Kansarkee ayaa ka faa'iidaysan doona in lagu daro Mushroomka Maitake cuntadooda?

Tilmaamaha

Mushroom Maitake waxaa si weyn loogu aqoonsaday faa'iidooyinkeeda caafimaad waxaana inta badan isticmaala bukaannada kansarka iyo kuwa halista ugu jira hidde-sidaha. Hase yeeshee, badbaadada iyo waxtarka Mushroom Maitake ee bukaannada kansarka waxay ku xiran tahay arrimo badan sida calaamadda kansarka, daaweynta kemotherabi, daawaynta kale, iyo hiddaha burada. Ogaanshaha in qaar ka mid ah cuntooyinka iyo kaabisyada, sida bambeelmada iyo isbinaajka, laga yaabo inay si liidata ula falgalaan daawooyinka kansarka oo ay keenaan fal-celin xun waa muhiim.

Cuntadu waxay muhiim u tahay daaweynta kansarka sababtoo ah waxay saameyn kartaa natiijooyinka daaweynta. Bukaannada kansarku waa inay si taxadar leh u doortaan oo ku daraan cuntooyinka ku habboon iyo kaabista cuntadooda. Tusaale ahaan, Mushroom Maitake waxa uu ka faa'iidaysan karaa kuwa qaba Kansarka Unugyada Xubinta Xubinta ee Guska ee ku socda Mitomycin, laakiin waxa laga yaabaa inaanay u fiicnayn bukaanada qaata Acalabrutinib ee Lymphoma Primary Non-Hodgkin. Intaa waxaa dheer, halka Maitake Mushroom uu caawin karo shakhsiyaadka leh khatarta hidde-sidaha "CDH1", waxaa laga yaabaa in aan loo soo jeedin kuwa leh khatarta hidde kale ee "ASXL1". Shakhsiyaynta qorshayaasha cuntada ee ku salaysan caafimaadka, daawaynta, iyo hidaha waa lama huraan.

Fahamka in go'aan ka gaarista ku habboonaanta Mushroom Maitake ee bukaanka kansarka uu u baahan yahay in la gaaryeelo waa muhiim. Qodobbada muhiimka ah sida nooca kansarka, hababka daawaynta, qurxinta hidda-socodka, khatarta hidda-socodka, da'da, miisaanka jidhka, iyo qaab nololeedka ayaa muhiim u ah go'aaminta haddii Mushroom Maitake yahay doorashada habboon. Genetics iyo genomics, gaar ahaan, waa tixgelin muhiim ah. Maadaama arrimahan ay kobci karaan, waxaa lama huraan ah in si joogto ah dib loogu eego oo la waafajiyo doorashooyinka cuntada si loo waafajiyo isbeddelada xaaladda caafimaadka iyo daaweynta.

Gebagebadii, habka guud ee doorashooyinka cuntada ayaa muhiim ah, iyadoo diiradda la saarayo saamaynta guud ee dhammaan qaybaha firfircoon ee cuntooyinka/kaabka sida Maitake Mushroom halkii laga qiimayn lahaa shay kasta oo firfircoon si gooni ah ama gebi ahaanba la iska indho-tiray. Aragtida ballaadhan waxay kobcinaysaa hab macquul ah oo cilmiyaysan oo loogu talagalay qorsheynta cuntada ee kansarka.

Dulmar Kooban

Isticmaalka cuntooyinka dhirta ku salaysan iyo waxyaalaha dheeriga ah, sida fiitamiinada, geedo yaryar, macdanta, probiotics, iyo supplements-ka gaarka ah ee kala duwan, ayaa ku soo badanaya bukaannada kansarka. Kaabayaashan waxaa loogu talagalay in lagu bixiyo uruurin sare oo ah maaddooyin firfircoon oo gaar ah, kuwaas oo qaar badan oo ka mid ah ay sidoo kale ku jiraan cuntooyin kala duwan. U fiirsashada iyo kala duwanaanta maaddooyinka firfircooni waxay ku kala duwan yihiin cuntooyinka oo dhan iyo kaabista. Cuntooyinka sida caadiga ah waxay bixiyaan noocyo kala duwan oo maaddooyin firfircoon ah laakiin xaddi hoose, halka kaabayaashu ay bixiyaan uruurin sare oo ah maaddooyin gaar ah.

