Nderipi gomarara raizobatsirwa nekubatanidza Lycopene mukudya kwavo?

Muchidimbu

Lycopene inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevanorwara nekenza uye avo vari panjodzi yemagene. Asi, kuchengetedzeka uye kushanda kweLycopene yevarwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, kumwe kurapwa, uye genetics yebundu. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinachi, zvinogona kudyidzana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye kuisa chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuenzaniso, Lycopene inogona kubatsira avo vane Primary Mucinous colorectal adenocarcinoma vari pasi peCetuximab, asi zvingasava zvakanaka kune varwere vanowana Radiation yePrimary Adamantinoma. Uyezve, nepo Lycopene inogona kubatsira vanhu vane genetic risk factor "CDH1", inogona kunge isingaratidzirwe kune avo vane genetic risk yakasiyana "ASXL1". Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kweLycopene kune murwere wegomarara kunoda kuve munhu mumwe kwakakosha. Zvinhu zvakakosha serudzi rwegomarara, nzira dzekurapa, genetic makeup, genetic njodzi, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Lycopene iriyo sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, nzira yakasarudzika yesarudzo yekudya yakakosha, kutarisa kune yakazara mhedzisiro yezvinhu zvese zvinoshanda muzvikafu / zvekuwedzera seLycopene pane kuongorora yega yega inoshanda chimedu zvakasiyana kana kuregeredza zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Iwe unofanirwa here kuisa Lycopene mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinokurudzirwa here kushandisa Lycopene kana uine genetic predisposition kune cancer yakabatana neCDH1 gene? Ko kana pachinzvimbo chako genetic njodzi ichibva kuASXL1 gene? Zvinobatsira here kuisa Lycopene mukudya kwako kana ukabatwa nePrimary Adamantinoma, kana kuti chirwere chako chiri Primary Mucinous colorectal adenocarcinoma? Uyezve, manwiro ako eLycopene anofanira kugadziriswa sei kana uri kurapwa neCetuximab kana chirongwa chako chekurapa chichibva kuCetuximab kuenda kuRadiation? Izvo zvakakosha kuti uzive kuti kutaura kwakapusa senge 'Lycopene ndeyechisikigo, saka inogara ichibatsira' kana 'Lycopene inosimudzira kusadzivirirwa' haina kukwana kune ruzivo rwechikafu/yekuwedzera sarudzo.

Uyezve, zvakakosha kuti uongorore zvakare kukodzera kwekubatanidza Lycopene mukudya kwako kana pane kuchinja muhutano hwako. Muchidimbu, kana uchiita sarudzo dzekubatanidza chikafu kana ma supplements seLycopene mukudya kwako nekuda kwemabhenefiti ayo, unofanirwa kufunga nezvesese biochemical mhedzisiro yezvese zvinongedzo, uchifunga nezvemhando dzakadai serudzi rwegomarara, marapirwo chaiwo auri kuita, genetic predispositions. , uye sarudzo dzemararamiro.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana ukangoonekwa uine imwe mhando yegomarara, yakadai sePrimary Mucinous colorectal adenocarcinoma kana Primary Adamantinoma, nzira dzekurapa dzinofanirwa kugadziridzwa zvichienderana nebundu remunhu genetics, danho rechirwere, pamwe nezvinhu zvakaita sezera uye murume.

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti ungakonzeresa njodzi dzemajini uye negomarara rekuongororwa kana uchifunga nezvesarudzo dzekudya, seLycopene. Ko genetic njodzi yegomarara kubva mukuchinjika muCDH1 ine zvakafanana biochemical nzira nzira sekuchinja muASXL1? Kubva pane zvinovaka muviri, njodzi inosanganisirwa nePrimary Mucinous colorectal adenocarcinoma inofanana nePrimary Adamantinoma? Uyezve, kutariswa kwechikafu kunoramba kwakafanana here kune avo vari kuenda kuRadiation sevaya vanogamuchira Cetuximab? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Lycopene - A Nutritional Supplement

Iyo yekuwedzera Lycopene inotenderedza huwandu hwezvinhu zvinoshanda, kusanganisira Lycopene, imwe neimwe iripo panguva dzakasiyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya RAS-RAF Signaling, Oxidative Stress, Post Translation Modification uye MYC Signaling, iyo inodzora zvinhu zvakakosha zvegomarara padanho remasero, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza akakodzera ekuwedzera seLycopene, ari ega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga nezvekushandisa Lycopene yegomarara, zvakakosha kufunga nezve izvi zvakasiyana siyana uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapa cancer, kushandiswa kweLycopene haisi sarudzo yepasirese yakakodzera kune vese cancer asi inoda kuve munhu.

Kusarudza Lycopene Supplements

Kutarisana nemubvunzo 'Ndirini pandinofanira kudzivisa Lycopene mumamiriro ezvinhu eCancer' zvinonetsa nokuti mhinduro yacho ndeyemunhu oga - zvinongoreva 'Zvinoenderana!'. Zvakafanana nemabatiro ekurapa kwegomarara anogona kusashanda kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eLycopene anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yekenza, genetic predispositions, kurapwa kwemazuva ano, zvimwe zvinowedzera kutorwa, mararamiro emararamiro, BMI, uye chero kupi zvako kunokonzera zvose zvinotora basa pakuona kana Lycopene yakakodzera kana kuti inofanira kudziviswa, ichisimbisa kukosha kwekufunga kwevanhu pachavo. zvisarudzo zvakadaro.

