Nderipi gomarara raizobatsirwa nekubatanidza Naringenin mukudya kwavo?

Muchidimbu

Naringenin inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevanorwara nekenza uye avo vari panjodzi yemagene. Asi, kuchengetedzeka uye kushanda kweNaringenin yevarwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, kumwe kurapwa, uye genetics yebundu. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinashi, zvinogona kupindirana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye nekubatanidza chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuenzaniso, Naringenin inogona kubatsira avo vane Primary Urethral Adenocarcinoma vari pasi peRadiation, asi zvingasava zvakanaka kune varwere vanowana Radiation yePrimary Embryonal Carcinoma. Uyezve, nepo Naringenin inogona kubatsira vanhu vane genetic risk factor "ERBB2", inogona kunge isingafungidzirwe kune avo vane imwe genetic njodzi. Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kweNaringenin kune murwere wegomarara kunofanirwa kuve munhu mumwe kwakakosha. Zvinhu zvakakosha serudzi rwegomarara, nzira dzekurapa, genetic makeup, genetic njodzi, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Naringenin iriyo sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, nzira yakasarudzika yesarudzo yekudya yakakosha, tichitarisa pane zvese zvinokonzeresa zvese zvinoshanda zvinoringana muzvikafu / zvekuwedzera seNaringenin pachinzvimbo chekuongorora chimwe nechimwe chinoshandiswa chinoshandiswa zvakasiyana kana kuregeredza zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Iwe unofanirwa here kuisa Naringenin mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinokurudzirwa here kushandisa Naringenin kana uine genetic predisposition kune cancer yakabatana neERBB2 gene? Ko kana pachinzvimbo njodzi yako yemajini ichibva kune gene? Zvinobatsira here kuisa Naringenin mukudya kwako kana wabatwa nePrimary Embryonal Carcinoma, kana kuti chirwere chako chiri Primary Urethral Adenocarcinoma? Uyezve, manwiro ako eNaringenin anofanira kugadziriswa sei kana uri kurapwa neRadiation kana chirongwa chako chekurapa chichibva paRadiation kuenda kuRadiation? Izvo zvakakosha kuti uzive kuti zvirevo zviri nyore senge 'Naringenin ndeyechisikigo, saka zvinogara zvichibatsira' kana 'Naringenin inosimudzira kusadzivirirwa' haina kukwana kune ruzivo rwechikafu/yekuwedzera sarudzo.

Uyezve, zvakakosha kuti uongorore zvakare kukodzera kwekubatanidza Naringenin mukudya kwako kana pane shanduko mukurapa kwako. Muchidimbu, kana uchiita sarudzo dzekuisa chikafu kana ma supplements seNaringenin mukudya kwako kune mabhenefiti ayo, iwe unofanirwa kufunga nezvese biochemical mhedzisiro yezvese zvinongedzo, uchifunga nezvemhando dzakadai serudzi rwegomarara, marapirwo chaiwo auri kuita, genetic predispositions. , uye sarudzo dzemararamiro.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana ukangoonekwa uine imwe mhando yegomarara, sePrimary Urethral Adenocarcinoma kana Primary Embryonal Carcinoma, nzira dzekurapa dzinoda kugadziridzwa zvichienderana nebundu remunhu genetics, danho rechirwere, pamwe nezvinhu zvakaita sezera uye murume.

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti ungakonzeresa njodzi dzemajini uye negomarara chairo kana uchifunga nezvesarudzo dzekudya, senge Naringenin. Ko genetic njodzi yegomarara kubva mukushanduka muERBB2 ine zvakafanana biochemical nzira nzira sekuchinja mune imwe gene? Kubva pakuona kwekudya, njodzi inosanganisirwa nePrimary Urethral Adenocarcinoma inoenzana nePrimary Embryonal Carcinoma? Uyezve, kutariswa kwechikafu kunoramba kwakafanana here kune avo vari kuenda kuRadiation sekune avo vanogamuchira Radiation? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Naringenin - A Nutritional Supplement

Iyo yekuwedzera Naringenin inotenderedza huwandu hwezvinhu zvinoshanda, zvinosanganisira Naringenin uye Naringetol, yega yega iripo panguva dzakasiyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya TGFB Signaling, Oxidative Stress, WNT Beta Catenin Signaling uye Phospholipase Signaling, iyo inodzora zvinhu zvakakosha zvegomarara padanho remasero, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza akakodzera anowedzera seNaringenin, ari ega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga kushandisa Naringenin yegomarara, zvakakosha kuti utarise izvi zvakasiyana-siyana zvinhu uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapa cancer, kushandiswa kweNaringenin haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Naringenin Supplements

Kugadzirisa mubvunzo 'Ndirini pandinofanira kudzivisa Naringenin mumamiriro ezvinhu eCancer' zvinonetsa nokuti mhinduro yacho ndeyemunhu oga - zvinongoreva 'Zvinoenderana!'. Zvakafanana nemabatiro ekurapa kwegomarara anogona kusashanda kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eNaringenin anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yegomarara, genetic predispositions, marapirwo azvino, mamwe ma supplements ari kutorwa, mararamiro, BMI, uye chero allergies zvese zvine basa mukuona kuti Naringenin yakakodzera here kana kuti inofanira kudziviswa, zvichisimbisa kukosha kwekufunga kwemunhu zvisarudzo zvakadaro.