Iyadoo la tixgalinayo shaqooyinka kala duwan ee sayniska iyo bayooloji ee walax kasta oo firfircoon heerka molecular, waxaa muhiim ah in lagu xisaabtamo saamaynta isku dhafan ee qaybahan marka la go'aaminayo cuntooyinka iyo kaabayaasha in la cuno iyo in kale.

Su'aasha muhiimka ah ayaa soo baxaysa: Ma ku daraa likaha Maitake cuntadaada sida shay cunto ama kabitaan ahaan? Ma lagugula talinayaa inaad isticmaasho Mushroomka Maitake haddii aad leedahay cudurka kansarka ee la xiriira hiddo-wadaha CDH1? Maxaa dhacaya haddii taa beddelkeeda khatartaada hidde-sidaha ay ka timid hidda-wadaha ASXL1? Faa'iido ma tahay in lagu daro likaha Maitake ee cuntadaada haddii lagaa helo Lymphoma Primary non-Hodgkin Lymphoma, ama haddii cilad-sheegashadaadu tahay Kansarka Unugyada Xubinta Xubinta Hore? Waxaa intaa dheer, sidee loo hagaajin karaa isticmaalka Mushroomka Maitake haddii lagugu daweynayo Mitomycin ama haddii qorshahaaga daawaynta uu ka wareego Mitomycin una wareego Acalabrutinib? Waa lagama maarmaan in la aqoonsado in sheegashada fudud sida 'Mushroom Maitake' ay tahay mid dabiici ah, marka had iyo jeer waa faa'iido' ama 'Mushroom Maitake wuxuu xoojiyaa difaaca' kuma filna doorashada cuntada/kabka.

Intaa waxaa dheer, waa lama huraan in dib loo qiimeeyo ku habboonaanta in lagu daro Mushroomka Maitake ee cuntadaada haddii ay jiraan isbeddelo ku yimaadda habka daaweyntaada. Isku soo wada duuboo, markaad go'aan ka gaadhayso ku darida cuntooyinka ama kaabista sida Maitake Mushroom ee cuntadaada faa'iidooyinkeeda, waa inaad tixgelisaa saamaynta guud ee bayoolaji ee dhammaan maaddooyinka, adoo tixgelinaya arrimo ay ka mid yihiin nooca kansarka, daawaynta gaarka ah ee aad marayso, hiddaha predispositions, iyo doorashada hab nololeedka.

Kansarka

Kansarka ayaa weli ah caqabad weyn oo dhanka caafimaadka ah, isagoo inta badan keena walaac baahsan. Si kastaba ha ahaatee, horumarradii ugu dambeeyay ayaa hagaajiyay natiijooyinka daaweynta, gaar ahaan iyada oo loo marayo hababka daawaynta shakhsi ahaaneed, hababka kormeerka aan fiicneyn ee dhiigga iyo shaybaarada candhuufta, iyo horumarinta immunotherapy. Ogaanshaha hore iyo ka-hortagga wakhtiga ayaa ahaa mid muhiim u ah si wax ku ool ah u saameeya natiijooyinka guud ee daaweynta.

Tijaabada hidde-sidaha waxay bixisaa ballan-qaad muhiim ah oo lagu qiimeeyo khatarta kansarka iyo u nuglaanta goor hore. Si kastaba ha ahaatee, shakhsiyaad badan oo qaba qoyska iyo hidde-sidaha kansarka, fursadaha faragelinta daweynta, xitaa la socodka joogtada ah, badanaa waa xaddidan yihiin ama midna. Marka lagu ogaado nooc gaar ah oo kansar ah, sida Kansarka xubinta taranka ee xubinta taranka ama Primary non-Hodgkin Lymphoma, xeeladaha daawaynta waxay u baahan yihiin in la habeeyo iyadoo lagu saleynayo hidde-sideyaasha buro ee qofka, heerka cudurka, iyo sidoo kale arrimo ay ka mid yihiin da'da iyo jinsiga .”

Daawaynta ka dib, la socodka joogtada ahi waa lama huraan si loo ogaado calaamad kasta oo ah soo noqoshada kansarka iyo in lagu wargeliyo go'aamada xiga. Bukaanno badan oo kansar ah iyo kuwa halista ku jira ayaa inta badan raadsada talo ku saabsan ku daridda cuntooyinka qaarkood iyo kaabisyada cuntadooda, taas oo door muhiim ah ka ciyaarta guud ahaan habka go'aan qaadashada ee ku saabsan maaraynta caafimaadka.

