Nderipi gomarara raizobatsirwa nekubatanidza Cinchona mukudya kwavo?

Muchidimbu

Cinchona inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevarwere vegomarara uye avo vari panjodzi yemajini. Asi, kuchengetedzeka uye kushanda kweCinchona yevarwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, kumwe kurapwa, uye genetics yebundu. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinachi, zvinogona kudyidzana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye nekubatanidza chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuyenzaniso, Cinchona inogona kubatsira avo vane Primary Squamous Cell Carcinoma yeVulva kana Vagina iri pasi pePaclitaxel, asi zvingasava zvakanaka kune varwere vanogamuchira Vismodegib yePrimary Basal Cell Carcinoma. Uyezve, nepo Cinchona ichigona kubatsira vanhu vane genetic risk factor "CALR", inogona kunge isinga taurirwe kune avo vane imwe genetic ngozi "ERBB2". Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kweCinchona kune murwere wegomarara kunofanirwa kuve munhu mumwe kwakakosha. Zvinhu zvakakosha serudzi rwegomarara, nzira dzekurapa, genetic makeup, genetic njodzi, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Cinchona iriyo sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, nzira yakasarudzika yesarudzo yekudya yakakosha, kutarisa kune yakazara mhedzisiro yezvinhu zvese zvinoshanda muzvokudya / zvinowedzera seCinchona panzvimbo yekuongorora imwe neimwe inoshanda chimedu zvakasiyana kana kusafuratira zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Iwe unofanirwa here kuisa Cinchona mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinokurudzirwa here kushandisa Cinchona kana uine genetic predisposition kune cancer yakabatana neCALR gene? Ko kana pachinzvimbo njodzi yako yemajini ichibva kuERBB2 gene? Zvinobatsira here kuisa Cinchona mukudya kwako kana wabatwa nePrimary Basal Cell Carcinoma, kana kuti chirwere chako chiri Primary Squamous Cell Carcinoma of the Vulva or Vagina? Uyezve, manwiro ako eCinchona anofanira kugadziriswa sei kana uri kurapwa Paclitaxel kana chirongwa chako chekurapa chichibva paPaclitaxel kuenda kuVismodegib? Izvo zvakakosha kuti uzive kuti zvirevo zviri nyore senge 'Cinchona ndezvakasikwa, saka zvinogara zvichibatsira' kana kuti 'Cinchona inowedzera kusadzivirirwa' hazvina kukwana pasarudzo dzechikafu/ dzekuwedzera.

Pamusoro pezvo, zvakakosha kuti uongorore zvakare kukodzera kwekubatanidza Cinchona mukudya kwako kana paine shanduko muchirongwa chako chekurapa. Muchidimbu, kana uchiita sarudzo nezve kubatanidza chikafu kana ma supplements seCinchona mukudya kwako kune mabhenefiti ayo, unofanirwa kufunga nezvese biochemical mhedzisiro yezvese zvinongedzo, uchifunga nezvemhando dzakadai serudzi rwegomarara, marapirwo chaiwo auri kuita, genetic predispositions. , uye sarudzo dzemararamiro.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana ukangoonekwa uine imwe mhando yegomarara, yakadai sePrimary Squamous Cell Carcinoma yeVulva kana Vagina kana Primary Basal Cell Carcinoma, nzira dzekurapa dzinofanirwa kugadziridzwa zvichienderana nebundu remunhu genetics, nhanho yechirwere, pamwe nezvinhu zvakaita se. zera uye murume kana mukadzi.”

