Nderipi gomarara raizobatsirwa nekubatanidza Quercetin mukudya kwavo?

Muchidimbu

Quercetin inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevanorwara nekenza uye avo vari panjodzi yemagene. Asi, kuchengetedzeka uye kushanda kweQuercetin yevarwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, mamwe marapirwo, uye bundu genetics. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinashi, zvinogona kupindirana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye nekubatanidza chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuyenzaniso, Quercetin inogona kubatsira avo vane Primary Mucinous colorectal adenocarcinoma vari pasi peCetuximab, asi zvingasava zvakanaka kune varwere vanowana Radiation yePrimary Adamantinoma. Uyezve, nepo Quercetin ichigona kubatsira vanhu vane genetic risk factor "TERT", inogona kunge isingafungirwe kune avo vane imwe genetic njodzi. Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kweQuercetin kune murwere wegomarara kunofanirwa kuve munhu mumwe kwakakosha. Zvinhu zvakakosha serudzi rwegomarara, nzira dzekurapa, genetic makeup, genetic njodzi, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Quercetin iriyo sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, nzira yakasarudzika yesarudzo yekudya yakakosha, kutarisa kune yakazara mhedzisiro yezvinhu zvese zvinoshanda mukudya / zvinowedzera seQuercetin pachinzvimbo chekuongorora chega chega chega chega kana kuchiregeredza zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Iwe unofanirwa here kuisa Quercetin mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinogoneka here kushandisa Quercetin kana iwe uine genetic predisposition kune cancer yakabatana neTERT gene? Ko kana pachinzvimbo njodzi yako yemajini ichibva kune gene? Zvinobatsira here kuisa Quercetin mukudya kwako kana ukabatwa nePrimary Adamantinoma, kana kuti chirwere chako chiri Primary Mucinous colorectal adenocarcinoma? Uyezve, manwiro ako eQuercetin anofanira kugadziriswa sei kana uri kurapwa neCetuximab kana chirongwa chako chekurapa chichibva kuCetuximab kuenda kuRadiation? Izvo zvakakosha kuti uzive kuti zvirevo zviri nyore senge 'Quercetin ndeyechisikigo, saka zvinogara zvichibatsira' kana 'Quercetin inosimudzira kusadzivirirwa' haina kukwana kune ruzivo rwechikafu/yekuwedzera sarudzo.

Uyezve, zvakakosha kuti uongorore zvakare kukodzera kwekubatanidza Quercetin mukudya kwako kana pane shanduko mukurapa kwako. Muchidimbu, kana uchiita sarudzo dzekuisa chikafu kana ma supplements seQuercetin mukudya kwako nekuda kwemabhenefiti ayo, iwe unofanirwa kufunga nezvese biochemical mhedzisiro yezvese zvinongedzo, uchifunga nezvemhando dzakadai serudzi rwegomarara, marapirwo chaiwo auri kuita, genetic predispositions. , uye sarudzo dzemararamiro.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana ukangoonekwa uine imwe mhando yegomarara, yakadai sePrimary Mucinous colorectal adenocarcinoma kana Primary Adamantinoma, nzira dzekurapa dzinofanirwa kugadziridzwa zvichienderana nebundu remunhu genetics, danho rechirwere, pamwe nezvinhu zvakaita sezera uye murume.

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti ungakonzeresa njodzi dzemajini uye negomarara rekuongororwa kana uchifunga nezvesarudzo dzekudya, senge Quercetin. Ko genetic njodzi yegomarara kubva mukushanduka muTERT ine zvakafanana biochemical nzira nzira sekuchinja mune imwe gene? Kubva pane zvinovaka muviri, njodzi inosanganisirwa nePrimary Mucinous colorectal adenocarcinoma inofanana nePrimary Adamantinoma? Uyezve, kutariswa kwechikafu kunoramba kwakafanana here kune avo vari kuita Radiation sevaya vanogamuchira Cetuximab? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Quercetin - A Nutritional Supplement

Iyo yekuwedzera Quercetin inotenderedza huwandu hwezvinhu zvinoshanda, kusanganisira Quercetin, imwe neimwe iripo panguva dzakasiyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya RAS-RAF Signaling, Oxidative Stress, DNA Repair uye Angiogenesis, iyo inogadzirisa zvakakosha zvegomarara padanho remasero, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza iyo yakakodzera yekuwedzera seQuercetin, yega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga nezve kushandisa Quercetin kenza, zvakakosha kuti utarise izvi zvakasiyana zvinhu uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapa cancer, kushandiswa kweQuercetin haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Quercetin Supplements

Kugadzirisa mubvunzo 'Ndirini pandinofanira kudzivirira Quercetin mumamiriro ezvinhu eCancer' zvinonetsa nokuti mhinduro yacho ndeyemunhu oga - zvinongoreva 'Zvinoenderana!'. Zvakafanana nemabatiro ekurapa kwegomarara anogona kusashanda kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eQuercetin anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yegomarara, genetic predispositions, marapirwo azvino, mamwe ma supplements ari kutorwa, mararamiro, BMI, uye chero allergies zvese zvine basa mukuona kuti Quercetin yakakodzera here kana kuti inofanira kudziviswa, zvichisimbisa kukosha kwekufunga kwemunhu zvisarudzo zvakadaro.