Su'aasha muhiimka ah ayaa ah in la tixgalinayo khatarta hidda-socodka iyo ogaanshaha kansarka gaarka ah marka la go'aaminayo doorashooyinka cuntada, sida Maitake Mushroom. Khatarta hidde-sidaha kansarka ee ka imanaysa isu-beddelka CDH1 ma leedahay saameyn la mid ah dariiqa biochemical ee isbeddelka ASXL1? Marka loo eego dhinaca nafaqeynta, khatarta la xiriirta kansarka xubinta taranka ee xubinta taranka ee xubinta taranka ma la mid tahay Lymphoma Primary non-Hodgkin? Intaa waxaa dheer, tixgelinta cuntadu miyay la mid tahay kuwa lagu sii wado Acalabrutinib iyo kuwa qaata Mitomycin? Tixgelintan ayaa muhiim u ah samaynta doorashooyin cunto oo xog-ogaal ah oo loogu talagalay shakhsiyaadka leh khataraha hidde-sidaha ee kala duwan iyo daaweynta kansarka.

Mushroom Maitake - Kaab Nafaqo ah

Kabka Maitake Mushroom waxa uu ka kooban yahay noocyo kala duwan oo maaddooyin firfircoon ah, oo ay ku jiraan Gfg-3a, D-jajab iyo Gfp-a, mid walbana waxa uu joogaa tirooyin kala duwan. Maaddooyinkaani waxay saameeyaan dariiqyada molecular, gaar ahaan MAPK Signaling, C-nooca Lectin Receptor Signaling iyo Endoplasmic Reticulum Stress, kaas oo nidaamiya dhinacyada muhiimka ah ee kansarka ee heerka gacanta, sida koritaanka burada, fiditaanka, iyo dhimashada unugyada. Marka la eego saamaynta bayoolojiga, xulashada kaabayaasha ku habboon sida Maitake Mushroom, kaligii ama isku darka, waxay noqotaa go'aan muhiim ah marka la eego macnaha nafaqeynta kansarka. Markaad ka fekereyso isticmaalka Maitake Mushroom ee kansarka, waa lagama maarmaan in la tixgeliyo arrimahan iyo hababka kala duwan. Tani waa sababta oo ah, oo la mid ah daawaynta kansarka, isticmaalka Mushroomka Maitake maaha go'aan caalami ah oo ku habboon dhammaan kansarrada laakiin wuxuu u baahan yahay in la shakhsiyeeyo.

Doorashada Kaabayaasha Mushroom Maitake

Wax ka qabashada su'aasha 'Goorma ayaan ka fogaanayaa likaha Maitake ee macnaha guud ee Kansarka' waa caqabad sababtoo ah jawaabtu waa mid si gaar ah loo gaar yeelay - si fudud ayay ku xiran tahay!' Si la mid ah sida daawaynta kansarku aanay waxtar ugu yeelan bukaan kasta, ku habboonaanta iyo badbaadada ama faa'iidooyinka Mushroom Maitake way kala duwan yihiin iyadoo ku xidhan duruufaha shakhsi ahaaneed. Waxyaabaha ay ka midka yihiin nooca kansarka ee gaarka ah, saadaalin hidde-sidaha, daawaynta hadda, kaabisyada kale ee la qaato, hab-nololeedka, BMI, iyo xasaasiyad kasta ayaa dhammaantood door ka ciyaara go'aaminta in likaha Maitake uu ku habboon yahay ama ay tahay in laga fogaado, iyada oo hoosta ka xariiqaysa muhiimadda tixgelinta shakhsi ahaaneed. go'aamadan oo kale.

1. Kaabista likaha ma ka faa'iidaysan doontaa Bukaannada Aasaasiga ah ee aan Hodgkin Lymphoma ahayn Bukaanada lagu wado daawaynta Acalabrutinib?

