Tilmaamaha
Ma jiro laba kansar oo isku mid ah, isku midna laguma daweeyo, mana aha in nafaqadu ay isku mid noqoto qof kasta. Nafaqada waxaa ka mid ah cuntooyinka sida digirta, khudaarta, miraha, lawska, saliidda, geedo yaryar iyo xawaashka. Sidoo kale nafaqeynta waxaa ku jira kaabooyin kuwaas oo ah cuntooyin aad u badan ama maaddooyin gaar ah oo laga helo cuntooyinka. Kansarrada sida Multiple Myeloma marka lagu jiro kiimoterabi ama marka aad go'aansato inaad leedahay khatar hidde-sidaha ah oo lagu horumarinayo Multiple Myeloma sababtoo ah NRAS iyo isbeddellada hidda-wadaha BRAF, su'aal aad muhiim u ah ayaa ah "Cunto noocee ah ayaan iska ilaaliyaa iyo cunnooyinka lagu taliyay gaar ahaan aniga?" . Su'aasha kale ee la xiriirta waa "Maxay kaabisyada nafaqeynta ah ee aan iska ilaalinayaa?".
Ma jirto hal jawaab oo su'aashan Kansarka sida Multiple Myeloma oo laga heli karo raadinta internetka. Jawaabta su'aasha waa "Waxay ku xiran tahay" sababtoo ah qorshaha nafaqeynta wuxuu u baahan yahay in adiga laguu gaaryeelo. Nafaqadu waa inay ku xidhan tahay tilmaanta kansarka, macluumaadka hidda-socodka, qaangaarka ama dhakhtarka carruurta, diyaarinta, heerka koowaad ama sare, sare, metastatic, soo noqoshada ama dib u noqoshada, daawaynta socota haddii ay jiraan, kaabisyada nafaqeynta ee la qaatay, da'da iyo arrimaha sida jinsiga, miisaanka, dhererka, qaab nololeedka Xasaasiyadda iyo dookhyada cuntada.
Marka la soo koobo - habka looga jawaabo su'aalaha ay ka mid yihiin "Miyaan ka fogaadaa cunista khudradda xamaasadda leh" ama "Ku dar khudradda Partridgeberry cuntadayda" ama "Miyaan yareeyaa isticmaalka Yamka khudradda" ama "Miyaan qaadan karaa Ellagic Acid iyo Dim supplements" maaha sida sahlan sida raadinta internetka. Nidaamku waa mid aad u adag jawaabahana waxay ku saleysan yihiin aqoonta hidde-sideyaasha, ficilka daaweynta, maaddooyinka firfircoon ee cuntooyinka iyo ficilkooda noole ee la xiriira. Ugu dambeyntii jawaabta su'aasha nafaqeynta waxay u baahan tahay in adiga lagu gaaryeelo.
TALO: U ILMI CUNTADAADA IYO KAABAYAASHAAGA SI AY U BADAN YIHIIN Myeloma, daawaynta, macluumaadka hidda-socodka, iyo shuruudo kale.
Ujeedada guud ee nafaqeynta shakhsi ahaaneed ee Multiple Myeloma waa in la yareeyo cuntooyinka iyo kaabayaasha nafaqada kuwaas oo leh isdhexgalka xun ee darawalada unugyada kansarka iyo daaweynta socota. Oo la ogaado cuntooyinka iyo kaabayaasha kuwaas oo leh ficil faa'iido leh. Mar kasta oo ay jiraan isbeddelo daawaynta ama ogaanshaha - waxaa muhiim ah in la xasuusto in cuntooyinkaaga iyo kaabistaadu ay u baahan yihiin dib-u-qiimayn. Jawaabaha su'aasha nafaqaduna way ka duwanaan kartaa iyadoo lagu saleynayo macnaha cusub.
TALO: U cusboonaysii nafaqeyntaada MYELOMA BADAN, MARKII DAAWAYNAHA, XAALADA CUDURKA IYO ISBEDDELKA XAALADAHA KALE.
Ku saabsan Multiple Myeloma
cBioPortal waa hal il laga helo kansarka xogta bukaanka laga helay tijaabooyin caafimaad oo dhan 350 oo lagu daray calaamadaha kansarka. Xogta laga helay tijaabo caafimaad kasta waxaa ku jira magaca tijaabada caafimaadka iyo faahfaahinta daraasadda sida tirada bukaannada, da'da, jinsiga, qowmiyadda, daawaynta, goobta burada, cilladaha hidde-sideyaasha ee la helay iyo falanqaynta dhammaan xogta. cBioPortal ee Kansarka Genomics-ka waxaa asal ahaan laga soo saaray Memorial Sloan Kettering Cancer Center (MSK). Bogga cBioPortal ee dadweynaha waxaa martigeliyay Xarunta Kansarka Molecular Oncology ee MSK - https://www.cbioportal.org/about.
