Nderipi gomarara raizobatsirwa nekubatanidza Kutinhira Mwari mukudya kwavo?

Muchidimbu

Kutinhira Mwari kunozivikanwa zvakanyanya nekuda kwehutano hwakanaka uye kunowanzoshandiswa nevarwere vegomarara uye avo vari panjodzi yemajini. Asi, kuchengetedzeka uye kushanda kweKutinhira Mwari kune varwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, kumwe marapirwo, uye genetics yebundu. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinachi, zvinogona kudyidzana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye nekubatanidza chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuenzaniso, Kutinhira Mwari vanogona kubatsira avo vane Primary Mucinous colorectal adenocarcinoma vari pasi peCetuximab. Uyezve, nepo Kutinhira kwaMwari kuchigona kubatsira vanhu vane genetic risk factor "KIT", inogona kunge isingafungidzirwe kune avo vane imwe genetic njodzi "ASXL1". Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kweKutinhira kwaMwari kune murwere wegomarara kunofanirwa kuve munhu mumwe kwakakosha. Zvinhu zvakakosha zvakaita serudzi rwegomarara, nzira dzekurapa, genetic makeup, genetic njodzi, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Kutinhira Mwari iri sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, maitiro akazara esarudzo dzekudya akakosha, achitarisa pane zvese zvinokonzeresa zvese zvinobatika zvinoriumba muzvokudya/zvinowedzera zvakaita seKutinhira Mwari pachinzvimbo chekuongorora chimwe nechimwe chinoshandiswa chinoshandiswa zvakasiyana kana kuchiregeredza zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Unofanira kubatanidza Kutinhira kwaMwari mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinogoneka here kudya Kutinhira Mwari kana uine genetic predisposition kune cancer yakabatana neKIT gene? Ko kana pachinzvimbo chako genetic njodzi ichibva kuASXL1 gene? Zvinobatsira here kuisa Kutinhira Mwari mukudya kwako kana uchinge wabatwa nePrimary Mucinous colorectal adenocarcinoma? Uyezve, mashandisiro ako eKutinhira Mwari anofanira kugadziriswa sei kana uri kurapwa neCetuximab kana chirongwa chako chekurapa chichibva kuCetuximab? Izvo zvakakosha kuti uzive kuti kutaura kwakapusa senge 'Kutinhira Mwari ndekwechisikigo, saka zvinogara zvichibatsira' kana 'Kutinhira Mwari kunosimudzira kusadzivirirwa' hakuna kukwana kune ruzivo rwechikafu / chekuwedzera sarudzo.

Uyezve, zvakakosha kuti uongorore zvakare kukodzera kwekubatanidza Kutinhira Mwari mukudya kwako kana pane shanduko mukurapa kwako. Muchidimbu, kana uchiita sarudzo nezve kubatanidza chikafu kana ma supplements seKutinhira Mwari mukudya kwako kune zvakanakira, iwe unofanirwa kufunga nezvesese biochemical mhedzisiro yezvese zvinongedzo, uchifunga nezvezvinhu zvakaita serudzi rwegomarara, marapirwo chaiwo auri kuita, genetic. predispositions, uye mararamiro esarudzo.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana ukangoonekwa uine imwe mhando yegomarara, yakadai sePrimary Mucinous colorectal adenocarcinoma, nzira dzekurapa dzinofanirwa kugadziridzwa zvichienderana nebundu remunhu genetics, danho rechirwere, pamwe nezvinhu zvakaita sezera uye murume.

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti ungakonzeresa njodzi dzemajini uye negomarara chairo kana uchifunga nezvesarudzo dzekudya, senge Kutinhira Mwari. Ko genetic njodzi yegomarara kubva mukushanduka muKIT ine zvakafanana biochemical nzira nzira sekuchinja muASXL1? Kubva pane zvinovaka muviri, njodzi inosanganisirwa nePrimary Mucinous colorectal adenocarcinoma inofananidzwa neimwe cancer here? Uyezve, kutariswa kwekudya kunoramba kwakafanana here kune avo vari kurapwa kumwe kune avo vanogamuchira Cetuximab? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Kutinhira Mwari - A Nutritional Supplement

Iyo yekuwedzera Kutinhira Mwari kunobatanidza huwandu hwezvinhu zvinoshanda, zvinosanganisira Celastrol uye Triptolide, imwe neimwe iripo panguva dzakasiyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya MAPK Signaling, Suppressive Histone Methylation uye PI3K-AKT-MTOR Signaling, iyo inoronga zvakakosha zvegomarara padanho remaserura, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza akakodzera anowedzera seKutinhira Mwari, ega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga nezvekushandisa Kutinhira Mwari kwegomarara, zvakakosha kuti titarise izvi zvakasiyana siyana uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapwa kwegomarara, kushandiswa kweKutinhira Mwari haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Kutinhira Mwari Kunowedzera

Kutarisana nemubvunzo wekuti 'Ndirini pandinofanira kudzivirira Kutinhira kwaMwari mumamiriro eCancer' zvinonetsa nekuti mhinduro yacho ndeyemunhu mumwe nemumwe - zvinongoreva 'Zvinoenderana!'. Zvakafanana nemabatiro ekurapa kwegomarara kusingashande kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eKutinhira Mwari kunosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yegomarara, genetic predispositions, marapirwo aripo, zvimwe zvekuwedzera zviri kutorwa, mararamiro, BMI, uye chero allergies zvese zvine basa mukuona kuti Kutinhira kwaMwari kwakakodzera here kana kudziviswa, zvichisimbisa kukosha kwekufunga nezvemunhu. muzvisarudzo zvakadaro.

