Nderipi gomarara rinogona kubatsira nekubatanidza D-limonene mukudya kwavo?

Muchidimbu

D-limonene inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevanorwara nekenza uye avo vari panjodzi yemajini. Asi, kuchengetedzeka uye kushanda kweD-limonene yevarwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, kumwe kurapwa, uye genetics yebundu. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinachi, zvinogona kudyidzana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye nekubatanidza chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuyenzaniso, D-limonene inogona kubatsira avo vane Primary Mucinous colorectal adenocarcinoma vari pasi peCetuximab, asi zvingasava zvakanaka kuvarwere vari kuwana Radiation for Primary Adamantinoma. Uyezve, nepo D-limonene inogona kubatsira vanhu vane genetic risk factor "KMT2D", inogona kunge isinga taurirwe kune avo vane genetic ngozi yakasiyana. Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kweD-limonene kune murwere wegomarara kunofanirwa kuve munhu mumwe kwakakosha. Zvinhu zvakakosha serudzi rwegomarara, nzira dzekurapa, genetic makeup, genetic njodzi, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana D-limonene iriyo sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, nzira yakazara yezvisarudzo zvekudya zvakakosha, kutarisa pamigumisiro yose yezvikamu zvose zvinoshanda muzvokudya / zvinowedzera seD-limonene panzvimbo yekuongorora chimwe nechimwe chinoshandiswa zvakasiyana kana kusazvidza zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo unokosha unomuka: Iwe unofanirwa here kuisa D-limonene mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinogoneka here kushandisa D-limonene kana uine genetic predisposition kune cancer yakabatana neKMT2D gene? Ko kana pachinzvimbo njodzi yako yemajini ichibva kune gene? Zvinobatsira here kuisa D-limonene mukudya kwako kana waonekwa kuti une Primary Adamantinoma, kana kuti chirwere chako chiri Primary Mucinous colorectal adenocarcinoma? Uyezve, manwiro ako eD-limonene anofanira kugadziriswa sei kana uri kurapwa neCetuximab kana chirongwa chako chekurapa chichibva kuCetuximab kuenda kuRadiation? Zvakakosha kuziva kuti zvirevo zviri nyore senge 'D-limonene ndezvemuzvarirwo, saka zvinobatsira nguva dzose' kana kuti 'D-limonene inosimudzira kudzivirirwa kwemuviri' hazvina kukwana pakusarudza zvekudya/zvekuwedzera.

Pamusoro pezvo, zvakakosha kuti uongorore zvakare kukodzera kwekubatanidza D-limonene mukudya kwako kana paine shanduko muchirongwa chako chekurapa. Muchidimbu, kana uchiita sarudzo dzekubatanidza chikafu kana ma supplements seD-limonene mukudya kwako kune zvakanakira, iwe unofanirwa kufunga nezvese biochemical mhedzisiro yezvese zvinongedzo, uchifunga nezvemhando dzakadai serudzi rwegomarara, marapirwo chaiwo auri kuita, genetic predispositions, uye sarudzo dzemararamiro.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana ukangoonekwa uine imwe mhando yegomarara, yakadai sePrimary Mucinous colorectal adenocarcinoma kana Primary Adamantinoma, nzira dzekurapa dzinofanirwa kugadziridzwa zvichienderana nebundu remunhu genetics, danho rechirwere, pamwe nezvinhu zvakaita sezera uye murume.

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti ungakonzeresa njodzi dzemajini uye negomarara rekuongororwa kana uchifunga nezvesarudzo dzekudya, senge D-limonene. Ko genetic njodzi yegomarara kubva mukushanduka muKMT2D ine zvakafanana biochemical nzira nzira sekuchinja mune imwe gene? Kubva pane zvinovaka muviri, njodzi inosanganisirwa nePrimary Mucinous colorectal adenocarcinoma inofanana nePrimary Adamantinoma? Uyezve, kutariswa kwechikafu kunoramba kwakafanana here kune avo vari kuenda kuRadiation sevaya vanogamuchira Cetuximab? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

D-limonene – A Nutritional Supplement

Iyo yekuwedzera D-limonene inosanganisira huwandu hwezvinhu zvinoshanda, zvinosanganisira D-limonene, imwe neimwe iripo panguva dzakasiyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya MAPK Chiratidzo uye Oxidative Stress, iyo inoronga zvakakosha zvegomarara padanho remaserura, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza iyo yakakodzera yekuwedzera senge D-limonene, yega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga nezvekushandisa D-limonene yegomarara, zvakakosha kuti utarise izvi zvakasiyana-siyana zvinhu uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapa cancer, kushandiswa kweD-limonene haisi sarudzo yepasirese yakakodzera kune vese cancer asi inoda kuve munhu.