Waxyaabaha muhiimka ah ee soo socda ayaa laga soo qaatay xogta caafimaad ee Multiple Myeloma ee cBioPortal. Bukaannada ku jira daraasadaha Multiple Myeloma waxay da'doodu u dhaxaysaa 24 ilaa 82 da'doodu tahay 61. 66.2% ragga iyo 33.8% dumarka ayaa ahaa qaybinta jinsiga ee daraasaddan caafimaad. Laga soo bilaabo cabbirka muunadda bukaanka ee 212; Hidde-sidayaasha ugu sarreeya ee leh isbeddellada iyo cilladaha kale ee aan caadiga ahayn ee Multiple Myeloma waxaa ka mid ah hiddo-wadaha KRAS, NRAS, TP53, BRAF iyo MUC16. Qaybinta soo noqnoqda dhacdooyinka ee hiddo-wadahan siday u kala horreeyaan waa 22.0%, 18.0%, 7.3%, 6.3% iyo 6.3%. Faahfaahintan hidde-sidaha burooyinka ee Multiple Myeloma waxaa lagu jaangooyay dariiqyada biochemical ee wadayaasha kansarka si ay u bixiyaan qeexida sifooyinka sifo ee Multiple Myeloma.
Multiple myeloma waa kansarka dhiiga ee unugyada balaasmaha ee laga helo dhuuxa lafta, unug isbonjiyada ah oo ku dhex jira lafahayaga, kaas oo sida caadiga ah abuura qaybaha kala duwan ee dhiigayaga. Unugyada Plasma waa qayb muhiim ah oo ka mid ah habka difaaca jidhka. Waxay soo saaraan unugyada difaaca jirka ka caawiya inuu la dagaallamo caabuqa. Myeloma waxay bilaabataa marka unugyada balasmaha ee caafimaadka qaba ay isbedelaan oo ay ka baxaan kontoroolka. Tani waxay keeni kartaa dhaawacyo badan oo lafo ah kuwaas oo kordhiya khatarta jabka lafaha, oo loo yaqaan 'multiple myeloma'. Unugyada balaasmaha ee aan caadiga ahayn ee si degdeg ah u qaybsada waxay soo ururiyaan ama xakameeyaan koritaanka unugyada kale ee dhuuxa lafta, oo ay ku jiraan unugyada dhiigga cas, unugyada dhiigga cad iyo platelets. Tani ma aha oo kaliya inay hoos u dhigto difaaca jirka, laakiin sidoo kale waxay keeni kartaa dhiig-yaraan ka timaadda unugyada dhiigga cas, dhiigbaxa xad-dhaafka ah ee jeexjeexyada yar yar iyo nabarrada sababtoo ah yaraanta platelet, iyo awoodda la dagaalanka caabuqa oo yaraada, yaraanta unugyada dhiiga cad. . Unugyada Myeloma ma awoodaan inay soo saaraan unugyada difaaca jirka ee shaqeeya laakiin taa beddelkeeda waxay sameeyaan borotiinka M kaas oo ku urursan kara dhiigga iyo kaadida, taasoo suurtogal ah inay waxyeello u geystaan kelyaha iyo xubnaha kale, marka laga reebo yaraynta difaaca. Qofka caafimaadka qaba ee laga helo qadar yar oo borotiinka M ah ayaa la sheegay inuu qabo monoclonal gammopathy oo aan la go'aamin muhiimada (MGUS), horudhaca myeloma badan.
Qiyaasta kiisaska cusub ee myeloma-ka badan ee 2022 ayaa ka badan 30,000, qiyaastii 1.8% dhammaan kiisaska cusub ee kansarka. Heerka badbaadada 5-sano ee bukaanada qaba myeloma badan waa qiyaastii 58% (Tixraac: seer.cancer.gov). Daaweynta myeloma badan waxaa ka mid ah daaweynta si loo xakameeyo cudurka iyo sidoo kale daryeelka taageerada si loo hagaajiyo tayada nolosha, sida in la yareeyo calaamadaha iyo ilaalinta nafaqo wanaagsan oo leh cuntooyinka saxda ah iyo kaabayaasha dabiiciga ah. Qorshaha daawaynta waxaa ku jira daawaynta kicinta ee xakamaynta degdega ah ee kansarka; daawaynta xoojinta oo leh kiimoterabi badan ama dhuuxa lafta/lafta unugyada xubinta taranka iyo daaweynta dayactirka muddo dheer si looga hortago soo noqoshada kansarka. Daawaynta waxaa ka mid ah kiimoterabiga, daawaynta la beegsaday, daawooyinka immunomodulatory, steroids, dawooyinka wax ka beddelka lafaha, iyo daaweynta difaaca jirka. Cuntooyinka saxda ah iyo kaabayaasha dabiiciga ah ee ku habboon daawaynta ayaa sii caawin kara hagaajinta fayoobida bukaanka. (Tixraac: https://www.cancer.net/cancer-types/multiple-myeloma/introduction; https://www.cancer.org/cancer/multiple-myeloma/about/key-statistics.html)
Muhiimadda Nafaqadu u leedahay Multiple Myeloma
Dhammaan cuntooyinka iyo kaabayaasha nafaqadu waxay ka kooban yihiin hal ama in ka badan oo maaddooyin kiimiko ah oo firfircoon oo qiyaas iyo tiro kala duwan leh. Ficilka qaar ka mid ah maaddooyinka firfircoon ee cuntada ku jira waxay yeelan karaan is-dhexgal xun halka maaddooyinka kale ee firfircoon ee isla cuntada laga yaabo inay taageeraan macnaha Multiple Myeloma. Sidaa darteed isla cuntadu waxay leedahay ficillo wanaagsan oo aan sidaa u fiicneyn iyo falanqaynta saameynta la isku daray ayaa loo baahan doonaa si loo helo qorshe nafaqo oo gaar ah.
