Nderipi gomarara raizobatsirwa nekubatanidza Alpha Lipoic Acid mukudya kwavo?

Muchidimbu

Alpha Lipoic Acid inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevarwere vegomarara nevaya vari panjodzi yemajini. Asi, kuchengetedzeka uye kushanda kweAlpha Lipoic Acid yevarwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, kumwe marapirwo, uye genetics yebundu. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinachi, zvinogona kudyidzana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye nekubatanidza chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuenzaniso, Alpha Lipoic Acid inogona kubatsira avo vane Primary Glioblastoma vari pasi peTemozolomide, asi zvinogona kunge zvisina kunaka kune varwere vanowana kumwe kurapwa. Uyezve, nepo Alpha Lipoic Acid inogona kubatsira vanhu vane genetic risk factor "CDH1", inogona kunge isingafungirwe kune avo vane imwe genetic njodzi. Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kweAlpha Lipoic Acid kune murwere wegomarara kunofanirwa kuve munhu mumwe kwakakosha. Zvinhu zvakakosha semhando yegomarara, nzira dzekurapa, genetic makeup, genetic njodzi, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Alpha Lipoic Acid iriyo sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, maitiro akazara esarudzo dzechikafu akakosha, tichitarisa pane zvese zvinokonzeresa zvese zvinoshanda zvinoringana muzvikafu / zvekuwedzera seAlpha Lipoic Acid pachinzvimbo chekuongorora chega chega chinoshanda chakasiyana kana kufuratira zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Iwe unofanirwa here kubatanidza Alpha Lipoic Acid mukudya kwako sechinhu chechikafu kana chekuwedzera? Zvinokurudzirwa here kushandisa Alpha Lipoic Acid kana uine genetic predisposition kune cancer yakabatana neCDH1 gene? Ko kana pachinzvimbo njodzi yako yemajini ichibva kune gene? Zvinobatsira here kuisa Alpha Lipoic Acid mukudya kwako kana ukaonekwa uine Primary Glioblastoma? Uyezve, manwiro ako eAlpha Lipoic Acid anofanira kugadziriswa sei kana uri kurapwa neTemozolomide kana chirongwa chako chekurapa chichibva kuTemozolomide? Izvo zvakakosha kuti uzive kuti zvirevo zviri nyore senge 'Alpha Lipoic Acid ndezvakasikwa, saka zvinogara zvichibatsira' kana kuti 'Alpha Lipoic Acid inosimudzira kusadzivirirwa' haina kukwana kune ruzivo rwekudya / yekuwedzera sarudzo.

Pamusoro pezvo, zvakakosha kuti uongorore zvakare ikodzera kwekubatanidza Alpha Lipoic Acid mukudya kwako kana paine shanduko muchirongwa chako chekurapa. Muchidimbu, kana uchiita sarudzo nezve kubatanidza chikafu kana ma supplements seAlpha Lipoic Acid mukudya kwako kune mabhenefiti ayo, iwe unofanirwa kufunga nezvese biochemical mhedzisiro yezvese zvinongedzo, uchifunga zvinhu zvakaita serudzi rwegomarara, kurapwa chaiko kwauri kuita, genetic predispositions, uye sarudzo dzemararamiro.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana ukangoonekwa uine imwe mhando yegomarara, sePrimary Glioblastoma, nzira dzekurapa dzinofanirwa kugadziridzwa zvichienderana nebundu remunhu, danho rechirwere, pamwe nezvinhu zvakaita sezera uye murume.

