Nderipi gomarara raizobatsirikana nekubatanidza Mbeu Nhema mukudya kwavo?

Muchidimbu

Mbeu Nhema inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevarwere vegomarara uye avo vari panjodzi yemajini. Asi, kuchengetedzeka uye kushanda kweMbeu Nhema kune varwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, kumwe kurapwa, uye genetics yebundu. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinachi, zvinogona kudyidzana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye kuisa chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuyenzaniso, Mbeu nhema inogona kubatsira avo vane Primary Glioblastoma vari pasi peTemozolomide. Uyezve, nepo Mbeu nhema ichigona kubatsira vanhu vane genetic risk factor "TERT", inogona kusapihwa kune avo vane imwe genetic njodzi. Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kweMbeu Nhema kune murwere wegomarara kunofanirwa kuve munhu mumwe kwakakosha. Zvinhu zvakakosha serudzi rwegomarara, nzira dzekurapa, genetic makeup, njodzi dzemajini, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Mbeu Nhema iriyo sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, nzira yakasarudzika yesarudzo yekudya yakakosha, tichitarisa pane zvese zvinokonzeresa zvese zvinobatika zvinoriumba muzvikafu/zvinowedzera seMbeu Nhema pachinzvimbo chekuongorora chega chega chega chega chega kana kufuratira zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Unofanira kubatanidza Mbeu Nhema mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinogoneka here kudya Mbeu Nhema kana uine genetic predisposition kugomarara rakabatana neTERT gene? Ko kana pachinzvimbo njodzi yako yemajini ichibva kune gene? Zvinobatsira here kuisa Mbeu Nhema mukudya kwako kana ukawanikwa uine Primary Glioblastoma? Uyezve, kushandisa kwako Mbeu Nhema kunofanira kugadziriswa sei kana uri kurapwa neTemozolomide kana chirongwa chako chekurapa chichibva kuTemozolomide? Izvo zvakakosha kuti uzive kuti kutaura kwakapusa senge 'Mbeu Nhema ndeyemusikirwo, saka inogara ichibatsira' kana 'Mbeu Nhema inosimudzira kusadzivirirwa' hakuna kukwana kune ruzivo rwechikafu / chekuwedzera sarudzo.

Pamusoro pezvo, zvakakosha kuti uongorore zvakare kukodzera kwekubatanidza Mbeu Nhema mukudya kwako kana paine shanduko muchirongwa chako chekurapa. Muchidimbu, kana uchiita sarudzo dzekuisa chikafu kana ma supplements seMbeu nhema mukudya kwako nekuda kwemabhenefiti ayo, iwe unofanirwa kufunga nezvese biochemical mhedzisiro yezvese zvinongedzo, uchifunga nezvemhando dzakadai serudzi rwegomarara, marapirwo chaiwo auri kuita, genetic. predispositions, uye mararamiro esarudzo.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana ukangoonekwa uine imwe mhando yegomarara, sePrimary Glioblastoma, nzira dzekurapa dzinofanirwa kugadziridzwa zvichienderana nebundu remunhu, danho rechirwere, pamwe nezvinhu zvakaita sezera uye murume.

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti ungakonzeresa njodzi dzemajini uye negomarara chairo kana uchifunga nezvesarudzo dzekudya, senge Mbeu Nhema. Ko genetic njodzi yegomarara kubva mukuchinjika muTERT ine zvakafanana biochemical nzira nzira sekuchinja mujini? Kubva pane zvinovaka muviri, njodzi inosanganisirwa nePrimary Glioblastoma inofananidzwa neimwe cancer here? Uyezve, kutariswa kwekudya kunoramba kwakafanana kune avo vari kurapwa kumwe kune avo vanogamuchira Temozolomide? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Mbeu Nhema – Mushonga wekudya kunovaka muviri