Tusaale ahaan Miraha Xamaasada waxaa ka mid ah maaddooyinka firfircoon ee Vitamin C, Oleic Acid, Linolenic Acid, Linoleic Acid, Vitamin A iyo kuwa kale. Partridgeberry waxaa ku jira maaddooyin firfircoon Resveratrol, Beta-sitosterol, Stigmasterol iyo kuwa kale. Waxay u badan tahay in qaar ka mid ah maaddooyinkan firfircoon ee isku midka ah ay yeelan karaan saameyn liddi ku ah sidaa darteed waxaa lagu talinayaa in la aqoonsado cuntooyinka lagu taliyay iyadoo lagu saleynayo falanqaynta dhammaan maaddooyinka tirada badan ee ku jira cuntooyinka.
Kansarrada sida Multiple Myeloma, firfircoonida ama joojinta dariiqyada biochemical ee la xushay sida Calaamadeynta Sababta Kobaca, Dib-u-habaynta Matrix-ka-baxa, Calaamadeynta RAS-RAF, Calaamadeynta MAPK waxay door muhiim ah ka ciyaartaa wadista koritaanka kansarka. Sidoo kale daawaynta kala duwan waxay ku shaqeeyaan ficillo molecular oo kala duwan kuwaas oo aan waligood la baabi'in cuntadaada iyo kaabistaada. Cuntooyinka iyo kaabayaasha nafaqadu waxay ka kooban yihiin maaddooyin firfircoon oo kala duwan mid kasta oo ka mid ah wuxuu leeyahay ficil gaar ah oo unugyo ah oo ku saabsan waddooyinka biochemical ee kala duwan. Sidaa darteed, cunista cuntooyinka qaarkood iyo kaabayaasha nafaqeynta ayaa lagula talin lahaa daawaynta gaarka ah ee Multiple Myeloma, halka cunista cuntooyinka kale iyo kaabayaasha laga yaabo inaan lagu talin.
Hal qalad oo caadi ah marka la helo cunto la cuno ama aan la cunin - waa in la tixgeliyo kaliya dhowr maaddooyinka firfircoon ee ku jira cuntooyinka ku salaysan raadinta internetka oo iska indhatiraan inta kale. Sababtoo ah maaddooyinka kala duwan ee firfircoon ee ku jira cuntooyinka ayaa laga yaabaa inay saameyn iska soo horjeeda ku yeeshaan dariiqyada biochemical ee la xiriira - waxaa lagu talinayaa in la tixgeliyo dhammaan maaddooyinka firfircoon ee tirada badan ee ku jira wax muhiim ah oo aad uga weyn tirada cuntada.
TALO: Si aad u hesho CUNTOOYINKA LAGU SOO TALIYEY IYO AAN LAGULA TALIN EE MYELOMA BADAN – U fiirso maaddooyinka firfircoon ee tirada badan ee ku jira cunnada.
Cuntooyinka loogu talagalay Multiple Myeloma ee lagu daweynayo daaweynta kemotherabi
Multiple Myeloma - hiddo-wadaha KRAS, NRAS, TP53, BRAF iyo MUC16 waxay leeyihiin dhacdooyin sare oo aan caadi ahayn oo genomic ah. Dhammaan hiddo-wadahani maaha kuwo khuseeya kansarka - inkastoo la soo sheegay. Qaar ka mid ah hidde-sideyaashan ayaa si toos ah ama si aan toos ahayn u dhammeeya inay wax ka beddelaan kansarka kala duwan ee la xidhiidha dariiqyada bayoolojiga. Qaar ka mid ah dariiqyada u ah darawallada ku habboon Multiple Myeloma waa Calaamadeynta Sababta Kobaca, Dib-u-habaynta Matrix-ka Ka-baxsan, Angiogenesis iyo kuwa kale. Bortezomib waa mid ka mid ah daawoyinka kiimiko ee loo isticmaalo daawaynta kansarka. Ujeedada daawaynta waa in la diido ama la baabi'iyo saamaynta wadayaasha dariiqa biochemical ee Calaamadaynta Xuddunta Kobaca, Dib-u-habaynta Matrixka Ka baxsan, Angiogenesis si loo yareeyo horumarka cudurka loona joojiyo koritaanka. Cuntooyinkaas waxqabadkooda isku-darka ah ee maaddooyinka firfircooni waxay taageeraan ficilka daawaynta oo aan kor u qaadin darawaliinta cudurrada waxaa lagula talinayaa cuntooyin iyo kaabooyin kuwaas oo lagu dari doono nafaqeynta shakhsi ahaaneed. Iyo si la mid ah - cuntooyinkan ficilkooda isku-darka ah ee maaddooyinka firfircooni aanay taageerayaan ficilka daawaynta balse ay ku dhammaato kor u qaadida wadeyaasha cudurrada laguma talin doono qorshahaaga nafaqeynta ee gaarka ah.
