansarku waa - kansarka sida Kansarka sambabada unugyada aan yareyn miyay muhiim tahay cuntooyinka aan cuno iyo kuwa aanan samayn? Mise haddii aan raaco cunto ku salaysan geedka waa taas ku filan kansarka sida Kansarka sambabada Unug yar?

Tusaale ahaan macne miyay tahay haddii Cauliflower khudaarta la isticmaalo in ka badan marka la barbar dhigo Salad Rocket (ssp.)? Miyay wax farqi ah samaynaysaa haddii khudaarta Malus (carsaanyo Apple) laga door bido Black Mulberry? Sidoo kale haddii xulashooyin la mid ah loo sameeyo nuts/abuurka sida Butternut oo ka sarreeya Chestnut Yurub iyo garaacyada sida Gram Bean oo ka sarreeya Mung Bean. Oo haddii waxa aan cunaa ay arrintu khusayso - markaa sidee qofku u aqoonsan karaa cuntooyinka lagu taliyey Kansarka sambabada Unug yar oo aan isku mid ahayn ma u tahay qof kasta oo leh isla cudurka ama khatarta hidde-sidaha?

Haa! Cuntooyinka aad cuntid waxay udub dhexaad u yihiin Kansarka sambabada Unug aan Yarayn!

Talooyinka cuntadu waxay noqon karaan kuwo isku mid ah qof kasta oo way ka duwanaan karaan xitaa ogaanshaha isku midka ah iyo khatarta hidda-socodka.

Dhammaan cuntooyinka ( khudaarta, miraha, lawska, iniinaha, garaaca, saliidaha iwm.) iyo kaabayaasha nafaqadu waxay ka kooban yihiin wax ka badan hal walxo molecular ama bio-actives oo qiyaas iyo tiro kala duwan leh. Walax kasta oo firfircooni waxay leedahay hab u gaar ah oo wax qabad - kaas oo noqon kara firfircooni ama xannibaadda dariiqyada biochemical ee kala duwan. Cuntooyinka si fudud loo sheegay iyo kaabisyada lagu taliyay waa kuwa aan keenin korodhka wadayaasha molecular ee kansarka laakiin la yareeyo. Haddii kale cuntooyinkaas waa inaan lagu talin. Cuntooyinka waxaa ku jira maaddooyin badan oo firfircoon - markaa marka la qiimeynayo cuntooyinka iyo kaabayaasha waxaad u baahan tahay inaad tixgeliso saameynta dhammaan maaddooyinka firfircoon si wadajir ah halkii aad ka ahaan lahayd mid gaar ah.

Tusaale ahaan Malus (carsaanyo Apple) waxa ku jira maaddooyin firfircoon Curcumin, Delphinidin, Lycopene, Isoliquiritigenin, Formononetin. Mulberry-madow waxa ku jira maaddooyin firfircoon oo ay ka mid yihiin Quercetin, Curcumin, Delphinidin, Isoliquiritigenin, Formononetin iyo kuwo kale oo suurtogal ah.

Khalad caadi ah oo la sameeyo marka la go'aaminayo oo la dooranayo cuntooyinka la cuno ee Kansar sambabada Unug yar - waa in la qiimeeyo oo kaliya maaddooyinka firfircoon ee la doortay ee ku jira cuntooyinka oo la iska indhatiro inta kale. Sababtoo ah maaddooyinka kala duwan ee firfircoon ee ku jira cuntooyinka ayaa laga yaabaa inay saameyn iska soo horjeeda ku yeeshaan darawalada kansarka - ma qaadan kartid maaddooyinka firfircoon ee cuntooyinka iyo kaabayaasha si aad u go'aansato nafaqeynta Kansarka Sambabka Unug yar.

HAA – DOORASHOOYINKA CUNTADA EE KANSARKA WAXAY U TAAGAN YAHAY. GO'AANKA NAFAQADA waa in ay tixgeliyaan dhammaan walxaha firfircoon ee CUNTADA.

Xirfadaha Looga Baahan Yahay Nafaqaynta Shakhsiyaynta Kansarka Unugyada Aan Yarayn?

Nafaqada shakhsi ahaaneed ee kansarrada sida Kansarka sambabada unugyada aan-yarayn waxa uu ka kooban yahay cuntooyin/kaabyo lagu taliyey; Cuntooyinka aan lagu talin/kabka tusaale ahaan cunto karinta kuwaas oo mudnaanta siiya isticmaalka cuntooyinka lagu taliyay. Tusaale nafaqeynta gaarka ah ayaa tan lagu arki karaa link.

