Nderipi gomarara raizobatsirwa nekubatanidza Kava mukudya kwavo?

Muchidimbu

Kava inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevarwere vegomarara uye avo vari panjodzi yemajini. Asi, kuchengetedzeka uye kushanda kweKava kune varwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, kumwe kurapwa, uye genetics yebundu. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinachi, zvinogona kudyidzana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye nekubatanidza chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuenzaniso, Kava inogona kubatsira avo vane Primary Penile Squamous Cell Carcinoma vari pasi peMitomycin, asi zvingasava zvakanaka kune varwere vanowana Gemcitabine yePrimary Urachal adenocarcinoma. Uyezve, nepo Kava ichigona kubatsira vanhu vane genetic risk factor "TERT", inogona kunge isinga taurirwe kune avo vane imwe genetic ngozi "ASXL1". Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kweKava kune murwere wegomarara kunofanirwa kuve munhu mumwe kwakakosha. Zvinhu zvakakosha serudzi rwegomarara, nzira dzekurapa, genetic makeup, genetic njodzi, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Kava iriyo sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, maitiro akazara ekusarudzwa kwekudya kwakakosha, kutarisa kune yakazara mhedzisiro yezvinhu zvese zvinoshanda muzvokudya / zvinowedzera seKava panzvimbo yekuongorora imwe neimwe inoshanda chigadziro zvakasiyana kana kuregeredza zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Iwe unofanirwa here kuisa Kava mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinokurudzirwa here kushandisa Kava kana uine genetic predisposition kune cancer yakabatana neTERT gene? Ko kana pachinzvimbo chako genetic njodzi ichibva kuASXL1 gene? Zvinobatsira here kuisa Kava mukudya kwako kana waonekwa kuti une Primary Urachal adenocarcinoma, kana kuti chirwere chako chiri Primary Penile Squamous Cell Carcinoma? Uyezve, kushandisa kwako Kava kunofanira kugadziriswa sei kana uri kurapwa neMitomycin kana kana chirongwa chako chekurapa chichibva kuMitomycin kuenda kuGemcitabine? Izvo zvakakosha kuti uzive kuti zvirevo zviri nyore senge 'Kava ndeyechisikigo, saka zvinogara zvichibatsira' kana 'Kava inosimudzira kusadzivirirwa' haina kukwana kune ruzivo rwekudya / yekuwedzera sarudzo.

Uyezve, zvakakosha kuti uongorore zvakare kukodzera kwekubatanidza Kava mukudya kwako kana pane shanduko mukurapa kwako. Muchidimbu, kana uchiita sarudzo dzekuisa chikafu kana ma supplements seKava mukudya kwako kune mabhenefiti ayo, iwe unofanirwa kufunga nezvese biochemical mhedzisiro yezvese zvinongedzo, uchifunga zvinhu zvakaita serudzi rwegomarara, marapirwo chaiwo auri kuita, genetic predispositions. , uye sarudzo dzemararamiro.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana ukangoonekwa uine imwe mhando yegomarara, yakadai sePrimary Penile Squamous Cell Carcinoma kana Primary Urachal adenocarcinoma, nzira dzekurapa dzinofanirwa kugadziridzwa zvichienderana nebundu remunhu, danho rechirwere, pamwe nezvinhu zvakaita sezera uye murume.

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti ungakonzeresa njodzi dzemajini uye negomarara rekuongororwa kana uchifunga nezvesarudzo dzekudya, seKava. Ko genetic njodzi yegomarara kubva mukushandurwa muTERT ine zvakafanana biochemical nzira nzira sekuchinja muASXL1? Kubva pane zvinovaka muviri, njodzi inosanganisirwa nePrimary Penile Squamous Cell Carcinoma inoenzana nePrimary Urachal adenocarcinoma? Uyezve, kutariswa kwekudya kunoramba kwakafanana kune avo vari kuenda kuGemcitabine kune avo vanogamuchira Mitomycin? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Kava – A Nutritional Supplement

Iyo yekuwedzera Kava inosanganisa huwandu hwezvinhu zvinoshanda, zvinosanganisira Kavain uye Flavokawain B, yega yega iripo pane akasiyana siyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya Apoptosis, Oxidative Stress, Cytokine Signaling uye Angiogenesis, iyo inodzora zvinhu zvakakosha zvegomarara padanho remasero, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza akakodzera ekuwedzera seKava, ega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga kushandisa Kava yegomarara, zvakakosha kufunga nezve izvi zvakasiyana zvinhu uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapa cancer, kushandiswa kweKava haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Kava Supplements

Kupindura mubvunzo wekuti 'Ndirini pandinofanira kudzivirira Kava mumamiriro ezvinhu eCancer' zvinonetsa nekuti mhinduro yacho ndeyemunhu mumwe nemumwe - zvinongoreva 'Zvinoenderana!'. Zvakafanana nemabatiro ekurapa kwegomarara anogona kusashanda kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eKava anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yegomarara, genetic predispositions, marapirwo azvino, mamwe ma supplements ari kutorwa, mararamiro ehupenyu, BMI, uye chero allergies zvese zvine basa mukuona kana Kava yakakodzera kana kudziviswa, zvichisimbisa kukosha kwekufunga kwemunhu mu. zvisarudzo zvakadaro.