TALO: KA FOG AQOONSIGA IYO CUNTADA AAN TAAGEERAYNAYN TALLAABADA DAWAYNTA KANSARKA BALKII HORUMARINTA WADAYAASHA CUDURKA.
Cun cuntooyin badan, digir-madow-madow ama digir qoolley?
Pulses waa qayb muhiim ah oo ka mid ah cuntooyin badan. Maaddooyinka firfircoon ee ku jira digirta isha madow waa Vitamin C, Daidzein, Oleic Acid, Linolenic Acid, Beta-carotene iyo kuwo kale. Halka maaddooyinka firfircoon ee ku jira Digirta Qoolleyda ay yihiin Vitamin C, Oleic Acid, Linolenic Acid, Genistein, Linoleic Acid iyo kuwo kale.
Faytamiin C waxa uu maamuli karaa dariiqyada biochemical ee WNT Beta Catenin Signaling, Angiogenesis iyo Hypoxia. Daidzein waxay leedahay ficil bayooloji ah oo ku saabsan dariiqyada biochemical ee PI3K-AKT-MTOR Calaamadeynta, Cadaadiska Oxidative iyo Cadaadiska Endoplasmic Reticulum.
Genistein waxa uu wax ka qaban karaa dariiqyada biochemical ee Cadaadiska Oxidative. Faytamiin A wuxuu leeyahay ficil bayooloji ah oo ku saabsan dariiqyada biochemical ee Dib-u-habaynta Matrix-ka Extracellular. Iyo wixi la mida.
Marka lagu daweynayo Multiple Myeloma kiimoterabi Bortezomib - Cuntooyinka sida digir-madowga leh ayaa lagula talinayaa marka la barbar dhigo digirta qoolleyda. Tani waa sababta oo ah maaddooyinka firfircoon ee Genistein iyo Faytamiin A ee ku jira Digirta Qoolleyda ayaa farageliya ficilka daawaynta iyaga oo baabi'inaya dariiqyada biochemical ee ay kimikalku ku shaqeyso. Iyadoo maaddooyinka firfircoon ee Vitamin C iyo Daidzein ee ku jira digir-madow ay taageeraan ficilka daawaynta iyaga oo kor u qaadaya saamaynta dariiqa kiimikaad ee ay kimikalku u shaqeyso.
TALO: digir-madow-madow ayaa lagula talinayaa digir xamaam ah oo loogu talagalay Myeloma BADAN oo lagu daweynayo kiimiko BORTEZOMIB xaaladaha qaarkood.
Cun khudaar badan, Giant Butterbur ama Yam?
Khudaarta ayaa qayb muhiim ah ka ah cuntooyin badan. Maaddooyinka firfircoon ee ku jira Giant Butterbur waa Vitamin C, Melatonin, Beta-sitosterol, Kaempferol, Vitamin A iyo kuwo kale. Halka maaddooyinka firfircoon ee ku jira Yam ay yihiin Vitamin C, Beta-sitosterol, Oleic Acid, Linolenic Acid, Dioscin iyo kuwo kale.
Faytamiin C waxa uu maamuli karaa dariiqyada biochemical ee WNT Beta Catenin Signaling, Angiogenesis iyo Hypoxia. Melatonin waxay leedahay ficil bayooloji ah oo ku saabsan dariiqyada kiimikaad ee PI3K-AKT-MTOR Calaamadeynta, Calaamadeynta Sababta Kobaca iyo Cadaadiska Oxidative.
Citric Acid waxa ay maareyn kartaa dariiqyada biochemical ee Cadaadiska Oxidative. Dioscin waxay leedahay ficil bayooloji ah oo ku saabsan dariiqyada biochemical ee Calaamadaynta. Iyo wixi la mida.
Marka lagu daweynayo Multiple Myeloma kiimoterabi Bortezomib - Cuntooyinka sida Giant Butterbur ayaa lagula talinayaa marka la barbardhigo Yam. Tani waa sababta oo ah maaddooyinka firfircoon ee Citric Acid iyo Dioscin ee ku jira Yam waxay farageliyaan ficilka daawaynta iyaga oo baabi'inaya dariiqyada biochemical ee ay kimikalku ku shaqeyso. Iyadoo maaddooyinka firfircoon ee Fitamiin C iyo Melatonin ee ku jira Giant Butterbur ay taageeraan ficilka daawaynta iyaga oo kor u qaadaya saamaynta dariiqa kiimikaad ee uu kiimikaadku shaqeeyo.
TALO: GIANT BUTTERBUR ayaa lagula talinayaa in la dhaafo YAM si loogu daweeyo Myeloma badan
Ku guuldareystay in lagu xiro MySQL: Ma jirto waddo loo maro martigelinta
Cun miro badan, Partridgeberry ama Miraha Xamaasada?
Miraha waa qayb muhiim ah oo ka mid ah cuntooyin badan. Maaddooyinka firfircoon ee ku jira Partridgeberry waa Resveratrol, Beta-sitosterol, Stigmasterol iyo kuwo kale. Halka maaddooyinka firfircoon ee ku jira khudradda Passion ay yihiin Vitamin C, Oleic Acid, Linolenic Acid, Linoleic Acid, Vitamin A iyo kuwo kale.
