Nderipi gomarara raizobatsirwa nekubatanidza Melatonin mukudya kwavo?

Muchidimbu

Melatonin inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevarwere vegomarara uye avo vari panjodzi yemajini. Asi, kuchengetedzeka uye kushanda kweMelatonin yevarwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, kumwe kurapwa, uye genetics yebundu. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinashi, zvinogona kupindirana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye nekubatanidza chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuenzaniso, Melatonin inogona kubatsira avo vane Primary Penile Squamous Cell Carcinoma vari pasi peMitomycin, asi zvingasava zvakanaka kune varwere vanowana Radiation for Primary Sclerosing Epithelioid Fibrosarcoma. Uyezve, nepo Melatonin inogona kubatsira vanhu vane genetic risk factor "CDH1", inogona kunge isinga taurirwe kune avo vane imwe genetic ngozi "B2M". Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kweMelatonin kune murwere wegomarara kunofanirwa kuve munhu mumwe kwakakosha. Zvinhu zvakakosha serudzi rwegomarara, nzira dzekurapa, genetic makeup, njodzi dzemajini, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Melatonin iri sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, maitiro akazara esarudzo dzekudya akakosha, achitarisa pane zvese zvinokonzeresa zvese zvinoshanda zvinoringana muzvikafu / zvekuwedzera seMelatonin panzvimbo yekuongorora imwe neimwe inoshanda musanganiswa kana kuifuratira zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Iwe unofanirwa here kuisa Melatonin mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinokurudzirwa here kushandisa Melatonin kana uine genetic predisposition kune cancer yakabatana neCDH1 gene? Ko kana pachinzvimbo chako genetic njodzi ichibva kuB2M gene? Zvinobatsira here kuisa Melatonin mukudya kwako kana ukawanikwa uine Primary Sclerosing Epithelioid Fibrosarcoma, kana kuti chirwere chako chiri Primary Penile Squamous Cell Carcinoma? Uyezve, manwiro ako eMelatonin anofanira kugadziriswa sei kana uri kurapwa neMitomycin kana chirongwa chako chekurapa chichibva kuMitomycin kuenda kuRadiation? Izvo zvakakosha kuti uzive kuti kutaura kwakapusa senge 'Melatonin ndeyechisikigo, saka inogara ichibatsira' kana 'Melatonin inowedzera kusadzivirirwa' haina kukwana kune ruzivo rwechikafu/yekuwedzera sarudzo.

Pamusoro pezvo, zvakakosha kuti uongorore zvakare kukodzera kwekusanganisira Melatonin mukudya kwako kana paine shanduko muchirongwa chako chekurapa. Muchidimbu, kana uchiita sarudzo dzekusanganisa chikafu kana ma supplements seMelatonin mukudya kwako nekuda kwemabhenefiti ayo, unofanirwa kufunga nezvesese biochemical mhedzisiro yezvese zvinongedzo, uchifunga nezvemhando dzakadai serudzi rwegomarara, marapirwo chaiwo auri kuita, genetic predispositions. , uye sarudzo dzemararamiro.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana ukangoonekwa kuti une imwe mhando yegomarara, yakadai sePrimary Penile Squamous Cell Carcinoma kana Primary Sclerosing Epithelioid Fibrosarcoma, nzira dzekurapa dzinoda kugadziriswa zvichienderana nebundu remunhu, danho rechirwere, pamwe nezvinhu zvakaita sezera uye murume kana mukadzi. ”

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti ungakonzeresa njodzi dzemajini uye negomarara rekuongororwa kana uchifunga nezvesarudzo dzekudya, senge Melatonin. Ko genetic njodzi yegomarara kubva mukuchinjika muCDH1 ine zvakafanana biochemical nzira nzira sekuchinja muB2M? Kubva pane zvinovaka muviri, njodzi inosanganisirwa nePrimary Penile Squamous Cell Carcinoma inofananidzwa nePrimary Sclerosing Epithelioid Fibrosarcoma? Uyezve, kutariswa kwekudya kunoramba kwakafanana here kune avo vari kuita Radiation sekune avo vanogamuchira Mitomycin? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Melatonin - A Nutritional Supplement