Iyo yekuwedzera Mbeu Nhema inotenderedza huwandu hwezvinhu zvinoshanda, zvinosanganisira Thymol, Carvacrol uye Thymoquinone, imwe neimwe iripo panguva dzakasiyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya MAPK Signaling, Diki Molecule Yekutakura uye Cell Cycle, iyo inoronga zvakakosha zvegomarara padanho remaserura, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza akakodzera anowedzera seMbeu Nhema, ari ega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga kushandisa Mbeu Nhema yegomarara, zvakakosha kuti utarise izvi zvakasiyana zvinhu uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapa gomarara, kushandiswa kweMbeu Nhema haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Mbeu nhema dzekuwedzera

Kugadzirisa mubvunzo wekuti 'Ndirini pandinofanira kudzivirira Mbeu nhema mumamiriro ezvinhu eCancer' zvinonetsa nekuti mhinduro yacho ndeyemunhu mumwe chete - zvinongoreva 'Zvinoenderana!'. Zvakafanana nemabatiro ekurapa kwegomarara anogona kusashanda kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eMbeu Nhema anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yegomarara, genetic predispositions, marapirwo aripo, zvimwe zvekuwedzera zviri kutorwa, mararamiro, BMI, uye chero allergies zvese zvine basa mukuona kuti Mbeu Nhema yakakodzera here kana kuti inofanira kudziviswa, zvichisimbisa kukosha kwekufunga nezvemunhu. muzvisarudzo zvakadaro.

1. Ko Mishonga yeMbeu nhema ichabatsira Varwere vePrimary Glioblastoma vari kurapwa neTemozolomide here?

Primary Glioblastoma inocherechedzwa nechaiyo genetic mutations, seTRBV7-7, TAS2R46 uye TP53, izvo zvinokonzeresa shanduko mubiochemical nzira, kunyanya MAPK Signaling, Cell Cycle Checkpoints uye Apoptosis. Kubudirira kwekurapa kenza, seTemozolomide, inotarwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yemunhu yekurapa. Muchirevo chechinyorwa chino, zvikafu kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, yeBlack Mbeu yekuwedzera isarudzo ine musoro kune avo vane Primary Glioblastoma vari pasi peTemozolomide. Izvi zvinodaro nekuti Mbeu Nhema inokanganisa nzira dzakadai seMAPK Signaling, iyo inogona kuvharidzira zvinhu zvinotyaira Primary Glioblastoma kana kubatsira kushanda kweTemozolomide.

2. Ko Mishonga yeMbeu Dtema Yakachengeteka Kuvanhu Vane Utano Vane TERT Mutation Associated Genetic Risk?

TERT inoita basa rakakosha mukuongorora njodzi yegomarara. Shanduko muTERT inogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira Cell Cycle uye DNA Repair, izvo zvinokanganisa kukura kwegomarara. Kana genetic panel yako ikaratidza shanduko muTERT ine chekuita neHematological Cancer, funga kuisa Mbeu nhema dzekuwedzera muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kupesvedzera nzira dzakaita seCell Cycle, kubatsirwa nekupa rutsigiro rwakakodzera kune vanhu vane TERT shanduko uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, kusanganisira chikafu uye zvekuwedzera seMbeu Nhema, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• cBioPortal yeCancer Genomics
• Cytochrome P450 uye P-Glycoprotein-Mediated Interactions Inosanganisira African Herbs Inoratidzwa kune Zvirwere Zvisingatapuriki.
• MEK-ERK kusaina kunoraira DNA-kugadzirisa gene MGMT kutaura uye temozolomide kuramba kwe stem-kunge glioblastoma masero kuburikidza neMDM2-p53 axis.
• Kumini yakasviba (Nigella sativa) uye chikamu chayo (thymoquinone): wongororo pamhedzisiro yeantimicrobial.
• Carvacrol inhibits kuwanda uye induces apoptosis mumunhu colon cancer maseru.
• Iyo somatic genomic landscape ye glioblastoma.
• Carvacrol inodzvinyirira mhinduro dzekuzvimba mu rheumatoid arthritis fibroblast-se synoviocytes.