Resveratrol waxa ay maareyn kartaa dariiqyada kiimikaad ee Hypoxia, Angiogenesis iyo Cadaadiska Reticulum Endoplasmic. Beta-sitosterol waxay leedahay ficil bayooloji ah oo ku saabsan dariiqyada biochemical ee WNT Beta Catenin Signaling, PI3K-AKT-MTOR Signaling iyo Oxidative Stress.
Faytamiin A wuxuu wax ka beddeli karaa dariiqyada biochemical ee Dib-u-habaynta Matrix-ka-ka-baxsan. Citric Acid waxay leedahay ficil bayooloji ah oo ku saabsan waddooyinka biochemical ee Cadaadiska Oxidative. Iyo wixi la mida.
Marka lagu daweynayo Multiple Myeloma kiimoterabi Bortezomib - Cuntooyinka sida Partridgeberry ayaa lagu talinayaa marka la barbar dhigo midhaha xamaasadda. Tani waa sababta oo ah maaddooyinka firfircoon ee Fiitamiin A iyo Citric Acid ee Jacaylka Miraha waxay farageliyaan ficilka daawaynta iyaga oo baabi'inaya dariiqyada biochemical ee uu ku shaqeeyo kiimiko. Iyadoo maaddooyinka firfircoon ee Resveratrol iyo Beta-sitosterol ee ku jira Partridgeberry ay taageeraan ficilka daawaynta iyaga oo kor u qaadaya saamaynta dariiqa kiimikaad ee ay kimikalku ku shaqeyso.
TALO: PARTRIDGEBERRY waxaa lagula talinayaa in la siiyo miro xamaasad leh oo loogu talagalay MYELOMA BADAN oo lagu daweynayo kiimiko BORTEZOMIB xaaladaha qaarkood.
Cun badan nuts, Chestnut ama Macadamia Nut?
Miraha waa qayb muhiim ah oo ka mid ah cuntooyin badan. Maaddooyinka firfircoon ee ku jira Chestnut waa Quercetin, Ellagic Acid, Vitamin C, Oleic Acid, Betulin iyo kuwo kale. Halka maaddooyinka firfircoon ee ku jira Macadamia Nut ay yihiin Beta-sitosterol, Lauric Acid, Palmitic Acid, Myristic Acid, Folic Acid iyo kuwo kale.
Ellagic Acid waxa ay wax ka qaban kartaa dariiqyada biochemical ee WNT Beta Catenin Signaling, Angiogenesis iyo Dib-u-habaynta Matrix-ka ka baxsan. Betulin waxay leedahay ficil bayooloji ah oo ku saabsan dariiqyada biochemical Hypoxia, Stress Oxidative iyo PI3K-AKT-MTOR Signaling.
Lauric Acid waxa ay wax ka beddeli kartaa dariiqyada biochemical ee PI3K-AKT-MTOR Signaling. Palmitic Acid waxay leedahay ficil bayooloji ah dariiqyada biochemical ee WNT Beta Catenin Signaling, Angiogenesis iyo Dib-u-habaynta Matrix Ka-baxsan. Iyo wixi la mida.
Marka lagu daweynayo Multiple Myeloma kiimoterabi Bortezomib - Cuntooyinka sida Chestnut ayaa lagula talinayaa marka la barbar dhigo Macadamia Nut. Tani waa sababta oo ah maaddooyinka firfircoon ee Lauric Acid iyo Palmitic Acid ee Macadamia Nut waxay farageliyaan ficilka daawaynta iyaga oo baabi'inaya dariiqyada biochemical ee ay ku shaqeyso daaweynta kiimikaad. Iyadoo maaddooyinka firfircoon ee Ellagic Acid iyo Betulin ee ku jira Chestnut ay taageeraan ficilka daawaynta iyaga oo kor u qaadaya saamaynta dariiqa kiimikaad ee ay kimoteradu ku shaqeyso.
TALO: xabadka waxaa lagula talinayaa in la siiyo looska MACADAMIA si loogu daweeyo Myeloma badan
Cuntooyinka loogu talagalay Khatarta Hidde ee Myeloma-da badan
Mid ka mid ah siyaabaha lagu qiimeeyo khatarta kansarka waa iyada oo la hubinayo jiritaanka cilladaha hidde-sideyaasha ee qayb ka mid ah hidde-sideyaasha. Waxaa jira macluumaad hore oo ku saabsan liiska hiddo-wadaha kuwaas oo isbeddelkooda iyo cilladaha kale ay door ka ciyaari karaan khatarta kansarka kala duwan. NRAS iyo BRAF waa laba hidde-sideyaal kuwaas oo aan caadi ahayn ay yihiin arrimo halis u ah Multiple Myeloma. Xaaladdan oo kale ah khatarta kansarka - iyada oo aan sida caadiga ah jirin daweyn uu takhtarku qori karo - dariiqooyinka kala duwan ee biochemical kuwaas oo ah darawallada molecular ee Multiple Myeloma ayaa loo isticmaali karaa hage si loo helo qorshe nafaqo oo shakhsi ahaaneed oo lagu taliyey. Hidde-sidaha Multiple Myeloma NRAS waxa uu saamayn sababa ku leeyahay dariiqooyinka bayooloji sida G-protein-ku-xidhan yahay calaamadaynta soo-dhowaynta, calaamadaynta qodobka koritaanka iyo calaamadaynta RAS-RAF. BRAF-na waxay saameyn sababa ku leedahay dariiqooyinka noolaha sida RAS-RAF Signaling, Signaling MAPK iyo Soo bandhigida Antigen-ka. Cuntooyinka iyo kaabayaasha nafaqeynta kuwaaso leh fal molecular si ay u baabi'iyaan dariiqyada biochemical ee saamaynta hiddo-wadaha sida NRAS iyo BRAF waa in lagu daraa qorshe nafaqo oo shakhsi ahaaneed. Cuntooyinkaas iyo kaabeyaasha kor u qaada saamaynta hidde-sideyaasha NRAS iyo BRAF waa in laga fogaadaa.