Iyo yekuwedzera Melatonin inosanganisira huwandu hwezvinhu zvinoshanda, zvinosanganisira Melatonin, imwe neimwe iripo panguva dzakasiyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya PI3K-AKT-MTOR Chiratidzo, TGFB Chiratidzo uye Kukura Factor Signaling, iyo inogadzirisa zvakakosha zvegomarara padanho remaserura, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza iyo yakakodzera yekuwedzera seMelatonin, yega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga nezve kushandisa Melatonin yegomarara, zvakakosha kuti utarise izvi zvakasiyana zvinhu uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapa cancer, kushandiswa kweMelatonin haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Melatonin Supplements

Kugadzirisa mubvunzo wekuti 'Ndirini pandinofanira kudzivisa Melatonin mumamiriro ezvinhu eCancer' zvinonetsa nokuti mhinduro yacho ndeyemunhu oga - zvinongoreva 'Zvinoenderana!'. Zvakafanana nemabatiro ekurapa kwegomarara anogona kusashanda kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eMelatonin anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yegomarara, genetic predispositions, marapirwo azvino, zvimwe zvekuwedzera zviri kutorwa, mararamiro, BMI, uye chero allergies zvese zvine basa mukuona kuti Melatonin yakakodzera here kana kuti inofanira kudziviswa, zvichisimbisa kukosha kwekufunga kwemunhu zvisarudzo zvakadaro.

1. Ko Melatonin Supplements ichabatsira here Primary Sclerosing Epithelioid Fibrosarcoma Varwere vari kurapwa neRadiation?

Primary Sclerosing Epithelioid Fibrosarcoma inoratidzwa neakanyanya genetic mutations, anoti PBRM1, ATRX uye PIK3C2G, izvo zvinotungamira kune shanduko munzira dzebiochemical nzira, kunyanya TGFB Signaling uye Inositol Phosphate Signaling. Kubudirira kwekurapwa kwegomarara, senge Radiation, zvinoenderana nemaitiro ayo ekuita pane idzi nzira dzakananga. Iro zano rakakodzera rinosanganisira kuenzanisa chiito chekurapa nenzira dzinotyaira cancer, nekudaro kuve nechokwadi chemunhu uye nzira inoshanda. Mumamiriro ezvinhu akadai, kudzivirira chikafu kana kudya kunovaka muviri kunogona kupokana nemhedzisiro yekurapa kana kuderedza kurongeka uku kwakakosha. Semuyenzaniso, iyo Melatonin yekuwedzera, iyo inobata iyo TGFB Chiratidzo, inogona kunge isiri iyo sarudzo yakanaka munyaya yePrimary Sclerosing Epithelioid Fibrosarcoma paunenge uchiitwa neRadiation. Izvi zvinodaro nekuti zvinogona kuwedzera kufambira mberi kwechirwere kana kukanganisa kushanda kwekurapa. Pakusarudza chirongwa chekudya, zvakakosha kuti utarise zvinhu zvakaita serudzi rwegomarara, marapirwo anoenderera mberi, zera, murume kana mukadzi, BMI, mararamiro, uye chero inozivikanwa genetic mutations.

2. Ko Melatonin Supplements ichabatsira here Varwere vePenile Squamous Cell Carcinoma vari kurapwa neMitomycin?

Primary Penile Squamous Cell Carcinoma inotaridzwa neakananga genetic mutations, senge ABRAXAS1, PIK3CB uye NUP93, izvo zvinokonzeresa shanduko mubiochemical nzira, kunyanya PI3K-AKT-MTOR Signaling, Hematopoiesis uye Inositol Phosphate Signaling. Kushanda kwekurapa kenza, seMitomycin, kunotemerwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yemunhu yekurapa. Muchirevo chechinyorwa chino, zvikafu kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, iyo Melatonin yekuwedzera isarudzo ine musoro kune avo vane Primary Penile Squamous Cell Carcinoma iri pasi peMitomycin. Izvi zvinodaro nekuti Melatonin inokanganisa nzira dzakadai sePI3K-AKT-MTOR Chiratidzo, chinogona kuvharisa zvinhu zvinotyaira Primary Penile Squamous Cell Carcinoma kana kubatsira kushanda kweMitomycin.

