Nderipi gomarara raizobatsirikana nekubatanidza Beta-carotene mukudya kwavo?

Muchidimbu

Beta-carotene inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevarwere vegomarara uye avo vari panjodzi yemajini. Asi, kuchengetedzeka uye kushanda kweBeta-carotene yevarwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, kumwe kurapwa, uye genetics yebundu. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinachi, zvinogona kudyidzana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye nekubatanidza chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuenzaniso, Beta-carotene inogona kubatsira avo vane Primary Head neNeck Squamous Cell Carcinoma vari pasi peCisplatin, asi zvingasava zvakanaka kune varwere vanowana Radiation yePrimary Well Differentiated Liposarcoma. Uyezve, nepo Beta-carotene inogona kubatsira vanhu vane genetic risk factor "TERT", inogona kunge isingakurudzirwe kune avo vane imwe genetic njodzi "ALK". Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kweBeta-carotene kune murwere wegomarara kunofanirwa kuve munhu mumwe kwakakosha. Zvinhu zvakakosha serudzi rwegomarara, nzira dzekurapa, genetic makeup, genetic njodzi, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Beta-carotene iriyo sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, maitiro akazara esarudzo dzekudya akakosha, achitarisa pane zvese zvinokonzeresa zvese zvinoshanda zvinoringana muzvikafu / zvekuwedzera seBeta-carotene pachinzvimbo chekuongorora chega chega chega chega chega kana kufuratira zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Iwe unofanirwa here kuisa Beta-carotene mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinokurudzirwa here kushandisa Beta-carotene kana uine genetic predisposition kune cancer yakabatana neTERT gene? Zvakadini kana panzvimbo yako njodzi yemajini ichibva kune ALK gene? Zvinobatsira here kuisa Beta-carotene mukudya kwako kana ukawanikwa uine Primary Well Differentiated Liposarcoma, kana kuti chirwere chako chiri Primary Head and Neck Squamous Cell Carcinoma? Uyezve, manwiro ako eBeta-carotene anofanira kugadziriswa sei kana uri kurapwa neCisplatin kana chirongwa chako chekurapa chichibva kuCisplatin kuenda kuRadiation? Izvo zvakakosha kuti uzive kuti kutaura kwakapusa senge 'Beta-carotene ndeyechisikigo, saka inogara ichibatsira' kana 'Beta-carotene inosimudzira kusadzivirirwa' haina kukwana kune ruzivo rwechikafu/yekuwedzera sarudzo.

Pamusoro pezvo, zvakakosha kuti uongorore zvakare kukodzera kwekusanganisira Beta-carotene mukudya kwako kana paine shanduko muchirongwa chako chekurapa. Muchidimbu, kana uchiita sarudzo dzekubatanidza chikafu kana ma supplements seBeta-carotene mukudya kwako nekuda kwemabhenefiti ayo, unofanirwa kufunga nezvese biochemical mhedzisiro yezvese zvinongedzo, uchifunga zvinhu zvakaita serudzi rwegomarara, marapirwo chaiwo auri kuita, genetic predispositions, uye sarudzo dzemararamiro.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana waonekwa kuti une imwe mhando yegomarara, yakadai sePrimary Head neNeck Squamous Cell Carcinoma kana Primary Well Differentiated Liposarcoma, nzira dzekurapa dzinofanirwa kugadziridzwa zvichienderana nebundu remunhu genetics, danho rechirwere, pamwe nezvinhu zvakaita sezera uye. murume kana mukadzi.”