1. Ko Lycopene Supplements ichabatsira Primary Adamantinoma Varwere vari kurapwa neRadiation?

Primary Adamantinoma inoratidzwa neakanyanya genetic mutations, anoti ARHGAP45, PI4KB uye SDSL, izvo zvinotungamira kune shanduko mubiochemical nzira, kunyanya Oxidative Stress uye Inositol Phosphate Signaling. Kubudirira kwekurapwa kwegomarara, senge Radiation, zvinoenderana nemaitiro ayo ekuita pane idzi nzira dzakananga. Iro zano rakakodzera rinosanganisira kuenzanisa chiito chekurapa nenzira dzinotyaira cancer, nekudaro kuve nechokwadi chemunhu uye nzira inoshanda. Mumamiriro ezvinhu akadai, kudzivirira chikafu kana kudya kunovaka muviri kunogona kupokana nemhedzisiro yekurapa kana kuderedza kurongeka uku kwakakosha. Semuenzaniso, iyo Lycopene yekuwedzera, iyo inobata iyo Oxidative Stress, inogona kunge isiri iyo sarudzo yakanaka munyaya yePrimary Adamantinoma kana ichiitwa neRadiation. Izvi zvinodaro nekuti zvinogona kuwedzera kufambira mberi kwechirwere kana kukanganisa kushanda kwekurapa. Pakusarudza chirongwa chekudya, zvakakosha kuti utarise zvinhu zvakaita serudzi rwegomarara, marapirwo anoenderera mberi, zera, murume kana mukadzi, BMI, mararamiro, uye chero inozivikanwa genetic mutations.

2. Ko Lycopene Supplements ichabatsira Primary Mucinous colorectal adenocarcinoma Varwere vari kurapwa Cetuximab?

Primary Mucinous colorectal adenocarcinoma inotaridzwa neakananga genetic mutations, seTTN, APC uye KRAS, izvo zvinoguma nekuchinja kwebiochemical nzira, kunyanya RAS-RAF Signaling, Angiogenesis, G-protein-coupled Receptor Signaling uye Growth Factor Signaling. Kushanda kwekurapa cancer, senge Cetuximab, kunotemerwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yemunhu yekurapa. Muchirevo chechinyorwa chino, zvikafu kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, iyo Lycopene yekuwedzera isarudzo ine musoro kune avo vane Primary Mucinous colorectal adenocarcinoma iri pasi peCetuximab. Izvi zvinodaro nekuti Lycopene inokanganisa nzira dzakaita seRAS-RAF Signaling, inogona kuvharisa zvinhu zvinotyaira Primary Mucinous colorectal adenocarcinoma kana kubatsira kushanda kweCetuximab.

3. Ko Lycopene Supplements Yakachengeteka Kune Vane Utano Vanhu vane ASXL1 Mutation Associated Genetic Risk?

Makambani akasiyana-siyana anopa gene mapaneru ekuongorora njodzi yemajini emhando dzakasiyana dzegomarara. Aya mapaneru anosanganisira majini akabatana nezamu, ovarian, uterine, prostate, uye gomarara remudumbu. Kuedza aya majini kunogona kusimbisa kuongororwa uye kuzivisa kurapwa uye manejimendi nzira. Kuziva musiyano unokonzera chirwere kunogona kubatsira mukuyedza uye kuongororwa kwehama dzinogona kunge dziri panjodzi. Iyo ASXL1 gene inowanzo verengerwa mune aya mapaneru ekuongorora njodzi yegomarara.

Shanduko muASXL1 gene inokanganisa nzira dzebiochemical kana maitiro, akadai sePost Translation Modification, Oncogenic Cancer Epigenetics uye Suppressive Histone Methylation, idzo dzakanangana kana zvisina kunanga mukutyaira cancer padanho remamorekuru. Kana genetic panel inozivisa shanduko muASXL1 yakabatana nenjodzi yakawedzera yeChronic Myelomonocytic Leukemia, chikonzero chesainzi chinoratidza kudzivirira kushandiswa kwekuwedzera Lycopene. Izvi zvinodaro nekuti yekuwedzera Lycopene inopesvedzera nzira dzakaita sePost Dudziro Kugadziriswa, izvo zvinogona kutungamira kune yakaipa mhedzisiro mumamiriro eiyo ASXL1 mutation uye ane hukama nekenza mamiriro.

4. Ko Lycopene Supplements Yakachengeteka Kune Vanhu Vane Utano Vane CDH1 Mutation Associated Genetic Risk?

CDH1 inobata basa rakakosha mukuongorora njodzi yegomarara. Shanduko muCDH1 inogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira MYC Signaling, Adherens junction uye Epithelial kuenda kuMesenchymal Transition, iyo inokanganisa kukura kwegomarara. Kana yako genetic panel inoratidza shanduko muCDH1 yakabatana neGastric Cancer, funga kuisa Lycopene zvinowedzera muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kukanganisa nzira dzakaita seMYC Signaling, kubatsirwa nekupa rutsigiro rwakakodzera kune vanhu vane CDH1 shanduko uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, kusanganisira chikafu uye zvekuwedzera seLycopene, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• Basa re KEAP1/NRF2 uye TP53 Mutations muLung Squamous Cell Carcinoma Development uye Radiation Resistance.
• cBioPortal yeCancer Genomics
• Lycopene zvakasiyana-siyana inokonzera quiescence uye apoptosis mune androgen-inopindura uye -yakazvimirira prostate cancer cell mitsara.
• Pan-cancer kuongororwa kweiyo genomes yakazara.
• cBioPortal yeCancer Genomics
• Iko kukosha kwekufungidzira kweKRAS, NRAS, BRAF, PIK3CA uye PTEN yeAnti-EGFR kurapwa mune metastatic colorectal cancer: A systematic review uye meta-analysis.
• Mhedzisiro ye lycopene paprotein kutaura mumunhu wekutanga prostatic epithelial masero.
• In vitro mhedzisiro uye maitiro e lycopene muMCF-7 masero egomarara rezamu remunhu.