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti ungakonzeresa njodzi dzemajini uye negomarara rekuongororwa kana uchifunga nezvesarudzo dzekudya, seCinchona. Ko genetic njodzi yegomarara kubva mukushandurwa muCALR ine zvakafanana biochemical nzira nzira sekuchinja muERBB2? Kubva pakuona kwekudya, njodzi inosanganisirwa nePrimary Squamous Cell Carcinoma yeVulva kana Vagina inoenzana nePrimary Basal Cell Carcinoma? Uyezve, kutariswa kwechikafu kunoramba kwakafanana here kune avo vari kuita Vismodegib sevaya vanogamuchira Paclitaxel? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Cinchona – A Nutritional Supplement

Iyo yekuwedzera Cinchona inosanganisira huwandu hwezvinhu zvinoshanda, zvinosanganisira Quinine Sulfate, Cinchonine uye Quinidine, imwe neimwe iripo panguva dzakasiyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya NFKB Chiratidzo, Nutrient sensing uye G-protein-coupled Receptor Signaling, iyo inodzora zvinhu zvakakosha zvegomarara padanho remasero, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza akakodzera anowedzera seCinchona, ari ega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga kushandisa Cinchona yegomarara, zvakakosha kuti utarise izvi zvakasiyana-siyana zvinhu uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapa cancer, kushandiswa kweCinchona haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Cinchona Supplements

Kugadzirisa mubvunzo wekuti 'Ndirini pandinofanira kudzivisa Cinchona mumamiriro ezvinhu eCancer' zvinonetsa nokuti mhinduro yacho ndeyemunhu oga - zvinongoreva 'Zvinoenderana!'. Zvakafanana nemabatiro ekurapa kwegomarara anogona kusashanda kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eCinchona anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yegomarara, genetic predispositions, marapirwo azvino, zvimwe zvekuwedzera zviri kutorwa, mararamiro, BMI, uye chero allergies zvese zvine basa mukuona kuti Cinchona yakakodzera here kana kuti inofanira kudziviswa, zvichisimbisa kukosha kwekufunga kwemunhu zvisarudzo zvakadaro.

1. Ko Cinchona Supplements ichabatsira Varwere veBasal Cell Carcinoma vari kurapwa neVismodegib?

Primary Basal Cell Carcinoma inoratidzwa nekumwe kushanduka kwemajini, zvinoti PTCH1, CSMD3 uye CSMD1, izvo zvinotungamira kune shanduko mubiochemical nzira, kunyanya Nutrient sensing. Kubudirira kwekurapwa kwegomarara, seVismodegib, zvinoenderana nemabatiro ayo ekuita pane idzi nzira. Iro zano rakakodzera rinosanganisira kuenzanisa chiito chekurapa nenzira dzinotyaira cancer, nekudaro kuve nechokwadi chemunhu uye nzira inoshanda. Mumamiriro ezvinhu akadai, kudzivirira chikafu kana kudya kunovaka muviri kunogona kupokana nemhedzisiro yekurapa kana kuderedza kurongeka uku kwakakosha. Semuenzaniso, iyo Cinchona yekuwedzera, iyo inobata iyo Nutrient sensing, inogona kunge isiri iyo sarudzo yakanaka munyaya yePrimary Basal Cell Carcinoma paunenge uchienda kuVismodegib. Izvi zvinodaro nekuti zvinogona kuwedzera kufambira mberi kwechirwere kana kukanganisa kushanda kwekurapa. Pakusarudza chirongwa chekudya, zvakakosha kuti utarise zvinhu zvakaita serudzi rwegomarara, marapirwo anoenderera mberi, zera, murume kana mukadzi, BMI, mararamiro, uye chero inozivikanwa genetic mutations.

2. Ko Cinchona Supplements ichabatsira here Primary Squamous Cell Carcinoma yeVulva kana Vagina Varwere vari pasi pePaclitaxel Treatment?

Primary Squamous Cell Carcinoma yeVulva kana Vagina inocherechedzwa nechaiyo genetic mutations, senge MAML2, SYNE1 uye ODF1, izvo zvinokonzeresa shanduko mubiochemical nzira, kunyanya NFKB Signaling uye Notch Signaling. Kushanda kwekurapa cancer, sePaclitaxel, kunotemerwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yemunhu yekurapa. Muchirevo chechinyorwa chino, zvikafu kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, iyo Cinchona yekuwedzera isarudzo ine musoro kune avo vane Primary Squamous Cell Carcinoma yeVulva kana Vagina iri pasi pePaclitaxel. Izvi zvinodaro nekuti Cinchona inokanganisa nzira dzakadai seNFKB Signaling, iyo inogona kuvharisa zvinhu zvinotyaira Primary Squamous Cell Carcinoma yeVulva kana Vagina kana kubatsira kushanda kwePaclitaxel.