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakakosha ndewekuti ungakonzeresa njodzi dzemajini uye negomarara rekuongororwa kana uchifunga nezvesarudzo dzekudya, senge Beta-carotene. Ko genetic njodzi yegomarara kubva mukushanduka muTERT ine zvakafanana biochemical nzira nzira sekuchinja muALK? Kubva pane zvinovaka muviri, njodzi inosanganisirwa nePrimary Head neNeck Squamous Cell Carcinoma inofanana nePrimary Well Differentiated Liposarcoma? Uyezve, kutariswa kwechikafu kunoramba kwakafanana here kune avo vari kuenda kuRadiation sekune avo vanogamuchira Cisplatin? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Beta-carotene - A Nutritional Supplement

Iyo yekuwedzera Beta-carotene inosanganisira huwandu hwezvinhu zvinoshanda, kusanganisira Beta-carotene, imwe neimwe iripo panguva dzakasiyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya DNA Kugadzirisa, PI3K-AKT-MTOR Signaling, MAPK Signaling uye Angiogenesis, iyo inoronga zvakakosha zvegomarara padanho remaserura, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza iyo yakakodzera yekuwedzera seBeta-carotene, yega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga nezve kushandisa Beta-carotene yegomarara, zvakakosha kuti utarise izvi zvakasiyana zvinhu uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapa cancer, kushandiswa kweBeta-carotene haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Beta-carotene Supplements

Kutarisana nemubvunzo wekuti 'Ndirini pandinofanira kudzivirira Beta-carotene mumamiriro eCancer' zvinonetsa nekuti mhinduro yacho ndeyemunhu mumwe chete - zvinongoreva 'Zvinoenderana!'. Zvakafanana nemabatiro ekurapa kwegomarara anogona kusashanda kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eBeta-carotene anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yegomarara, genetic predispositions, marapirwo azvino, mamwe ma supplements ari kutorwa, mararamiro, BMI, uye chero allergies zvese zvine basa mukuona kuti Beta-carotene yakakodzera here kana kuti inofanira kudziviswa, zvichisimbisa kukosha kwemunhu. kufunga muzvisarudzo zvakadaro.

1. Ko Beta-carotene Supplements ichabatsira Varwere vePrayimari Yakasiyana-siyana yeLiposarcoma vari kurapwa neRadiation?

Primary Well Differentiated Liposarcoma inoratidzwa nekumwe kushanduka kwemajini, anoti FGFR1, COL1A1 uye ZFHX3, izvo zvinotungamira kune shanduko mubiochemical nzira, kunyanya PI3K-AKT-MTOR Signaling, Angiogenesis, MAPK Signaling, Extracellular Matrix Remodeling uye Epithelial Transfer to Mesen. Kubudirira kwekurapwa kwegomarara, senge Radiation, zvinoenderana nemaitiro ayo ekuita pane idzi nzira dzakananga. Iro zano rakakodzera rinosanganisira kuenzanisa chiito chekurapa nenzira dzinotyaira cancer, nekudaro kuve nechokwadi chemunhu uye nzira inoshanda. Mumamiriro ezvinhu akadai, kudzivirira chikafu kana kudya kunovaka muviri kunogona kupokana nemhedzisiro yekurapa kana kuderedza kurongeka uku kwakakosha. Semuyenzaniso, iyo Beta-carotene yekuwedzera, iyo inobata iyo PI3K-AKT-MTOR Signaling, inogona kunge isiri iyo sarudzo yakanaka munyaya yePrimary Well Differentiated Liposarcoma kana ichiitwa neRadiation. Izvi zvinodaro nekuti zvinogona kuwedzera kufambira mberi kwechirwere kana kukanganisa kushanda kwekurapa. Pakusarudza chirongwa chekudya, zvakakosha kuti utarise zvinhu zvakaita serudzi rwegomarara, marapirwo anoenderera mberi, zera, murume kana mukadzi, BMI, mararamiro, uye chero inozivikanwa genetic mutations.

2. Ko Beta-carotene Supplements ichabatsira Primary Head uye Neck Squamous Cell Carcinoma Varwere vari kurapwa neCisplatin?

Primary Head uye Neck Squamous Cell Carcinoma inoratidzwa nemhando dzakasiyana dzekuchinja, dzakadai seFRG1BP, TP53 uye PCDH11X, izvo zvinoguma nekuchinja mumararamiro ehupenyu, kunyanya DNA Repair, Cell Cycle Checkpoints uye Apoptosis. Kushanda kwekurapa cancer, seCisplatin, kunotemerwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yemunhu yekurapa. Muchirevo chechinyorwa chino, zvekudya kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, iyo Beta-carotene yekuwedzera isarudzo ine musoro kune avo vane Primary Head uye Neck Squamous Cell Carcinoma iri pasi peCisplatin. Izvi zvinodaro nekuti Beta-carotene inokanganisa nzira dzakadai seDNA Repair, iyo inogona kuvharidzira zvinhu zvinotyaira Primary Head uye Neck Squamous Cell Carcinoma kana kubatsira kushanda kweCisplatin.