Lymphoma aasaasiga ah ee aan Hodgkin ahayn waxaa lagu gartaa isbeddellada hidde-sidaha gaarka ah, kuwaas oo kala ah TET2, RHOA iyo CDK12, kuwaas oo horseedaya isbeddel ku yimaadda waddooyinka biochemical, gaar ahaan nooca C-Lectin Restor Signaling, Oncogenic Cancer Epigenetics, Cytoskeletal Dynamics iyo Adherens junction. Waxtarka daaweynta kansarka, sida Acalabrutinib, waxay ku xiran tahay habkeeda ficil ee waddooyinkan gaarka ah. Istaraatiijiyadda ugu habboon waxay ku lug leedahay in la waafajiyo ficilka daawaynta iyo waddooyinka kansarka, si loo hubiyo hab shakhsiyeed oo waxtar leh. Xaaladahan oo kale, ka fogaanshaha cuntooyinka ama dheellitirka nafaqeynta ee laga yaabo inay ka hortagaan saameynta daaweynta ama hoos u dhigta isku-habayntan ayaa muhiim ah. Tusaale ahaan, kabka Maitake Mushroom, kaas oo saameeya calaamada soo dhaweynta nooca C-nooca Lectin, waxaa laga yaabaa inaysan ahayn doorashada saxda ah ee kiiska Lymphoma Primary non-Hodgkin marka la marinayo Acalabrutinib. Tani waa sababta oo ah waxay ka sii dari kartaa horumarka cudurka ama waxay faragelin kartaa waxtarka daaweynta. Markaad dooranayso qorshaha nafaqeynta, waxaa muhiim ah in la tixgeliyo arrimo ay ka mid yihiin nooca kansarka, daawaynta socota, da'da, jinsiga, BMI, qaab nololeedka, iyo isbeddellada hidde-sidaha ee la yaqaan.

2. Kaabista likaha ma ka faa'iidaysan doontaa Kansarka xubinta taranka ee xubinta taranka ah Bukaannada loo maro daawaynta Mitomycin?

Kansarka xubinta taranka ee xubinta taranka waxaa lagu gartaa isbeddellada hidde-sidaha gaarka ah, sida ABRAXAS1, PIK3CB iyo NUP93, taasoo keenta isbeddel ku yimaadda dariiqyada biochemical, gaar ahaan MAPK Signaling, Hematopoiesis iyo Inositol Phosphate Signaling. Waxtarka daaweynta kansarka, sida Mitomycin, waxaa lagu go'aamiyaa la falgalka waddooyinkan. Ujeeddadu waa in la hubiyo in daawadu ay si fiican ula jaanqaado dariiqooyinka keena kansarka, taasoo awood u siinaysa hab daawaynta shakhsi ahaaneed. Xaaladdan oo kale, cuntooyinka ama kaabeyaasha ku habboon daawaynta ama kor u qaadaysa isku-habayntan waa in la tixgeliyo. Tusaale ahaan, kabka Mushroomka Maitake waa ikhtiyaar maangal ah oo loogu talagalay kuwa qaba Kansarka Unugyada Xubinta Xubinta Xubinta ee ay marayso Mitomycin. Tani waa sababta oo ah Mushroom Maitake wuxuu saameeyaa dariiqyada sida MAPK Signaling, kaas oo joojin kara waxyaabaha keenaya Kansarka Unugyada Xubinta Xubinta Hore ama faa'iido u leh waxtarka Mitomycin.

3. Kaabayaasha likaha Maitake ma badbaado u yihiin shakhsiyaadka caafimaadka qaba ee leh ASXL1 Mutation Associated Khatarta Hiddaha?

Shirkado kala duwan ayaa bixiya unugyada hidde-sidaha si ay u qiimeeyaan halista hidde-sidaha ee noocyada kala duwan ee kansarrada. Qaybahaan waxaa ka mid ah hidde-sideyaasha ku xiran naaska, ugxan-sidaha, uterineine-ka, qanjirka 'prostate', iyo kansarka mindhicirka. Tijaabinta hidde-sideyaashan waxay xaqiijin kartaa ogaanshaha cudurka waxayna ku wargelin kartaa daaweynta iyo xeeladaha maaraynta. Aqoonsiga kala duwanaanshaha sababa cudurku waxa uu sii caawin karaa baadhista iyo ogaanshaha qaraabada khatarta ku jira. Hidde-sidaha ASXL1 waxa caadi ahaan lagu daraa qaybahan si loo qiimeeyo khatarta kansarka.