Cun cuntooyin badan, Mung Bean ama Adzuki Bean?
Maaddooyinka firfircoon ee ku jira Mung Bean waa Quercetin, Oleic Acid, Linolenic Acid, Vitamin C, Vitexin iyo kuwo kale. Halka maaddooyinka firfircoon ee ku jira Adzuki Bean ay yihiin Isoliquiritigenin, Glucaric Acid, Genistein, Folic Acid iyo kuwa kale.
Quercetin waxa ay wax ka tari kartaa dariiqyada kiimikaad ee MAPK Calaamadaynta, Isbaarada Wareegga Gacanta iyo Calaamadaynta RAS-RAF. Faytamiin C waxa uu leeyahay ficil bayooloji ah oo ku saabsan dariiqyada biochemical ee P53 Signaling, MYC Signaling iyo PI3K-AKT-MTOR Signaling.
Folic Acid waxa ay maamuli kartaa dariiqyada kiimikaad ee MAPK Calaamadeynta, Isbaarada Wareegga Unugyada iyo Calaamadeynta RAS-RAF. Iyo wixi la mida.
Khatarta hidda-socodka ee Multiple Myeloma sababtoo ah cilladaha aan caadiga ahayn ee hiddo-wadaha NRAS iyo BRAF - Cuntooyinka sida Mung Bean ayaa lagula talinayaa marka la barbardhigo Adzuki Bean. Tani waa sababta oo ah maaddooyinka firfircoon ee Folic acid ee ku jira Adzuki Bean waxay sii kor u qaadaan saameynta hiddo-wadaha ee waddooyinka biochemical. Halka maaddooyinka firfircoon ee Quercetin iyo Vitamin C ee ku jira Mung Bean ay si wada jir ah u baabi'iyaan saamaynta hidde-sideyaasha ee waddooyinka biochemical.
TALO: MUNG BEAN ayaa lagula talinayaa digirta ADZUKI si ay u yareyso halista hidda-socodka ee Myeloma-ga badan oo ay ugu wacan tahay GENES NRAS iyo BRAF
Cun khudaar badan, Cassava ama seleri?
Maaddooyinka firfircoon ee ku jira Cassava waa Beta-sitosterol, Oleic Acid, Linolenic Acid, Vitamin C, Linoleic Acid iyo kuwo kale. Halka maaddooyinka firfircoon ee ku jira Seleri ay yihiin Apigenin, Quercetin, Oleic Acid, Linolenic Acid, Vitamin C iyo kuwo kale.
Faytamiin C waxa uu maamuli karaa dariiqyada kiimikaad ee MAPK Calaamadaynta, Isbaarada Wareegga Unugyada iyo Calaamadaynta RAS-RAF. Beta-sitosterol waxay leedahay ficil bayooloji ah oo ku saabsan dariiqyada biochemical ee P53 Signaling, Signaling MYC iyo PI3K-AKT-MTOR Signaling.
Luteolin waxa ay wax ka qaban kartaa dariiqyada biochemical ee Calaamadaynta MYC. Chrysin wuxuu leeyahay ficil bayooloji ah oo ku saabsan waddooyinka biochemical ee MYC Signaling. Iyo wixi la mida.
Khatarta hidde-sidaha ee Multiple Myeloma oo ay ugu wacan tahay cilladaha ku jira hiddo-wadaha NRAS iyo BRAF - Cuntooyinka sida Cassava ayaa lagula talinayaa marka la barbar dhigo Celery. Tani waa sababta oo ah maaddooyinka firfircoon ee Luteolin iyo Chrysin ee Seleri waxay sii kor u qaadaan saameynta hiddo-wadaha ee waddooyinka biochemical. Halka maaddooyinka firfircoon ee Vitamin C iyo Beta-sitosterol ee ku jira Cassava ay si wada jir ah u baabi'iyaan saamaynta hidde-sideyaasha ee waddooyinka biochemical.
TALO: CASAVA ayaa lagula talinayaa in la sii daayo si loo yareeyo khatarta hidda-socodka ee Myeloma BADAN oo ay sabab u tahay GENES NRAS iyo BRAF
Cuntooyinka la Cuno Ka Dib Baaritaanka Kansarka!
Ma jiraan laba kansar oo isku mid ah. Ka gudub tilmaamaha guud ee nafaqada ee qof walba oo samee go'aanno shaqsiyeed oo ku saabsan cuntada iyo kaabayaasha si kalsooni leh.
