Nderipi gomarara raizobatsirwa nekubatanidza Asafoetida mukudya kwavo?

Muchidimbu

Asafoetida inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevarwere vekenza uye avo vari panjodzi yemajini. Asi, kuchengetedzeka uye kushanda kweAsafoetida kune varwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, kumwe kurapwa, uye genetics yebundu. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinachi, zvinogona kudyidzana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye nekubatanidza chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuenzaniso, Asafoetida inogona kubatsira avo vane Primary Penile Squamous Cell Carcinoma vari pasi peMitomycin, asi zvingasava zvakanaka kune varwere vanogamuchira Radiation yePrimary Adamantinoma. Uyezve, nepo Asafoetida inogona kubatsira vanhu vane genetic risk factor "KMT2D", inogona kunge isinga taurirwe kune avo vane genetic ngozi yakasiyana "HRAS". Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kweAsafoetida kune murwere wekenza kunoda kuve munhu mumwe kwakakosha. Zvinhu zvakakosha serudzi rwegomarara, nzira dzekurapa, genetic makeup, genetic njodzi, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Asafoetida iriyo sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, nzira yakazara yesarudzo dzekudya yakakosha, kutarisa kune zvese zvinokonzeresa zvese zvinoshanda zvinoringana muzvokudya / zvekuwedzera seAsafoetida pane kuongorora chimwe nechimwe chinoshandiswa chinoshandiswa zvakasiyana kana kusachifuratira zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Iwe unofanirwa here kuisa Asafoetida mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinokurudzirwa here kushandisa Asafoetida kana iwe uine genetic predisposition kune cancer yakabatana neKMT2D gene? Ko kana pachinzvimbo njodzi yako yemajini ichibva kuHRAS gene? Zvinobatsira here kuisa Asafoetida mukudya kwako kana ukabatwa nePrimary Adamantinoma, kana kuti chirwere chako chiri Primary Penile Squamous Cell Carcinoma? Uyezve, manwiro ako eAsafoetida anofanira kugadziriswa sei kana uri kurapwa neMitomycin kana chirongwa chako chekurapa chichibva kuMitomycin kuenda kuRadiation? Izvo zvakakosha kuti uzive kuti zvirevo zviri nyore senge 'Asafoetida ndezvakasikwa, saka zvinogara zvichibatsira' kana 'Asafoetida inosimudzira kusadzivirirwa kwezvirwere' haina kukwana kune ruzivo rwekudya/yekuwedzera sarudzo.

Uyezve, zvakakosha kuti uongorore zvakare kukodzera kwekubatanidza Asafoetida mukudya kwako kana pane kuchinja muchirongwa chako chekurapa. Muchidimbu, paunenge uchiita sarudzo dzekuisa chikafu kana ma supplements seAsafoetida mukudya kwako nekuda kwemabhenefiti ayo, unofanirwa kufunga nezvesese biochemical mhedzisiro yezvese zvinongedzo, uchifunga nezvemhando dzakadai serudzi rwegomarara, marapirwo chaiwo auri kuita, genetic predispositions. , uye sarudzo dzemararamiro.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana ukangoonekwa uine imwe mhando yegomarara, yakadai sePrimary Penile Squamous Cell Carcinoma kana Primary Adamantinoma, nzira dzekurapa dzinofanirwa kugadziridzwa zvichienderana nebundu remunhu genetics, danho rechirwere, pamwe nezvinhu zvakaita sezera uye murume.

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti ungakonzeresa njodzi dzemajini uye negomarara rekuongororwa kana uchifunga nezvesarudzo dzekudya, senge Asafoetida. Ko genetic njodzi yegomarara kubva mukushanduka muKMT2D ine zvakafanana biochemical nzira nzira sekuchinja muHRAS? Kubva pane zvinovaka muviri, njodzi inosanganisirwa nePrimary Penile Squamous Cell Carcinoma inofanana nePrimary Adamantinoma? Uyezve, kutariswa kwekudya kunoramba kwakafanana here kune avo vari kuita Radiation sekune avo vanogamuchira Mitomycin? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Asafoetida – A Nutritional Supplement

Iyo yekuwedzera Asafoetida inosanganisira huwandu hwezvinhu zvinoshanda, zvinosanganisira Umbelliprenin uye Linoleic Acid, yega yega iripo pane akasiyana siyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya DNA Kugadzirisa, Epithelial kuenda kuMesenchymal Transition, Growth Factor Signaling uye PI3K-AKT-MTOR Signaling, iyo inodzora zvinhu zvakakosha zvegomarara padanho remasero, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza iyo yakakodzera yekuwedzera senge Asafoetida, yega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga nezve kushandisa Asafoetida yegomarara, zvakakosha kuti utarise izvi zvakasiyana siyana uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapa cancer, kushandiswa kweAsafoetida haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Asafoetida Supplements

Kugadzirisa mubvunzo wekuti 'Ndirini pandinofanira kudzivisa Asafoetida mumamiriro ezvinhu eCancer' zvinonetsa nokuti mhinduro yacho ndeyemunhu oga - zvinongoreva 'Zvinoenderana!'. Zvakafanana nemabatiro ekurapa kwegomarara kusingashande kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eAsafoetida anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yekenza, genetic predispositions, kurapwa kwemazuva ano, zvimwe zvinowedzera zviri kutorwa, mararamiro emararamiro, BMI, uye chero kupi zvako kunokonzera zvose zvinotora basa pakuona kuti Asafoetida yakakodzera here kana kuti inofanira kudziviswa, ichisimbisa kukosha kwekufunga kwevanhu zvisarudzo zvakadaro.