1. Ko Kutinhira kwaMwari Kuwedzera kuchabatsira Varwere veCetuximab here?

Primary Mucinous colorectal adenocarcinoma inotaridzwa nechaiyo genetic mutations, seTTN, APC uye KRAS, izvo zvinokonzeresa shanduko mubiochemical nzira, kunyanya MAPK Signaling, Angiogenesis, G-protein-coupled Receptor Signaling uye Growth Factor Signaling. Kushanda kwekurapa cancer, senge Cetuximab, kunotemerwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yemunhu yekurapa. Muchirevo chechinyorwa chino, zvikafu kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuyenzaniso, iyo Kutinhira Mwari yekuwedzera isarudzo ine musoro kune avo vane Primary Mucinous colorectal adenocarcinoma iri pasi peCetuximab. Izvi zvinodaro nekuti Kutinhira Mwari kunokanganisa nzira dzakaita seMAPK Chiratidzo, chinogona kuvharisa zvinhu zvinotyaira Primary Mucinous colorectal adenocarcinoma kana kubatsira kushanda kweCetuximab.

2. Ko Kutinhira kwaMwari Kunowedzera Kwakachengeteka Kune Vanhu Vane Utano Vane ASXL1 Mutation Associated Genetic Risk?

Makambani akasiyana-siyana anopa gene mapaneru ekuongorora njodzi yemajini emhando dzakasiyana dzegomarara. Aya mapaneru anosanganisira majini akabatana nezamu, ovarian, uterine, prostate, uye gomarara remudumbu. Kuedza aya majini kunogona kusimbisa kuongororwa uye kuzivisa kurapwa uye manejimendi nzira. Kuziva musiyano unokonzera chirwere kunogona kubatsira mukuyedza uye kuongororwa kwehama dzinogona kunge dziri panjodzi. Iyo ASXL1 gene inowanzo verengerwa mune aya mapaneru ekuongorora njodzi yegomarara.

Shanduko iri muASXL1 gene inokanganisa nzira dzebiochemical kana maitiro, akadai seOncogenic Cancer Epigenetics uye Suppressive Histone Methylation, ayo anobatanidzwa zvakananga kana zvisina kunanga mukutyaira cancer padanho remamorekuru. Kana genetic panel inozivisa shanduko muASXL1 yakabatana nenjodzi yakawedzera yeChronic Myelomonocytic Leukemia, chikonzero chesainzi chinoratidza kudzivirira kushandiswa kwekuwedzera Kutinhira Mwari. Izvi zvinodaro nekuti kuwedzera Kutinhira Mwari kunopesvedzera nzira senge Suppressive Histone Methylation, izvo zvinogona kutungamira kune yakaipa mhedzisiro mumamiriro eiyo ASXL1 mutation uye ane hukama nekenza mamiriro.

3. Ko Kutinhira kwaMwari Kunowedzera Kwakachengeteka Kune Vanhu Vane Utano Vane KIT Mutation Associated Genetic Risk?

KIT inoita basa rakakosha mukuongorora njodzi yegomarara. Shanduko muKIT inogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira PI3K-AKT-MTOR Kuratidzira uye Kukura Kwekuita Chiratidzo, izvo zvinokanganisa kukura kwegomarara. Kana yako genetic panel ikaratidza shanduko muKIT yakabatana neGastric Cancer, funga kubatanidza Kutinhira Mwari kunowedzera muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kupesvedzera nzira dzakaita sePI3K-AKT-MTOR Kuratidzira, kubatsirwa nekupa rutsigiro rwakakodzera kune vanhu vane KIT shanduko uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, kusanganisira chikafu uye zvinowedzera seKutinhira Mwari, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• Direct inhibition ye c-Myc-Max heterodimers ne celastrol uye celastrol-inspired triterpenoids.
• Triptolide Inosimudzira Senescence yeProstate Cancer Cells Kuburikidza neHistone Methylation uye Heterochromatin Kuumbwa.
• Pan-cancer kuongororwa kweiyo genomes yakazara.
• Antitumor chiitiko cheZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, mumasero emukenza evanhu ane akawana kuramba kune antiepidermal kukura factor receptor therapy.
• cBioPortal yeCancer Genomics
• Mhedzisiro ye deoxyribonuclease I pahuwandu nekureba kwemacheni epoly(ADP-ribose) akagadzirwa, in vitro.