3. Ko Cinchona Supplements Yakachengeteka Kune Vanhu Vane Utano Vane ERBB2 Mutation Associated Genetic Risk?

Makambani akasiyana-siyana anopa gene mapaneru ekuongorora njodzi yemajini emhando dzakasiyana dzegomarara. Aya mapaneru anosanganisira majini akabatana nezamu, ovarian, uterine, prostate, uye gomarara remudumbu. Kuedza aya majini kunogona kusimbisa kuongororwa uye kuzivisa kurapwa uye manejimendi nzira. Kuziva musiyano unokonzera chirwere kunogona kubatsira mukuyedza uye kuongororwa kwehama dzinogona kunge dziri panjodzi. Iyo ERBB2 gene inowanzobatanidzwa mune aya mapaneru ekuongorora njodzi yegomarara.

Kuchinja kweiyo ERBB2 gene kunokanganisa nzira dzebiochemical kana maitiro, akadai seNutrient sensing, Growth Factor Signaling uye PI3K-AKT-MTOR Signaling, iyo yakananga kana zvisina kunanga inobatanidzwa mukutyaira cancer padanho remamorekuru. Kana genetic panel ikaratidza shanduko muERBB2 yakabatana nenjodzi yakawedzera yeEsophageal Adenocarcinoma, chikonzero chesainzi chinoratidza kudzivirira kushandiswa kweCinchona yekuwedzera. Izvi zvinodaro nekuti kuwedzera Cinchona kunopesvedzera nzira senge Nutrient sensing, izvo zvinogona kutungamira kune yakaipa mhedzisiro mumamiriro eERBB2 mutation uye ane hukama nekenza mamiriro.

4. Ko Cinchona Supplements Yakachengeteka Kune Vanhu Vane Utano Vane CALR Mutation Associated Genetic Risk?

CALR inoita basa rakakosha mukuongorora njodzi yegomarara. Kuchinja muCALR kunogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira G-protein-coupled Receptor Signaling uye Antigen Presentation, iyo inokanganisa kukura kwegomarara. Kana yako genetic panel inoratidza shanduko muCALR yakabatana neMyeloproliferative Neoplasms, funga kuisa Cinchona supplements muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kukanganisa nzira dzakaita seG-protein-yakabatana Receptor Signaling, kubatsirwa nekupa rutsigiro rwakakodzera kune vanhu vane CALR shanduko uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, zvinosanganisira chikafu uye zvekuwedzera seCinchona kune mabhenefiti ayo, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• Tsamba: Kupihwa panguva imwe chete yeisoniazid neBCG kumucheche waamai vane tibhii.
• Iyo Molecular Landscape yeRecurrent uye Metastatic Head uye Neck Cancers: Insights Kubva kune Precision Oncology Sequencing Platform.
• cBioPortal yeCancer Genomics
• cBioPortal yeCancer Genomics
• Basa rekunyora reGli1 rinodzorwa zvisina kunaka neAMPK kuburikidza neHedgehog partial agonism muhepatocellular carcinoma.
• Toll-like receptor 4 ligation inopa chemoresistance kune docetaxel paPC-3 masero emukenza weprostate.
• Mutational siginicha uye chromosome alteration profiles ye squamous cell carcinomas ye vulva.
• MICE modhi: yepamusoro kune HERG modhi mukufanotaura Torsade de Pointes.
• Cinchonine Inodzivirira Kuwedzera-Fat-Diet-Induced Obesity kuburikidza neDownregulation yeAdipogenesis uye Adipose Inflammation.