3. Ko Melatonin Supplements Yakachengeteka Kune Vanhu Vane Utano Vane B2M Mutation Associated Genetic Risk?

Makambani akasiyana-siyana anopa gene mapaneru ekuongorora njodzi yemajini emhando dzakasiyana dzegomarara. Aya mapaneru anosanganisira majini akabatana nezamu, ovarian, uterine, prostate, uye gomarara remudumbu. Kuedza aya majini kunogona kusimbisa kuongororwa uye kuzivisa kurapwa uye manejimendi nzira. Kuziva musiyano unokonzera chirwere kunogona kubatsira mukuyedza uye kuongororwa kwehama dzinogona kunge dziri panjodzi. Iyo B2M gene inowanzo verengerwa mune aya mapaneru ekuongorora njodzi yegomarara.

Shanduko muB2M gene inokanganisa nzira dzebiochemical kana maitirwo, akadai seTGFB Signaling uye Antigen Presentation, ayo anobatanidzwa zvakananga kana zvisina kunanga mukutyaira cancer padanho remamorekuru. Kana genetic panel yakaratidza shanduko muB2M ine chekuita nenjodzi yakawedzera yeDiffuse Large B-cell Lymphoma, chirevo chesainzi chinoratidza kudzivirira kushandiswa kwekuwedzera Melatonin. Izvi zvinodaro nekuti yekuwedzera Melatonin inopesvedzera nzira dzakaita seTGFB Chiratidzo, izvo zvinogona kutungamira kune yakaipa mhedzisiro mumamiriro eiyo B2M shanduko uye ane hukama nekenza mamiriro.

4. Ko Melatonin Yekuwedzera Yakachengeteka Kuvanhu Vane Utano Vane CDH1 Mutation Associated Genetic Risk?

CDH1 inobata basa rakakosha mukuongorora njodzi yegomarara. Shanduko muCDH1 inogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira Kukura Kwekuita Chiratidzo, Adherens junction uye Epithelial kuMesenchymal Transition, iyo inokanganisa kukura kwegomarara. Kana genetic panel yako ikaratidza shanduko muCDH1 yakabatana neGastric Cancer, funga kuisa Melatonin yekuwedzera muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kupesvedzera nzira senge Growth Factor Signaling, kubatsirwa nekupa rutsigiro rwakakodzera kune vanhu vane CDH1 shanduko uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, kusanganisira chikafu uye zvinowedzera seMelatonin, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• Melatonin uye vhitamini D3 synergistically pasi-regulate Akt uye MDM2 inotungamira kuTGFβ-1-inotsamira kukura inhibition yekenza yemazamu maseru.
• cBioPortal yeCancer Genomics
• Hunhu hwe epidermal kukura factor receptors mune astrocytic glial uye neuronal masero mune yekutanga tsika.
• Cancer therapy inoumba kusimba kwenzvimbo ye clonal hematopoiesis.
• Radio kuramba mumasero egomarara rezamu inoyananiswa kuburikidza neTGF-β kusaina, hybrid epithelial-mesenchymal phenotype uye cancer stem masero.
• Mutational landscape yekenza yemetastatic yakaratidzwa kubva kune vangangove vanotarisirwa kutevedzana kwevarwere zviuru gumi.
• Melatonin Attenuates Her-2, p38 MAPK, p-AKT, uye MTOR Mazinga muOvarian Carcinoma yeEthanol-Preferring Rats.