1. Ko Asafoetida Supplements ichabatsira Varwere veParamende Adamantinoma vari kurapwa neRadiation?

Primary Adamantinoma inoratidzwa neakanyanya genetic mutations, anoti ARHGAP45, PI4KB uye SDSL, izvo zvinotungamira kune shanduko mubiochemical nzira, kunyanya Epithelial kuMesenchymal Transition uye Inositol Phosphate Signaling. Kubudirira kwekurapwa kwegomarara, senge Radiation, zvinoenderana nemaitiro ayo ekuita pane idzi nzira dzakananga. Iro zano rakakodzera rinosanganisira kuenzanisa chiito chekurapa nenzira dzinotyaira cancer, nekudaro kuve nechokwadi chemunhu uye nzira inoshanda. Mumamiriro ezvinhu akadai, kudzivirira chikafu kana kudya kunovaka muviri kunogona kupokana nemhedzisiro yekurapa kana kuderedza kurongeka uku kwakakosha. Semuenzaniso, iyo Asafoetida yekuwedzera, iyo inobata Epithelial kuMesenchymal Transition, inogona kunge isiri iyo sarudzo yakanaka munyaya yePrimary Adamantinoma kana ichiitwa neRadiation. Izvi zvinodaro nekuti zvinogona kuwedzera kufambira mberi kwechirwere kana kukanganisa kushanda kwekurapa. Pakusarudza chirongwa chekudya, zvakakosha kuti utarise zvinhu zvakaita serudzi rwegomarara, marapirwo anoenderera mberi, zera, murume kana mukadzi, BMI, mararamiro, uye chero inozivikanwa genetic mutations.

2. Ko Asafoetida Supplements ichabatsira here Primary Penile Squamous Cell Carcinoma Varwere vari kurapwa neMitomycin?

Primary Penile Squamous Cell Carcinoma inotaridzwa neakananga genetic mutations, senge ABRAXAS1, PIK3CB uye NUP93, izvo zvinokonzeresa shanduko mubiochemical nzira, kunyanya DNA Repair, Hematopoiesis uye Inositol Phosphate Signaling. Kushanda kwekurapa kenza, seMitomycin, kunotemerwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yemunhu yekurapa. Muchirevo chechinyorwa chino, zvikafu kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, iyo yekuwedzera yeAsafoetida isarudzo ine musoro kune avo vane Primary Penile Squamous Cell Carcinoma iri pasi peMitomycin. Izvi zvinodaro nekuti Asafoetida inokanganisa nzira dzakadai seDNA Repair, iyo inogona kuvharidzira zvinhu zvinotyaira Primary Penile Squamous Cell Carcinoma kana kubatsira kushanda kweMitomycin.

3. Ko Asafoetida Supplements Yakachengeteka Kune Vanhu Vane Utano Vane HRAS Mutation Associated Genetic Risk?

Makambani akasiyana-siyana anopa gene mapaneru ekuongorora njodzi yemajini emhando dzakasiyana dzegomarara. Aya mapaneru anosanganisira majini akabatana nezamu, ovarian, uterine, prostate, uye gomarara remudumbu. Kuedza aya majini kunogona kusimbisa kuongororwa uye kuzivisa kurapwa uye manejimendi nzira. Kuziva musiyano unokonzera chirwere kunogona kubatsira mukuyedza uye kuongororwa kwehama dzinogona kunge dziri panjodzi. Iyo HRAS gene inowanzobatanidzwa mune aya mapaneru ekuongorora njodzi yegomarara.

Shanduko iri muHRAS gene inokanganisa nzira dzebiochemical kana maitiro, akadai seKukura kweFactor Signaling uye RAS-RAF Signaling, ayo anobatanidzwa zvakananga kana zvisina kunanga mukutyaira gomarara padanho remamorekuru. Kana genetic panel yakaratidza shanduko muHRAS ine chekuita nenjodzi yakawedzera yePheochromocytoma Uye Paraganglioma, chikonzero chesainzi chinoratidza kudzivirira kushandiswa kwekuwedzera Asafoetida. Izvi zvinodaro nekuti kuwedzera Asafoetida kunokanganisa nzira dzakaita seKukura Factor Signaling, izvo zvinogona kutungamira kune yakaipa mhedzisiro mumamiriro ekuchinja kweHRAS uye ane hukama nekenza mamiriro.

4. Ko Asafoetida Supplements Yakachengeteka Kune Vanhu Vane Utano Vane KMT2D Mutation Associated Genetic Risk?

KMT2D inoita basa rakakosha mukuongorora njodzi yegomarara. Kuchinja muKMT2D kunogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira PI3K-AKT-MTOR Kuratidzira uye Oncogenic Histone Methylation, iyo inokanganisa kukura kwegomarara. Kana genetic panel yako ichiratidzira shanduko muKMT2D yakabatana neBladder Urothelial Carcinoma, funga kuisa Asafoetida zvinowedzera muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kupesvedzera nzira dzakaita sePI3K-AKT-MTOR Signaling, kubatsirwa nekupa rubatsiro rwakakodzera kune vanhu vane KMT2D shanduko uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, kusanganisira chikafu uye zvekuwedzera senge Asafoetida, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• cBioPortal yeCancer Genomics
• Kuita kwePPAR gamma uye delta ne conjugated linoleic acid inopindirana kudzivirira kubva mukuedza kwechirwere chechirwere chechirwere.
• cBioPortal yeCancer Genomics
• Pan-cancer kuongororwa kweiyo genomes yakazara.
• Cancer therapy inoumba kusimba kwenzvimbo ye clonal hematopoiesis.
• Radio kuramba mumasero egomarara rezamu inoyananiswa kuburikidza neTGF-β kusaina, hybrid epithelial-mesenchymal phenotype uye cancer stem masero.
• Basa re phospholipase D mukutama uye kupinda kunokonzerwa ne linoleic acid mumasero egomarara rezamu.