1. Ko Naringenin Supplements ichabatsira Varwere vePrimary Embryonal Carcinoma vari kurapwa neRadiation?

Primary Embryonal Carcinoma inoratidzwa neakanyanya genetic mutations, anoti CAPN7, B3GNT8 uye KNTC1, izvo zvinotungamira kune shanduko mubiochemical nzira, kunyanya Oxidative Stress. Kubudirira kwekurapwa kwegomarara, senge Radiation, zvinoenderana nemaitiro ayo ekuita pane idzi nzira dzakananga. Iro zano rakakodzera rinosanganisira kuenzanisa chiito chekurapa nenzira dzinotyaira cancer, nekudaro kuve nechokwadi chemunhu uye nzira inoshanda. Mumamiriro ezvinhu akadai, kudzivirira chikafu kana kudya kunovaka muviri kunogona kupokana nemhedzisiro yekurapa kana kuderedza kurongeka uku kwakakosha. Semuenzaniso, iyo Naringenin yekuwedzera, iyo inobata iyo Oxidative Stress, inogona kunge isiri iyo sarudzo yakanaka munyaya yePrimary Embryonal Carcinoma kana ichiitwa neRadiation. Izvi zvinodaro nekuti zvinogona kuwedzera kufambira mberi kwechirwere kana kukanganisa kushanda kwekurapa. Pakusarudza chirongwa chekudya, zvakakosha kuti utarise zvinhu zvakaita serudzi rwegomarara, marapirwo anoenderera mberi, zera, murume kana mukadzi, BMI, mararamiro, uye chero inozivikanwa genetic mutations.

2. Ko Naringenin Supplements ichabatsira here Varwere vepaUrethral Adenocarcinoma vari kurapwa neRadiation?

Yekutanga Urethral Adenocarcinoma inotaridzwa neyakajeka genetic mutations, senge KRAS, ATRX uye SMO, izvo zvinokonzeresa shanduko mu biochemical nzira, kunyanya TGFB Signaling, G-protein-yakabatana Receptor Signaling uye Growth Factor Signaling. Kushanda kwekurapa cancer, seRadiation, kunotemerwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yekurapa yemunhu. Muchirevo chechinyorwa chino, zvekudya kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, iyo Naringenin yekuwedzera isarudzo ine musoro kune avo vane Primary Urethral Adenocarcinoma iri kuita Radiation. Izvi zvinodaro nekuti Naringenin inokanganisa nzira dzakadai seTGFB Signaling, iyo inogona kuvharisa zvinhu zvinotyaira Primary Urethral Adenocarcinoma kana kubatsira kushanda kweRadiation.

3. Ko Naringenin Supplements Yakachengeteka Kune Vanhu Vane Utano Vane ERBB2 Mutation Associated Genetic Risk?

ERBB2 inoita basa rakakosha mukuongorora njodzi yegomarara. Kuchinja muERBB2 kunogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira Phospholipase Signaling, Growth Factor Signaling uye PI3K-AKT-MTOR Signaling, iyo inokonzera kukura kwekenza. Kana genetic panel yako ikaratidza shanduko muERBB2 yakabatana neEsophageal Adenocarcinoma, funga kuisa Naringenin supplement muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kupesvedzera nzira dzakaita sePhospholipase Signaling, kubatsirwa nekupa rubatsiro rwakakodzera kune vanhu vane ERBB2 mutations uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, kusanganisira chikafu uye zvekuwedzera seNaringenin, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• Basa re KEAP1/NRF2 uye TP53 Mutations muLung Squamous Cell Carcinoma Development uye Radiation Resistance.
• Hesperetin neNaringenin zvinokurudzira HER2 maseru egomarara kuti afe nekushanda seHER2 Tyrosine Kinase inhibitors.
• Imwe-molecule yekudzidza ye inhibition effect yeNaringenin pakushandura kukura factor-β ligand-receptor binding.
• cBioPortal yeCancer Genomics
• cBioPortal yeCancer Genomics
• Radio kuramba mumasero egomarara rezamu inoyananiswa kuburikidza neTGF-β kusaina, hybrid epithelial-mesenchymal phenotype uye cancer stem masero.
• Mutational landscape yekenza yemetastatic yakaratidzwa kubva kune vangangove vanotarisirwa kutevedzana kwevarwere zviuru gumi.
• Cell-of-Origin Patterns Inotonga Molecular Classification ye10,000 Tumors kubva ku33 Types dzeCancer.