Go'aaminta cuntooyinka lagu taliyey iyo in kale waa mid aad u adag, waxay u baahan tahay khibrad ku saabsan bayoolajiga kansarka sanbabada unugyada aan yareyn, sayniska cuntada, genetics, biochemistry oo ay weheliso faham wanaagsan oo ku saabsan sida daawaynta kansarku u shaqeyso iyo baylahda la xidhiidha kuwaas oo daaweyntu ay joojin karto waxtarka.

Khibradda UGU YAR EE AQOONTA EE LOO BAAHAN YAHAY NAFAQADA SHAQSIYADEEDKA KANSARKA WAA: NOLOLIGA KANSARKA, CUNTADA CUNTADA, DAAWAYNTA KANSARKA IYO HIDDAHA HIDDAHA.

Astaamaha kansarrada sida Kansarka sambabada unugga ee aan-yarayn

Dhammaan kansarrada sida Kansarka sambabada Unug-yar-yar waxa lagu gartaa hab gaar ah oo ah dariiqooyin kiimikaad - dariiqooyinka saxeexa Kansarka sambabada Unug yar-yar. Dariiqooyin kiimikaad sida RAS-RAF Signaling, Apoptosis, Transport Molecule Small, Extracellular Matrix Dib-u-habaynta waa qayb ka mid ah qeexida saxeexa Kansarka Sambabka Unug-yar ee Aan-yar-yarayn. Hidde-sideyaasha kansarku qof walba wuu ka duwanaan karaa sidaas darteed saxiixooda gaarka ah ee kansarku wuxuu noqon karaa mid gaar ah.

Daawaynta waxtarka u leh Kansarka sambabada Unug yar waxa ay u baahan yihiin in ay ogaadaan dariiqooyinka biochemical ee la xidhiidha saxeexa bukaan kasta oo kansar ah iyo qofkasta oo khatar ku jira. Sidaa darteed daawayn kala duwan oo leh habab kala duwan oo ficil ah ayaa waxtar u leh bukaanada kala duwan. Si la mid ah iyo sababo la mid ah cuntooyinka iyo kaabista waxay u baahan yihiin in shaqsi kasta loo gaaryeelo. Sidaa awgeed cuntooyinka iyo kaabista qaar ayaa lagula taliyaa Kansarka unugyada sambabada ee aan-yara ahayn marka la qaadanayo daawaynta kansarka Erlotinib, cuntooyinka iyo kaabista qaarna laguma talinayo.

Ilaha sida cBioPortal iyo qaar kale oo badan ayaa bixiya xogta bukaan-socodka ee aan la magacaabin ee laga helay tijaabooyinka bukaan-socodka ee dhammaan calaamadaha kansarka. Xogtan waxay ka kooban tahay tafaasiisha daraasadda tijaabada caafimaad sida cabbirka saamiga / tirada bukaannada, kooxaha da'da, jinsiga, qowmiyadda, daawaynta, goobta burooyinka iyo isbeddellada hidde-sidaha.

LRP2, CACNA1E, SI, TIAM1 iyo COL6A3 ayaa ah kuwa ugu sareeya ee la soo sheegay hidde-sideyaasha Kansarka Sambabada Unug aan Yarayn. LRP2 ayaa lagu soo warramey 10.1% bukaanada mataleysa dhamaan tijaabooyinka caafimaad. CACNA1E waxaa lagu soo warramey 9.4 %. Isku darka xogta bukaan-socodka ee dadweynaha waxay daboolaysaa da'da 37 ilaa 88. 49.4 % xogta bukaan-socodka waxaa loo aqoonsaday inay yihiin rag. Biology-ga Kansarka Sambabada Unug-yar ee Aan-yar-yar oo ay weheliso genetics-ka la soo sheegay ayaa si wada jir ah u qeexaya dariiqooyinka biochemical ee saxeexa dadweynaha ee kansarkan. Haddii genetics-ka burada kansarka shakhsi ahaaneed ama hiddo-wadaha ka qaybqaata khatarta sidoo kale waa la yaqaan markaa waa in sidoo kale loo isticmaalo shakhsiyaynta nafaqada.

Dookhyada nafaqeynta waa in ay iswaafaqaan shaqsi walba saxiixiisa.

