Nderipi gomarara raizobatsirwa nekubatanidza Butyric Acid mukudya kwavo?

Muchidimbu

Butyric Acid inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevarwere vegomarara uye avo vari panjodzi yemajini. Asi, kuchengetedzeka uye kushanda kweButyric Acid yevarwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, kumwe kurapwa, uye genetics yebundu. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinachi, zvinogona kudyidzana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye kuisa chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuenzaniso, Butyric Acid inogona kubatsira avo vane Primary Basal Cell Carcinoma vari pasi peVismodegib, asi zvingasava zvakanaka kune varwere vanogamuchira Romidepsin yePrimary Mycosis fungoides. Uyezve, nepo Butyric Acid inogona kubatsira vanhu vane genetic risk factor "CDKN2A", inogona kunge isingafungidzirwe kune avo vane imwe genetic njodzi "ASXL1". Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kweButyric Acid kune murwere wegomarara kunofanirwa kuve munhu mumwe kwakakosha. Zvinhu zvakakosha serudzi rwegomarara, nzira dzekurapa, genetic makeup, genetic njodzi, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Butyric Acid iriyo sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, maitiro akazara esarudzo dzekudya akakosha, achitarisa pane zvese zvinokonzeresa zvese zvinoshanda zvinoringana muzvikafu / zvekuwedzera seButyric Acid pachinzvimbo chekuongorora chimwe nechimwe chinoshanda chega kana kuchifuratira zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Iwe unofanirwa here kuisa Butyric Acid mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinokurudzirwa kushandisa Butyric Acid kana uine genetic predisposition kune cancer yakabatana neCDKN2A gene? Ko kana pachinzvimbo chako genetic njodzi ichibva kuASXL1 gene? Zvinobatsira here kuisa Butyric Acid mukudya kwako kana ukawanikwa uine Primary Mycosis fungoides, kana kuti chirwere chako chiri Primary Basal Cell Carcinoma? Uyezve, kushandisa kwako Butyric Acid kunofanirwa kugadziriswa sei kana uri kurapwa neVismodegib kana chirongwa chako chekurapa chichibva kuVismodegib kuenda kuRomidepsin? Izvo zvakakosha kuti uzive kuti zvirevo zviri nyore senge 'Butyric Acid ndezvakasikwa, saka zvinogara zvichibatsira' kana kuti 'Butyric Acid inowedzera kusadzivirirwa' hazvina kukwana pasarudzo dzechikafu/yekuwedzera.

Pamusoro pezvo, zvakakosha kuti uongorore zvakare kukodzera kwekusanganisira Butyric Acid mukudya kwako kana paine shanduko muchirongwa chako chekurapa. Muchidimbu, kana uchiita sarudzo dzekubatanidza chikafu kana ma supplements seButyric Acid mukudya kwako nekuda kwemabhenefiti ayo, iwe unofanirwa kufunga nezvese biochemical mhedzisiro yezvese zvinongedzo, uchifunga nezvemhando dzakadai serudzi rwegomarara, marapirwo chaiwo auri kuita, genetic. predispositions, uye mararamiro esarudzo.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana munhu aonekwa aine imwe mhando yegomarara, yakadai sePrimary Basal Cell Carcinoma kana Primary Mycosis fungoides, nzira dzekurapa dzinofanirwa kugadziridzwa zvichienderana nebundu remunhu, danho rechirwere, pamwe chete nezvinhu zvakaita sezera uye murume kana mukadzi.

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti ungakonzeresa njodzi dzemajini uye negomarara rekuongororwa kana uchifunga nezvechikafu sarudzo, senge Butyric Acid. Ko genetic njodzi yegomarara kubva mukuchinjika muCDKN2A ine zvakafanana biochemical nzira nzira sekuchinja muASXL1? Kubva pane zvinovaka muviri, njodzi inosanganisirwa nePrimary Basal Cell Carcinoma inofanana nePrimary Mycosis fungoides? Uyezve, kutariswa kwechikafu kunoramba kwakafanana here kune avo vari kuenda kuRomidepsin kune avo vanogamuchira Vismodegib? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Butyric Acid - A Nutritional Supplement

Iyo yekuwedzera Butyric Acid inosanganisira huwandu hwezvinhu zvinoshanda, zvinosanganisira Butyric Acid, imwe neimwe iripo panguva dzakasiyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya Oncogenic Cancer Epigenetics, Post Translation Modification, Chemokine Signaling uye Apoptosis, iyo inodzora zvinhu zvakakosha zvegomarara padanho remasero, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza akakodzera anowedzera seButyric Acid, ari ega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga nezve kushandisa Butyric Acid yegomarara, zvakakosha kuti utarise izvi zvakasiyana zvinhu uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapa cancer, kushandiswa kweButyric Acid haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Butyric Acid Supplements

Kugadzirisa mubvunzo wekuti 'Ndirini pandinofanira kudzivirira Butyric Acid mumamiriro eCancer' zvinonetsa nekuti mhinduro yacho ndeyemunhu mumwe chete - zvinongoreva 'Zvinoenderana!'. Zvakafanana nemabatiro ekurapa cancer anogona kusashanda kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eButyric Acid anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yegomarara, genetic predispositions, marapirwo azvino, mamwe ma supplements ari kutorwa, mararamiro, BMI, uye chero allergies zvese zvine basa mukuona kuti Butyric Acid yakakodzera here kana kuti inofanira kudziviswa, zvichisimbisa kukosha kwekufunga kwemunhu. muzvisarudzo zvakadaro.