Cun miro badan, Orange ama Strawberry?
Maaddooyinka firfircoon ee ku jira Orange waa D-limonene, Linalool, Citrus Pectin la beddelay, Oleic Acid, Linolenic Acid iyo kuwo kale. Halka maaddooyinka firfircoon ee ku jira Strawberry ay yihiin Ellagic Acid, Lupeol, Cianidanol, Beta-sitosterol, Oleic Acid iyo kuwo kale.
D-limonene waxa ay wax ka tari kartaa dariiqyada biochemical ee Calaamadaynta MAPK, Isbaarada Wareegga Gacanta iyo Calaamadaynta RAS-RAF. Faytamiin C waxa uu leeyahay ficil bayooloji ah oo ku saabsan dariiqyada biochemical ee P53 Signaling, MYC Signaling iyo PI3K-AKT-MTOR Signaling.
Fisetin waxay wax ka beddeli kartaa dariiqyada biochemical ee MYC Signaling. Pelargonidin wuxuu leeyahay ficil bayooloji ah oo ku saabsan dariiqyada kiimikaad ee isbaarada wareegga unugyada, Calaamadaynta PI3K-AKT-MTOR iyo Calaamadaynta MYC. Iyo wixi la mida.
Khatarta hidde-sidaha ee Multiple Myeloma sababtoo ah cilladaha aan caadiga ahayn ee hiddo-wadaha NRAS iyo BRAF - Cuntooyinka sida Orange ayaa lagula talinayaa marka la barbar dhigo Strawberry. Tani waa sababta oo ah maaddooyinka firfircoon ee Fisetin iyo Pelargonidin ee ku jira Strawberry waxay sii kor u qaadaan saameynta hidda-socodka ee waddooyinka biochemical. Iyadoo maaddooyinka firfircoon ee D-limonene iyo Vitamin C ee ku jira Orange ay si wada jir ah u baabi'iyaan saamaynta hiddo-wadaha ee waddooyinka biochemical.
TALO: Orange ayaa lagula talinayaa in ka badan strawberry si ay u yareeyaan khatarta hidda-socodka ee Myeloma badan oo ay sabab u tahay GENES NRAS iyo BRAF
Cun badan nuts, yicib ama cashew nuts?
Maaddooyinka firfircoon ee ku jira Almond waa Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid iyo kuwo kale. Halka maaddooyinka firfircoon ee ku jira lawska cashew ay yihiin Palmitic Acid, Beta-sitosterol, Vitamin C, Gallic Acid, Butyric Acid iyo kuwo kale.
Beta-sitosterol waxa ay wax ka qaban kartaa dariiqyada kiimikaad ee isbaarada wareegga unugyada, Calaamadaynta P53 iyo Calaamadaynta MYC. Quercetin waxay leedahay ficil bayooloji ah dariiqyada biochemical ee MAPK Signaling, RAS-RAF Signaling iyo PI3K-AKT-MTOR Signaling.
Palmitic Acid waxay wax ka beddeli kartaa dariiqyada biochemical ee MAPK Signaling. Lauric Acid waxay leedahay ficil bayooloji ah dariiqyada biochemical ee MYC Signaling, PI3K-AKT-MTOR Signaling iyo MAPK Signaling. Iyo wixi la mida.
Khatarta hidde-sidaha ee Multiple Myeloma oo ay ugu wacan tahay cilladaha ku jira hiddo-wadaha NRAS iyo BRAF - Cuntooyinka sida Almond-ka ayaa lagula talinayaa marka la barbar dhigo Cashew Nut. Tani waa sababta oo ah maaddooyinka firfircoon ee Palmitic Acid iyo Lauric Acid ee Cashew Nut waxay sii kor u qaadaan saamaynta hidda-socodka ee waddooyinka biochemical. Iyadoo maaddooyinka firfircoon ee Beta-sitosterol iyo Quercetin ee ku jira Almond ay si wada jir ah u baabi'iyaan saamaynta hiddo-wadaha ee waddooyinka biochemical.
TALO: Almond waxaa lagula talinayaa in la dhaafo cashew nuts si loo yareeyo khatarta hidda-socodka ee Myeloma badan oo ay sabab u tahay GENES NRAS iyo BRAF
Marka la soo koobo
Arrin muhiim ah in la xasuusto ayaa ah taas kansarka daawaynta waxaa laga yaabaa inaysan isku mid u ahayn qof walba - sidoo kale waa inay nafaqadu noqotaa. Nafaqada oo ay ku jirto cuntada iyo kaabayaasha nafaqeynta waa qalab aad wax ku ool ah oo aad maamusho.
"Maxaan cunaa?" waa su'aasha ugu badan ee la is weydiiyo marka laga hadlayo xaaladda kansarka. Xisaabinta jawaabta waa mid adag waxayna ku xiran tahay nooca kansarka, genomics-ka hoose, daawaynta hadda, xasaasiyad kasta, macluumaadka qaab nololeedka, iyo arrimo sida BMI.
Qorshaha nafaqaynta shakhsi ahaaneed ee addon wuxuu ku taliyaa cuntooyinka iyo kaabayaasha kuwaas oo yareeya isdhexgalka nafaqada oo dhiirigeliya taageerada daaweynta.
