Nderipi gomarara raizobatsirwa nekubatanidza Pomegranate mukudya kwavo?

Muchidimbu

Pomegranate inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevarwere vegomarara uye avo vari panjodzi yemajini. Asi, kuchengetedzeka uye kushanda kwePomegranate yevarwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, kumwe kurapwa, uye genetics yebundu. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinachi, zvinogona kudyidzana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye nekubatanidza chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuenzaniso, Damba rinogona kubatsira avo vane Primary Solitary Fibrous Tumor vari pasi peAvastin, asi zvingasava zvakanaka kune varwere vanowana Cisplatin yePrimary Head uye Neck Squamous Cell Carcinoma. Uyezve, nepo Pomegranate inogona kubatsira vanhu vane genetic risk factor "ERBB2", inogona kunge isingakurudzirwe kune avo vane imwe genetic ngozi "ERCC2". Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kwePomegranate kune murwere wegomarara kunoda kuve munhu mumwe kwakakosha. Zvinhu zvakakosha serudzi rwegomarara, nzira dzekurapa, genetic makeup, genetic njodzi, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Pomegranate iri sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, maitiro akazara esarudzo dzechikafu akakosha, tichitarisa pane zvese zvinokonzeresa zvese zvinoshanda zvinoringana muzvikafu/zvinowedzera zvakaita sePomegranate pachinzvimbo chekuongorora chega chega chega chega chega kana kusachifuratira zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Iwe unofanirwa here kuisa Pomegranate mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinokurudzirwa here kuti udye Pomegranate kana uine genetic predisposition kugomarara rakabatana neERBB2 gene? Ko kana pachinzvimbo chako genetic njodzi ichibva kuERCC2 gene? Zvinobatsira here kuisa Damba mukudya kwako kana uchinge wabatwa nePrimary Head and Neck Squamous Cell Carcinoma, kana kuti chirwere chako chiri Primary Solitary Fibrous Tumor? Uyezve, manwiro ako ePomegranate anofanira kugadziriswa sei kana uri kurapwa neAvastin kana kana chirongwa chako chekurapa chichichinja kubva kuAvastin kuenda kuCisplatin? Izvo zvakakosha kuti uzive kuti kutaura kwakapusa senge 'Pomegranate ndeyechisikigo, saka inogara ichibatsira' kana 'Pomegranate inosimudzira kusadzivirirwa' haina kukwana kune ruzivo rwechikafu / chekuwedzera sarudzo.

Uyezve, zvakakosha kuti uongorore zvakare kukodzera kwekubatanidza Pomegranate mukudya kwako kana pane shanduko mukurapa kwako. Muchidimbu, kana uchiita sarudzo dzekubatanidza chikafu kana ma supplements sePomegranate mukudya kwako kune zvakanakira, iwe unofanirwa kufunga nezvese biochemical mhedzisiro yezvese zvinongedzo, uchifunga nezvemhando dzakadai serudzi rwegomarara, marapirwo chaiwo auri kuita, genetic predispositions. , uye sarudzo dzemararamiro.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana waonekwa kuti une imwe mhando yegomarara, sePrimary Solitary Fibrous Tumor kana Primary Head neNeck Squamous Cell Carcinoma, nzira dzekurapa dzinofanirwa kugadziridzwa zvichienderana nebundu remunhu genetics, danho rechirwere, pamwe nezvinhu zvakaita sezera uye. murume kana mukadzi.”

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti ungakonzeresa njodzi dzemajini uye negomarara chairo kana uchifunga nezvesarudzo dzekudya, senge Pomegranate. Ko genetic njodzi yegomarara kubva mukushandurwa muERBB2 ine zvakafanana biochemical nzira nzira sekuchinja muERCC2? Kubva pane zvinovaka muviri, njodzi inosanganisirwa nePrimary Solitary Fibrous Tumor inofanana nePrimary Head neNeck Squamous Cell Carcinoma? Uyezve, kutariswa kwekudya kunoramba kwakafanana here kune avo vari kuita Cisplatin sekune avo vanogamuchira Avastin? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Damba – Mushonga Wekudya kunovaka muviri

Iyo yekuwedzera Pomegranate inosanganisira huwandu hwezvinhu zvinoshanda, zvinosanganisira Octadecanoic Acid, Hexadecanoic Acid, Betulinic Acid, Casuarinin uye Ursolic Acid, imwe neimwe iripo panguva dzakasiyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya MYC Signaling, Epithelial to Mesenchymal Transition, PI3K-AKT-MTOR Signaling uye Chromatin Remodeling, iyo inotonga zvakakosha zvegomarara padanho remasero, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza akakodzera ekuwedzera senge Pomegranate, ega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga nezve kushandisa Pomegranate yegomarara, zvakakosha kuti utarise izvi zvakasiyana zvinhu uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapwa kwegomarara, kushandiswa kwePomegranate haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Pomegranate Supplements

Kutarisana nemubvunzo wekuti 'Ndirini pandinofanira kudzivisa Pomegraneti mumamiriro ezvinhu eCancer' zvinonetsa nokuti mhinduro yacho ndeyemunhu oga - zvinongoreva 'Zvinoenderana!'. Zvakafanana nemabatiro ekurapa kwegomarara anogona kusashanda kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti ePomegranate anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yegomarara, genetic predispositions, marapirwo aripo, zvimwe zvekuwedzera zviri kutorwa, mararamiro, BMI, uye chero allergies zvese zvine basa mukuona kuti Pomegranate yakakodzera here kana kuti inofanira kudziviswa, zvichisimbisa kukosha kwekufunga kwemunhu zvisarudzo zvakadaro.