1. Ko Butyric Acid Supplements ichabatsira here Primary Mycosis fungoides Varwere vari kurapwa neRomidepsin?

Primary Mycosis fungoides inoratidzwa nekumwe kushanduka kwemajini, anoti PEG3, ABCA1 uye PRPF8, izvo zvinotungamira kushanduko munzira dzebiochemical, kunyanya Post Translation Modification. Kubudirira kwekurapwa kwegomarara, senge Romidepsin, zvinoenderana nemabatiro ayo ekuita pane idzi nzira dzakananga. Iro zano rakakodzera rinosanganisira kuenzanisa chiito chekurapa nenzira dzinotyaira cancer, nekudaro kuve nechokwadi chemunhu uye nzira inoshanda. Mumamiriro ezvinhu akadai, kudzivirira chikafu kana kudya kunovaka muviri kunogona kupokana nemhedzisiro yekurapa kana kuderedza kurongeka uku kwakakosha. Semuyenzaniso, iyo Butyric Acid yekuwedzera, iyo inokanganisa Post Translation Modification, inogona kunge isiri iyo sarudzo yakanaka panyaya yePrimary Mycosis fungoides kana ichiitwa Romidepsin. Izvi zvinodaro nekuti zvinogona kuwedzera kufambira mberi kwechirwere kana kukanganisa kushanda kwekurapa. Pakusarudza chirongwa chekudya, zvakakosha kuti utarise zvinhu zvakaita serudzi rwegomarara, marapirwo anoenderera mberi, zera, murume kana mukadzi, BMI, mararamiro, uye chero inozivikanwa genetic mutations.

2. Ko Butyric Acid Supplements ichabatsira Varwere veBasal Cell Carcinoma vari kurapwa neVismodegib?

Primary Basal Cell Carcinoma inotaridzwa neiyo chaiyo genetic mutations, yakadai sePTCH1, CSMD3 uye CSMD1, izvo zvinoguma nekuchinja mune biochemical pathways, kunyanya Oncogenic Cancer Epigenetics. Kushanda kwekurapa cancer, seVismodegib, kunotemerwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yemunhu yekurapa. Muchirevo chechinyorwa chino, zvekudya kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, iyo Butyric Acid yekuwedzera isarudzo ine musoro kune avo vane Primary Basal Cell Carcinoma iri pasi peVismodegib. Izvi zvinodaro nekuti Butyric Acid inokanganisa nzira dzakadai seOncogenic Cancer Epigenetics, inogona kuvharisa zvinhu zvinotyaira Primary Basal Cell Carcinoma kana kubatsira kushanda kweVismodegib.

3. Ko Butyric Acid Supplements Yakachengeteka Kune Vane Utano Vanhu vane ASXL1 Mutation Associated Genetic Risk?

Makambani akasiyana-siyana anopa gene mapaneru ekuongorora njodzi yemajini emhando dzakasiyana dzegomarara. Aya mapaneru anosanganisira majini akabatana nezamu, ovarian, uterine, prostate, uye gomarara remudumbu. Kuedza aya majini kunogona kusimbisa kuongororwa uye kuzivisa kurapwa uye manejimendi nzira. Kuziva musiyano unokonzera chirwere kunogona kubatsira mukuyedza uye kuongororwa kwehama dzinogona kunge dziri panjodzi. Iyo ASXL1 gene inowanzo verengerwa mune aya mapaneru ekuongorora njodzi yegomarara.

Shanduko muASXL1 gene inokanganisa nzira dzebiochemical kana maitirwo, akadai seChemokine Signaling, Oncogenic Cancer Epigenetics uye Suppressive Histone Methylation, ayo anobatanidzwa zvakananga kana zvisina kunanga mukutyaira cancer padanho remamorekuru. Kana genetic panel yakaratidza shanduko muASXL1 yakabatana nenjodzi yakawedzera yeChronic Myelomonocytic Leukemia, chikonzero chesainzi chinoratidza kudzivirira kushandiswa kwekuwedzera Butyric Acid. Izvi zvinodaro nekuti kuwedzera Butyric Acid inopesvedzera nzira senge Chemokine Signaling, iyo inogona kutungamira kune yakaipa mhedzisiro mumamiriro eiyo ASXL1 mutation uye ane hukama nekenza mamiriro.

4. Ko Butyric Acid Supplements Yakachengeteka Kune Vane Utano Vanhu vane CDKN2A Mutation Associated Genetic Risk?

CDKN2A inoita basa rakakosha mukuongorora njodzi yegomarara. Kuchinja muCDKN2A kunogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira Apoptosis, Cell Cycle Checkpoints uye Cell Cycle, izvo zvinokanganisa kukura kwegomarara. Kana genetic panel yako ikaratidza shanduko muCDKN2A ine chekuita neGanda Reganda, funga kuisa Butyric Acid supplements muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kupesvedzera nzira dzakaita seApoptosis, kubatsirwa nekupa rutsigiro rwakakodzera kune vanhu vane CDKN2A shanduko uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, zvinosanganisira chikafu uye zvekuwedzera seButyric Acid, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

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• cBioPortal yeCancer Genomics
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• cBioPortal yeCancer Genomics
• Monosodium urate uye karusiyamu pyrophosphate makristasi anosiyanisa iyo yekukurudzira-mhinduro yekubatanidza kutevedzana kwevanhu neutrophils.
• Genome-wide kurasikirwa-kwe-function skrini inoratidza basa rakakosha reproteasome muHDAC inhibitor-induced apoptosis.
• Combinatorial chemopreventive effect ye butyric acid, nicotinamide uye calcium glucarate inopesana ne7,12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis inowanikwa nekusimudzira kupinza kwezviitiko zvemukati apoptotic.