Kusarudza D-limonene Supplements

Kutarisana nemubvunzo 'Ndirini pandinofanira kudzivisa D-limonene mumamiriro ezvinhu eCancer' zvinonetsa nokuti mhinduro yacho ndeyemunhu oga - zvinongoreva 'Zvinoenderana!'. Zvakafanana nekurapwa kwegomarara kungave kusashanda kune wese murwere, kukosha uye chengetedzo kana mabhenefiti eD-limonene anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yegomarara, genetic predispositions, marapirwo azvino, mamwe ma supplements ari kutorwa, mararamiro ehupenyu, BMI, uye chero allergies zvese zvine basa mukuona kana D-limonene yakakodzera kana kudziviswa, zvichisimbisa kukosha kwemunhu. kufunga muzvisarudzo zvakadaro.

1. Ko D-limonene Supplements ichabatsira Varwere veParamende Adamantinoma vari kurapwa neRadiation?

Primary Adamantinoma inoratidzwa neakanyanya genetic mutations, anoti ARHGAP45, PI4KB uye SDSL, izvo zvinotungamira kune shanduko mubiochemical nzira, kunyanya Oxidative Stress uye Inositol Phosphate Signaling. Kubudirira kwekurapwa kwegomarara, senge Radiation, zvinoenderana nemaitiro ayo ekuita pane idzi nzira dzakananga. Iro zano rakakodzera rinosanganisira kuenzanisa chiito chekurapa nenzira dzinotyaira cancer, nekudaro kuve nechokwadi chemunhu uye nzira inoshanda. Mumamiriro ezvinhu akadai, kudzivirira chikafu kana kudya kunovaka muviri kunogona kupokana nemhedzisiro yekurapa kana kuderedza kurongeka uku kwakakosha. Semuenzaniso, iyo D-limonene yekuwedzera, iyo inobata iyo Oxidative Stress, inogona kunge isiri iyo sarudzo yakanaka munyaya yePrimary Adamantinoma kana ichiitwa neRadiation. Izvi zvinodaro nekuti zvinogona kuwedzera kufambira mberi kwechirwere kana kukanganisa kushanda kwekurapa. Pakusarudza chirongwa chekudya, zvakakosha kuti utarise zvinhu zvakaita serudzi rwegomarara, marapirwo anoenderera mberi, zera, murume kana mukadzi, BMI, mararamiro, uye chero inozivikanwa genetic mutations.

2. Ko D-limonene Supplements ichabatsira here Varwere vari kurapwa neCetuximab?

Primary Mucinous colorectal adenocarcinoma inotaridzwa nechaiyo genetic mutations, seTTN, APC uye KRAS, izvo zvinokonzeresa shanduko mubiochemical nzira, kunyanya MAPK Signaling, Angiogenesis, G-protein-coupled Receptor Signaling uye Growth Factor Signaling. Kushanda kwekurapa cancer, senge Cetuximab, kunotemerwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yemunhu yekurapa. Muchirevo chechinyorwa chino, zvikafu kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuyenzaniso, iyo D-limonene yekuwedzera isarudzo ine musoro kune avo vane Primary Mucinous colorectal adenocarcinoma vari pasi peCetuximab. Izvi zvinodaro nekuti D-limonene inokanganisa nzira dzakaita seMAPK Signaling, inogona kuvharisa zvinhu zvinotyaira Primary Mucinous colorectal adenocarcinoma kana kubatsira kushanda kweCetuximab.

3. Ko D-limonene Supplements Yakachengeteka Kune Vanhu Vane Utano Vane KMT2D Mutation Associated Genetic Risk?

KMT2D inoita basa rakakosha mukuongorora njodzi yegomarara. Kuchinja muKMT2D kunogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira MAPK Signaling uye Oncogenic Histone Methylation, iyo inokanganisa kukura kwegomarara. Kana genetic panel yako ikaratidza shanduko muKMT2D yakabatana neBladder Urothelial Carcinoma, funga kuisa D-limonene yekuwedzera muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kupesvedzera nzira dzakaita seMAPK Signaling, kubatsirwa nekupa rutsigiro rwakakodzera kune vanhu vane KMT2D shanduko uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, kusanganisira chikafu uye zvinowedzera seD-limonene, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• Basa re KEAP1/NRF2 uye TP53 Mutations muLung Squamous Cell Carcinoma Development uye Radiation Resistance.
• cBioPortal yeCancer Genomics
• Dziviriro Mhedzisiro yeD-Limonene inopesana neOxidative Stress-Induced Cell Damage muHuman Lens Epithelial Cells kuburikidza neP38 Pathway.
• D-Limonene inogadzirisa kuzvimba, oxidative kusagadzikana uye Ras-ERK nzira yekudzivisa murine ganda tumorigenesis.
• Pan-cancer kuongororwa kweiyo genomes yakazara.
• Antitumor chiitiko cheZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, mumasero emukenza evanhu ane akawana kuramba kune antiepidermal kukura factor receptor therapy.
• cBioPortal yeCancer Genomics