Cunnada iyo Kaabayaasha Kansarka Sambabada Unug Aan Yarayn

Bukaanka Kansarka

Bukaanjiifka kansarka ee ku jira daawaynta ama daryeelka palliative waxay u baahan yihiin inay go'aan ka gaadhaan cuntada iyo kaabista - kaloriinta cuntada ee loo baahan yahay, maaraynta waxyeellooyin kasta oo daawaynta iyo sidoo kale hagaajinta maaraynta kansarka. Dhammaan cuntooyinka dhirta ku salaysan maaha kuwo siman oo doorashada iyo kala horraysiinta cuntooyinka kuwaas oo shakhsi ahaan loo habeeyey oo loo habeeyey daawaynta kansarka ee socota waa muhiim oo dhib badan. Waa kuwan tusaalayaal siinaya tilmaamo lagu samaynayo go'aannada nafaqada.

Dooro CAULIFLOWER ama saladhka gantaalaha (SSP.)?

Cauliflower khudradda waxaa ku jira waxyaabo badan oo firfircoon ama bioactives sida Curcumin, Delphinidin, Isoliquiritigenin, Formononetin, Phloretin. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida Epithelial ilaa Mesenchymal Transition, P53 Signaling, WNT Beta Catenin Signaling iyo MYC Signaling iyo kuwa kale. Cauliflower ayaa lagula talinayaa Kansarka sambabada Unug aan yareyn marka daawaynta kansarka ee socota ay tahay Erlotinib. Tani waa sababta oo ah Cauliflower waxay wax ka beddeshaa dariiqyada biochemical ee si cilmiyeysan loo soo sheegay si loo dareemo saameynta Erlotinib.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee ku jira Salad Rocket Quercetin (ssp.) waa Quercetin, Curcumin, Delphinidin, Lycopene, Isoliquiritigenin. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida TGFB Signaling iyo PI3K-AKT-MTOR Signaling iyo kuwa kale. Salad Rocket (ssp.) laguma talinayo Kansarka sambabada Unug yar marka daawaynta kansarka ee socota ay tahay Erlotinib sababtoo ah waxay wax ka beddeshaa dariiqyada biochemical ee ka dhigaya daaweynta kansarku mid adkaysi u leh ama ka jawaabi kara.

ubaxa khudaarta leh waxaa lagula talinayaa saladhka gantaalaha (SSP.) ee Kansarka sambabada unug aan yarayn iyo daawaynta Erlotinib.

Dooro Miraha MULBERRY ama MALUS ( CAB APPLE)?

Mulberry madow wuxuu ka kooban yahay waxyaabo badan oo firfircoon ama bioactives sida Quercetin, Curcumin, Delphinidin, Isoliquiritigenin, Formononetin. Maaddooyinkan firfircooni waxay wax ka qabtaan dariiqooyin kiimikaad oo kala duwan sida Epithelial ilaa Mesenchymal Transition, Dib-u-habaynta Matrix-ka ka baxsan, Apoptosis iyo MAPK Signaling iyo kuwa kale. Mulberry madow waxa lagula talinayaa Kansarka sambabada unug aan yarayn marka daawaynta kansarka ee socota ay tahay Erlotinib. Tani waa sababta oo ah Mulberry Black wuxuu wax ka beddelaa dariiqyada biochemical ee si cilmiyeysan loo soo sheegay si loo dareemo saameynta Erlotinib.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee miraha Malus (carsaanyo Apple) waa Curcumin, Delphinidin, Lycopene, Isoliquiritigenin, Formononetin. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida TGFB Signaling iyo PI3K-AKT-MTOR Signaling iyo kuwa kale. Malus (carsaanyo Apple) laguma talinayo Kansarka sambabada unug yar marka daawaynta kansarku ay tahay Erlotinib sababtoo ah waxay wax ka beddeshaa dariiqyada biochemical ee ka dhigaya daaweynta kansarku mid adkaysi u leh ama ka jawaabi kara.

MALUS (CAB APPLE) FRUIT BLACK MUBERRY ayaa lagula taliyaa Kansarka Sambabada Unug aan Yarayn iyo daawaynta Erlotinib.

Dooro BUTTERNUT lowska ama XARUNTA YURUB?