Waxaad hadda bilaabi kartaa oo aad dejin kartaa qorshe nafaqeyn oo gaar ah Multiple Myeloma adiga oo ka jawaabaya su'aalaha ku saabsan nooca kansarka, daawaynta hadda, kaabista, xasaasiyadda, kooxda da'da, jinsiga, iyo macluumaadka qaab nololeedka.
Cuntada aad cunayso iyo waxyaalaha dheeraadka ah ee aad qaadato ayaa ah go'aanka aad gaadho. Go'aankaagu waa inuu ku jiraa tixgelinta isbeddellada hidda -wadaha kansarka, kansarka, daaweynta joogtada ah iyo kaabisyada, wixii xasaasiyad ah, macluumaadka hab -nololeedka, miisaanka, dhererka iyo caadooyinka.
Qorshaynta nafaqada kansarka ee addon kuma salaysna raadinta internetka. Waxay si otomaatig ah kuu siineysaa go'aanka adiga oo ku saleynaya sayniska molikalikada oo ay hirgeliyeen saynisyahannadeenna iyo injineerada software -ka. Iyadoo aan loo eegin haddii aad danaynayso inaad fahanto waddooyinka kelli -yaqaanka ee biochemical -ka hoose iyo haddii kale - qorshaynta nafaqada ee kansarka fahamka ayaa loo baahan yahay.
Hadda ku bilow qorshaynta nafaqada adiga oo ka jawaabaya su'aalaha ku saabsan magaca kansarka, isbeddellada hidda -socodka, daaweynta joogtada ah iyo kaabisyada, wixii xasaasiyad ah, caadooyin, hab -nololeed, kooxda da'da iyo jinsiga.
tixraacyada
- Saamaynta Msk 2017
- Heterogeneity hidde-sidaha baahsan ee myeloma-ka badan: saamaynta daawaynta la beegsaday.
- Faytamiin C wuxuu si xushmad leh u dila unugyada kansarka mindhicirka ee KRAS iyo BRAF iyadoo la beegsanayo GAPDH.
- Saamaynta Daidzein ee hoormoonka kansarka qanjirka 'prostate' ee vitro iyo in vivo marka la barbar dhigo genistein iyo soosaarka soy: awoodda shucaaca.
- Ku dheggan matrixka unugyada ka baxsan waxaa si togan u habeeya aashitada retinoic ee unugyada HepG2.
- Resveratrol waxay kicisaa autophagy iyadoo si toos ah u joojinaysa mTOR iyada oo loo marayo tartanka ATP.
- β-Sitosterol waxay bartilmaameedsataa Trx / Trx1 reductase si ay u keento apoptosis ee unugyada A549 iyada oo loo sii marayo ROS dhexdhexaadinta dysregulation mitochondrial iyo firfircoonida p53.
- Melatonin waxa ay nuugtaa Her-2, p38 MAPK, p-AKT, iyo mTOR Heerarka kansarka ugxansidaha ee Jiirka-doorbidayaa Ethanol.
- Saamaynta dioscin ee kor u qaadida dib-u-soo-noolaynta beerka iyada oo la dhaqaajinayo dariiqa calaamada ee Notch1/Jagged1.
- Indeno [1,2-b] derivatives indole sida fasalka cusub ee borotiinka aadanaha kinase CK2 inhibitors.
- Isbeddellada cudurrada wadnaha lagu dhasho ee dhalmada Degmada Dallas. 1971-1984.
- Taurine waxay wanaajisaa iska caabbinta insulin-ta ee arsenic-ka-hooseeya iyadoo kicinaysa calaamadaynta PPARγ-mTORC2 waxayna joojinaysaa autophagy-ga cagaarshow.
- Protein kinase iyo HDAC horjoogayaasha ka ah fangaska endophytic Epicoccum nigrum.
- Tibaaxaha protooncogene-ka ee isdaba jooga ee dib u soo noolaynta kelyaha ka dib dhaawac degdeg ah oo kelyaha ah.
- D-Limonene waxay hagaajisaa caabuqa, walbahaarka oksaydhka iyo dariiqa Ras-ERK si loo joojiyo burooyinka maqaarka ee maqaarka.
- Qaab-dhismeedka Crystal ee kinase 6-ku-tiirsanaanta bini'aadamka oo leh flavonol inhibitor ah, fisetin.
- Pelargonidin waxay xakameysaa adipogenesis ee unugyada 3T3-L1 iyada oo la xakameynayo dariiqa calaamadaha PPAR-γ.
- Farmashiyaha kiliinikada ee antihistamines.
- Resveratrol, pterostilbene, iyo piceatannol oo ku jira berry vaccinium.
- HyperFoods: Mashiinka khariidaynta caqliga leh ee unugyada kansarka garaaca ee cuntooyinka.
- Fisetin: antioxidant-ka cuntada ee kor u qaadida caafimaadka.
Nafaqada gaarka ah ee kansarka!
Kansarku wuu is beddelaa waqti ka dib. Habbee oo wax ka beddel nafaqadaada iyadoo lagu salaynayo calaamadda kansarka, daawaynta, qaab nololeedka, dookhyada cuntada, xasaasiyadda iyo arrimo kale.