Isbeddelka hiddasidaha ASXL1 wuxuu saameeyaa dariiqyada biochemical ama hababka, sida Cadaadiska Endoplasmic Reticulum Stress, Kansarka Oncogenic Epigenetics iyo Suppressive Histone Methylation, kuwaas oo si toos ah ama si dadban ugu lug leh wadista kansarka heerka molecular. Marka guddiga hidde-sidaha ay aqoonsadaan isbeddelka ASXL1 ee la xidhiidha khatarta sii kordheysa ee Myelomonocytic Leukemia, fikradda sayniska ayaa soo jeedinaysa in laga fogaado isticmaalka dheeriga ah ee Mushroom Maitake. Tani waa sababta oo ah kabka Maitake Mushroom wuxuu saameeyaa dariiqyada sida Endoplasmic Reticulum Stress, taas oo u horseedi karta saameyn xun marka la eego macnaha beddelka ASXL1 iyo xaaladaha kansarka ee la xiriira.

4. Kaabayaasha likaha Maitake miyay badbaado u yihiin Shakhsiyaadka Caafimaadka qaba ee leh CDH1 Mutation Associated Khatarta Hiddaha?

CDH1 waxay door muhiim ah ka ciyaartaa qiimaynta halista kansarka. Isbeddellada ku jira CDH1 waxay carqaladayn karaan dariiqyada biochemical ee muhiimka ah, oo ay ku jiraan MAPK Signaling, Adherens junction iyo Epithelial to Mesenchymal Transition, kuwaas oo saameeya horumarka kansarka. Haddii guddigaaga hidde-sidaha uu muujiyo isbeddellada CDH1 ee la xidhiidha Kansarka caloosha, tixgeli inaad ku darto kaabayaasha Mushroomka Maitake ee qorshahaaga nafaqeynta. Kaabayaashan waxay si togan u saameyn karaan dariiqyada sida MAPK Signaling, faa'iido siinta iyadoo la siinayo taageero ku habboon shakhsiyaadka leh isbeddellada CDH1 iyo walaacyada caafimaad ee la xiriira.

In Gabagabo

Labada shay ee ugu muhiimsan in la xasuusto waa in daawaynta kansarka iyo nafaqeynta aysan weligood isku mid ahayn qof walba. Nafaqada, oo ay ku jiraan cuntada iyo kaabista sida Maitake Mushroom, waa qalab wax ku ool ah oo aad xakameyn karto marka aad wajahayso kansar.

"Maxaan cunaa?" waa su'aasha ugu badan ee ay weydiiyaan bukaannada kansarka iyo kuwa halista ugu jira kansarka. Jawaabta saxda ah waa in ay ku xiran tahay arrimo ay ka mid yihiin nooca kansarka, hidde-sideyaasha burada, daawaynta hadda, xasaasiyadda, qaab nololeedka, iyo BMI.

Ka hel shakhsiyayntaada nafaqada ee kansarka addon adiga oo gujinaya xidhiidhka hoose oo ka jawaabaya su'aalaha ku saabsan nooca kansarka, daawaynta, qaab nololeedkaaga, xasaasiyadahaaga, da'da, iyo jinsigaaga.

tixraacyada

• Kobcinta Clonal taasoo horseedaysa iska caabbinta ibrutinib ee leukemia-da lymphocytic chronic.
• cBioPortal ee Kansarka Genomics
• Hypoxia waxay kor u qaadaa isku-dhafka u dhexeeya Mitomycin C iyo Bortezomib iyada oo loo marayo Hannaan isku dubaridan ee Bcl-xL Fosforyaalka iyo Mitochondrial Translocation ee p53.
• B-glucan milmay oo ka socda Grifola frondosa waxay keentaa dib-u-kicinta buro ee isku-dhafka TLR9 agonist iyada oo loo sii marayo difaaca dhexdhexaadinta unugyada dendritic.
• Daaweynta kansarku waxay qaabaysaa muuqaalka fayow ee hematopoiesis ee clonal.
• Dhaqdhaqaaqa antitumoral iyo antimetastatic ee Maitake D-Fraction ee unugyada kansarka naasaha ee saddex-geesoodka ah.
• Muuqaalka is-beddelka ee kansarka dheef-shiid kiimikaadka ayaa shaaca ka qaaday isku xigxiga mustaqbalka ee bukaan-socodka ee 10,000 bukaan.
• cBioPortal ee Kansarka Genomics
• Grifola frondosa Glycoprotein GFG-3a Waxay xidhay marxaladda S, waxay beddeshay Proteome, waxayna ku dhalisaa Apoptosis ee Unugyada Kansarka caloosha ee Aadanaha.