Butternut wuxuu ka kooban yahay waxyaabo badan oo firfircoon ama bioactives sida Curcumin, Delphinidin, Lycopene, Isoliquiritigenin, Formononetin. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida TGFB Signaling, P53 Signaling, MAPK Signaling iyo MYC Signaling iyo kuwa kale. Butternut ayaa lagula taliyaa Kansarka unugyada sambabada ee unugga aan yareyn marka daawaynta kansarka ee socota ay tahay Erlotinib. Tani waa sababta oo ah Butternut waxay wax ka beddeshaa dariiqyada biochemical ee si cilmiyeysan loo soo sheegay si loo dareemo saameynta Erlotinib.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee Chestnut Yurub waa Quercetin, Ellagic Acid, Curcumin, Delphinidin, Isoliquiritigenin. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimiko oo kala duwan sida TGFB Signaling, Epithelial to Mesenchymal Transition iyo WNT Beta Catenin Signaling iyo kuwa kale. Chestnut Yurub laguma talinayo Kansarka sambabada unugyada aan yareyn marka daawaynta kansarka ee socota ay tahay Erlotinib sababtoo ah waxay wax ka beddeshaa dariiqyada biochemical ee ka dhigaya daaweynta kansarku mid adkaysi u leh ama ka jawaabi kara.

BUTTERNUT ayaa lagula talinayaa laabta Yurub ee Kansarka Sambabada Unugyada Aan Yarayn iyo daawaynta Erlotinib.

Shakhsiyaadka leh Khatarta Hidde ee Kansarka

Su'aasha ay weydiiyaan shakhsiyaadka leh khatarta hidde-sidaha ee Kansarka sambabada Unug yar ama taariikhda qoyska waa "Maxaan Cunnaa si ka duwan kii hore?" iyo sida ay tahay inay doortaan cuntooyinka iyo kaabista si loo maareeyo khatarta cudurka. Maadaama khatarta kansarku aanay jirin wax la qaban karo marka la eego daawaynta - go'aamada cuntooyinka iyo kaabista ayaa noqda mid muhiim ah iyo mid ka mid ah waxyaallaha aadka u yar ee la qaban karo. Dhammaan cuntooyinka dhirta ku salaysan maaha kuwo siman oo ku salaysan hidde-sidaha la aqoonsaday iyo saxeexa dariiqa - doorashooyinka cuntada iyo kaabista waa in la shakhsiyeeyo.

Dooro Qudaar GIANT BUTTERBUR ama MOSHROOM OYSTER?

Khudaarta Giant Butterbur waxay ka kooban tahay waxyaabo badan oo firfircoon ama bioactives sida Apigenin, Curcumin, Lupeol, Formononetin, Daidzein. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida isgoysyada Adherens, P53 Signaling, Isgoysyada unugyada iyo RAS-RAF Signaling iyo kuwa kale. Giant Butterbur waxaa lagula talinayaa halista kansarka sambabada unugyada aan yareyn marka khatarta hidde-sidaha ay tahay CACNA1E. Tani waa sababta oo ah Giant Butterbur waxay kordhisaa dariiqyada biochemical ee ka soo horjeeda wadayaasha saxeexa.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee ku jira Mushroom Oyster khudradda waa Apigenin, Curcumin, Lupeol, Formononetin, Daidzein. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida Gaadiidka Molecule Small iyo PI3K-AKT-MTOR Signaling iyo kuwa kale. Mushroom Oyster laguma talinayo marka khatarta kansarka sambabada unugyada aan yareyn marka khatarta hidde-sidaha la xiriirta ay tahay CACNA1E sababtoo ah waxay kordhisaa dariiqooyinka saxiixa.

BUTTERBUR WAYN OO khudaar ah ayaa lagula talinayaa in lagu dul taliyo mowjka lohodka ee khatarta hidda-sidaha CACNA1E ee kansarka.

Dooro CLOUDBERRY ama PUMMELO?

Miraha Cloudberry waxay ka kooban yihiin waxyaabo badan oo firfircoon ama bioactives sida Apigenin, Curcumin, Quercetin, Ellagic Acid, Lupeol. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida isgoysyada Adherens, P53 Signaling iyo PI3K-AKT-MTOR Signaling iyo kuwa kale. Cloudberry waxaa lagula talinayaa halista kansarka sambabada unug aan yareyn marka khatarta hidde-sidaha la xiriirta ay tahay CACNA1E. Tani waa sababta oo ah Cloudberry waxay kordhisaa dariiqyada biochemical ee ka hortagaya darawallada saxiixa.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee ku jira miro Pummelo waa Apigenin, Curcumin, Quercetin, Lupeol, Formononetin. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida Dib-u-habaynta Matrix-ka Extracellular Matrix, Gaadiidka Molecule-yar, Dhaqdhaqaaqa Cytoskeletal iyo Isgoysyada Unugyada iyo kuwa kale. Pummelo laguma talinayo marka khatarta kansarka sambabada unugyada aan yareyn marka khatarta hidde-sidaha ay tahay CACNA1E sababtoo ah waxay kordhisaa dariiqyada saxiixa.