1. Ko Kava Supplements ichabatsira here Primary Urachal adenocarcinoma Varwere vari kurapwa Gemcitabine?

Yekutanga Urachal adenocarcinoma inoratidzwa neakanyanya genetic mutations, anoti NFE2L2, TP53 uye GNAS, izvo zvinotungamira kune shanduko mubiochemical nzira, kunyanya Oxidative Stress, Immune Checkpoints, Cell Cycle Checkpoints, Apoptosis, G-protein-yakabatana Receptor Signaling uye Reproductive Hormone. Kubudirira kwekurapwa kwegomarara, senge Gemcitabine, zvinoenderana nemaitiro ayo ekuita pane idzi nzira dzakananga. Iro zano rakakodzera rinosanganisira kuenzanisa chiito chekurapa nenzira dzinotyaira cancer, nekudaro kuve nechokwadi chemunhu uye nzira inoshanda. Mumamiriro ezvinhu akadai, kudzivirira chikafu kana kudya kunovaka muviri kunogona kupokana nemhedzisiro yekurapa kana kuderedza kurongeka uku kwakakosha. Semuenzaniso, iyo Kava yekuwedzera, iyo inobata iyo Oxidative Stress, inogona kunge isiri iyo sarudzo yakanaka munyaya yePrimary Urachal adenocarcinoma paunenge uchienda kuGemcitabine. Izvi zvinodaro nekuti zvinogona kuwedzera kufambira mberi kwechirwere kana kukanganisa kushanda kwekurapa. Pakusarudza chirongwa chekudya, zvakakosha kuti utarise zvinhu zvakaita serudzi rwegomarara, marapirwo anoenderera mberi, zera, murume kana mukadzi, BMI, mararamiro, uye chero inozivikanwa genetic mutations.

2. Ko Kava Supplements ichabatsira here Primary Penile Squamous Cell Carcinoma Varwere vari kurapwa Mitomycin?

Primary Penile Squamous Cell Carcinoma inotaridzwa nechaiyo genetic mutations, seABRAXAS1, PIK3CB uye NUP93, izvo zvinokonzeresa shanduko mubiochemical nzira, kunyanya Apoptosis, Hematopoiesis uye Inositol Phosphate Signaling. Kushanda kwekurapa kenza, seMitomycin, kunotemerwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yemunhu yekurapa. Muchirevo chechinyorwa chino, zvikafu kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, iyo Kava yekuwedzera isarudzo ine musoro kune avo vane Primary Penile Squamous Cell Carcinoma iri pasi peMitomycin. Izvi zvinodaro nekuti Kava inokanganisa nzira dzakaita seApoptosis, inogona kuvharisa zvinhu zvinotyaira Primary Penile Squamous Cell Carcinoma kana kubatsira kushanda kweMitomycin.

3. Ko Kava Supplements Yakachengeteka Kune Vane Utano Vanhu Vane ASXL1 Mutation Associated Genetic Risk?

Makambani akasiyana-siyana anopa gene mapaneru ekuongorora njodzi yemajini emhando dzakasiyana dzegomarara. Aya mapaneru anosanganisira majini akabatana nezamu, ovarian, uterine, prostate, uye gomarara remudumbu. Kuedza aya majini kunogona kusimbisa kuongororwa uye kuzivisa kurapwa uye manejimendi nzira. Kuziva musiyano unokonzera chirwere kunogona kubatsira mukuyedza uye kuongororwa kwehama dzinogona kunge dziri panjodzi. Iyo ASXL1 gene inowanzo verengerwa mune aya mapaneru ekuongorora njodzi yegomarara.

Shanduko iri muASXL1 gene inokanganisa nzira dzebiochemical kana maitiro, akadai seCytokine Signaling, Oncogenic Cancer Epigenetics uye Suppressive Histone Methylation, idzo dzakanangana kana zvisina kunanga kutyaira cancer padanho remamorekuru. Kana genetic panel inozivisa shanduko muASXL1 yakabatana nenjodzi yakawedzera yeChronic Myelomonocytic Leukemia, chikonzero chesainzi chinoratidza kudzivirira kushandiswa kwekuwedzera Kava. Izvi zvinodaro nekuti kuwedzera Kava kunopesvedzera nzira dzakaita seCytokine Signaling, iyo inogona kutungamira kune yakaipa mhedzisiro mumamiriro eiyo ASXL1 mutation uye ane hukama nekenza mamiriro.

4. Ko Kava Supplements Yakachengeteka Kune Vanhu Vane Utano Vane TERT Mutation Associated Genetic Risk?

TERT inoita basa rakakosha mukuongorora njodzi yegomarara. Shanduko muTERT inogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira Angiogenesis uye DNA Repair, izvo zvinokanganisa kukura kwegomarara. Kana yako genetic panel ikaratidza shanduko muTERT yakabatana neHematological Cancer, funga kuisa Kava supplement muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kukanganisa nzira seAngiogenesis, kubatsirwa nekupa rubatsiro rwakakodzera kune vanhu vane TERT shanduko uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, kusanganisira chikafu uye zvekuwedzera seKava, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• Flavokawain B inodzivisa kukura kwevanhu squamous carcinoma masero: kubatanidzwa kweapoptosis uye cell cycle dysregulation in vitro uye in vivo.
• In vivo antitumor uye antimetastatic mhedzisiro yeflavokawain B mune 4T1 kenza yemazamu cell-yakanetsa mbeva.
• cBioPortal yeCancer Genomics
• Cancer therapy inoumba kusimba kwenzvimbo ye clonal hematopoiesis.
• Mitomycin C inogona kuita TRAIL-induced apoptosis kuburikidza nep53-yakazvimiririra upregulation yekufa receptors: uchapupu hwebasa re c-Jun N-terminal kinase activation.
• Nzira dzekukunda Intrinsic Resistance kuGemcitabine muPancreatic Ductal Adenocarcinoma kuburikidza neRedox Modulation.
• Mutational landscape yekenza yemetastatic yakaratidzwa kubva kune vangangove vanotarisirwa kutevedzana kwevarwere zviuru gumi.