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti ungakonzeresa njodzi dzemajini uye negomarara rekuongororwa kana uchifunga nezvechikafu sarudzo, senge Alpha Lipoic Acid. Ko genetic njodzi yegomarara kubva mukuchinjika muCDH1 ine zvakafanana biochemical nzira nzira sekuchinja mune imwe gene? Kubva pakuona kwekudya, njodzi inosanganisirwa nePrimary Glioblastoma inofananidzwa nechimwe chiratidzo here? Uyezve, kutariswa kwekudya kunoramba kwakafanana kune avo vari kuita Temozolomide? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Alpha Lipoic Acid - A Nutritional Supplement

Iyo yekuwedzera Alpha Lipoic Acid inosanganisa huwandu hwezvinhu zvinoshanda, zvinosanganisira Alpha Lipoic Acid, yega yega iripo panguva dzakasiyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya PI3K-AKT-MTOR Signaling, iyo inoronga zvakakosha zvegomarara padanho remaserura, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza akakodzera anowedzera seAlpha Lipoic Acid, ega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga kushandisa Alpha Lipoic Acid yegomarara, zvakakosha kuti utarise izvi zvakasiyana zvinhu uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapa cancer, kushandiswa kweAlpha Lipoic Acid haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Alpha Lipoic Acid Supplements

Kugadzirisa mubvunzo wekuti 'Ndirini pandinofanira kudzivirira Alpha Lipoic Acid mumamiriro ezvinhu eCancer' zvinonetsa nekuti mhinduro yacho ndeyemunhu mumwe chete - zvinongoreva 'Zvinoenderana!'. Zvakafanana nemabatiro ekurapa kwegomarara anogona kusashanda kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eAlpha Lipoic Acid anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yegomarara, genetic predispositions, marapirwo aripo, zvimwe zvekuwedzera zviri kutorwa, mararamiro, BMI, uye chero allergies zvese zvine basa mukuona kuti Alpha Lipoic Acid yakakodzera here kana kuti inofanira kudziviswa, zvichisimbisa kukosha kwemunhu. kufunga muzvisarudzo zvakadaro.

1. Ko Alpha Lipoic Acid Supplements ichabatsira Varwere vePrimary Glioblastoma vari kurapwa neTemozolomide?

Primary Glioblastoma inocherechedzwa nechaiyo genetic mutations, seTRBV7-7, TAS2R46 uye TP53, izvo zvinokonzeresa shanduko mubiochemical nzira, kunyanya PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints uye Apoptosis. Kubudirira kwekurapa kenza, seTemozolomide, inotarwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yekurapa yemunhu. Muchirevo chechinyorwa chino, zvekudya kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, iyo Alpha Lipoic Acid yekuwedzera isarudzo ine musoro kune avo vane Primary Glioblastoma vari pasi peTemozolomide. Izvi zvinodaro nekuti Alpha Lipoic Acid inokanganisa nzira dzakadai sePI3K-AKT-MTOR Chiratidzo, chinogona kuvharisa zvinhu zvinotyaira Primary Glioblastoma kana kubatsira kushanda kweTemozolomide.

2. Ko Alpha Lipoic Acid Supplements Yakachengeteka Kune Vanhu Vane Utano Vane CDH1 Mutation Associated Genetic Risk?

CDH1 inobata basa rakakosha mukuongorora njodzi yegomarara. Kuchinja muCDH1 kunogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira PI3K-AKT-MTOR Kuratidzira, Adherens junction uye Epithelial kuMesenchymal Transition, iyo inokonzera kukura kwegomarara. Kana yako genetic panel ikaratidza shanduko muCDH1 yakabatana neGastric Cancer, funga kubatanidza Alpha Lipoic Acid yekuwedzera muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kupesvedzera nzira dzakaita sePI3K-AKT-MTOR Signaling, kubatsirwa nekupa rutsigiro rwakakodzera kune vanhu vane CDH1 shanduko uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, kusanganisira chikafu uye zvekuwedzera seAlpha Lipoic Acid, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• cBioPortal yeCancer Genomics
• NF-κB inoshandiswa mukupindura temozolomide nenzira yeAKT-inotenderera uye inopa dziviriro kubva pakukura kudzvinyirira maitiro emushonga.
• α-Lipoic acid inodzivisa kutama uye kupinda kwemasero emukenza wezamu kuburikidza nekuvharidzirwa kwechiratidzo cheTGFβ.
• Iyo somatic genomic landscape ye glioblastoma.