CARUURTA MIDHAHA waxaa lagula talinayaa PUMMELO oo loogu talagalay khatarta hidda-socodka CACNA1E ee kansarka.

Dooro Nut CHIA ama PISTACHIO?

Chia waxaa ku jira waxyaabo badan oo firfircoon ama bioactives sida Apigenin, Curcumin, Lupeol, Formononetin, Daidzein. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida P53 Signaling, Adhesion Focal, Isgoysyada unugyada iyo Gaadiidka Molecule Yar iyo kuwa kale. Chia waxaa lagula taliyaa halista Kansarka sambabada unugga ee aan yareyn marka khatarta hidde-sidaha la xiriirta ay tahay CACNA1E. Tani waa sababta oo ah Chia waxay kordhisaa dariiqooyinka biochemical ee ka soo horjeeda wadayaasha saxeexa.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee Pistachio waa Curcumin, Quercetin, Lupeol, Formononetin, Daidzein. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida Focal Adhesion, Cytoskeletal Dynamics iyo Isgoysyada unugyada iyo kuwa kale. Pistachio laguma talinayo marka khatarta kansarka sambabada unugyada aan yareyn marka khatarta hidda-socodka la xiriirta ay tahay CACNA1E sababtoo ah waxay kordhisaa dariiqooyinka saxiixa.

CHIA waxaa lagula talinayaa PistaCHIO KHATARTA hidda-socodka ee CACNA1E.

In Gabagabo

Cuntooyinka iyo Kaabayaasha la doortay ayaa ah go'aamo muhiim u ah kansarrada sida Kansarka sambabada ee unugga aan yareyn. Bukaannada Kansarka Sambabada unugga ee aan-yara ahayn iyo shakhsiyaadka leh khatarta hidde-sidaha waxay had iyo jeer qabaan su'aashan: "Waa maxay cuntooyinka iyo nafaqooyinka nafaqada ee lagu taliyey aniga iyo kuwa aan ahayn?" Waxaa jira aaminsanaan guud oo ah fikrad khaldan oo ah in dhammaan cuntooyinka dhirta ku salaysan ay faa'iido yeelan karaan ama aysan ahayn laakiin aan waxyeello lahayn. Cuntooyinka qaarkood iyo kaabisyada qaarkood waxay faragelin karaan daawaynta kansarka ama waxay kor u qaadi karaan wadayaasha dariiqyada molecular ee kansarka.

Waxaa jira noocyo kala duwan oo calaamado kansar ah sida Kansarka sambabada Unug yar, mid kasta oo leh hidde-sidaha burooyinka kala duwan oo leh kala duwanaansho genomic dheeraad ah oo qof kasta ah. Intaa waxaa dheer daawaynta kansar kasta iyo kiimoterabi kasta waxay leeyihiin hab wax-qabad oo gaar ah. Cunto kasta sida Cauliflower waxay ka kooban tahay bioactives kala duwan oo tirooyin kala duwan leh, kuwaas oo saameyn ku leh noocyo kala duwan oo kala duwan oo ah dariiqyada biochemical. Qeexida nafaqeynta shakhsi ahaaneed waa talooyinka cuntada ee gaarka ah ee tilmaamaya kansarka, daawaynta, genetics, qaab nololeedka iyo arrimo kale. Go'aannada shakhsiyaynta nafaqada ee kansarka waxay u baahan yihiin aqoonta bayoolajiga kansarka, sayniska cuntada iyo fahamka daaweynta kemotherabi ee kala duwan. Ugu dambeyntii marka ay jiraan isbeddel daaweyn ama genomics cusub ayaa la aqoonsaday - shakhsiyeynta nafaqeynta waxay u baahan tahay dib-u-qiimeyn.

Xalka shakhsiyaynta nafaqeynta ee addon ayaa ka dhigaysa go'aan qaadashada mid fudud oo meesha ka saaraysa dhammaan mala-awaalka ka jawaabaya su'aasha, "Cunto noocee ah ayaan dooran karaa ama ma dooran karaa Kansarka Unugyada Yaryar?" Kooxda edbinta badan ee addon waxaa ka mid ah dhakhaatiirta kansarka, saynisyahano caafimaad, injineerada software iyo saynisyahano xogta.

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