1. Ko Pomegranate Supplements ichabatsira Primary Head and Neck Squamous Cell Carcinoma Varwere vari kurapwa Cisplatin?

Primary Head and Neck Squamous Cell Carcinoma inoratidzirwa nekumwe kushanduka kwemajini, anoti FRG1BP, TP53 uye PCDH11X, izvo zvinotungamira kune shanduko mubiochemical nzira, kunyanya Epithelial kuMesenchymal Transition, Cell Cycle Checkpoints uye Apoptosis. Kubudirira kwekurapwa kwegomarara, senge Cisplatin, zvinoenderana nemaitiro ayo ekuita pane idzi nzira dzakananga. Iro zano rakakodzera rinosanganisira kuenzanisa chiito chekurapa nenzira dzinotyaira cancer, nekudaro kuve nechokwadi chemunhu uye nzira inoshanda. Mumamiriro ezvinhu akadai, kudzivirira chikafu kana kudya kunovaka muviri kunogona kupokana nemhedzisiro yekurapa kana kuderedza kurongeka uku kwakakosha. Semuenzaniso, iyo Pomegranate yekuwedzera, iyo inobata Epithelial kune Mesenchymal Transition, inogona kunge isiri iyo sarudzo yakanaka munyaya yePrimary Head uye Neck Squamous Cell Carcinoma kana ichiitwa Cisplatin. Izvi zvinodaro nekuti zvinogona kuwedzera kufambira mberi kwechirwere kana kukanganisa kushanda kwekurapa. Pakusarudza chirongwa chekudya, zvakakosha kuti utarise zvinhu zvakaita serudzi rwegomarara, marapirwo anoenderera mberi, zera, murume kana mukadzi, BMI, mararamiro, uye chero inozivikanwa genetic mutations.

2. Ko Pomegranate Supplements ichabatsira Varwere veAvastin Varwere veAvastin?

Primary Solitary Fibrous Tumor inotaridzwa neiyo chaiyo genetic mutations, senge BRD4, FLI1 uye KMT2C, izvo zvinoguma nekuchinja mune biochemical nzira, kunyanya MYC Signaling, Chromatin Remodeling, DNA Repair, Oncogenic Histone Methylation uye Amino Acid Metabolism. Kubudirira kwekurapwa kwegomarara, senge Avastin, kunotemerwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yemunhu yekurapa. Muchirevo chechinyorwa chino, zvekudya kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, iyo Pomegranate yekuwedzera isarudzo ine musoro kune avo vane Primary Solitary Fibrous Tumor iri pasi peAvastin. Izvi zvinodaro nekuti Damba rinopesvedzera nzira dzakadai seMYC Signaling, inogona kuvharisa zvinhu zvinotyaira Primary Solitary Fibrous Tumor kana kubatsira kushanda kweAvastin.

3. Ko Pomegranate Supplements Yakachengeteka Kune Vanhu Vane Utano Vane ERCC2 Mutation Associated Genetic Risk?

Makambani akasiyana-siyana anopa gene mapaneru ekuongorora njodzi yemajini emhando dzakasiyana dzegomarara. Aya mapaneru anosanganisira majini akabatana nezamu, ovarian, uterine, prostate, uye gomarara remudumbu. Kuedza aya majini kunogona kusimbisa kuongororwa uye kuzivisa kurapwa uye manejimendi nzira. Kuziva musiyano unokonzera chirwere kunogona kubatsira mukuyedza uye kuongororwa kwehama dzinogona kunge dziri panjodzi. Iyo ERCC2 gene inowanzobatanidzwa mune aya mapaneru ekuongorora njodzi yegomarara.

Kuchinja kweiyo ERCC2 gene kunokanganisa nzira dzebiochemical kana maitiro, akadai sePI3K-AKT-MTOR Signaling uye DNA Repair, izvo zvinobatanidzwa zvakananga kana zvisina kunanga mukutyaira cancer padanho remamorekuru. Kana genetic panel ikaratidza shanduko muERCC2 ine chekuita nenjodzi yakawedzera yeGomarara reGanda, chikonzero chesainzi chinoratidza kudzivirira kushandiswa kwekuwedzera kwePomegranate. Izvi zvinodaro nekuti yekuwedzera Pomegranate inopesvedzera nzira sePI3K-AKT-MTOR Chiratidzo, izvo zvinogona kutungamira kune yakaipa mhedzisiro mumamiriro eERCC2 mutation uye ane hukama nekenza mamiriro.

4. Ko Pomegranate Supplements Yakachengeteka Kune Vanhu Vane Utano Vane ERBB2 Mutation Associated Genetic Risk?

ERBB2 inoita basa rakakosha mukuongorora njodzi yegomarara. Kuchinja muERBB2 kunogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira Chromatin Remodeling, Growth Factor Signaling uye PI3K-AKT-MTOR Signaling, iyo inokonzera kukura kwekenza. Kana genetic panel yako ikaratidza shanduko muERBB2 yakabatana neEsophageal Adenocarcinoma, funga kuisa Pomegranate supplement muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kupesvedzera nzira dzakaita seChromatin Remodeling, kubatsirwa nekupa rubatsiro rwakakodzera kune vanhu vane ERBB2 mutations uye zvine chekuita nezvehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, kusanganisira chikafu uye zvekuwedzera senge Pomegranate, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• Mutational landscape yekenza yemetastatic yakaratidzwa kubva kune vangangove vanotarisirwa kutevedzana kwevarwere zviuru gumi.
• cBioPortal yeCancer Genomics
• Pan-cancer kuongororwa kweiyo genomes yakazara.
• Induction ye cell cycle kusungwa uye apoptosis mumunhu asiri diki cell kenza yemapapu A549 maseru ne casuarinin kubva pabark reTerminalia arjuna Linn.
• cBioPortal yeCancer Genomics
• Basa re tumor microenvironment mukupikisa anti-angiogenic therapy.