3. Ko Beta-carotene Supplements Yakachengeteka Kune Vanhu Vane Utano Vane ALK Mutation Associated Genetic Risk?

Makambani akasiyana-siyana anopa gene mapaneru ekuongorora njodzi yemajini emhando dzakasiyana dzegomarara. Aya mapaneru anosanganisira majini akabatana nezamu, ovarian, uterine, prostate, uye gomarara remudumbu. Kuedza aya majini kunogona kusimbisa kuongororwa uye kuzivisa kurapwa uye manejimendi nzira. Kuziva musiyano unokonzera chirwere kunogona kubatsira mukuyedza uye kuongororwa kwehama dzinogona kunge dziri panjodzi. Iyo ALK gene inowanzobatanidzwa mune aya mapaneru ekuongorora njodzi yekenza.

Kuchinja kweiyo ALK gene kunokanganisa nzira dzebiochemical kana maitirwo, akadai seMAPK Signaling uye Growth Factor Signaling, ayo akabatanidzwa zvakananga kana zvisina kunanga mukutyaira cancer padanho remamorekuru. Kana genetic panel yakaratidza shanduko muALK ine chekuita nenjodzi yakawedzera yeCentral Nervous System, chikonzero chesainzi chinoratidza kudzivirira kushandiswa kwekuwedzera Beta-carotene. Izvi zvinodaro nekuti kuwedzera Beta-carotene inopesvedzera nzira senge MAPK Signaling, iyo inogona kutungamira kune yakaipa mhedzisiro mumamiriro eiyo ALK mutation uye ane hukama nekenza mamiriro.

4. Ko Beta-carotene Supplements Yakachengeteka Kune Vanhu Vane Utano Vane TERT Mutation Associated Genetic Risk?

TERT inoita basa rakakosha mukuongorora njodzi yegomarara. Shanduko muTERT inogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira Angiogenesis uye DNA Repair, izvo zvinokanganisa kukura kwegomarara. Kana genetic panel yako ikaratidza shanduko muTERT yakabatana neHematological Cancer, funga kuisa Beta-carotene yekuwedzera muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kukanganisa nzira seAngiogenesis, kubatsirwa nekupa rubatsiro rwakakodzera kune vanhu vane TERT shanduko uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, zvinosanganisira chikafu uye zvekuwedzera seBeta-carotene kune mabhenefiti ayo, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• β-carotene Inodzivisa Kutaura kwe c-Myc uye Cyclin E muHelicobacter pylori-infected Gastric Epithelial Cells.
• Kukura kwekukurudzira kwemasero emunhu pulmonary adenocarcinoma uye madiki epithelial masero emhepo ne beta-carotene kuburikidza ne activation ye cAMP, PKA, CREB uye ERK1/2.
• Iyo PI3-K/AKT-nzira uye nemwaranzi kuramba nzira mune isiri-diki cell cancer yemapapu.
• cBioPortal yeCancer Genomics
• Kukanganisa muDNA Repair Genes Predict Response kune Neoadjuvant Cisplatin-based Chemotherapy muMuscle-invasive Bladder Cancer.
• Pan-cancer kuongororwa kweiyo genomes yakazara.
• Mhedzisiro yePasteurella haemolytica cytotoxin pabovine polymorphonuclear leukocytes inogona kudzikiswa nevanopikisa beta-adrenoceptor.
• cBioPortal yeCancer Genomics
• β-Carotene inhibits neuroblastoma cell invasion uye metastasis in vitro uye in vivo nekuderera kwemazinga e hypoxia-inducible factor-1α.
• Mutational landscape yekenza yemetastatic yakaratidzwa kubva kune vangangove vanotarisirwa kutevedzana kwevarwere zviuru gumi.