1. Ko Quercetin Supplements ichabatsira Primary Adamantinoma Varwere vari kurapwa neRadiation?

Primary Adamantinoma inoratidzwa neakanyanya genetic mutations, anoti ARHGAP45, PI4KB uye SDSL, izvo zvinotungamira kune shanduko mubiochemical nzira, kunyanya Oxidative Stress uye Inositol Phosphate Signaling. Kubudirira kwekurapwa kwegomarara, senge Radiation, zvinoenderana nemaitiro ayo ekuita pane idzi nzira dzakananga. Iro zano rakakodzera rinosanganisira kuenzanisa chiito chekurapa nenzira dzinotyaira cancer, nekudaro kuve nechokwadi chemunhu uye nzira inoshanda. Mumamiriro ezvinhu akadai, kudzivirira chikafu kana kudya kunovaka muviri kunogona kupokana nemhedzisiro yekurapa kana kuderedza kurongeka uku kwakakosha. Semuenzaniso, iyo Quercetin yekuwedzera, iyo inobata iyo Oxidative Stress, inogona kunge isiri iyo sarudzo yakanaka munyaya yePrimary Adamantinoma kana ichiitwa neRadiation. Izvi zvinodaro nekuti zvinogona kuwedzera kufambira mberi kwechirwere kana kukanganisa kushanda kwekurapa. Pakusarudza chirongwa chekudya, zvakakosha kuti utarise zvinhu zvakaita serudzi rwegomarara, marapirwo anoenderera mberi, zera, murume kana mukadzi, BMI, mararamiro, uye chero inozivikanwa genetic mutations.

2. Ko Quercetin Supplements ichabatsira Primary Mucinous colorectal adenocarcinoma Varwere vari kurapwa Cetuximab?

Primary Mucinous colorectal adenocarcinoma inotaridzwa neakananga genetic mutations, seTTN, APC uye KRAS, izvo zvinoguma nekuchinja kwebiochemical nzira, kunyanya RAS-RAF Signaling, Angiogenesis, G-protein-coupled Receptor Signaling uye Growth Factor Signaling. Kushanda kwekurapa cancer, senge Cetuximab, kunotemerwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yekurapa yemunhu. Muchirevo chechinyorwa chino, zvekudya kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, iyo Quercetin yekuwedzera isarudzo ine musoro kune avo vane Primary Mucinous colorectal adenocarcinoma iri pasi peCetuximab. Izvi zvinodaro nekuti Quercetin inokanganisa nzira dzakadai seRAS-RAF Signaling, inogona kuvharisa zvinhu zvinotyaira Primary Mucinous colorectal adenocarcinoma kana kubatsira kushanda kweCetuximab.

3. Ko Quercetin Supplements Yakachengeteka Kune Vanhu Vane Utano Vane TERT Mutation Associated Genetic Risk?

TERT inoita basa rakakosha mukuongorora njodzi yegomarara. Shanduko muTERT inogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira Angiogenesis uye DNA Repair, izvo zvinokanganisa kukura kwegomarara. Kana yako genetic panel ikaratidza shanduko muTERT yakabatana neHematological Cancer, funga kuisa Quercetin supplement muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kukanganisa nzira seAngiogenesis, kubatsirwa nekupa rubatsiro rwakakodzera kune vanhu vane TERT shanduko uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, kusanganisira chikafu uye zvekuwedzera seQuercetin, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• Basa re KEAP1/NRF2 uye TP53 Mutations muLung Squamous Cell Carcinoma Development uye Radiation Resistance.
• cBioPortal yeCancer Genomics
• Docking zvidzidzo pane isoform-specific inhibition ye phosphoinositide-3-kinases.
• Pan-cancer kuongororwa kweiyo genomes yakazara.
• Diki-molecule inhibitors yeNADPH oxidase 4.
• Inhibitors ye epidermal kukura factor receptor mune apuro juice inobvisa.
• cBioPortal yeCancer Genomics
• Pharmacogenomic uye pharmacoproteomic zvidzidzo zvecetuximab mune metastatic colorectal cancer: biomarker kuongororwa kwechikamu chekutanga-yekuwedzera kudzidza.